CHEMOTHERAPY
VOL:45, NO:1, FEBRUARY 1999

Pharmacology

1 Pharmacokinetics of Cefodizime in
Patients with Various Degrees of Rena)
Failure

Loffreda, A.; Lampa. E.; Lucarelli, C.; Amorena, M.;
Contaldi, C.; Calderaro, V.; Rossi, F. (Naples)

Microbiology

8 Prevalence of Antimicrobial Resistance in
Eighty Clinical Isolates of Heficobacter
pylori

lovene, M.R.; Rumano, M.; Pilloni, A.P.;
Giordano, B.; Montella, F.; Caliendo, S.;
Tufano, M.A. (Napoli)

15 Increasing Prevalence of Ampicillin-
Resistant, Non-Beta-Lactamase-
Producing Strains of Haemophilus
influenzae in Children in Japan
Seki, H.; Kasahara, Y.; Ohta, K.; Ohta, K.;
Saikawa, Y.; Sumita, R.; Yachie, A.; Fujita, S.;
Koizurni, S. (Kanazawa)

22 In vitro Activity of Trovafloxacin
(CP 99,219), a New Fluoroquinolone
against Hospital Isolates
Ling, T.K.W.; Liu, E.Y.M.; Cheng, A.F.B.
(Hong Kong) '

28 Effect of the Growth Rate of
Pseudomonas aeruginosa Biofilms on the
Susceptibility to Antimicrobial Agents:
ti-Lactams and Fluoroquinolones
Tanaka, G.; Shigeta, M.; Komatsuzawa, H.;
Sugai, M.; Suginaka, H.; Usui, T. (Fliroshima City)

37 Pole of Inhibition of Penicillin Binding
Proteins and Gell Wall Cross-Linking by
Beta-Lactam Antibiotics in Low- and
High-Level Methicillin Resistance of
Staphylococcus aureus
Higashi, Y. (Osaka/Tokyo); Wakabayashi, A.;
Matsumoto, Y.; Watanabe, Y. (Osaka); Ohno, A.
(Tokyo)

Experimental Chemotherapy

48 A New Fluoroquinolone Derivative
Exhibits Inhibitory Activity against
Human Immunodeficiency Virus
Type 1 Replication

Kashiwase, H.; Momota, K.; Ohmine, T.;
Komai, T. (Tokyo); Kimura, T.; Katsube, T.
(Yamaguchi); Nishigaki, T.; K-imura, S.;
Shimada, K.; Furukawa, H. (Tokyo)

56 Reduction of Mucoid Staphylococcus
epidermidis Adherence to Intraocular
Lenses by Selected Antimicrobial Agents
Kadry, A.A.; Tawfik, A.-K.F.; Abu EI-Asrar, A.A.;
Shibi, A.M. (Riyadh)

61 Enhanced Cytogenetic and
Antineoplastic Effects by the Combined
Action of Two Esteric Steroidal
Derivatives of Nitrogen Mustards
P agageorgiou, A. (Thessaloniki);
Nikolaropoulos, S.S.; Arsenou, E.S. (Patras);
Karaberis, E.; Mourelatos, D.; Kotsis, A.;
Chryssogelou, E. (Thessaloniki)

Clinical Report

68 Treatment of Malaria tropica with a Fixed
Combination of Rifampicin,
Co-Trimoxazole and Isoniazid: A Clinical
Study
Goerg, H. (Mbita); Ochola, S.A. (Mbita/Homa Bay);
Goerg, R. (Löwenstein)
77 Book Reviews

_______________________________________

Chemotherapy

Vol. 45, No. 2, 1999

83 (beta)-Lactam-Resistant Streptococcus pneumoniae:
Epidemiology and Evolutionary Mechanism
Hakenbeck. R. (Kaiserslautern)

95 Mycobacteria: Genetics of Resistance and Implications for
Treatment
Sander, P.; Buttger, E.C. (Hannover)

109 Epidemiology of Mycobacterial Resistance
(Especially Mycobacterium tuberculosis)
Fischer, B. (Mainz)

121 Epidemiology of Methicillin-Resistant Staphylococcus
aureus
Filickiger, U.; Widmer, A.F. (Basel)

135 Enterococci
Witte, W. (Wernigerode); Wirth, R. (Regensburg); Klare, 1.
(Wernigerode)

________________________________________

CHEMOTHERAPY
VOL:45, NO:3, MAY 1999

Pharmacology

147 Phase l Pharmacokinetic Study of a New
3-Azinomethyl-Rifamycin (Rifametane) äs
Compared to Rifampicin
Potkar, C.; Gogtay, N.; Gokhaie, P.; Kshirsagar, N.A.:
Ajay, S.; Cooveiji, N.D. (Bombay); Bruzzese, T. (Milan)

Microbiology

154 In vitro Activities of Pazufloxacin, a Novel
Injectable Quinolone, against Bacteria Causing
Infections in Obstetric and Gynecological
PatientS

