AMERICAN JOURNAL OF HEMATOLOGY

Volume 60, Number 1, January 1999

ORIGINAL ARTICLES

Primary Thrombophilia in Mexico: A Prospective Study
Guillermo J. Ruiz-Argtielles, Sonia GonzaIez-Estrada, Javier Garces-Eisele, and
Alejandro Ruiz-ArgUelles ............................................................................................................................. 1

Effects of Low Molecular Weight Heparin, Alone or Combined With Antithrombin III, on
Mortality, Fibrin Deposits and Hemostatic Parameters in Endotoxin-induced Disseminated
Intravascular Coagulation in Rabbits
J. Hermida, R. Montes, M.C. Munoz, J. Orbe, J.A. Paramo, and E. Rocha ..................................................... 6

Assessment of Alkaline Phosphatase on the Surface Membrane of Neutrophils
by Immunofluorescence
Masaru Shibano, Takashi Machii, Yoshitaka Nishimori, lchiro Nakamoto, Etsliko Ueda,
Kensaku Masuhara, and Teruo Kitani ............................................................................................................... 12

Use of Platelet Histogram Maximum in Evaluating Thrombocytopenia
Andreas G. Niethammer and Edwin N. Forman .................................................................................................. 19

Deferoxamine Treatment During Pregnancy: Is it Harmful?
Sylvia Titi Singer and Elliott P. Vichinsky .............................................................................................................. 24

Binding of HMG-I(Y) Elicits Structural Changes in a Silencer of the Human p-Globin Gene
Michael B. Chase, Susanne B. Haga, W. David Hankins, Donna M. Williams, Zhigang Bi,
Jeffrey W. Strovel, Christine Obriecht, and Patricia E. Berg ................................................................................... 27

Evidence for Involvement of Tumor Necrosis Factor-a in Apoptotic Death of Bone Marrow Cells
in Myelodysplastic Syndromes
Suneel D. Mundle, Arnbereen Ali, Jonathan D. Cartlidge, Samina Reza, Sairah Alvi,
Margaret M. Showel, B. Yifwayirnare Mativi, Vilasini T. Shetty, Parameswaran Venugopal,
Stephanie A. Gregory, and Azra Raza ..................................................................................................................... 36

CONCISE REVIEWS

Factor XI Deficiency in Women
R.A. Kadir, D.L. Economides, and C.A. Lee ............................................................................................................ 48

Erythropoietin Receptor and Hematological Disease
Mary Frances McMullin and Melanie J. Percy ............................................................................................................. 55

CASE REPORTS

Hepato-Splenic ^8 T-Cell Lymphoma: A Rare Entity Mimicking the Hemophagocytic Syndrome
Annamaria Nosari, Pier Luigi Oreste, Andrea Biondi, Maurizio Caroli Costantini, Luca Santoleri,
Liliana Intropido, Giuliana Muti, Ester Pungolino, Livio Gargantini, and Enrica Morra ............. ...................................... 61

Coagulation Abnormalities in the Carbohydrate-Deficient Glycoprotein Syndrome: Case Report
and Review of the Literature
Guy Young and M. Catherine Driscoll .............................................. ............................................................................. 66

BRIEF REPORTS

Acquired Factor VIII Inhibitors—Successful Treatment With an Oral Outpatient Regimen
Ruthee-Lu Bayer, Stuart M. Lichtman, Steven L. Alien, Daniel R. Budman, Aby Buchbinder,
James Fetten, Jonathan Kolitz, and John Loscaizo .......................................................................................................... 70


Exclusion of the Stomatin, a-Adducin and p-Adducin Loci in a Large Kindred With Dehydrated
Hereditary Stomatocytosis
David Scott Innes, John H. Sinard, Diana M. Gilligan, L. Michael Snyder, Patrick G. Gallagher, and
Jon S. Morrow ..................................................................................................................................................... 72

Severe Tumor Lysis Syndrome Following Splenic Irradiation
Theodor Schifter, Amos Cohen, and Uri H. Lewinski .................................... .......................................................... 75

A Novel Isoform of Platelet Glycoprotein lb(x Is Prevalent in African Americans
Kaelen M. Ararnaki and Alexander P. Reiner ......................................... .................................................................. 77

LETTERS AND CORRESPONDENCE

Platelet Cold Agglutinins and Cardiac Surgery Hypothermia
Nicola Bizzaro .......................................................................................................................................................... 80

The -- THAI and--FIL Determinants of a Thalassemia in Taiwan
Douglas R. Higgs, Helena Ayyub, and Samuel S. Chong ........................................................................................... 80

Fatal G-CSF-Induced Pulmonary Toxicity

Guillerrno J. Ruiz-Arguelles, Daniel Arizpe-Bravo, Sergio Sanchez-Sosa, Sergio Rojas-Ortega,
Valdeinar Moreno-Ford, and Alejandro Ruiz-Arguelles ............................................................................................ 82

