CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Vol 115, No 2, February 1999

CONTENTS

Allergy

E. R. JARMAN, A. KUBA, E. MONTERMANN, R. R. BARTLETT
& A. B. RESKE-KUNZ: Inhibition ofrnurine lgE and
immediate cutaneous hypersensitivity responses to
ovalbumin by the immunomodulatory agent leflunomide 221

Cancer immunology

V. V^TVICKA, M. HANIKYROVA, J. VETVICKOVA & G. D. ROSS:
Regulation ofCR3 (CDIIb/CD18)-dependent natural killer
(NK) cell cytoto-xicity by tumour target cell MHC class
I molecules 229

Cardiac disease

P. SKYLLOURIOTIS, M. SKYLLOURIOTIS-LAZAROU, S. NATTER,
R. STEINER, S. SPITZAUER, S. KAPIOTIS, P. VALENT,
A. M. HIRSCHL, S. E. GUBER, G. LAUFER, G. WOLLENEK,
E. WOLNER, M. WIMMER & R. VALENTA: lgG subclass
reactivity to human cardiac myosin in cardiomyopathy
patients is indicative of a Th I-like autoimmune disease 236

Endocrine disease

T. c. MARTINS & A. P. AGUAS: Mechanisms of Mycobacterium
avium-mduced resistance against insulin-dependent diabetes
mellitus (IDDM) in non-obese diabetic (NOD) mice: role of
FasandThIcells 248

E. AHMED, S. NITYANAND, A. MUSTAFA, K. BRISMAR &
A. K. LEFVERT: Anti-cardiolipin antibodies and circulating
immune complexes in type I diabetes mellitus: increased
prevalence and relation to vascular complications 255

v. ABLAMUNITS, D. ELIAS & l. R. COHEN: The pathogenicity
of islet-infiltrating lymphocytes in the non-obese diabetic
(NOD) mouse 260

Experimental models of autoimmunity

G. KINOSHITA, A. W. PURCELL, C. L. KEECH, A. D. FARRIS,
J. McCLUSKEY & T. p. GORDON: Molecular chaperoncs are
targets of autoimmunity in Ro(SS-A) immune mice 268

M. SUTMULLER, J. J. BAELDE, M. P. MADAIO, J. A. BRUIJN
& E. DE HEER: Idiotype usage by polyclonally activated
B cells in experimental autoimmunity and infection 275

M. LE HIR, M. MARTIN & c. HAAS: A syndrome resembling
human systemic sclerosis (scleroderma) in MRL/lpr mice
lacking interferon-gamma (IFN-y) receptor (MRL/lpryR-/-) 281

Eye immunology

1. J. CRANE, M. C. KUPPNER, S. McKILLOP-SMITH,
c. A. WALLACE & J. v. FORRESTER: Cytokine regulation of
granulocyte-macrophage colony-stimulating factor
(GM-CSF) production by human retinal pigment epithelial
cells 288

Gut disease

G. BOUMA, J. B. A. CRUSIUS, M. A. GARCfA-GONZALEZ,
B. U. G. A. MEIJER, H. P. R. HELLEMANS, R. J. HAKVOORT,
G. M. TH. SCHREUDER, P. J. KOSTENSE, S. G. M. MEUWISSEN
& A. s. PENA: Genetic markers in clinically well defined
patients with ulcerative colitis (UC) 294

Human immunology

T. SATO, A. DEIWICK, G. RADDATZ, K. KOYAMA & H. J. SCHLITT:
Interactions of allogeneic human mononuclear cells in the
two-way mixed leucocyte culture (MLC): influence of cell
numbers, subpopulations and cyclosporin 301

A. KOTIRANTA-AINAMO, M. APAJASALO, M. POHJAVUORI,
N. RAUTONEN & J. RAUTONEN: Mononuclear cell
subpopulations in preterm and full-term neonates:
independent effects of gestational age, neonatal infection,
maternal pre-eclampsia, maternal betamethason therapy,
and mode of delivery 309




M. J. HIESMAYR, A. SPITTLER, A. LASSNIGG, R. BERGER,
G. LAUFER, A. KOCHER, 0. ARTEMIOU, G. BOLTZ-NITULESCU
& E. ROTH: Alterations in the number of circulating
leucocytes, phenotype of monocyte and cytokine production
in patients undergoing cardiothoracic surgery 315

Contents continued from back cover

Immunity to infection

G. DAS, H. VOHRA, B. SAHA, J. N. AGREWALA & G. C. MISHRA:
Apoptosis of Th I-like cells in experimental tuberculosis
(TB) 324

A. MARKOTIC, G. DASIC, A. GAGRO, A. SABIONCELLO,
S. RABATIC, 1. KUZMAN, R. ZGORELEC, 1. SMOLJAN, 1. BEUS,
T. A. ^UPANC & D. DEKARIS: Role of peripheral blood
mononuclear cell (PBMC) phenotype changes in the
pathogenesis of haemorrhagic fever with renal syndrome
(HFRS) 329