Mikamo, U.; Sato, Y.; Uayasaki, Y.; Kawazoe, K.:
Tamaya, T. (Gifu)

158 Genetic Analysis of Serotype 23F Streptococcus
pneumoniae Isolates from Several Countries by
Penicillin-Binding Protein Gene Fingerprinting
and Pulsed-Pield Gel Electrophoresis
Yoshida, R.; Hirakata, Y. (Nagasaki); Kaku, M. (Kawasaki);
Tomono, K.; Maesaki, S,; Yamada,Y.; Kamihira, S,
(Nagasaki); Jacobs, M.R. (Cleveland, Ohio);
Appelbaum, P.C. (Hershey, Penn.); Kohno, S. (Nagasaki)

166 Influence of Sub-Minimum Inhibitory
Concentrations of Cefodizime on the
Phagocytosis, Intracellular Killing and Oxidative
Bursts of Human Polymorphonuclear
Leukocytes
Braga, P.C.; Dal Sasso, M.; Mancini, L.; Sala, M.T. (Milan)

175 Mechanisrns of Action of Quinolones against
Staphylococci and Relationship with Their
in vitro Bactericidal Activity
Ramon, M.S,; Cantön, E.; Pemän, J.; Pastor, A.;
Martinez, J.P. (Valencia)

Experimental Chemotherapy

183 Therapeutic Effect of Oral Levofloxacin,
Ciprofloxacin, and Ampicillin on Experimental
Murine Pneumonia Caused by Penicillin
Intermediate Streptococcus pneumoniae for
Which the Minimum Inhibitory Concentrations
of the Quinolones Are Similar
lshida, Y.; Kurosaka, Y.; Murakami, Y.; Otani, T.;
Yamaguchi, K. (Tokyo)

192 Synthesis and Screening for Anti-HIV Activity of
Sorne N-Mannich Bases of lsatin Derivatives
Pandeya, S.N.; Yogeeswari, P.; Sriram, D. (Varanasi);
de Clercq, E.; Pannecouque, C.; Witvrouw, M. (Leuven)
197 Intrapleural Administration of Cisplatin and
Etoposide to Treat Malignant Pleural Effusions
in Patients with Non-Small Cell Lung Cancer
Tohda, Y.; Iwanaga, T.; Takada, M.; Yana, T.;
Kawahara, M.; Negoro, S.; Okishio, K.; Kudoh, S.;
Flikuoka, M.; Furuse, K. (Osaka)

Clinical Reports

205 Low-Dose Amphotericin B Lipid Complex for
the Treatment of Persistent Fever of Unknown
Origin in Patients with Hematologic
Malignancies and Prolonged Neutropenia
Martino, R.; Subirä, M.; Domingo-Albös, A.; Sureda, A.;
Bruiiet, S.; Sierra, J. (Barcelona)

213 Postprostatectomy Orchitis: Reduction in
Incidence Using Perioperative Ceftriaxone and
Postoperative Ciprofloxacin
Anyanwu, S.N.C. (Nnewi)

217 Long-Acting versus Short-Acting
Cephalosporins for Preoperative Prophylaxis in
Breast Surgery: A Randomized Double-Blind
Trial Involving 1,766 Patients
Thomas, R.; Alvino, P.; Cortino, G.R.; Accardo, R.;
Rinaldo, M.; Pizzorusso, M.; Cesareo, E.; D'Aiuto, G.
(Naples)

224 Antifungal Prophylaxis in Neutropenic Patients
with Hematologic Malignancies: IsThere a Real
Benefit?
Böhme, A. (Frankfurt); Karthaus, M. (Hannover);
Hoelzer, D. (Frankfurt)

Scientific Correspondence
233 Commentson
'Preventive Effect of Dapsone on Renal Scarring
following Mannose-Sensitive Piliated Bacterial
Infection' by Mochida et al.
(Chemotherapy 1998;44:36-41)
Wozel, G.; Blümlein, K.; Blasum, C.; Lehmann, B.;
Winter, C. (Dresden)

235 Reply
to the Comment of Wozel et al. on the Paper by
Mochida et al.
(Chemotherapy 1998;44:36-41)
Matsumoto, T.; Mochida, 0. (Kitakyushu/Fukuoka)

236 Book Review

Chemotherapy
VOL. 45, NO. 4, JULY_ AUGUST 1999

237 European Surveillance of Infections in
Cancer Patients - ESIC
Karthaus, M. (Hannover); Buchheidt, D.
(Mannheim); Hiddemann, W. (Munich);
Donnelly, J.P. (Nijmegen); Krcmery, V.
(Bratislava); Schiel, X. (Munich); Wilhelm, M.
(Wiirzburg); Helmerking, M. (Munich)

