BIOCHEMICAL PHARMACOLOGY (PAPER EDITION)

VOL. 57, NO. 1, JANUARY 1999



Commentaries
1 Nuclear factor-KB/Rel proteins: A point of conver-
gence of signalling patl^ways relevant in neuronal
function and dysfunction
Mariagrazia Grilli and Maurizio Memo


9 Innovative treatment programs against cancer: II.
Nuclear factor-KB (NF-KB) as a molecular target
Kevin G. Wadilick and Faith M. Uckun

MOLECULAR AND CELLULAR PHARMACOLOGY

19 Prevention of oxidant-induced cell deatli in Caco-2
colon carcinoma cells after inhibition of poly (ADP-
ribose) polymerase and Ca clielation: Involvement
of a common meclianism
Jurgen M. Karczewski, Janny G. P. Peters and
]an Noordhoek

27 Quinone toxicity in DT-diapliorase-efficient and
-deficient colon carcinoma cell lines
Jurgen M. Karczewski, ]anny G. P. Peters and
Jan Noordhoek

39 Inhibition of calmodulin-stimulated (Ca(2+) + Mg(2+))-
ATPase activity l)y dimethyl sulfoxide
Elizabeth J. McCoimell, Michael J. Wagoner,
Catherine E. Keenan and Beat U. Raess

45 Internalisation of the bleomycin molecules responsi'
ble for bleomycin toxicity: A receptor-mediated en-
docytosis mechanism
Geraldine Pron, Nawel Mahrour, Stephane Orlowski,
Omar Tounekti, Bruno Poddevin, Jean BelehradekJr
and Lluis M. Mir


57 Tyrosine kinase activity of purified recombinant cy-
toplasmic domain of platelet-derived growth factor '
B-receptor (B-PDGFR) and discovery of a novel
inhibitor of receptor tyrosine kinases
Guido J. R. Zaman, PaulM. F. Vink,
Antoon A. van den Doelen, Gerritt H. Veeneman
and HenriJ. M. Theunissen

65 Differences in the order of potency for agonists but not
antagonists at human and rat adenosine A(2A) receptors
BJorn Kull, Guilia Arslan, Chister Nilsson,
Christer Owman,Anna Lorenzen ,Ulrich Schwabe
and Bertil B. Fredholm

77 Methylenedioxy group and cyclooctadiene ring as
structural determinants of schisandrin in protecting
against myocardial ischemia- reperfusion injury in rats

Tze Kin Yim and Kam Ming Ko

CHEMOTHERAPY AND METABOLIC INHIBITORS

83 Metabolism of antitumor acylfulvene by rat liver cytosol
Trevor C. McMoms, Amssa N. Elayadi, Jian Yu and
Michael J Kelner

89 Metabolic effects of a methylthioadenositle phos-
phorylase substrate analog on African trypanosomes
Cyrus J. Bacchi, Burt Goldberg, Donna Rattendi,
Thomas E. Gorrell, Arthur J. Spiess and
J anice R. Sufrm

97 Induction of human breast cancer cell apoptosisfrom.
G2/M preceded by stimulation into the cell cycle by''
Z-l,l-dichloro-2,3"dipehnylcyclopropane

Ragahavan Balachandran, Ernst ter Hoar,
Jack C. Yalowich, MandaJ. Welsh, Stephen G. Grant
and Billy W .Day


111 Inhibition by tetanus toxin of sodium-dependent,
high-affinity [3H]5-hydroxytryptamine uptake in rat
synaptosomes
Javier Inserte, Abderrahim Najib, Patricia Pelliccioni,
Carles Gil and Jose Aguilera

___________________________________
Biochemical Pharmacology

Volume. 57, Number. 2 , 15 January 1999

Commentaries
121 Epithelial peptide antibiotics
Jens-M Schroder


135 A commentary on glial cell line-clerived neutropl^ic
factor (GDNF)
Martha C. Bo/in

MOLECULAR AND CELLULAR PHARMACOLOGY


143 Induction of Bax protein and degradation of lamin A
during p5 3-dependent apoptosis induced by chemo-
therapeutic agents in human cancer cell lines
Yuan-Soon Ho, Horng-Mo Lee, Chuang-Rung Chang
and Jen-Kun Lin


155 Pharmacological cl^aracterization of dopamine-stim-
ulated [35S]-guanosine 5'(r-thiotriphosphate) (35S]
CTPrS) binding in rat striatal membranes
Ago Rinken, Ulla-Britt Fmnman and Kjell Fuxe


163 Effect ofpiracetam on polypliosphoinositide metabo-
lism, cytosolic calcium release, and oxidative burst in
human polymorplionuclear cells: Interaction with
fMLP-induced stimulation
Michele Tissot, Gilles Sarfari, Monique Roch-Arveiller
and Jean-Paul Giroud


171 Characterization of the subtype selectivity of tlie
allosteric modular lieptane-1,7-bis-(dimethyl-3'
pl'ltlralimidopropyl) ammonium broniide (C7/3phth)
at cloned muscarinic acetylcholine receptors
Arthur C/m.stopoulos, Jennifer L. Sonrian,
Fred Mitchelson and Esam E. El-Fakahany


181 Competitive and allosteric interactions of 6-chloro-
5,10-dihydro-5-[(metl1yl-4-piperidinyl)acetyl]-l IH-
dibenzo[b,e][l,4]diazepine-ll-one hydrochloride
(LJH-AH 37) at muscarine receptors, via distinct
epitopes
John Ellis and Margaret Seidenberg

187 Effect of selenium of rat thioredoxin reductase activ-
ity: Increase by suprenutritional selenium and de'
crease by selenium deficiency
Margareta M. Berggren, Jose P. Mangm,
John R. Gasdaska and Garth Powis


CHEMOTHERAPY AND METABOLIC INHIBITORS

195 Kinetic properties of the human liver cytosolic alde-
hyde dehydrogenase for retinal isomers
Pangala V. Bhat and Hiba Samaha

NEUROSCIENCE

199 Influence of the antioxidant quercetin in vivo on the
level of nitric oxide determined by electron paramag-
netic resonance in rat brain during global ischemia
and reperfusion
Zhanna Shutenko, Yann Henry, Elisabeth Pinard,
Jacques Seyla^, Pierre Potier, Pabienne Berthet,
Pierre Girard and Richard Sercombe