The MERRF Mutation of Mitochondrial DNA in the Bone Marrow of a Patient With Acquired
Idiopathic Sideroblastic Anemia
Yan-Ling Wang, Hi-Kyung Choi, Carlo Aul, Norbert Gattermann, and JUrgen Heinisch ............................................. 83

Successful Hydroxyurea Treatment of a Patient With SD Hemoglobinopathy
Mark M. Udden, My-Ngi Lo, and David A. Sears ..................................................................................................... 84

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AMERICAN JOURNAL OF HEMATOLOGY

Volume 60, Number 2, February 1999

ORIGINAL ARTICLES

Acute Promyelocytic Leukemia: All-trans Retinoic Acid (ATRA) Along With Chemotherapy Is
Superior to ATRA Alone
Suresh H. Advani, Reena Nair, Ajay Bapna, Betty Gladstone, Pratibha Kadam, Tapan K. Saikia,
Purvish M. Parekh, Ramakrishnan Gopal, and Chandrica N. Nair ............................. ................................................ 87

Increased Truncated Form of Plasma Tissue Factor Pathway Inhibitor Levels in Patients With
Disseminated Intravascular Coagulation
Minori Shimura, Hideo Wada, Takashi Nakasaki, Katsuyo Hiyoyama, Yositaka Mori,
Masakatsli Nishikawa, Hiroshi Deguchi, Katsumi Deglichi, Esteban C. Gabazza, and Hiroshi Shiku . . . . ................... 94

Epstein-Barr Virus Infection in Richter's Transformation
Stephen M. Ansell, Chin-Yang Li, Ricardo V. Lloyd, and Robert L. Phyliky .............................................................. 99

Circulating Cytokines Response and the Level of Erythropoiesis in Sickle Cell Anemia
Helena Croizat and Ronald L. Nagel ......................................................................................................................... 105

Schistocytosis and a Thrombotic Microangiopathy-Like Syndrome in Hospitalized
HIV-Infected Patients
Richard D. Moore .................................................................................................................................................... 116

Serum Transferrin Receptor as a Marker of Erythropoiesis Suppression in Patients on
Chronic Transfusion
Jakica Tancabelic, Sujit Sheth, Myunghee Paik, and Sergio Piomelli ........................................................................... 121

A Novel and De Novo Spontaneous Point Mutation (Glu271STOP) of the Antithrombin Gene
Results in a Type I Deficiency and Thrombophilia
Michael D. Tarantino, Sharon M. Curtis, G. Stephan Johnson, John S. Waye, and Morris A. Blajchman . .................. . 126

Pulmonary Hypertension in Patients With Myelofibrosis Secondary to Myeloproliferative Diseases
Guillermo Garcfa-Manero, Stephen J. Schuster, Herbert Patrick, and Jose Martinez ..................................................... 130

CASE REPORTS

Neonatal Hyperbilirubinemia Associated With Southeast Asian Ovalocytosis
Vichai Laosombat, Supaporn Dissaneevate, Chayanon Peerapittayarnongkol, and Masafumi Matsuo . . .......................... 136

Myeloma Ascites—A Favorable Outcome With Cyclophosphamide Therapy
Dean Keren, Lilian Schliamser, Dina Adas, Daniel Yeshurun, and Eli Zuckerman .............................................................. 140

Chronic Eosinophilic Pneumonia Associated With Cutaneous T-Cell Lymphoma
Boaz Hirshberg, Mordechai R. Kramer, Michal Lotem, Vivian Barak, Larisa Shustin, Gail Amir,
Dina Ben-Yehuda, and Arie Ben-Yehuda ......................................................................................................................... 143

Hydroxyurea Use During Pregnancy: A Case Report in Sickle Cell Disease and Review of
the Literature
Orna Diav-Citrin, Laura Hunnisett, Graham D. Sher, and Gideon Keren ........................................................................... 148

Idiopathic Immune-Mediated Acquired von Willebrand's Disease in a Patient With
Angiodysplasia: Demonstration of an Unusual Inhibitor Causing a Functional Defect and Rapid
Clearance of von Willebrand Factor
Salah A. Aihumood, Dana V. Devine, Laurie Lawson, Stephen H. Nantel, and Cedric J. Carter ........................................ 151


BRIEF REPORTS

Heterogeneity of Clonal Development in Chronic Myeloproliferative Disorders
Anna Maria Ferraris, Rosa Mangerini, Omar Racchi, Davide Rapezzi, Michela Rolfo, Salvatore Casciaro,
and Gian Franco Gaetani ............................................................................................................................................ 158

Quiescent Nasal T/NK Cell Lymplioma Manifested as Primary Central Nervous
System Lymphoma
Kun-Huei Yeh, Huang-Chun Lien, Su-Ming Hsu, and Ann-Lii Cheng ........................................................................... 161

Persistent Parvovirus B19 Related Anemia of Seven Years' Duration in an HIV-Infected Patient:
Complete Remission Associated With Highly Active Antiretroviral Therapy
Eleftherios Mylonakis, Brian P. Dickinson, Maria D. Mileno, Timothy Flanigan, Fred J. Schiffman,
Anthony Mega, and Josiah D. Rich ............................................................................................................................. 164