Microbiology

242 Minimum Inhibitory and Minimal Lethal
Concentration against Chlamydia
trachomatis Dependent on the Tme of
Addition and the Duration of the
Presence of Antibiotics
Notomi, T.; Ikeda, Y.; Nagayama, A. (Fukuoka)

249 In vitro Bactericidal Activities of a New
Oral Cephalosporin, El 100, and
Morphologic Changes on Escherichia coli
Mikamo, H. (Gifu); Satoh, M.; Kai, J. (Tokyo,);
Sato, Y.; Hayasaki, Y.; Tamaya, T. (Gifu)

253 In vitro Activities of Meropenern and
Other Antimicrobial Agents against
British Meningococcal Isolates
Abadi, F.J.R.; Yakubu, D.E.; Pennington, T.H.
(Aberdeen)

Experimental Chemotherapy

258 Apoptosis of Cultured Neuroblastoma
Cells Is Induced by Ceramide and Not by
Ligation of the Fas/Apo-1/CD95 Receptor
Barthlen, W.; Schafer, J.; Girgert, R.; Schuster, M.;
Schweizer, P. (Ttibingen)

268 Killing of Gram-Negative Bacteria by
Ciprofloxacin within both Healthy Human
Neutrophils and Neutrophils with
Inactivated O(2)-Dependent Bactericidal
Mechanisms
Canton, E.; Peman, J.; Cabrera, E.; Velert, M.;
Orero, A.; Pastor, A.; Gobernado, M. (Valencia)

277 Effect of Fluconazole on Human
Polymorphonuclear Leucocyte FUhctions
ex vivo against Candida albicans
Giirer, U.S.; Cevikba?. A.; Johansson, C.;
Derici,K.;Yardimci,T. (Istanbul)

284 Pharmacodynamics of Intermittent- and
Continuous-Infusion Cefepime Alone and
in Combination with Once-Daily
Tobramycin against Pseudomonas
aeruginosa in an in vitro Infection Model
Tessier, P.R. (Hartford, Conn.); Nicolau, D.P.
(Hartford, Conn./Storrs, Conn.); Onyeji, C.O.
(Hartford, Conn.); Nightingale, C.H.
(Hartford, Conn./Storrs, Conn.)

296 Ionic Binding of (3)H-Gentamicin and
Short-Time Bactericidal Activity of
Gentamicin against Pseudomonas
aeruginosa Isolates with Different
Lipopolysaccharide Structures
Saika, T.; Hasegawa, M.; Kobayashi, 1.; Nishida, M.
(Tokyo)

303 Nitazoxanide, a Nitrothiazolide
Antiparasitic Drug, Is an
Anti-Helicobacter pylori Agent with
Anti-Vacuolating Toxin Activity
Yamamoto, Y.; Hakki, A.; Friedman, H.
(Tampa, Fla.); Okubo, S.; Shimamura, T. (Tokyo);
Hoffman, P.S. (Halifax); Rossignol, J.-F.
(Tampa, Fla.)

Letter to the Editor

313 Nosocomial Staphylococcal Meningitis in
Neonates Successfully Treated with
Intraventricular Teicoplanin
Kralinsky, K.; Lako, J.; Diuholucky, S.;
Krcmery, V., Jr. (Banska Bystrica/Bratislava)

Chemotherap

Vol. 45, No. 5, June 1999


Contents

The Challenge of Invasive Fungal Infection 1
de Pauw, B.E.; Meunier, F. (Brussels)


Amphotericin B Colloidal Dispersion. Pre-Clinical Review 15
Working, P.K. (Menlo Park, Calif.)



Clinical Efficacy of Amphotericin B Colloidal Dispersion 27
against Infections Caused by Candida spp
Dupont, B. (Paris)



Clinical Efficacy of Amphotericin B Colloidal Dispersion 34
against Infections Caused by Aspergillus spp
Gurwith, M. (Menlo Park, Calif.)



Renal Sparing by Amphotericin B Colloidal Dispersion: 39
Clinical Experience in 572 Patients
Gurwith, M.; Mamelok, R.; Pietrelli, L.; Du Mond, C.
(Menlo Park, Calif.)



The Population Pharmacokinetics of Amphotericin B 48
Colloidal Dispersion in Patients Receiving Bone Marrow
Transplants
Amantea, M.A. (Menlo Park, Calif.); Bowden, R.A. (Seattle, Wash.);
Forrest, A. (New York, N.Y.); Working, P.K.; Newman, M.S.;
Mamelok, R.D. (Menlo Park, Calif.)



Treatment of Visceral Leishmaniasis with Amphotericin B 54
Colloidal Dispersion
Berman, J. (Washington, D.C.); Dietze, R. (Espirito Santo)



Safety and Efficacy of Amphotericin B Colloidal Dispersion. 67
An Overview
Herbrecht, R.; Letscher, V.; Andres, E.; Cavalier, A. (Strasbourg)


Author Index 77

Subject Index 77