HORMONES AND GROWTH FACTORS

209 Selective inl^ibition of potassium-stimulated rat ad-
renal glomerulosa cells by ruthenium red
Gyorgy Szabadkai, Peter Varnal and Peter Enyedi

STRUCTURAL BIOLOGY

219 All alometric model for predicting blood ethanol
elimination in mammals
Hiroshi Matsumoto, Yasushi Mmoiva, Yoko Nishitani
and Yuko Fukui

_______________________________________

BIOCHEMICAL PHARMACOLOGY (PAPER EDITION)

VOL. 57, NO. 3, FEBRUARY 1999

Commentaries

225 The three-dimensional structure of human bacteri-
cidal/permeability-increasing protein: Implications
for understanding protein-lipopolysaccharide inter-
actions
Lesa Deamer, Stephen F. Carroll and David Eisenberg

231 Reactive oxygen intermediates as mediators of pro-
grammed cell death in plants and animals
Thorsten Jabs

MOLECULAR AND CELLULAR PHARMACOLOGY

247 Interaction of indomethacin and naproxen with gas-
tric surface-active phospholipids: A possible mecha-
nism for the gastric toxicity of nonsteroidal anti-
inflammatory drugs (NSAIDS)
Marie-Noelle Giraud, Claude Motta,
Jimmy J. Romero, Gilles Bommelaer and
Lenard M. Lichtenberger

255 Cytochrome IAI induction by primaquine in human
hepatocytes and HepG2 cells: Absence of binding to
the aryl hydrocarbon receptor
Frank Fontome, Chantal Delescluse, Georges de
Sousa, Pierre Lesca and Roger Rahmanti

263 Heterogeneous platelet-activating factor (PAF) re-
ceptors and calcium increase in platelets and macro-
phages
Carlo Centemeri, Susanna Colli, Davide Tosarello,
Paola Ciceri and Simonetta Nicosia

273 Protective effect of ebselen against hydrogen perox-
ide-induced cytotoxicity and DNA damage in HepG2
cells
Cheng-Feng Yang, tian-Ming Shen and
Choon-Nam Ong

281 Different early effects of tyrphostin AG957 and
geldanamycins on mitogen-activated protein kinase
and p1 20cbl phosphorylation in anti CD-3-stimulated
T-lymphoblasts
Michael D. Losiewicz, Gurmeet kaur and
Edward A. Sausville


291 Enhancement of the surface expression of tumor
necrosis factor (x (TNFa) but not the p55 TNFa .
receptor in the THP-I monocytic cell line by matrix
metalloprotease inhibitors
Keith B. Closer, Lori Pease , Junling Li and
Douglas W. Morgan


303 Rapid hydrolysis and slow a,p-dicarbonyl cleavage of
an agent proposed to cleave glucose-derived protein
cross-links
Paul J. Thomalley and Harjit S, Minhas

CHEMOTHERAPY AND METABOLIC INHIBITORS

309 Plasmalemmal pH-gradients in drug-senbsitive and
drug-resistant MCF-7 human* breast carcinoma xetlo-
grafts measured by 31P magnetic resonance spectros-
copy
Natarajan Raghunand, Maria I. Altbachf
Robert van Sluis, Brenda Baggett, Charles W, Taylor,
Zaver M. Bhujwalla and Robert J. Gillies

INFLAMMATION AND IMMUNOPHARMACOLOGY

313 lbuprofen: New explanation for an old phenomenon
Karl M. Stuhlmeier, Hui Li and Janet J. Kao

_______________________________________

Bloclienncal Pharmacology

Volume 57, Number 4, February 1999

Commentaries
321 Protein phosphatase 2A: Who shall regulate the
regulator?
Yves Goldberg

329 The importance of being Jehydroepiandrosterone
sulfate (in the blood of primates): A longer and
healthier life?
Eugene Roberts

MOLECULAR AND CKLLULAR PHARMACOLOGY

347 Modulation of excision repair cross complementation
group I (ERCC-1) mRNA expression by pharmaco-
logical agents in human ovarian carcinoma cells
Qingdi Li, Byron Tsang, Frieda Dostick-Bruton and
Eddie Reed

355 Involvement of P1 receptors in the effect offorskolin on
cyclic AMP accumulation and export in PC12 cells
Chiara Florio, Fabiana Frausin, Rodolfo Vertua and
Rosa Maria Gaion


365 Inhibition of human smooth muscle cell proliferation
in culture by farnesyl pyropliosphate analogues, in'
hibitors of in vitro protein:farnesyl transferase
Louis H. Cohen, Elsbet Pieterman,
Rick E. W, van Leeuwen, Junrong Du,
Pascale Negre-Aminou, A. Rob P. M. Valentijn,
Mark Overhand, Gijs A. van der Marel and
Jacilues H. van Boom


375 Peroxidase-catalyzed effects of indole' 3-acetic acid
and analogues on lipid meml^ranes, DNA, and mam-
malian cells in vitro
Lisa K. Folkes, Madeleine F. Dennis,
Michael R. L. Stratford, Luis P. Candeias and
Peter Wardman

383 the expression of the lectin'like oxidized low-density
lipoprotein receptor (LOX-1) on human vascular
smooth muscle cells and monocytes and its down-
regulation by lovastatin
Georg Draude, Nina Hrhoticky and
Reinhard L. Lorenz


CHEMOTHERAPY AND METABOLIC INHIBITORS

387 Distinct regulation of glucose transport by interleu-
kin-3 and oncogenes in a murine bone marrow-
derived cell line
Nuzhat Ahmed and Michael V. Berridge

397 Decreased resistance to gerncitabine (2',2'difluoro-
deoxycitidine) ofcytosine arabinoside-resistant myelo-
blastic murine and rat leukemia cell lines: Role of
altered activity and substrate specificity of deoxy-
cytidine kinase
Andries M. Bergman, Herbert M. Pmedo,
Ans P. Jongsma, Marjoleine Brouwer,
Veronique W. T. Ruiz van Haperen,
Gijsbert Veerman, Albert Leyva, Steffan Eriksson and
Godefridus J. Peters