LETTERS AND CORRESPONDENCE

Lymphadenopathy Associated With Monoamine Oxidase Inhibitors
Andre M. Kallab, Eileen M. Marley, and Debra Frei-Lahr .......................................................................................... 167

Fulminant Brain Lymphoid Infiltration in a Patient With Chronic Lymphocytic Leukemia
Venancio Conesa, Angela Mompel, Jose Ruiz, Amparo Gornez, Pascual Fernandez, Javier Lucas, and
Ignacio Aranda ........................................................................................................................................................... 167

Successful Treatment for Acute Lymphoblastic Leukemia Without Blood Transfusion in a
Jehovah's Witness
Shogo Takeuchi, Atae Utsunomiya, Torahiko Makino, Shigemi Shimotakahara, Yoshifusa Takatsuka,
Hisashi Kawabata, and Akira Nakashima ............................................. ........................................................................168

Possible Role of Soyabean Therapy in Isolated Platelet Factor 3 (PF3) Availability Defect
R. Saxena, V.P. Choudhry, D.K. Mishra, R. Kashyap, and S. Mohanty ........................................................................ 170

Acute Promyelocytic Leukemia Relapse in the Central Nervous System During Hematologic and
Molecular Remission
Eduardo Anguita, Ana Villegas, F. Ataulfo Gonzalez, Joaqum Dfaz-Mediavilla, and Francesco Lo Coco . ..................... 170

Thrombotic Thrombocytopenic Purpura
Mehtap Yeter and Goksen Bagcecik ............................................................................................................................ 171

CORRIGENDUM

Molecular Characterization of the - Fil- Determinant ofAlpha-Thalassemia
Tsang-Ming Ko and Shue-Fun Li ................................................................................................................................. 173

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AMERICAN JOURNAL OF HEMATOLOGY

Volume 60, Number 3 , March 1999

ORIGINAL ARTICLES

Decreased Plasma Tissue Factor Pathway Inhibitor in Women Taking Combined
Oral Contraceptives

Geoffrey M. Harris, Caroline L. Stendt, Beverley J. Vollenhoven, T. Eng Gan, and
Peter G. Tipping .............................................................................................................................................................. 175

Lack of Association Between Venous Thrombosis and Subsequent Malignancy in a Retrospective
Cohort Study in Young Patients
Maricel Subira, Jose Mateo, Juan C. Souto, Albert Altes, and Jordi Foutcuberta .............................................................. 181

Serum Macrophage Colony-Stimulating Factor (M-CSF) Level Is Klevated in Patients With Old
Cerebral Infarction Related to Vascular Damage
Akira Suehiro, Hiroshi Tsujioka, Hiroshi Yoshimoto, Satoshi Higasa, and Eizo Kakishita ................................................... 185

Expression of Bcl-2 by Human Bone Marrow Mast Cells and its Overexpression in Mast
Cell Leukemia
Carlos Cervero, Luis Escribano, Jesus F. San Miguel, Beatriz Dfaz-Agustfn, Pilar Bravo, Jesus
Villarrubia, Ramon Garcia-Sanz, Jose L. Velasco, Pilar Herrera, Mario Vargas, Marcos Gonzalez,
Jose L. Navarro, and Alberto Orfao ................................................................................................................................. 191

Study of Fibrinolytic Parameters in Different Types of Polycythemia
G. Lugassy and 1. Filin ..................................................................................................................................................... 196

Myelodysplastic Syndromes With Nephrotic Syndrome
Takayuki Saitoh, Hirokazu Murakami, Hideki LJchiumi, Kazliaki Moridaira, Tadashi Maehara,
Takafumi Matsushima, Norifumi Tsukamoto, Jun'ichi Tamura, Masamitsu Karasawa, Takuji Naruse,
and Jun Tsuchiya .............................................................................................................................................................. 200

Detection of Epstein-Barr Virus in Korean Peripheral T-Cell Lymphoma
Jooryung Hub, Kwanghyun Cho, Dae Seog Heo, Ji Eun Kirn, and Chul Woo Kim ............................................................ 205

CASE REPORTS

Human Herpesvirus-8 (HHV-8) Associated With Small Non-Cleaved Cell Lymphoma in a Child
With AIDS

Charles T. Leach, Christopher Frantz, David R. Head, Shou-Jiang Gao, Kenneth L. McClain,
Maimon Cohen, Andrew B. Campbell, Brad H. Pollock, Sharon B. Murphy, and Hal B. Jenson ......................................... 215

Successful Treatment of Persistent Erythroid Aplasia Caused by Parvovirus B19 Infection in a
Patient With Common Variable Immunodeficiency With Low-Dose Immunoglobulin
Tatsuya Chuhjo, Shinji Nakao, and Tamotsu Matsuda ........................................................................................................ 222

Danazol Therapy in Cyclic Acquired Amegakaryocytic Thrombocytopenic Purpura:
A Case Report
Rajesh Kashyap, V.P. Choudhry, and H.P. Pati ............................................................................................................ 225