Y. LU, K.-Q. XIN, K. HAMAJIMA, T. TSUJI, 1. AOKI, J. YANG,
S. SASAKI, J. FUKUSHIMA, T. YOSHIMURA, S. TODA, E. OKADA
& K. OKUDA: Macrophage inflammatory protein-la (MIP-la)
expression plasmid enhances DNA vaccine-induced immune
response against HIV-1 335

M. SOTO, J. M. REQUENA, L. QUIJADA, M. J. PEREZ, C. G. NIETO,
F. GUZMAN, M. E. PATARROYO & C. ALONSO: Antigenicity of
the Leishmania infantum histones H2B and H4 during
canine viscerocutaneous leishmaniasis 342

J. WATTAVIDANAGE, R. CARTER, K. L. R. L. PERERA,
A. MUNASINGHA, S. BANDARA, D. McGUINNESS,
A. R. WICKRAMASINGHE, H. K. ALLES, K. N. MENDIS &
s. PREMAWANSA: TNF(x*2 marks high risk of severe disease
during Plasmodiurnfalciparum malaria and other infections
in Sri Lankans 350

Immunodeficiency

S. KUMAKI, H. D. OCHS, K. K. KUROPATWINSKI, T. KONNO,
M. S. TIMOUR, D. COSMAN & H. BALJMANN: A novel inulant
yc chain from a patient with typical phenotype ofX-linked
severe combined immunodeficiency (SCID) has partial
signalling function for mediating IL-2 and IL-4 receptor
action 356

Vasculitis

M. DE BANDT, 0. MEYER, L. DACOSTA, C. ELBIM & C. PASQUIER:
Anli-proteinase-3 (PR3) antibodies (C-ANCA) recognize
various targets on the human umbilical vein endothelial cell
(HUVEC) membrane 362

1. C. LOCKE, B. LEAKER & G. CAMBRIDGE: A comparison of
the characteristics of circulating anti-myeloperoxidase
autoantibodies in vasculitis with those in non-vasculitic
conditions 369

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CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Vol 116, No 1, April 1999

Reviews

c. J. coRRKiAN: Eolaxiii and asthma: sonic answers, more
questions 1

C. E. H. SIRGERT, M. D. KAZATCHKINE, A. SJOHULM, R. WORZNER,
M. LOOS & M. R. DAHA: AutoantibocHes against Clq: view on
clinical relevance and pathogenic roles 4

Ageing/n utrition

W. BERGLER, S. ADAM, H.-J. GROSS, K. HORMANN &
R. SCHWARTZ-ALBIEZ: Age-dependent altered proportions in
subpopulations of tonsillar lymphocytes 9

E. MARIANI, G. RAVAGLIA, P. FORTI, A. MENEGHETTI, A. TAROZZI,
F. MAIOLI, F. BOSCHI, L. PRATELLI, A. PIZZOFERRATO, F. PIRAS &
A. FACCHINI: Vitamin D, thyroid hormones and muscle mass
influence natural killer (NK) innate immunity in healthy
nonagenarians and centenarians 19

J. TAMURA, K. KUBOTA, H. MURAKAMI, M. SAWAMURA,
T. MATSUSHIMA, T. TAMURA, T. SAITOH, H. KURABAYSHI &
T. NARUSE: Immunomodulation by vitamin B12: augmentation
of CD8^ T lymphocytes and natural killer (NK) cell activity in
vitamin B12-deficient patients by methyl-B12 treatment 28

Cancer immunology

F. MOTA, N. PAYMENT, S. CHONG, A. SINGER & B. CHAIN:
The antigen-presenting environment in normal and human
papillomavirus (HPV)-related premalignant cervical
epithelium 33

P. UTAISINCHAROEN, S. UBOL, N. TANGTHAWORNCHAIKUL,
P. CHAISURIYA & s. SIRISINHA: Binding of tumour necrosis
factor-alpha (TNF-a) to TNF-RI induces caspase(s)-dependent
apoptosis in human cholangiocarcinoma cell lines 41

S. J. PETTIT, S. ALI, E. O'FLAHERTY, I. R. L. GRIFFITHS,
D. E. NEAL & J. A. KIRBY: Bladder cancer immunogenicity:
expression ofCD8() and CD86 is insufficient to allow primary
CD4^ T cell activation in vitro 48

M. TANAKA, J. HONDA, Y. IMAMURA, K. SHIRAISHI, K. TANAKA &
K. OIZUMI: Surface phenotype analysis of CD 16^ monocytes
from leukapheresis collections for peripheral blood
progenitors 57

Endocrine immunology/disease

Z. WU. P. A. BIRO, R. MIRAKIAN, L. HAMMOND, F. CURCIO,
I F. S. AMBESI-lMPIOMBATO & G. F. BOTTAZZO: HLA-DMB
expression by thyrocytes: indication of the antigen-processing
and possible presenting capability of thyroid cells 62