407 Combination chemotherapy studies with gerncitabine
and etoposide in non-small cell lung and ovarian
cancer cell lines
CatharinaJ. A. van Moorsel, Herbert M. Pinedo,
Gijsert Veerman, Assen Guechev, Kees Smid,
Willem J. P. Loves, Jan B. Vermorken,
pieter E. Postmus and Godefridus* J. Peters

NEUROSCIENCE

417 Enzymes of porcine brain hydrolyzing 2-arachidonoyl-
glycerol, an endogenous ligand ofcannabinoid recep-
tors
Sravan Kumar Goparaju, Natsuo Ueda,
Kyoko Taniguchi and Shozo Yamamoto

HORMONES AND GROWTH FACTORS

425 Epidermal growth factor and angiotensin II regulation
of extracellular signal-regulated protein kinase in rat
liver epithelial WB cells
Li-Jun Yang, Yan-Lin Guo, Oxana Trygankova,
Qui-Yang Li, Judith A. Maloney, Melinda Steinhauer
and John R. Williamson


INFLAMMATION AND IMMUNOPHARMACOLOGY

33 Anti-inflammatory mechanism of alminoprofen: Ac-
tion on the phospholipid metabolism pathway
Celine Raguenes-Nicol, Fran^oise Russo-Marie,
Gisele Domage, Nadia Diab, Egle Solito,
Fernand Dray, Jose L. Garcia Mace and
Gilles Streichenberger

445 Inhibition of leukocyte 5-lipoxygenasc by phenolics
from virgin olive oil
Rocio de la Puerta, Valentina Ruiz Gutierrez and
J. Robin S. Hoult

BIOCHEMICAL PHARMACOLOGY (PAPER EDITION)

VOL. 57, NO. 5, MARCH 1999


Commentaries

451 Chemokine receptors—Future therapeutic
targets for HIV?
Amanda E.I. Proudfoot, Timothy N.C. Wells w]d
Paul R. Clapham

465 Integrated cytochrome P450 reaction phenotyping:
Attempting to bridge the gap between cDNA-ex-
pressed cytochromes P450 and native human liver
microsomes
A. David Rodrigues

MOLECULAR AND CELLULAR PHARMACOLOGY

481 Structural and functional impairment ot mitochon-
dria in adriamycin-induced cardiomyopathy in mice:
Suppression of cytochrome c oxidase II gene expres-
sion
LefKothea C. Papadopoulou, Qeorge Tluophilidis,
George N. Thomopoulos and Astenos S. Tsiftsoglou

491 Identification of a novel complement-dependent se'
rum-elicited inward current in the Xenopus oocyte
provoldng Ca(2+) influx and subsequent activation of
Cl- channels
Philip Newsholme, Michael L. J. Ashford and
C. Nicholas Hales

503 Influence of antiallergic drug oxatomide and deriva-
tives on membrane structures: Relation with inhibi-
tion of calcium influx in rat basophilic leukemia cells
JeannetteJ.C. Paulussen, Marcel J.E. Elscher,
NlcolaasJ. Zuidam, J. Gees v. Miltenurg,
Nico J. de Mol and Lambert H.M. Janssen

511 The high-affinity binding of [3 Hinorharman ([3H]B-
carboline) to the ethanol-inducible cytochrome P450
2EI in rat liver
Philipp Stawowy, Ragnhlid Bonnet and
Han.s Romnielspacher

521 Greater synergism of retinoic acid receptor (RAR)
agonists with vitamin D3 than that of retinoid X
receptor (RXR) agonists with regard to growth inhi-
bition and differentiation induction in monoblastic
leukemia cells
Makoto Makishima, Koichi Shudo and Yoshlo Horlma


531 Removal by human apurinic/apyrimidinic endonucle-
ase I (Ape 1) and Eschenchia coli exonuclease III of
3'-phosphoglycolates from DNA treated with neocar-
zinostatin, calicheamicin, and r-radiation
M. Ahmod chaudry , Peter C. Dedon,
David M. Wllson III, Bruce Demple and
Michael Wernfeld

539 Agonist-induced release of splice variants of the a
subunit of the stimulatory G-protein from rat cardiac
membranes
Klaus Witte, Anke Schnecko and BJorn Lemmer

545 Reduced sensitivity of HeLa cells to cis-platinum by
Simultaneous overexpression of copper, zinc-superox-
ide dismutase and catalase
Toshlko Tanaka-Kagawa, Jun Kitahara,
Yoshiyuki Seko, Haruka Toyoda, Nobumasa lmura
and Akira Naganuma

CHEMOTHERAPY AND METABCXIC INHIBITORS

549 Enzymatic reduction studies of nitroheterocycles
Ceclie Vlode, Nadir Bettache, Narimantas Cenas,
R. Luise Krauth-Slegel, Gerard Chauvlere,
Norbert Bakalara and Jacques Perie

559 In vivo iron mobilisation evaluation ofhydroxypyridi-
nones in (59)Fe-ferritin-loaded rat model
zu Dong Liu, Shu Li Lu and Robert C. Hlder

567 Folic acid-enhanced synergy for the combination of
trimetrexate plus the glycinamide ribonucleotide
formyltransferase inhibitor 4-[2-(2-amino-4-oxo-
4,6,7,8-tetrahydm-3H-pyrimidino[5,4,6][l,4]thiaxin-
6-yl)-(S)-ethyl]-2,5-thienoylaiTiino-L-glutamic acid
(AG2034): Comparison across sensitive and resistant
human tumor cell line
Helene M. Faessel, Harry K. Slocum,
Youcef M. Rustum and William R. Greco

__________________________________
BIOCHEMICAL PHARMACOLOGY (PAPER EDITION)

Volume 57, Number 6 , March 1999

Commentaries
583 Trioscs and related substances: Tools for the study of
pancreatic B-cell function
Leonard Best and Paul J Thornalley


589 Chemotherapy by slowing glucosphingolipid synthesis
Norman S. Radin


RAPID COMMUNICATION

597 Interaction of human estrogen receptors a and with
the same naturally occurring estrogen response ele-
ments
Salmon M. Hyder, Constance Chia^etta and
George M. Stancel