Waldenstrom's Macroglobulinemia in Young African-American Adults
Shabbir Ahrned, Muhammad S. Shurafa, Carter R. Bishop, and Mary Varterasian ............................................................. 229

Anticoagulant-Induced Skin Necrosis in a Patient With Hereditary Deficiency of Protein S
David Gailani and Eugene P. Reese, Jr. .............................................................................................................................. 231


BRIEF REPORTS

Takayasu's Arteritis Associated With Factor V Leiden
Daniel D. Shin and John E. Godwin .................................................................................................................... 237

Risk Factors for Thrombosis in Nonembolic Cerebrovascular Disease
Sujata Mohanty, Renu Saxena, and Madhuri Behari ............................................................................................ 239

Vitamin E (a-Tocopherol) Does Not Inhibit Platelet Stimulation by Oxidized Low Density
Lipoprotein In Vitro
T. Szliwart, R.B. Dierichs, and B. Zhao .............................................................................................................. 242

Successful Prevention of Post-Transfusion Rh Alloimmunization by Intravenous Rho (D) Immune
Globulin (WinRho SD)
Barry Andersen, Aziza T. Shad, Joseph E. Goolenberg, and S. Gerald Sandier ...................................................... 245

LETTERS AND CORRESPONDENCE

A Case of Primary Refractory Hodgkin's Disease Treated Successfully With Paclitaxel
Andre M. Kallab and Paul Dainer .......................................................................................................................... 248

Recurrent Lymphocytic Pleural Effusion After Intravenous Immunoglobulin
Javier Bolanos-Meade, Yi-Kong Keung, and Everardo Cobos .............................................................................. 248

Analysis of the Sinad5 Gene in Hematological Malignancies
Takayuki Ikezoe, Seisho Takeuchi, Makoto Kobayashi, and Hirokuni Taguchi ......................................................... 249

Vancomycin-Associated Thrombocytopenia: Case Report and Review of the Literature
Janaki C. Kuruppu, Thong P. Le, and Carmelita U. Tuazon ..................................................................................... 249

Hemoglobin SC and Multiple Myeloma
Aryel Nicoleau, Barry Kaplan, and Jean D. Baizora ................................................................................................ 250

Desmoid Tumors Supervening in Two Patients With Chronic Lymphocytic Leukemia
Marc Pulik, Laure Jary, Francois Lionnet, Philippe Genet, Alain Gaulier, and Hossein Mossafa ................................. 251

Severe Life-Threatening Hyperphosphatemia Associated With Tumor Lysis in a Patient With
Acute Lymphoblastic Leukemia
Haralampos J. Milionis and Moses S. Elisaf .............................................................................................................. 252

Low Seroprevalence of Helicobacter pylori in Patients With Leukemia
Yoshil^iro Matsukawa, Takeyoshi ltoh, Susurnu Nisliinarita, Toshiteru Ohshirna, Takashi Horie,
Shin Aizawa, Akitaka SuzLiki, Keisuke Toyama, Satoshi Takahashi, Shigetaka Asano, and
Tetsuya Mine .......................................................................................................................................................... 253

Uterine Infiltration as First Sign of Acute Myeloid Leukemia
Thomas Matthes, Claudia Collao, Kaveh Sarnii, Bernard Cliapuis, Christophe Girardet, and
Sophie Diebold-Berger .................................................................................................................................................. 253

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AMERICAN JOURNAL OF HEMATOLOGY

Volume 60, Number 4 , April 1999

ORIGINAL ARTICLES

Effects of Methylprednisolone on Human Myeloid Leukemic Cells In Vitro
Narnik Ozbek, Esra Erdemli, Gonul Hicsonmez, Hamza Okur, and Meral Tekelioglu ........................................................ 255

Modifications in Accessibility of Membrane Glycoproteins, Binding of Specific Ligands and
Coagulation Factor V During the Activation of Platelets in Blood Emerging From Bleeding
Time Wounds
Gines Escolar, Miguel Lozano, Maribel Diaz-Ricart, Gundu H.R. Rao, Antonio Ordinas, and
James G. White ........................................................................................................................................................... 260

Role of Positron Emission Tomography in Determining the Extent of CNS Ischemia in Patients
With Sickle Cell Disease
W. Reed, W. Jagust, M. AI-Mateen, and E. Vichinsky .................................................................................................... 268

Hemostatic Molecular Markers Before the Onset of Disseminated Intravascular Coagulation
Hideo Wada, Nobuo Sakuragawa, Yositaka Mori, Mikio Takagi, Takahiro Nakasaki, Minori Shimura,
Kazuyo Hiyoyarna, Masakatu Nisikawa, Esteban C. Gabazza, Katsurni Deglichi, Mutuyoshi Kazama,
and Hiroshi Shiku ............................................................................................................................................................. 273

Hemoglobin S/OARAB: Thirteen New Cases and Review of the Literature
Sherri A. Zimmerman, Erin E. O'Branski, Wendell F. Rosse, and Russell E. Ware ............................................................ 279