E. SAVILAHTI, T. ORMALA, T. SAUKKONEN,
U. SANDINI-POHJAVUORI, J. M. KANTELE, A. ARATO, J. ILONEN
& H. K. AKERBLOM: Jejuna of patients with insulin-dependent
diabetes mellitus (IDDM) show signs of immune activation 70

E. SABBAH, K. SAVOLA, P. KULMALA, H. REIJONEN, R. VEIJOLA,
P. VAHASALO, J. KARJALAINEN, J. ILONEN, H. K. AKERBLOM,
M. KNIP & THE CHILDHOOD DIABETES IN FINLAND STUDY
GROUP: Disease-associated autoantibodies and HLA-DQB I
genotypes in children with newly diagnosed insulin-dependent
diabetes mellitus (IDDM) 78

Gut immunology

Y. MORIMOTO, A. HIZUTA, E. X. DING, T. ISHII, T. HONGO,
T. FUJIWARA, H. IWAGAKI & N. TANAKA: Functional expression
of Fas and Fas ligand on human intestinal intraepithelial
lymphocytes 84

A. ANDOH, T. KIMURA, M. FUKUDA, Y. ARAKI, Y. FUJIYAMA &
T. BAMBA: Rapid intestinal ischaemia-reperfusion injury is
suppressed in genetically mast cell-deficient Ws/Wy rats 90

Immunity to infection

L. E. BERMUDEZ, A. PARKER & M. PETROFSKY: Apoptosis of
Mycobacterium avium-infected macrophages is mediated by
both tumour necrosis factor (TNF) and Fas, and involves the
activation of caspases 94

A. BHATNAGAR, A. GROVER & N. K. GANGULY: Superantigen-
induced T cell responses in acute rheumatic fever and chronic
rheumatic heart disease patients 100

E. D. WILLIAMSON, P. M. VESEY, K. J. GILLHEPSY, S. M. ELEY,
M. GREEN & R. w. TITBALL: An lgGI titre to the Fl and V
antigens correlates with protection against plague in the
mouse model 107

continued from back cover

NOU, P. AUKRUST, D. KVALE, F. MULLER &
\ND: IL-IO in HIV infection: increasing serum IL-IO
h disease progression-down-regulatory effect of
i-retroviral therapy 115

ORATI, A. PALARETI, P. DOLZANI, C. A. BUSACHI,
i & A. FACCHINI: A mathematical model predicting
:itis B virus surface antigen (HBs) decay after
)n against hepatitis B 121

1. LOUZIR, A. BEN SALAH, M. MOKNI, A. BEN OSMAN
AGI: Leishmanin skin test lymphoproliferative
and cytokine production after symptomatic or
natic Leishmania major infection in Tunisia 127

ase

iER, A. G. DIAMOND, S. J. YEAMAN, M. F. BASSENDINE
'ONES: T cell responses to the putative dominant
)e in primary biliary cirrhosis (PBC) 133

)A, K. KUROKOHCHI, K. ARIMA & M. NISHIOKA:
bcl-2 expression in lymphocytes and its association
tocellular damage in patients with autoimmune 140

Rheumatic disease

M. MOLTENI, S. DELLA BELLA, B. MASCAGNI, S. BAZZI,
c. ZULIAN, s. COMPASSO, M. LESSI & R. SCORZA: Increased
interferon-gamma (IFN-gamma) levels produced in vitro by
alloactivated T lymphocytes in systemic sclerosis and
Ray naud's phenomenon 164

Y. TOKANO, S. MORIMOTO, H. KANEKO, H. AMANO, K. NOZAWA,
Y. TAKASAKI & H. HASHIMOTO: Levels of lL-L2 in the sera of
patients with systemic lupus erythematosus (SLE)-relation
to Th I - and Th2-derived cytokines 169

M. OKAWA-TAKATSUJI, S. AOTSUKA, M. FUJI. 'AMI, S. UWATOKO,
M. KINOSHITA & M. SUMIYA: Up-regulation of intercellular
adhesion molecule-1 (ICAM-I), endothelial leucocyte
adhesion molecule-1 (ELAM-1 ) and class II MHC molecules
on pulmonary artery endothelial cells by antibodies against
Ul-ribonucleoprotein 174
Tolerance

B. S. LUNDIN, M. R. KARLSSON, L. A. SVENSSON, L. A. HANSON,
u. i. H. DAHLGREN & E. TELEMO: Active suppression in orally
tolerized rats coincides with in situ transforming growth
factor-beta (TGF-p) expression in the draining lymph nodes 181

Whole body hyperthermia

R. J. KEARNS, S. RINGLER, S. KRAKOWKA, R. TALLMAN, J. SITES
& M. J. OGLESBEE: The effects of extracorporeal whole body
hyperthermia on the functional and phenotypic features of
canine peripheral blood mononuclear cells (PBMC) 188