MOLKCULAR AND CKLLULAR PHARMA(.X)I,OGY

603 Activation of human vascular endothelial cells by
factor Xa: Effect of specific inhibitors
Jean-Pascal tierault, Francoise Bono, Corinne Avril,
Paul Schaeffer and Jean-Marc Herbert


611 N'domain selectivity of angiotensin I-converting en-
zyme as assessed by structure-function studies of its
highly selective substrate, N-acetyl-setryl-aspartyl-ly-
syl-proline
Annie Michaud, Marie-Therese Ghauvet and
Pierre Corvol

619 Regulation of cytochrome P4501BI (CYPIBI) in
mouse embryo fibroblast (C3HIOTI/2) cells by pro-
tein kinase C (PKC:)
Fidelis 1. lkegwuonu) Maro Christou and
Colin R. Jefcoate

631 Inhibition ofprostaglandin H synthase and activation
of 12-lipoxygenase by 8,11,14,17-eicosatetraenoic
acid in human endothelial cells and platelets
Marline Croset, Jean Claude Bordet and
Michel Lagarde


639 Free radical modulation of insulin release in INS-1
cells exposed to alloxan
Danilo Janjic, Pierre Maechler, Nobllo Sekine,
Clarissa Bartley, Anne-Sofie Annen and
Claes B. Wollheim

649 Mediation by G protein Br subunits of the opioid
stimulation of adenyl cyclase activity in rat
olfactory bulb
Maria C. Olianas and Pierluigi Ondli


653 Mono- and diglucuronide formation from benzo-
Hpyrene and chrysene diphenols by AHH-I cell-
expressed UDP-glucuronosyltransferase UGTIA7
Karl Walter Bock, Frank T. Raschko,
Harald Gschaidmeier, Albrecht Seidel, Franz Oesch,
Andrew D. Grove and Joseph K. Ritter

657 Modifications of benzylphenoxy ethanamine anti-
estrogen molecules: Influence affinity for antiestrogen
binding site (AEBS) and cell cytotoxicity
Frederic Delarue, Blandine Kedjouar,
Fabienne Mesange, Francis Bayard, Jean-Charles Faye
and Marc Poirot

CHEMOTHERAPY AND METABOLIC INHIBITORS

663 Inhibitors of mammalian melanocyte tyrosinase: In
vitro comparisons of alkyl esters of gentisic acid with
other putative inhibitors
Ernest V. Curio, Cecil Kwong, Heino Hermersdorfer,
Hansruedi Glatt, Chie Santis, Victoria Virador,
Vincent J. Hearing, Jr and Thomas P. Dooley


673 Distribution of pharmacokinetics of the prodrug
daunorubicin-GA3 in nude mice bearing human
ovarian cancer xenografts
Pieter H. J. Houba, Epie Boven,
Ida J. van der Meulen-Muileman,
Ruben G. G. Leenders, Johannes W. Scheeren,
Herbert M. Pinedo and Hidde J. Haisma

_______________________________________

BIOCHEMICAL PHARMACOLOGY

VOL. 57, NO. 7, APRIL 1999


Commentaries

721 Muscarinic cholinergic receptor signal transcluction
as a potential target for the devefopmentaf neurotox-
icity of eth'anol
Lucio G. Costa and Marina Gui^eui

727 A critical evaluation of the mechanisms of action
proposed for the an ti tinner effects of the anthracy-
chne antihiotics acfriainyciri and daunoruhlcin
David A. Gewirtz

MOLECULAR AND CELLULAR PHARMACOLOGY


743 Inhibition and uncoupling of oxidative pho.splioryla-
lion hy nonsteroiclal anti-inflammatory drugs: Study
in initochondria, subinitochondrial particles, cells,
and whole heart
Rafael Moreno-Sanche!, Concepcion Bravo,
Cesar Vasquez, Guadalupe Ayala, Luis H. Silveira
and Manuel MartinezLavln

753 Cytolcinetics of a novel 1,2,3-triazene-containing
heterocycle, 8-nitro-3-ii1ethyl-henzo-J,2,3,5-tetraz-
epin-4(3H)-one (NIME), in the human epithelial
ovarian cancer cell line OVCAR-3
Bertrand Jacques jean-Claude, Amir Mustafa,
Zoe damian, josie de marte, Daniela Eliza Vasilescu,
Rose Yen, Thak Hang Chan and Brian Ley land-Jones

763 Suppression of tumor necrosis factor-activated nu-
clear transcription factor-KB, activator protein-I, c-
Jun N-terminal kinase, and apoptosis by B-lapaclione
Sunil K. Manna, Yash P. Gad, Asok Mukhopadhyay
and Bharat B. Aggarwal

775 Interaction of the transactivating protein HIV-1 tat
with sulphated polysaccharides
Keith Watson, NigelJ. Uooderham, Donald S. Davies
and Robert J. Edwards

785 N-ethylmaleimide-stimulated arachidonic acid re-
lease in human platelets
Giuliana Leoncini and Maria Grazia Signorello

793 Inhibition of [3H]thymidine incorporation into DNA
of rat regenerating liver by 2',2'-difluorodeoxycyti-
dine coupled to lactosaminated poly-L-lysine
Giuseppina Di Stefano, Corrado Busi,
Allesandro Mattioli, Massimo Derenzini, Davide Trere
and Luigi Fiume

CHEMOTHERAPY AND METABOLIC INHIBITORS

801 Inhibition of protein prenylation by metabolites of
liinonene
I an R. Hardcastle, Martin G. Rowlands,
Amelia Moreno Barber, Rachel M. Grimshaw,
Mukesh K. Mohan, Bernard P. Nutley and
Michael Jarman

811 Inhibition of human prenatal biosynthesis of all-
fmm-retinoic acid by ethanol, ethanol metabolires,
and products of lipid peroxidation reactions; A pos-
sible role for CYP2EI
Mehraneh Khalighi, Monica R. Brzezinski, Hao Chen
and Mont R. Juchau

823 Inhibition by ascorbic acid* of apoptosis induced by
oxidative stress in HL-60 myeloid leulcemia cells
Bruria Witenberg, Henry H. Kalir, Ziv Raviv,
Yehudith Kletter, Vladimir Kravstov and Ina Fabian