Autologous Rosette Formation by Human Blood Monocyte-Derived Macrophages
and Lymphocytes
Humberto R.A. Cabral and lvon T.C. Novak ................................................................................................................... 285

Assessment of Iron Stores in Children With Transfusion Siderosis by Biomagnetic
Liver Susceptometry

Roland Fischer, Christian D. Tiemann, Rainer Engelhardt, Peter Nielsen, Matthias Dlirken,
Erich E. Gabbe, and Gritta E. Janka ......................................................................................................................... 289

CASE REPORTS

Acute Promyelocytic Leukemia After Treatment for Non-Hodgkin's Lymphoma With Drugs
Targeting Topoisomerase II
A. De Renzo, L.F.E. Santoro, R. Notaro, F. Pane, M.R. Buonaluto, L. Luciano, and B. Rotoli ........................................ 300

Abnormal Proliferation of CD4- CD8 +rD+ T Cells With Chromosome 6 Anomaly: Role of Fas
Ligand Expression in Spontaneous Regression of the Cells
Naoaki Ichikawa, Kiyoshi Kitano, Toshiro lto, Takayuki Nakazawa, Shigetaka Shimodaira,
Furnihiro Ishida, and Kendo Kiyosawa ..................................................................................................................... 305

BRIEF REPORT

Identification of a New Candidate Mutation, G1629R, in a Family With Type 2A
von Willebrand Disease
Pilar Casana, Francisco Martfnez, SatLirnino Haya, and Jose A. Aznar ............................................................................. 309

LETTERS AND CORRESPONDENCE

\\\~trans Retinoic Acid-Induced Multiple Mononeuropathies
Satoshi Yarnaji, Heiwa Kanamori, Aki Mishirna, Shin Fujisawa, Shigeki Motornura, and
Hiroshi Mohri ................................................................................................................................................................. 311


Soft Drink Abuse, Malnutrition, and Folic Acid Deficiency
Guyiaine Gaudet and Jacques Laplante ................................................................................................. 311

Sex Difference in Myeloperoxidase Activity of Neutrophils
Osamu Kabutomori, Takehiko Yanagihara, Yoshinori lwatani, Atsushi Kawarazaki, and
Miwako Kabutomori ...................................................................................................................................... 312

Case of Hepatosplenic yfi T-Cell Lyniphonia Presenting With Severe Hypersplenism
Guncag Dincol, Meliha Nalcaci, A. Selim Yavuz, Huseyin Keskin, Melih Aktan, Oner Dogan,
Mehrnet Agan, Ugur Ozbek, and Koray Din^ol ........................................................................................ 313

Author Index to Volume 60 .......................................................................................................................... 315
Subject Index to Volume 60 .......................................................................................................................... 318

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AMERICAN JOURNAL OF HEMATOLOGY

VOL. 61, NO. 1, 1999

ORIGINAL ARTICLES

A Novel 105 Basepair Deletion Causing ^-Thalassemia in Members of a Thai Family
Chamnong Nopparatana, Vannarat Saechan, Chawadee Nopparatana, Malida Pornpatkul, Vicharn Panich,
and Yasuyuki Fukumaki ................................................................................................................................................. 1

Telomere Length Shortening Is Associated With Disease Evolution in Chronic
Myelogenous Leukemia
Jackie Boultwood, Carrie Fidler, Patricia Shepherd, Fiona Watkins, Joanna Snowball,
Sara Haynes, Rajko Kusec, Alex Gaiger, Timothy J. Littlewood, Andrew J. Peniket, and
James S. Wainscoat ........................................................................................................................................................ 5

Population-Based Incidence and Survival Figures in Essential Thrombocythemia and Agnogenic
Myeloid Metaplasia: An Olmsted County Study, 1976-1995
Ruben A. Mesa, Murray N. Silverstein, Steven J. Jacobsen, Peter C. Wollan, and
Ayalew Tefferi .................................................................................................................................................................. 10

Chronic Pure Red Cell Aplasia Caused by Parvovirus B19 in AIDS: Use of Intravenous
Immunoglobulin—A Report of Eight Patients
Prasad Rao Koduri, Rudolf Kurnapley, Jose Valladares, and Caroline Teter ..................................................................... 16

Plasma sFas and sFas Ligand Levels in Patients With Thrombotic Thrombocytopenic Purpura
and in Those With Disseminated Intravascular Coagulation
Yasuhide Hori, Hideo Wada, Yoshitaka Mori, Minori Shirnura, Kazuyo Hiyoyarna, Takahiro Nakasaki,
Kazuhiro Nishii, Shigehisa Tamaki, Masakatsu Nishikawa, Katsurni Deguchi, Nobuyuki Minami, and
Hiroshi Shiku ..................................................................................................................................................................... 21

Restricted Diversification of T-Cells in Chronic Active Epstein-Barr Virus Infection: Potential
Inclination to T-Lymphoproliferative Disease
Shouichi Ohga, Nobuhiro Kimura, Hidetoshi Takada. Mituyuki Nagano, Kohichi Ohshima,
Akihiko Nomura, Kenji Muraoka, Hiromichi Take, Shunji Yamamori, and Toshiro Hara ................................................... 26