__________________________________________________________________

CLINICAL AND EXPRIMENTAL IMMUNOLOGY VOL 116, NO 3, JUNE 1999 CONTENTS Review

M. G. HUMPHREYS-BEHER, A. B. PECK, H. DANG & N. TALAL: The role of apoptosis in the initiation of the autoimmune response in Sjogren's syndrome 382

Cancer immunology

M. HISHII, J. T. KURNICK, T. RAMIREZ-MONTAGUT & F. PANDOLFI: Studies of the mechanism of cytolysis by tumour-infiltrating lymphocytes 388

Complement

F. J. M. BEURSKENS, J. D. M. KUENEN, F. HOFHUIS, A. C. FLUIT, D. M. ROBINS & H. VAN DIJK: Sex-limited protein: in vitro and in vivo functions 395

Ear disease

M. NARKIO-MAKELA, J. JERO & S. MERI: Complement activation and expression of membrane regulators in the middle ear mucosa in otitis media with effusion 401

Eye disease

M. MUHAYA, V. L. CALDER, H. M. A. TOWLER, G. JOLLY, M. MCLAUCHLAN & s. LIGHTMAN: Characterization of phenotype and cytokine profiles of T cell lines derived from vitreous humour in ocular inflammation in man 410

Gut disease

A. M. WILLIAMS, C. V. WHITING, K. BONHAGEN, J. REIMANN, S. BREGENHOLT, M. H. CLAESSON & P. W. BLAND: Tumour necrosis factor-alpha (TNF-a) transcription and translation in the CD4^ T cell-transplanted scid mouse model of colitis 415

Human immunology

L. LLORENTE, Y. RICHAUD-PATIN, A. DIAZ-BORJON, J. JAKEZ-OCAMPO & C. ALVARADO-DE LA BARRERA: Increased collagenase and dipeptidyl peptidase I activity in leucocytes from healthy elderly people 425

M. LUKKARINEN, K. PARTO, 0. RUUSKANEN, 0. VAINIO, H. KAYHTY, R.-M. OLANDER & 0. SIMELL: B and T cell immunity in patients with lysinuric protein intolerance 430

G. WEISS, C. MURR, H. ZOLLER, M. HAUN, B. WIDNER, c. LUDESCHER & D. FUCHS: Modulation of neopterin formation and tryptophan degradation by Thi- and Th2-derived cytokines in human monocytic cells 435

S.-C. HUANG, A. M. GLAS, G. V. PINCHUK, E. H. N. VAN MONTFORT, S. P. RAO, R. JIANG & E. C. B. MILNER: Human B cells accumulate immunoglobulin V gene somatic mutations in a cell contact-dependent manner in cultures supported by activated T cells but not in cultures supported byCD401igand 441

Immunology of reproduction

T. YAMAMOTO, Y. TAKAHASHI, N. KASE & H. MORI: Role of decidual natural killer (NK) cells in patients with missed abortion: differences between cases with normal and abnormal chromosome 449

Immunity to infection

M. GALDIERO, A. FOLGORE, M. MOLITIERNO & R. GRECO: Porins and lipopolysaccharide (LPS) from Salmonella typhimurium induce leucocyte transmigration through human endothelial cells in vitro 453

M. S. PALERMO, M. F. ALVES ROSA, N. VAN ROOIJEN & M. A. ISTURIZ: Depletion of liver and splenic macrophages reduces the lethality of Shiga toxin-2 in a mouse model 462

W. J. JABS, M. PAULSEN, H. J. WAGNER, H. KIRCHNER & H. KLUTER: Analysis ofEpstein-Barr virus (EBV) receptor CD21 on peripheral B lymphocytes of long-term EBV adults 468

0. JOBE, K. ARIYOSHI, A. MARCHANT, S. SABALLY, T. CORRAH, N. BERRY, S. JAFFAR & H. WHITTLE: Proviral load and immune function in blood and lymph node during HIV-I and HIV-2 infection 474


Contents continued from back cover

K. F. T. COPELAND, P. J. McKAY, J. NEWTON & K. L. ROSENTHAL: CD8^ T cell-mediated enhancement of tumour necrosis factor-alpha (TNF-oc) production and HIV-1 LTR-driven gene expression in human monocytic cell is pertussis toxin-sensitive 479

S. ZANUSSI, C. SIMONELLI, M. T. BORTOLIN, M. D^ANDREA, C. CREPALDI, E. VACCHER, G. NASTI, D. POLITI, L. BARZAN, u. TIRELLI & P. DE PAOLI: Immunological changes in peripheral blood and in lymphoid tissue after treatment of HIV-infected subjects with highly active anti-retroviral therapy (HAART) or HAART + IL-2 486