833 Sister ofP-glycoprotein expression in different tissues
Michael Torok, Heike Gutmann, Gert Fricker and
Jiirgen Drewe

INFLAMMATION AND IMMUNOPHARMACOLOGY

837 Stereoselective and substrate-dependent inhibition of
hepatic mitochondrial B-oxidation and oxidative
phosphorylation by the non-steroidal anti-inflamma-
tory drugs Jbuprofen, Flurbiprofen, and Ketorolac
Gary S. Browne, Carolyn Nelson, Tuan N guy en,
Bronwyn A. Ellis, Richard 0. Day and
Kenneth M. Williams

__________________________________

BIOCHEMICAL PHARMACOLOGY

VOL. 57, NO. 8, APRIL 1999


Commentaries

845 Molecular mechanisms of Fyn-tyrosine kinase for
regulating inaimnalian behaviors and ethanol sensi-
tivity
Takeshi Yagi

851 ADP-induced platelet aggregation and inhibition of
adenylyl cyclase activity stimulated by prostaglan-
dins: Signal transduction mechanisms
Rajinder N. Puri

MOLECULAR AND CELLULAR PHARMACOLOGY

861 Decreased cisplatin damage-dependent DNA synthe-
sis in cellular extracts of mismatch repair deficient
cells
Katherine V. Ferry, Daniel Fink, Sloven W. Johnson,
Sibylle Nebel, Thomas C. Hamilton and
Stephen B. tiowell

869 Effects of tiadenol and di-(2-ethylhexyl)phthalate on
the metabolism of phosphatidylcholine and phos-
phatidylethanolamine in the liver of rats: Compari-
son with clofibric acid
Hiroki Mizugllchi, Naomi Kudo, Takeshi Qhya and
Yoichi Kawashima

877 Selectivity of the molecular chaperone-specific im-
munosuppressive agent 15-deoxyspergualin: Modula-
tion ofHsc70 ATPase activity without compromising
DnaJ chaperone interactions
Jeffrey L. Brodsky

881 Site-specific DNA methylation and apoptosis: induc-
tion by diabetogenic streptozotocin
Mariko Murata, Ayako Takahashi Isao Saito and
Shosuke Kawanishi

889 Mechanism of anti-HIV activity of succinylated hu-
man serum albumin
Mirjam E. Kuipers, Marjan v. d. Berg,
pieter J. Swart, Jon D. Laman, Dirk K. Meijer,
Marco H. G. M. Koppelman and Han Huisman

899 Effects of tyrosine289phenylalanine mutation on
binding and functional properties of the human
tachykinin NK2 receptor stably expressed in Chinese
liamster ovary cells
Anna Rita Renzetti, Rose-Marie Caialioto,
Cristina Carloni, Marco Criscuoli, Paola Cucchi,
Alessandro Giolitti, Sabrina Zappitelli,
Luigi Rotondaro and Carlo Alberto Maggi

907 Effect of chronic chloroquine administration on iron
loading in the liver and reticuloendothelial system on
oxidative responses by the alveolar macrophages
Rachida Legssyer, Roberta]. Ward,
Robert R. Crichton andJohan R. Boelaert

913 efficacy of isatin analogues as antagonists of rat brain
and heart atrial natriuretic peptide receptors coupled
to particulate guanylyl cyclase
Alexei E. Medvedev, Brian L. Goodwin,
Merton Sandier and Vivette Glover

HORMONES AND GROWTH FACTORS

917 Irreversible inhibition of epidermal growth factor
receptor tyrosine kinase with m vivo activity by
N-[4-[(3-bromoplienyl)amino]-6-quinazolinyl]-2-
butynamide (CL-387,785)
Carolyn M. Discafani, Marion L. Carroll,
M. Brawner Floyd, Jr, lrwinJ. Hollander,
Zaheed Husain, Bernard D. Johnson, Douglas Kitchen,
Michael K. May, Madhu S. Malo, Albert A. Minnick, Jr,
Rantoswamy Nilal<antan, Ru Shen, Yu-Fen Wang,
Allan Wissner and Le M. Greenberger

STRUCTURAL BIOLOGY


927 Lowering of trichosanthin immunogenicity by site-
specific coupling to dextran
Wah-Luh Chan, Pang-Ghui Shaw, Xiao-Bing Li,
Qiong-Fang Xu, Xian-Hui He and Siu'Cheung Tarn


_______________________________________

BIOCHEMICAL PHARMACOLOGY (PAPER EDITION)

VOL. 57, NO. 9, MAY 1999

Commentaries

965 Cyclic nucleotkie pliosphocliesterasc (PDE) inhibi-
tors and immunomodulation
David M. Essayan

975 Receplors mediating adenovirus attachment and in-
ternalization
JeffTey M. Bergelsun

Molecular and cellular PHARMACOLOGY

981 Membrane interaction of an antitlimor antibiotic,
mithramycin, with anionic pbospliolipid vesicles
Sangita Majee and Abhijit Chakraharti

989 tert-butyl hydroperoxide/bemo^lobin-induced ox Ida-
tive stress and damage to vascular smooth muscle cells:
Different effects of nitric oxide and nitrosotliiols
Anna A. Shvedova, Yulia Y. TyuYma,
Nikolai V. Gorhlmov, Vladimir A. Tyurin,
Vincent Castranova, Choudari Kommineni,
Jacqueline O^mba, Robin Gandley,
Margaret K. McLaughlin and Valerian E. Kagan

1003 Pliarmacological cl^aracterization of glucocorticoid
receptors in primary lhuman bronchial epithelial cells
Tncia D. LeVan, Elizabeth A. Balnn,
Henry L Yarnamu7'a and John W. Bloom

1011 Mitochondrial 3-liydroxy-3-methylglutaryl coenzyme
A syntliase and carnitine palmitoyltransferase II as
potential control sites for ketogenesis during mito-
cliondrion and peroxisome proliferation
Lise Madsen, Alexis CJarras, Guillermina Asins,
Dolors Serra, Fausto G. Hegardt and Rolf K. Berge