Activation of Coagulation Factor VII by Tissue-Type Plasminogen Activator
Hiroshi Tsujioka, Akira Suehiro, and Eizo Kakishita .................................... ....................................................................... 34

Spontaneous Erythroid Colony Formation in Brazilian Patients With Sickle Cell Disease
R.C.R. Perlingeiro, F.F. Costa, S.T.O. Saad, V.R. Arruda, and M.L.S. Queiroz ............................................................... 40

Expression of Regeneration and Tolerance Factor on B Cell Chronic Lymphocytic Leukemias:
A Possible Mechanism for Escaping Immune Surveillance
Cheryl J. Aslakson, Gerald Lee, Jonathan S. Boomer, Alice Gilman-Sachs, Omer Kucuk, and
Kenneth D. Beaman .......................................................................................................................................................... 46

TECHNIQUE

Determination of Heparin-induced Thrombocytopenia: A Rapid Flow Cytometric Assay for Direct
Demonstration of Antibody-Mediated Platelet Activation
Aaron Tomer, Cynthia Masalunga, and Thomas C. Abshire ................................................................................................ 53


CASE REPORTS

Sebastian Syndrome: Case Report and Review of the Literature
Guy Young, Naomi L.C. Luban, and James G. White ...................................................................................... 62

Hyperfibrinolysis in a Case of Myelodysplastic Syndrome With Leukemic Spread of Mast Cells
F. Wimazal, W.R. Sperr, H.-P. Horny, V. Carroll, B.R. Binder, C. Fonatsch, S. Walchshofer,
M. Fodinger, 1. Schwarzinger, P. Samorapoompichit, A. Chott, A.M. Dvorak, K. Lechner, and
P. Valent .......................................................................................................................................................... 66

BRIEF REPORT

High Prevalence of HTLV-I Infection Among the Family Members of a Patient With Adult T-Cell
Leukemia/Lymphoma From Northeastern Japan
Kazuyuki Shimizu ............................................................ .................................................................................... 78

LETTERS AND CORRESPONDENCE

Acute Intravascular Haemolytic Transfusion Reaction Due to Anti-c Undetected by Conventional
Pretransfusion Cross-Matching Tests
Dileshwari Pradhan and Rajendra Chaudhary .......................................................................................................... 82

Trisomy 10 in Adult Pre-B-Cell Leukemia
Atsuo Okamura, Akinori Yamaguchi, Shinichi Shimizu, Seizo Kadowaki, Kazuo Chihara,
Toshimitsu Matsui, Takao Fujimoto, Kaori Kanki, and Kazuyoshi Fujio .................................................................... 83

Thrombotic Thrombocytopenic Purpura and Hypothyroidism
J.M. Durand, C. Gautier, S. Salas, F. Retornaz, and P. Lefevre ............................. .................................................... 83

_______________________________________

AMERICAN JOURNAL OF HEMATOLOGY

Volume 61, Number 3 , July 1999

ORIGINAL ARTICLES

Advanced Stage and Unfavorable Hodgkin's Disease in the Chinese—a 20-Year Experience
C.S. Chim, Y.L. Kwong, A.K.W. Lie, C.K. Lee, RC.S. Ho, and R. Liang ...................... ......................................159

Regional Patterns in the Incidence of Aplastic Anemia in Thailand
Surapol Issaragrisil, Paul E. Leaverton, Kanchana Chansung, Tharatorn Thamprasit,
Yaowarat Porapakharn, Sathit Vannasaeng, Anong Piankijaglim, David W. Kaufinan,
Theresa E. Anderson, Samuel Shapiro, Neal S. Young, and the Aplastic Anemia Study Group ................................ 164

Hematopoietic Differentiation Activity of a Recomhinant Human lnterleukin-6 (IL-6) Isoform
Resulting from Alternatively Spliced Deletion of the Second Exon
Daniel P. Kestler, Keith M. Goldstein, Sujata Agarwal, Joseph E. Fuhr, Richard Andrews, and
Robert E. Hall ........................................................................................................................................................ 169

CD7 Expression on CD34+ Cells from Chronic Myeloid Leukaemia in Chronic Phase
G.A. Martm-Henao, R. Quiroga, A. Sureda, J. Garcia ............................................................................................. 178

Hb Iraq-Halabja 310 (A7) Ala- Val (GCC->GTC): A New B-Chain Silent Variant in a Family
with Multiple Hb Disorders
S. Deutsch, R. Darbellay, R. Offord, A. Frutiger, J. Kister, H. Wajcman, and Ph. Beris ............................................ 187

Effect of Zinc Supplementation on Incidence of Infections and Hospital Admissions in Sickle
Cell Disease (SCD)
Ananda S. Prasad, Frances W.J. Beck, Joseph Kaplan, Pranatharthi H. Chandrasekar, Jesus Ortega,
James T. Fitzgerald, and Paul Swerdlow .................................................................................................................... 194