A. B. SIDDIQUE, N. AHLBORG, M. WARSAME, P. PERLMANN & K. BERZINS: Antibodies to a non-repeat region of Plasmodiurnfalciparum antigen Pfl55/RESA in individuals from malaria-endemic areas 493

K. KEMP, M. KEMP, A. KHARAZMI, A. ISMAIL, J. A. L. KURTZHALS, L. HVIID & T. G. THEANDER: Leishmania-specific T cells expressing interferon-gamma (IFN-y) and IL-IO upon activation are expanded in individuals cured of visceral leishmaniasis 500

Immunodeficiency

J. AITTONIEMI, S. KOSKINEN, P. LAIPPALA, S. LAINE & A. MIETTINEN: The significance ofIgG subclasses and mannan-binding lectin (MBL) for susceptibility to infection in apparently healthy adults with IgA deficiency 505

W. A. C. SEWELL, M. E. NORTH, R. CAMBRONERO, A. D. B. WEBSTER & J. FARRANT: In vivo modulation of cytokine synthesis by intravenous immunoglobulin 509

E. G. DE LA CONCHA, M. FERNANDEZ-ARQUERO, A. MARTINEZ, F. VIDAL, P. VIGIL, L. CONEJERO, M. C. GARCIA-RODRIGUEZ & G. FONTAN: HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID) 516

Neonatal immunology 1^^

M.-M. GRONLUND, J. NUUTILA, L. PELTO, E.-M. LILIUS, E. ISOLAURI, S. SALMINEN, P. KERO & O.-P. LEHTONEN: Mode of delivery directs the phagocyte functions of infants for the first 6 months of life 521

E. EARLY & D. J. REEN: Rapid conversion of naive to effector T cell function counteracts diminished primary human newborn T cell responses 527

Rheumatic disease

c. A. JONSSON, L. SVENSSON & H. CARLSTEN: BeneFicial effect of the inosine monophosphate dehydrogenase inhibitor mycophenolate mofetil on survival and severity ofglomerulo-nephritis in systemic lupus erythematosus (SLE)-prone URLlpr/lpr mice 534

M. KAWANO, T. SEYA, 1. KONI & H. MABUCHI: Elevated Serum levels of soluble membrane cofactor protein (CD46, MCP) in patients with systemic lupus erythematosus (SLE) 542

Skin disease

M. KURITA, M. MATSUMOTO, S. TSUJI, M. KAWAKAMI, Y. SUZUKI, H. HAYASHI, K. TOYOSHIMA & T. SEYA: Antibody-independent classical complement pathway activation and homologous C3 deposition in xeroderma pigmentosum cell lines 547

Vasculitis
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CliNICAL AND EXPERIMENTAL IMMUNOLOGY
Vol: 117, No: 1, July 1999

Cancer
M. INOUE, M. OKUMURA, S. MIYOSHI. H. SFHONO, K. FUKUHARA,
Y. KADOTA, R. SHIRAKURA & H. MATSUDA: Impaired expression
of MHC class II molecules in response to interferon-gamma
(IFN-Y) on human thymoma neoplastic epithelial cells l

S. J. HILL, S. H. PETERS, M. J. AYLIFFE, J. MF.RCEICA &
A. s. BANSAL: Reduced IL-4 and interferun-gamma (IFN-y)
expression by CD4 T cells in patients with chronic
lymphocytic leukaernia 8

Complement
B. D. REILLY: Analysis of human C4A and C4B binding to an
immune complex in serum 12

Endocritle disease
j. GUO, Y. WANG, J. C. JAUME, B. RAPOTORT &
s. M. MCLACHLAN: Rarity of autoantibodies to a major
autoantigen, thyroid peroxidase, that interact with denatured
antigen or with epitopes olitside the immunodominant region 19

F. RHARBAOUl, A. MAYER. C. GRANIER, M. BOUANANI,
C. IHIVOLET, B. PAU, J. ORGIAZZI & A.-M. MADEC: T cell
response pattern to glutarnic acid decarboxylase 65 (GAD65)
peptides ofnewiy diagnosed type l diabetic patients sharing
susceptible HLA haplotypes 30

M. SHINOMIYA, S. M. FAZLE AKBAR, H. SHINOMIYA & M. ONJI:
Transfer ofdendritic cells (DC) ex vivo stimulated with
interferon-gamma (IFN-Y) down-modulates autoimmune
diabetes in non-obese diabetic (NOD) mice 38

S. STOSIC-GRUJICIC, M. DIMITRIJEVIC & R. BARTLETT:
Leflunomide protects mice from multiple low dose
streptozotocin (MLD-SZ)-induced insulitis and diabetes 44

Gut disease
S. ILTANEN, K. HOLM, M. ASHORN, T. RUUSKA, P. LAIPPALA &
M. MÄKI; Changing jejunal ^5 T cell receptor (TCR)-bearing
intraepithelial lymphocyte density in coeliac disease 51
Immunity to infection