1021 Protective effect of docosahexaenoic acid against
hydrogen peroxide-induced oxidative stress in human
lymphocytes
Shaliha bechoua, Madeleine Dubois,
Zury Dominguez, Aurora Goncak'es, Georges Nernoz,
Mlchel Lagarde and Annie-France Pngent

1031 Competition between iron(lll)-selective clielators
and zinc-finger domains for zinc(ll)

CHEMOTHERAPY AND METABOLIC INHIBITORS

1037 pH and drug resistance, I. Functional expression of
plasmalemmal V-type H+-ATPase in drug-resistant
human breast carcinoma cell lines
Raul Martinez-Zaguilan, Natarajan Raghunand,
Ronald M. Lynch, William Bellamy,
Gloria M. Martinet, Bertha Rojas, Douglas Smith,
William S. Dalton and Robert J. Gillies


1047 pH and drug resistance. II. Turnover of acidic vesicles
and resistance to weakly basic chemotherapeutic drugs
Natarajan Raghunand, Raul Martmez- Zagullan,
Stephen H. Wright and Robert J. Gillies

NEUROSCIENCE

1059 Effects of selected histamine 143 receptor antagonists
on tele-methylhistamine levels in rat cerebral cortex
Stephen L. Yates, Clark E. Tedford, Rosilyn Gregory,
Gary P. Pawlowski, Michael K. Handley, D. L. Boyd
and Lindsay B. Hough

HORMONES AND GROWTH FACTORS

1067 Sex-dependent induction of alcohol dehydrogenase
activity in rats
Llsbeth Aasmoe and Jarle Aarbakke

GENE EXPRESSION AND DEVELOPMENT

1073 Positive regulation of the rat CYP2B2 phenobarbital
response unit by the nuclear receptor hexamer half-
site. nuclear factor I complex
Catherine Stoltz and Alan Anderson

1077 Additions and Corrections

__________________________________

biochemical Pharmacology

Volume 57, Number 11, June 1999

Commentaries

1209 Exocytosis of neutrophil granulocytes
Erzsehet Ligeti and Attila Mocsai

1215 Possible mechanisms ofpaclitaxel-induced apoptosis
Weimin Fan

RAPID COMMUNIC-ATIONS

1223 Time-dependent production of nitric oxide by rat
hepatocyte suspensions
Felicity A. Nicholls-GrZemski, Kiark A. Tirmenstein
and Marc W. Fariss

1227 UncHanged cytoclirome P450 3A (CUPP3A) expres-
sion and metabolism of midazolam, triazolam, and
dexamentbasone in mdr(— /—) mouse liver microsomes
Michael D. Perloff, Lisa L. van Moltke,
Monette M. Cotreau and David J. Greenblatt

MOLKCULAR AND CELLULAR PUARMACOLOGY


1233 An NMR analysis of the reaction of ubiquitin with
[acetyl-\13 C] aspirin
Jeffrey M. Macdonald, Darryl A. LeBlanc,
Arthur L. Jlaas and Robert E. London

1245 Enhanced mRNA expression of neurotilament sub-
units in the brain and spinal cord of diisopropyl
phosphorofluoridate-treated hens
Ram P. Gupta, Wciquan W. Lm and
Mohamed B. Abou-Donia

1253 Divergent mechanisms for loss ofAh-responsiveness in
benzo[a[pyrene- and AdriamycinR-resistant MCJF-7 cells
Joseph A. Caruso and Gerald Batist

1265 A study of correlation between NPM-translocation
and apoptosis in cells induced by daunomycin
Pui K. Chan and Fung Y. Ghan

1275 Role of ascorbic acid in transferrin-independent re-
duction and uptake of iron by U-937 cells
James M. May, Zhi-chao Qu and Shalu Mendiratta


1283 Selective toxicity of the tricyclic thiophene NSC
652287 in renal carcinoma cell lines: Differential
accumulation and metabolism
Maria I. Rivera, Sherman F. Stinson,
David T. Vistica, Jean L. Jorden, Susan Kenney and
Edward A. Sausville

1297 Human CYP2C-mediated stereoselective phenytoin ,
hydroxylation in Japanese: Difference in chiral pref-
erence ofCYP2C9 and CYP2CI9
Toshio Yasumori, Lai-shun Chen, Qing-hua Li,
Masakazu Veda, Toshiharu Tsuzuki,
Joyce A. Goldstein, Ryuichi Kato and Yasushi Yamazoe

1305 Investigation into the correlation between the struc-
ture of hydroxypyridinones and blood-brain barrier
permeability
Mark D. Habgood, Zu Dong Liu,
Lotfollah S. Dehkordi, Hicham H. Khodr, Joan Abbott
and Robert C. Hider

CHEMOTHERAPY AND METABOLIC INHIBITORS

1311 Effect othydrazine upon vitamin B12 -dependent me-
thionine synthase activity and the sulphur amino acid
pathway in isolated rat hepatocytes
Susan H. Kenyan, Catherine J. Water field,
Daniel S. Asker, Mariko Kudo, David W. Moss,
Timothy E. Bates, Anna Nicolaou,
William A. Gibbons and John A. Timbrell

NEUROSCIENCE

1321 Different modulation ofcholinergic neuronal systems
by dynorphin A (1-13) in carbon monoxide-exposed
mice
Masayuki Hiramatsu, Masoaki Murai and
Tsutomu Kameyama

CARDIOVASCULAR AND PULMONARY PHARMACOLOGY

1331 Inhibition of rat vascular smooth muscle cell prolif-
eration by taurine and taurine analogues
XinJian Zhang, Thomas E. Tenner, Jr. and
John B. Lombardini


_________________________________

BIOCHEMICAL PHARMACOLOGY (PAPER EDITION)

VOL. 57, NO. 12, JUNE 1999


Commentaries
1341 Histainine, Polyainines, and Cancer
Miguel Angel Meclina, Ana Rodrlguez Qnesaclcl,
lgnacio Nunez de Castro and
Francisca Sanchez-Jimenez


1345 Therapy by Taking Away: The Case of Iron
Barbara S. Polla

RAPID COMMUNICATION

1351 Sensitivity ofL-(-)2'3' -dideoxythiacytidine resistant
hepatitis B virus to other antiviral nucleosicle ana-
logues
Lei Fu, Shwu-Huey Liu and Yung-Chi Cheng

