Annual Review of Immunology

Volume 17 (1999)

CONTENTS

DISCOVERING THE ORIGINS OF IMMUNOLOGICAL COMPETENCE,

Jacques F. A. P. Miller 1

THE MULTIFACETED REGULATION OF lNTERLEUKIN-15 EXPRESSION

AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION

AND HOST RESPONSE TO INTRACELLULAR PATHOGENS,

T. A. Waldmann and Y. Tagaya 19

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX

CLASS I-RESTRICTED T LYMPHOCYTE RESPONSES,

Jonathan W. Yewdell and Jack R. Bennink 51

INTEGRATION OF T CELL RECEPTOR-DEPENDENT SIGNALING

PATHWAYS BY ADAPTER PROTEINS, James L. Clements,

Nancy J. Boerth, Jong Ran Lee, and Gary A. Koretiky 89

EVOLUTION OF ANTIGEN BINDING RECEPTORS, Gary W. Litman,

Michele K. Anderson, and Jonathan P. Rast 109

TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT

AND FUNCTION, Chay T. Kuo and Jeffrey M. Leiden 149

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: FUNCTION AND

REGULATION BY INNATE CYTOKINES, Christine A. Biron,

Khuong B. Nguyen, Gary C. Pien, Leslie P. Cousens,

and Thais P. Salazar-Mather 189

MATURE T LYMPHOCYTE APOPTOSIS-IMMUNE REGULATION IN A

DYNAMIC AND UNPREDICTABLE ANTIGENIC ENVIRONMENT,

Michael Lenardo, Francis Ka-Ming Chan, Felicita Homung,

Hugh McFarland, Richard Siegel, Jin Wang, and Lixin Zheng 221

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY

HYPERRESPONSIVENESS, Marsha Wills-Karp 255

REGULATION OF T CELL FATE BY NOTCH, Ellen Robey 283

THE GDI SYSTEM: ANTIGEN-PRESENTING MOLECULES FOR T CELL

RECOGNITION OF LIPIDS AND GLYCOLIPIDS, Steven A. Porcelli

and Robert L. Modlin 297

TUMOR NECROSIS FACTOR RECEPTOR AND FAS SIGNALING

MECHANISMS, D. Wallach, E. E. Varfolomeev, N. L. Malimn,

Yuri V. Goltsev, A. V. Kovalenko, and M. P. Boldin 331

STRUCTURAL BASIS OF T CELL RECOGNITION, K. Christopher

Garcia, Luc Teyton, and lan A. Wilson 369

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID

TISSUES, Yang-Xin Fu and David D. Chaplin 399

THE STRUCTURAL BASIS OF T CELL ACTIVATION BY

SUPERANTIGENS, Hongmin Li, Andrea Llera, Emilio L. Malchiodi,

and Roy A. Mariazza 435

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: COMPLEX

ORCHESTRATION AND THE KEY ROLES OF TEMPO AND

COOPERATION, Ronald N. Germain and Irena Stefanova 467

THE REGULATION OF CD4 AND CD8 CORECEPTOR GENE

EXPRESSION DURING T CELL DEVELOPMENT, Wilfried Ellmeier,

Shinichiro Sawada, and Dan R. Littman 523

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING,

Tomohiro Kurosaki 555

MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES, Man Aderem

and David M. Underhill 593

POPULATION BIOLOGY OF HIV-1 INFECTION: VIRAL AND CD4+

T CELL DEMOGRAPHICS AND DYNAMICS IN LYMPHATIC TISSUES,

A. T. Haase 625

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: ROLES IN

VIRAL ENTRY, TROPISM, AND DISEASE, Edward A. Berger,

Philip M. Murphy, and Joshua M. Farber 657

THE IL-4 RECEPTOR: SIGNALING MECHANISMS AND BIOLOGIC

FUNCTIONS, Keats Nelms, Achsah D. Keegan, Jose Zamorano,

John J. Ryan, and William E. Paul 701

DEGRADATION OF CELL PRO.TEINS AND THE GENERATION

OF MHC CLASS I-PRESENTED PEPTIDES, Kenneth L. Rock

and Alfred L. Goldberg 739

THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM,

Jeffrey C. Rathmell and Craig B. Thompson 781

SELECTION OF THE T CELL REPERTOIR, Eric Sebzda, Sanjeev

Mariathasan, Toshiaki Ohteki, Russell Jones, Martin F. Bachmann,

and Pamela S. Ohashi 829

REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY

RECEPTORS, Erik 0. Long 875

THE WISKOTT-ALDRICH SYNDROME PROTEIN (WASP): ROLES IN

SIGNALING AND CYTOSKELETAL ORGANIZATION, Scott B. Snapper

and Fred S. Rosen 905

ON THE HIGH AFFINITY IGE RECEPTOR (FCeRI): FROM PHYSIOLOGY

TO PATHOLOGY, Jean-Pierre Kinet, Scott C. Garman,

and Theodore S. Jardetzky 931

INDEXES

Subject Index 977

Cumulative Index of Contributing Authors, Volumes 1-17 1008

Cumulative Index of Chapter Titles, Volumes 1-17 1015