A. GUPTA, V. K. SHARMA, H. VOHRA & N. K. GANGULY:
Inhibition ofapoptosis by ionornycin and zinc in peripheral
blood mononuclear cells (PBMC) of leprosy patients 56

N. NILSSON, T. BREMELL, A. TARKOWSKT & H. CARLSTEN:
Protective role of NK l .1^ cells in experimental
Staphylococcus aureus arthritis 63

F. LECHNER, A. SCHÜTTE, U. VON BODUNGEN, G. BERTONI,
H. PFISTER, T. W. JUNGI & E. PETERHANS: Inducible nitric Oxide
synthase is expressed in joints of goats in the late stage of
infection with caprine arthritis eneephalitis virus 70

H. MÜLLER, G. MAYER, B. BEHNKE, E. HEIMÜLLER,
G. HAMSCHER, D. IMMLER, C. SIETHOFF, H. E. MEYER &
M. SCHREIBER: Enhancing ofanti-viral activity against HIV-1
by Stimulation of CD8^ T cells with thyrnic peptides 76

A. KUMAR, J. B. ANGEL, S. AUCOIN, W. D. CREERY,
M. P. DAFTARIAN, D. W. CAMERON, L. FILION & F. DIAZ-MITOMA:
Dysregulation of B7.2 (CD86) expression on monocytes of
HIV-infected individuais is associated with altered production
of lL-2 84

N. TEDLA, J. DWYER, P. TRUSKETT, D. TAUB, D. WAKEFIELD &
A. LLOYD: Phenotypic and functional characterization of
lymphocytes derived from normal and HIV-1 -infected human
lymph nodes 92

S. JUHELA, H. HYÖTY, R. UIBO, S. H. MERISTE, 0. UIBO,
M. LÖNNROT, M. HALMINEN, 0. SIMELL & l. ILONEN:
Comparison of enterovirus-specific cellular immunity in two
populations ofyoung children vaccinated with inactivated or
live poliovirus vaccines 100

R. LAYLOR, N. PORAKISHVILI, J. B. DE SOUZA, J. H. L. PLAYFAIR,
P. J. DELVES & T. LUND: DNA vaccination favours memory
rather than effector B cell responses 106

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CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Vol 117, No 2, August 1999

Editorial review

c. c. BUNN & c. M. BLACK: Systemic sclerosis: an
autoantibody mosaic 207

Allergy

T. RUSTEMEYER, S. DE LIGTER, B. M. E. VON BLOMBERG,
P. J. FROSCH & R. J. SCHEPER: Human T lymphocyte priming
in vitro by haptenated autologous dendritic cells 209

S. LISBY, L. H. HANSEN, T. MENNE & 0. BAADSGAARD:
Nickel-induced proliferation of both memory and naive
T cells in patch test-negative individuals 217

A. M. DAS, M. N. AJUEBOR, R. J. FLOWER, M. PERRETTI &
s. R. MCCOLL: Contrasting roles for RANTES and macrophage
inflammatory protein-la (MIP-loc) in a murine model of
allergic peritonitis 223

C. 1. BALDWIN, A. TODD, S. J. BOURKE, A. ALLEN &
J. E. CALVERT: Pigeon fanciers' lung: identification of disease-
associated carbohydrate epitopes on pigeon intestinal mucin 230

Y. HATANO, K. KATAGIRI & s. TAKAYASU: Increased levels
in vivo of mRNAs for IL-8 and macrophage inflammatory
protein-1 (x (MIP-1 a), but not of RANTES mRNA in
peripheral blood mononuclear cells of patients with atopic
dermatitis (AD) 237

Cancer immunology

T. ISHIDA, S. CHADA, M. STIPANOV, S. NADAF, F. 1. CIERNIK,
D. i. GABRILOVICH & D« P. CARBONE: Dendritic cells
transduced with wild-type p53 gene elicit potent anti-tumour
immune responses 244

H. M. OGMUNDSDOTTIR, S. SVEINSDOTTIR, A. SIGFUSSON,
1. SKAFTADOTTIR, J. G. JONASSON & B. A. AGNARSSON:
Enhanced B cell survival in familial macroglobulinaemia is
associated with increased expression of Bcl-2 252

Complement

C. WANG, P. T. BOZZA, S. F. BARBASHOV, A. SAUTY &
A. NICHOLSON-WELLER: In vitro and in vivo responses of
murine granulocytes to human complement-derived,
haemolytically-inactive C5b67 (iC5b67) 261

Gut immunology/disease

J. O'KEEFFE, K. MILLS, J. JACKSON & C. FEIGHERY: T cell
proliferation, MHC class II restriction and cytokine products
of gliadin-stimulated peripheral blood mononuclear cells
(PBMC) 269

K. H. THIELKE, R. PABST & H. J. ROTHKOTTER: Quantification
of proliferating lymphocyte subsets appearing in the intestinal
lymph and the blood 277