MOLECULAR AND CELLULAR PHARMACOLOGY

1361 Involvement of hydrogen peroxide and hydroxyl
radical in chemically induced apoptosis of HL-60
cells
Kazumi Ikeda, Kazumi Kajiu'ara, Eiko Tanahe,
Sadako Tokumaru, Etsu Kishida, Yasuo Masuzawa
and Shosuke Kojo

1367 Role of tyrosine kinase activity in 2,2',2"-tripyridine-
induced nitric oxide generation in macrophages
Bar-Sen Wang, Jen-Kun Lin and Shoei-Yn Lin-Shiau


1375 Development of a recombinant cell-based system for
the characterisation of phosphodiesterase 4 isoforms
and evaluation of inhibitors
Rodger A. Alien, Mark W. Merriman,
Martin J. perry and Raymond J. OWens

CHKMOTHERAVY AND METABOLIC; INHIBITORS

1383 Interactions of prostaglandin A2 with the glutathione-
mediated biotransformation system
Marlou L. P. S. van lersel, Nicole. H.P. Cnubben,
Natasja Smink, Jan H. Koeman and
Peter J, van Bladeren

HORMONLS AND GROWTH FACTORS

1391 Synergistic effects of neurotensin ,and B-adrenergic
agonist on 3',5'-cyclic adenosine monophosphate
accumulation and DNA synthesis -m prostate cancer
PC3 cells
Sankar P. Mitra and Robert E. Carraway

1399 Effects of the binding of a dextran derivative on
fibroblast growth factor 2: Secondary structure and
receptor-binding studies
Patrick Bittoun, Rozita Bagheri-Yarmand,
Frederic Chaubet, Michel Crepin,
Jacqueline Jozefonvicz and Serge Fermandjian

GENE EXPRESSION AND DEVELOPMENT

1407 Expression of CYP2A genes in human liver and
extrahepatic tissues
Satu Koskela, Jukka Hakkola, Janne Hukkanen,
Olavi Pelkonen, Martti Sorri, Antti Saranen,
Sisko Anttila, Pedro Fernandez-Salguero,
Frank Gonzalez and Hannu Rtlunio

1415 Enhancement of excision repair of ciplatin-DNA
adducts be cell-free extract from a cisplatin-resistant
rat cell line
Yasuhide Hibino, Yoshitaka Hiraoka, Shiny a Kamiuchi,
Eiji Kusashio and Nobuhiko Sugano

1423 Up-regulation of interleukin-1 B-stimulated interleu-
kin-8 in human keratinocytes by nitric oxide
Penelope J. Andrew, Hanna Harant and
Ivan J. D. Lindley

INFLAMMATION AND IMMUNOPHARMACOLOGY

1431 Inhibitory effect of tetrahydroswertianolin on tumor
necrosis factor-a-dependent hepatic apoptosis in mice
Koji Hase, Quanbo Xiong, Purusotam Basnet,
Tsuneo Namba and Shigetoshi Kadota



1439 Inhibition of complement by covalent attachment of
rosmarinic acid to activated C3b
Arvind Sahu, Nenoo Rawal and Michael K. Panghurn

1447 Additions and Corrections

1449 Contents of Volume 57

1461 Author Index for Volume 57

1465 Subject Index for Volume 57

_______________________________________

BIOCHEMICAL PHARMACOLOGY

VOL. 58, NO. 7, OCTOBER 1999

1081 G-protein colipled receptors: Conformations and
states
Philip G. Strange


1089 Mechanisms of p53-induced apoptosis
Martin R. Bennelt

MOLECIULAR AND CELLULAR PHARMACOLOGY

1097 Sulindac derivatives inhibit growth and induce apop-
tosis in human prostate cancer cell lines
Jin T. E. Lim, Gary A. Piazza, Edward Kyu-Ho Han,
Thomas M. Delohery, llan Li, Tyler S. Finn,
Ralph Duttyan, Hirofumi Yamamoto, Gerhard J. Sperl,
Klaus Brendel, Paul H . Gross, Rifat pamukcu and
I. Bernard Weinstein

1109 Lack of modulation by phenobarhital of cyclic AMP
levels or protein kinase A activity in rat primary
hepatocytes
Nancy B. Beck and Curtis J. Omiecinski

1115 Synergistic eFfect ofestramustine and [3'-keto-Bmtll-
IValZJ-cyclosporine (PSC 833) on the inhibition of
androgen receptor phosphorylation in LNCaP cells
Long G. Wang, Xiao M. Liu, Daniel R. Budman and
Willi Kreis

1123 Potentiation of mitochondrial Ca2+ secuiestration by
taurine
Mitri Palmi, Gisele lchuisseu Youmbi, Fahio Fusi,
Gian P Sgaragli, Henry B. F. Dixon, Maria Frosini
and Keith Tipton

1133 Methylated eicosapentaenoic acid and tetradecyl-
tilioacetic acid: Effects on fatty acid metabolism
liege Vaagenes, Lisa Madsen, Endre Dyr0y,
Morten Elholm, Agnete Stray-pedersen,
Livar Fr0yland., 0yvind Lie and Rolf K. Berge

1145 Modulation of cytochrome P4501AI activity by
ascorbigen in murine hepatoma cells
pernille Uldall Stephensen, Christine Bonnesen,
Leonard F. Bjeldanes and Ole Vang

1155 Biochemical and functional characterization of nitric
oxide synthase III gene transfer using a replication-
deficient adenoviral vector
Armm Frey, Sonja Schneider-Rasp., Uta Marienfeld,
Julie C.-M. Yu, Martin Paul, Wolfgang Roller and
Plarald H. H. W. Schmidt

1167 Inhibitory effect of curcumin, a food spice from
turmeric, on platelet-activating factor- and arachi-
donic acid-mecdiated platelet aggregation through in-
hibition ofthromboxane formation and Ca2+ signal-
ing
Bukhtiar H. Shah, Zafar Nawaz, Sharnim A. Pertani,
Asad Roomi, Hammad Mahmood, Sheikh A. Saeed
and AnwarH. Gilani