IMAGES IN HEMATOLOGY

Multiple Myeloma in the Breast
Kenneth 1. Ataga, Mark L. Graham, Ha N. Evans, Patricia Braeuning, and Eugene P. Orringer .................................... 203

CASE REPORTS

Acute Profound Thrombocytopenia Following C7E3 Fab (Abciximab) Therapy: Case Reports,
Review of the Literature and Implications for Therapy
Steven J. Jubelirer, Both A. Koenig, and Mark C. Bates ................................................................................................ 205

Acute Pure Red Cell Aplasia Associated with Allopurinol Therapy
Ying-Wei Lin, Shin Okazaki, Keigo Hamahata, Ken-ichiro Watanabe, lkuya Usami,
Muneo Yoshibayashi, Yuichi Akiyama, and Masaru Kubota ........................................................................................... 209

Portal, Mesenteric, and Splenic Vein Thromboses After Splenectomy in a Patient With Chronic
Myeloid Leukemia Variant With Thrombocythemic Onset
Je Jung Lee, Hyeoung Joon Kim, lk Joo Chung, Moo Rim Park, Kang Seok See, Yong Yeon Jeong,
and Jae Kyu Kim ...................................................................................................................................................... 212


LETTERS AND CORRESPONDENCE

Undetectable Plasma L-Arginine Level before Visible Hemolysis in Thrombotic
Thrombocytopenic Purpura
William H. Waugh, Charles L. Knupp, and Daria K. Liles .......................................................................... 216

Parkinson's Syndrome Preceding Clinical Manifestation of Gaucher's Disease
Maciej Machaczka, Malgorzata Rucinska, Aleksander B. Skotnicki, and Wojciech Jurczak .......................... 216

Multiple Myeloma Presenting As Sjogren's Syndrome
S.A.W. Fadilah and S.K. Cheong .................................................................................................................. 217

Lack of Compliance and Late-Onset Warfarin-induced Skin Necrosis
Prasad Rao Koduri and Rabia Parveez ........................................................................................................... 218

Evan's Syndrome Precipitated by Fludarabine Therapy in a Case of CLL
Kaushik Sen and Matt Kalaycio ...................................................................................................................... 219


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AMERICAN JOURNAL OF HEMATOLOGY

Volume 61, Number 4 , August 1999



ORIGINAL ARTICLES


Paroxysmal Nocturnal Hemoglobinuria: Analysis of the Effects of Mlitant PIG-A on
Gene Expression
Nobuko Kanai, Theresa M. Vreeke, and Charles J. Parker 221



Prognostic Significance of the S-phase Fraction of Light-Chain-Rcstricted Cytoplasmic
Immunoglobulin (cig) Positive Plasma Cells in Patients with Newly Diagnosed Multiple Myelonia
Enrolled on Eastern Cooperative Oncology Group Treatment Trial E9486
M.C. Trendle, T. Leong, R.A. Kylc, J.A, Kat/mann, MM. Oken, N.E. Kay, B.G. Van Ness. and
P.R. Greipp . 232



Changes of Plasma Hemostatic Markers during Percutaneous Transluminal Coronary Augioplasty
in Patients with Chronic Coronary Artery Disease
Yasuhiro Saito, Hideo Wada, Miho Yamamuro, Akiko Inoue, Minon Shimlini, Kazyo Hiyoyama,
Esteban C, Gabazza, Naoki Isaka, Hiroshi Shiku. Himyliki Takeya, Koji Suzuki, Kolisuke Kumeda,
Hisao Kato, and Takeshi Nakano 238


Up-Regulation ofAmphotrophic Retroviral Receptor Expression in Human Peripheral Blood
CD34+ Cells
Andreas Kaubisch, Maureen Ward, Stuti Schoetz, Cliarles nesdoifTer, and Artluir Bank 243


IMAGES IN HEMATOLOGY


Microangiopathic Hemolytic Anemia Associated with Metastatic Breast Carcinoma
Kenneth I. Ataga and Mark L. Graham 254


CASE REPORT


Expression of Fas Ligand in Langerhans' Cell Histiocytosis: A Case Report of a Boy with
Multisystem Involvement
Ching-Tien Peng, Kuan-Chih Chow, Wu-Chung Chang, Chang-Hai Tsai, Tze-Yi Lin. Sheng-Shing Lin,
and Chan-Fang Chiu 256


BRIEF REPORTS


Secondary Hemochromatosis as a Long-Term Complication of tlie Treatment of
Hematologic Malignancies
Stuart M. Lichtman, Lori Attivissimo, Ira S. Goidman, Michael W, Schuster, and
Aby Buchbinder 262


Prevalence of Factor V Leiden, Prothrombin G20210A, and MTIIFR 0677T Mutations in a Greek
Population of Blood Donors
T. Antoniadi, T. Hatzis, C. Kroupis, E, Econoinou-Petersen, and M,B. Petersea 265