Human immunology

s. AGGARWAL & s. GUPTA: Increased activity of caspase 3 and
caspase 8 in anti-Fas-induced apoptosis in lymphocytes from
ageing humans 285

M. KRAMPERA, F. VINANTE, L. TAVECCHIA, L. MOROSATO,
M. CHILOSI, S. ROMAGNANI, M. E. ZANOLIN & G. PIZZOLO:
Progressive polarization towards a T helper/cytotoxic type-1
cytokine pattern during age-dependent maturation of the
immune response inversely correlates with CD30 cell
expression and serum concentration 291
E. N. MUGNAINI, T. EGELAND, A. SPURKLAND &
J. E. BRINCHMANN: The T cell receptor repertoire of
CD8^CD28~ T lymphocytes is dominated by expanded
clones that persist over time 298

Immunity to infection

G. VITALE, S. MANSUETO, G. GAMBINO, C. MOCCIARO,
C. LA RUSSA, P. MANSUETO, M. A. L. ZAMBITO, V. FERLAZZO,
C. BARBERA, M. LA ROSA, S. MILANO & E. CILLARI: Differential
up-regulation of circulating soluble selectins and endothelial
adhesion molecules in Sicilian patients with Boutonneuse
fever 304

G. ENTRICAN, R. WILKIE, P. McWATERS, J.-P. SCHEERLINCK,
P. R. WOOD & J. BROWN: Cytokine release by ovine
macrophages following infection with Chlamydia psittaci 309
J. BAUDITZ, M. ORTNER, M. BIERBAUM, G. NIEDOBITEK,
H. LOCHS & s. SCHREIBER: Production oflL-12 in gastritis
relates to infection with Helicobacter pylori 316
z. TOOSSI, L. XIA, M. wu & A. SALVEKAR: Transcriptional
activation of HIV by Mycobacterium tuberculosis in human
monocytes 324

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CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Vol. 117, No. 3, September 1999

Editorial review
R. PABST: Regeneration of autotransplanted splenic
fragments: basic immunological and clinical relevance 423


Cancer immunology

M. D. BARBER, J. J. POWELL, S. F. LYNCH, N. J. GOUGH,
K. c. H. FEARON & J. A. ROSS: Two polymorphisms of the
tumour necrosis factor gene do not influence survival in
pancreatic cancer 425


N. YOSHIDA, T. YOSHIKAWA, S. NAKAGAWA, K. SAKAMOTO,
Y. NAKAMURA, Y. NAITO & M. KONDO: Effect of shear stress
and a stable prostaglandin 12 analogue on adhesive
interactions of colon cancer cells and endothelial cells 430



Complement

C. SUANKRATAY, Y. ZHANG, D. JONES, T. F. LINT &
H. GEWURZ: Enhancement of lectin pathway haemolysis
by immunoglobulins 435

C. SUANKRATAY, C. MOLD, Y. ZHANG, T. F. LINT & H. GEWURZ:
Mechanism of complement-dependent haemolysis via the
lectin pathway: role of the complement regulatory proteins 442


Experimental model of autoimmunity

R. N. BARKER, R. D. YOUNG, K. A. LEADER & C. J. ELSON:
Galactosylation of serum lgG and autoantibodies in murine
models of autoimmune haemolytic anaemia 449


Eye disease

P. I. MURRAY, C. D. CLAY, C. MAPPIN & M. SALMON: Molecular
analysis of resolving immune responses in uveitis 455


Gut disease/immunology

N. HAMAMOTO, K. MAEMURA, I. HIRATA, M. MURANO,
s. SASAKI & K. KATSU: Inhibition of dextran sulphate
sodium (DSS)-induced colitis in mice by intracolonically
administered antibodies against adhesion molecules
(endothelial leucocyte adhesion molecule-1 (ELAM-1 ) or
intercellular adhesion molecule-1 (ICAM-I)) 462

G. MONTELEONE, T. PARRELLO,I. MONTELEONE, S. TAMMARO,
F. LUZZA & F. PALLONE: Interferon-gamma (IFN-y) and
prostaglandin E2 (PGE2) regulate differently IL-12
production in human intestinal lamina propria mononuclear
cells (LPMC) 469
]

Human immunology

D. G. YOUNG, G. SKIBINSKI, J. I. MASON & K. JAMES:
The influence of age and gender on serum dehydro-
epiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble
receptor (IL-6sR) and transforming growth factor-beta I
(TGF-BI) levels in normal healthy blood donors 476


W. K. CHANG, K. D. YANG & M. F. SHAIO: Lymphocyte
proliferation modulated by glutamine: involved in the
endogenous redox reaction 482


Immunity to infection

L TEKSTRA, H: BEEKHUIZEN, J. S. VAN DE GEVEL,
I. J. VAN BENTEN, C. W. TUK & R. H. J. BEELEN: Infection of
human endothelial cells with Staphylococcus aureus induces
the production ofmonocyte chemotactic protein-1 (MCP-I)
and monocyte chemotaxis 489