CHEMOTHERAPY AND METABOLIC INHIBITORS


1173 Induction of STAT and NFKB activation by the
antitumor agents 5,6-dimethylxantheonone-4-acetic
acid and flavone acetic acid in a murine macrophage
cell line
Lai-Ming Ching, Howard A. Young, Kara Eberly and
Cheng-Rong Yu

NEUROSCIENCE

1183 LDeprenyl, blocking apoptosis and regulating gene
expression in cultured retinal neurons
Lin Xu, Jianfang Ma, Gail M. Seigel and

1209 Hypocholesterolemic effects of 3-hydroxy-3-methyl-
glutaryl coenzyme A (HMG-CoA) redlictase inhibi-
tors in the guinea pig: Atorvastatin versus simvastatin
Karin Conde, Graciela Pineda, Roger S. Newton and
Maria Luz Femandez

GASTROINTHSTINAL AND RKNAI. PHARMACXXOGY

1221 Inhibitory effect of macrophage-derived factors on
the recovery of wounds induced in rat gastric epithe-
lial monolayers
Eiji Nakamura, Satoru Takahashi, Makoto lshikawa
and Susumil Okabe

Jian-xing Ma

HORMONES AND GROWTH FACTORS

1191 Profound differences in the transport of steroids by
two mouse P-glycoproteins
lDonald J. Gruol, Quang D. Vo and Michele C. Zee

GENE EXPRESSION AND DEVELOPMENT

1201 Participation of CYPZC8 in retinoic acid 4-hydroxyl-
ation in human hepatic microsomes
Louise Nadin and Michael Murray

______________________________________

BIOLOGICAL PHARMACOLOGY (PAPER EDITION)

VOL. 58, NO. 8, OCTOBER 1999



Commentaries

1229 Effects of psychotropic druges on cell prolifemtion and
differentiation
Jardena Nordenherg, Eyal Fenig, Marinn Landau,
Ronit Weizman and Abraham Weizman

1237 Cyclooxygenase knockolit mice: Models for elucidat-
ing isoforiu-specific functions
Robert Lang enbach, Charles Lofin, Christopher
and Howard Tiano

MOLIICULAR AND CJILI.IJI.AI^ PllAI^MACOLOC.Y


1247 Induction of apoptosis by dexraoxane (ICRF-187)
tlirough caspases in the absence of c-jun expression
and c-jun NH2-terminal kinase I (JNKI) activation
in VM-26-resistant CEM cells
Tayeb Khelifa and William T. Beck

1259 Affinity labeling of the androgen receptor with non'
steroidal chemoaffinity ligands
Arnab Mukherjee, leonid I. Kirkovsky,
Yasahiro Kimura, Michele M. Marvel,
Duane D. Miller and James T. Dalton

1269 A1 adenosine receptor of human and mouse adipose
tissues: Cloning, expression, and characterization
Irene Tatsis-Kotsidis and Bernard F. Erlanger

1279 Role of codon 160 in the sensitivity of human
O6-alkylguanine-DNA alkyltransferase to O6-benzyl-
guanine
Meng Xu-Wellwer, jose leitao, Sreenivas Kanugula
William J. Meehan and Anthony E. Pegg

1287 Levels and suhcellular distributions of detoxifying
enzymes in the ovarian Corpus Luteum of the preg-
nant and non-pregnant pig
Maria Eliasson, Malin Bostrom and
Joseph W. DePierre

1293 N-etliylmaleimide inhibition of thrombin-induced
platelet aggregation
Giuliana leoneini and Maria Grazia Signorello

1301 Suppression of both basal and arutigen-induced lipid
peroxidation in ring dove heterophils by melatonin
Ana B. Rodriguez, Gabriel Nogales,
Jose M. Marchena, Eduardo Ortaga'and
Carmen Barriga

1307 Stimulation of topoisomerase ll-mediated DNA
cleavage by an indazole analogue of lucanthone
Laurent Dassonneville and Christian Bailly


CHEMOTHERAPY AND METABOLIC INHIBITORS


1313 Potent antioxidant activity of a dithiocarbamate-
related compound from a marine hydroid
Mellissa K, Johnson, Karen E. Alexander,
Niels Lindquist and George Loo


1321 Inilibitory effects of prostaglandin Ai on membrane
transport of folates mediated by both the reduced
folate carrier and ATP-driven exporters
Yehuda G. Assaraf, Esteban E. Sierra,
Solomon Balmni and J. David*Goldman

NEUROSCIENCE

1329 5-HT (2A/2C). receptor agonist- induced increase in uri-
nary isatin excretion in rats: Reversal by both diaze-
pam and dexamethasone
Yumiko Toiawa, Akira Ueki, Tatsuo Shimosawa and
Toshiro Fujita

HORMONES AND GROWTH FACTORS

1335 Regulation of adenosine 3',5' -cyclic monophosphate
(cAMP) accumulation in UMR-106 osteoblast-like
cells: Role of cAMP-pliosphodiesterase and cAMP
efflux
Mikael Ahlstrom and Christel Lamberg-Allardt


INFLAMMATION & IMMUNOPHARMACOLOGY


1341 Inhibition of platelet-activating factor synthesis in
human neutrophils and platelets by propionyl-L-car-
nitine
Massimo Triggiani, Alfonso Oriente, Paolo Golino,
Marco Gentile, Carmine Battaglia, Gregorio Drevetti
and Gianni Marone

GASTROINTESTINAL & RENAL PHARMACOLOGY

1349 Correlation between acid secretion and proton pump
activity during inhibition by the proton pump inhib-
itors omeprazole and pantoprazole
Kinue Nishioka, Taku Nagao and Tetsuro Urnshidani


1361 Carnitine transport and its inhibition by sulfonyl'
ureas in human kidney proximal tuluilar epithelial
cells
Wei Huang, Sobia N. Shaikh, Malliga E. G anapathy,
Ullrich Hopfer, Frederick H. Leihach, A. Lee Carter
and Vadivel Ganapathy

1371 Inhibitory effect of valproate on weak organic acid
uptake in rat renal proximal tubules
Ekaterina I .Zagryadskaya, lrina B. Ostresova and
Anatolii A. Nikiforov

1379 Additions and Corrections

_________________________________________