Thrombotic Thrombocytopenic Purpura—Hemolytic Uremic Syndrome (TTP-HVS) Following
Treatment with Deoxycoformycin in a Patient with Cutaneous T-Cell Lymphonia (Senary
Syndrome): A Case Report
Joseph W. Leach, Trinh Pham, Dimitris Diamandidis, and James N. George 268



Low Fibrinogen Level: A Predisposing Factor for Venous Thromhoembolic Events with Hormone
Replacement Therapy
Maura K. Whiteman, Yadong Cui, Jodi A. Flaws, Mark Espeland, and Trudy L. Bush 271

LETTERS AND CORRESPONDENCE

Transitional Pre-B-Cell Acute Lymphoblastic Leukemia in Adults
Xavier Lopez-Karpovilch and JoseFa Pieciras 274



Mixed Connective Tissue Disease with Heinolytic Anemia and Severe Thrombocytopenia due to
Throinbotic Thrombocytopenic Purpura
Pascalc Poullin, Patrice Lefevre, and Jean Marc Durand 275



Absence of C282Y and H63D Mutations of the Hemochromatosis Gene in Japanese Patients with
Sidcroblastic Anemia
K. Furuyama, M, Kondo, H. Fujita, N. Hayashi, K.E. Andersen, and S. Sassa 276



ERRATUM 277


ANNOUNCEMENT 278


Author Index to Volume 61 279


Subject Index to Volume 61 282


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AMERICAN JOURNAL OF HEMATOLOGY
Volume 62, Number 1, September 1999




ORIGINAL ARTICLES
Outpatient Management of Fever in Children With Skkle Cell Disease (SCD) in an African
Setting
Mohamed CherifRahimy, Annick Gangbo, Gilbert Ahouignan, Severin Anagonou, Vlcencia Boco, and
Eusebe Alihonou 1




Phenotypic Variability of Filipino (beta) (omicron)Thalassemia/HbE Patients in Indonesia
lswari Setianingsih, Robert Williamson, Dasril Daud. Alida Harahap. Sangkot Marzuki, and
Susan Forrest 7



Stability and Sterility of a Recombinant Factor VIII Concentrate Prepared for Continnous
Infusion Administration
Asim F. Belgaumi, Christian C, Patrick, and Stevcn R, Deilcher 13


N-Acetylcysteine and Clotrimazole Inhibit Sickle Erythrocyte Dehydration Induced
by l-Chloro-2,4-Dinitrobenzene
Archil Shanava. Arvind K. Shah, and Steven R. Goodman 19



Molecular Basis for Rh(null) Syndrome: Identification of Three New Missense Mutations in the Rh50
Glycoprotein Gene
Cheng-Han Huang, Guangjie Cheng, Zhi Liu, Ying Chen, Marion E. Reid, Gregory Halverson, and
Yasuto Okubo 25



In yitro Effect on Human Leukemic K562 Cells of Co-Administration of Liposome-Associated
Reiinoids and Cytosine Arabinoside (Ara-C)
R. Cortesi, V. Gui, R. Gambari, and C. Nastruzzi 33



CASE REPORTS
Multicentric Warfarin-Induced Skin Necrosis Complicating Heparin-induced Thrombocytopenia
Theodore E. Warkentin, William M. Sikov, and David P. Lillicrap 44



Loss of Maternal Allele in a Child With Myelodysplastic Syndrome and Monosomy 7
Dilek Aktas, Idil Yenicesu, Gonul Hicsonmez, and Ergul Tuncbiiek 49


Carbamazepine-induced Thrombocytopenia Delmed by a Challenge Test
Takashi Ishikita, Akira Ishiguro, Kohji Fujisawc, Ichiro Tsukimoto, and Tosbikazu Shimbo 52


BRIEF REPORTS

Splenectomy During Partial Remission in Thrombotic Thrombocytopenic Purpura With Prolonged
Plasma Exchange Dependency
Michael J. Mant, A. Robert Turner, D. Bruce C. Ritchie, and Loree M, Larralt 56


Spontaneous Venous Thrombosis in a Young Patient With Combined Factor V Leiden and
Lupus Anticoagulant
Francisco F. Lopez, Joseph D- Sweeney, Abbe J> Blair, and William M, Sikov 58


LETTERS AND CORRESPONDENCE

Pernicious Anemia (PA) Subsequent to Insulin-Dependent Diabetes Mellitus and ldiopathic
Thrombocytopenic Purpura, and Elects of Oral Cobalannn on PA
Haruki Kondo and Takaaki Jmamura 61



A 78-Year-Old Man With Sickle-Cell Anemia
Prasad Rao Koduri. Monica Leon, George R, Honig, and Shi-Jiang Lu 62



Splenic Infarction From Factor V Leiden Mutation
Francisco Lopez, Anthony Mega, Fred Schiffman, and Joseph Sweeney 62



Possible CyclosporIn-Danazol Interaction in a Patient With Aplastic Anaen
J, Borras-Blasco, J.D. Rosique-Robles, J, Peris-Marti, J. Navarro-Ruiz, M. GonzaIez-Delgado, and
V. Conesa-Garcia 63

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