F. POLTL-FRANK, R. ZURBRIGGEN, A. HELG, F. STUART,
J. ROBINSON, R. GLUCK & G. PLUSCHKE: Use of reconstituted
influenza virus virosomes as an immunopotentiating
delivery system for a peptide-based vaccine 496


Y. MURAYAMA, R. MUKAI, M. INOUE-MURAYAMA &
Y. YOSHIKAWA: An African green monkey lacking peripheral
CD4 lymphocytes that retains helper T cell activity and
coexists with SIVagm 504


M. DE MARTINO, M. E. ROSSI, C. AZZARI, M. G. GELLI,
F. CHIARELLI, L. GALLI & A. VIERUCCI: Viral load and CD69
molecule expression on freshly isolated and cultured
mitogen-stimulated lymphocytes of children with perinatal
HIV-I infection 513


G. R. STEWART, M. BOUSSINESQ, T. COULSON,
L. ELSON, T. NUTMAN & J. E. BRADLEY: Onchocerciasis
modulates the immune response to mycobacterial antigens 517


S. KAHl, G. J. N. COZON, J. M. PINON, T. GREENLAND,
M. WALLON, M. AL KURDI, J. FERRANDIZ & F. PEYRON:
A switch towards Th2 during serological rebound in children
with congenital toxoplasmosis 524


H. AKUFFO, A. ALEXIS, L. EIDSMO, A. SAED, S. NYLEN
& K. MAASHO: Natural killer cells in cross-regulation of
IL-12 by IL-IO in Leishmania antigen-stimulated blood
donor cells 529


Immunodeficiency

J. REICHENBACH, R. SCHUBERT, C. SCHWAN, K. MULLER,
H. J. BOHLES & s. ZIELEN: Anti-oxidative capacity in patients
with ataxia telangiectasia 535


Immunology of reproduction

M. GORIVODSKY, A. TORCHINSKY, J. SHEPSHELOVICH,
s. SAVION, A. FEIN, H. CARP & v. TODER: Colony-stimulating
factor-1 (CSF-I) expression in the uteroplacental unit of mice
with spontaneous and induced pregnancy loss 540


S. SAITO, M. SAKAl, Y. SASAKI, K. TANEBE, H. TSUDA
& T. MICHIMATA: Quantitative analysis of peripheral blood
ThO, Thi, Th2 and the Thl:Th2 cell ratio during normal
human pregnancy atld preeclampsia 550


Liver disease

C. FABRIS, M. DEL FORNO, E. FALLETI, P. TONIUTTO &
M. PIRISI: Kinetics of serum soluble tumour necrosis factor
receptor (TNF-R) type-I and type-ll after a single interferon-
alpha (IFN-a) injection in chronic hepatitis C 556

Lung disease

R. MAHADEVA, A. C. DUNN, R. C. WESTERBEEK, L. SHARPLES,
D. B. WHITEHOUSE, N. R. CARROLL, R. 1. ROSS-RUSSELL,
A. K. WEBB, D. BILTON, D. A. LOMAS & C. M. LOCKWOOD:
Anti-neutrophil cytoplasmic antibodies (ANCA) against
bactericidal/permeability-increasing protein (BPI) and cystic
fibrosis lung disease 561


Rheumatic disease/vasculitis

H. LOCHT, T. SKOGH & E. KIHLSTROM: Anti-laCtofemU
antibodies and other types of anti-neutrophil cytoplasmic
antibodies (ANCA) in reactive artliritis and ankylosing
spondylitis 568


G. LAKOS, E. KISS, N. REGECZY, P. TARJAN, P. SOLTESZ,
M. ZEHER, E. BODOLAY, SZ. SZAKONY, S. SIPKA & GY. SZEGEDI:
Isotype distribution and clinical relevance ofanti-B2
glycoprotein I (B2-GPI) antibodies: importance ofIgA
isotype 574


Skin disease

A. S. GUDMIJNDSDOTTIR, H. SIGMUNDSDOTTIR,
b. SIGURGUIRSSON, M. K dOOl), H. VALDIMARSSON &
I. JONSDOIIIR: Is an epitope on keratin 17 a major target
for autoreactive T lymphocytes in psoriasis? 580


Thymus immunology

S. MARUYAMA, A. TSIJKAHARA, S. SUZUKI, T. TADA,
M. MINAGAWA, H. WATANABE, K. HATAKEYAMA & T. ABO:
Quick recovery in the generation of self-reactive CD4(low)
natural killer (NK) T cells by an alternative intrathymic
pathway when restored from acute thymic atrophy 587

Transplantation

R. LHEMANS, G. HARMS, G. T. RIJKLRS & W. TIMENS: Spleen
autotransplantalion provides restoration of functional
splenic lymphoid compartments and improves the humoral
immune response to pneumococcal polysaccharide vaccine 596




 

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