_______________________________________

CLINICAL CHEMISTRY & LABORATORY MEDICINE
VOL. 37, NO. 2, 1999



Guest Editorial

Matthew J. McQueen
Evolution or Revolution in Clinical Chemistry ............................................................. . 89




Review
Andrew Myron Johnson
Low Levels of Plasma Proteins: Malnutrition or
Inflammation?........................................................................................................................ 91



Review - Current Opinion
M a re k H. Dominiczak
Laboratory Medicine: The Need for a Broader View
The "Multiple Bundle" Model of Clinical Laboratory
Function............................................................................................................................. 97




Clinical and Experimental Research
Karl RolfKlingler, Stefan G rote, Guido Hölzern and
Klaus Wie Icke n s
Activated Protein C (APO-Resistance: Automated
Detection of the Point Mutation at Position 1691
in the Factor V Gene ....................................................................................................... 101





Christopher P. Price, Jacqui Calvin, Susan A. Walker,
Andrew Trull, David J. Newman and Eileen G. Gorman
A Rapid and Sensitive Automated Light Scattering
Immunoassay for Serum C-Reactive Protein and
the Definition of a Reference Range in Healthy
Blood Donors........................................................................................................................ 109





Viola Schlosser, Ossi R. Koechli, Rosanna Cattaneo,
Brigitte Jentsch, Urs Hallerand Heinrich Walt
Photodynamic Effects In Vitro in Fresh Gynecologic
Tumors Analyzed with a Bioluminescence
Method...................................................................................................................................... 115




Boris Vaisman, Paolo Santambrogio, Paolo Arosio,
Eitan Fibach and Abraham M. Konijn
An ELISA for the H-Subunit of Human Ferritin which
Employs a Combination of Rabbit Poly- and Mice
Monoclonal Antibodies and an Enzyme Labeled
Anti-Mouse-IgG ........................ ................................................................................................... 121




Harry A. Bonte, Ron J. van den Hoven, Gertjan van der
Sluijs Veer and Istvan Vermes
The Use of Free Cortisol Index for Laboratory
Assessment of Pituitary-Adrenal Function . . . . ............................................................................. 127




Claire Ravard-Goulvestre, Catherine Boucly, Bertille
Mathieu, Genevieve Van Amerongen, Louis Viollet,
Brigitte Estournet, Annie Barois and Philippe de
Mazancourt
Allele-Specific Amplification for the Diagnosis of
Autosomal Recessive Spinal Muscular Atrophy.............................................................................. 133



Epidemiology and Evaluation

Necat Yilmaz, Metin Bayram, A. Binnur Erbagci
and M. Sahin Kilincer
Diagnostic Value of Biochemical Markers of Bone
Turnover and Postmenopausal Osteoporosis. . ............................................................................. 137



Loch Chrostek and Madej Szmitkowski
Isoenzmyes of Class I and II Alcohol Dehydroge-
nase in Chronic Hepatitis. .................................................................................................................... 145



Michael J. Pugia, John A. Lott, Junko Kajima,
Takaaki Saambe, Miyuki Sasaki, Kooichi Kuro-
moto, Reiko Nakamura, Hisae Fusegawa and
YoshihideOhta
Screening School Children forAlbuminuria,
Proteinuria and Occult Blood with Dipsticks. . . ............................................................................... 149



Michael Vogeser, Peter Knesewitsch, Karl Jacob
and Dietrich Seidel
Evaluation of the First Automated Thyroglobulin
Assay....................................................................................................................................................... 159



Letters to the Editor
Moses Elisaf, Alekos Tselepis and Kostas
Siamopoulos
Selective Imidazoline ReceptorAgonists and
Lipid Metabolism ........................................................................................................................................ 165



Callum G. Fräser
Judgement on Analytical Quality Requirements
from Published Clinical Vignette Studies Is
Flawed .................................................................................................. 167



Rainer Haeckef
The Meaning of Good Laboratory Practice (GLP)
for the Medical Laboratory ............................................................... 169



Gottfried A. Harffand Maria J. A. van den Bosch
Improved Procedure of Measuring on Radiometer
500 and 600 Series Bloodgas Analysers. .................................... 171


Book Reviews
Jacqueline M. Atkinson
Scientific Papers and Presentations
by Martha Davis ............................................................................... 173



R. J. Spooner
New Myocardial Marker Proteins in Acute
Myocardial Infarction. Quantitative Aspects
by J. A. Kragten. .............................................................................. 174


C. van Heyningen
Normalwerte
by Michael Jakob .............................................................................. 175

_______________________________________

_______________________________________

CLINICAL CHEMISTRY & LABORATORY MEDICINE

VOL. 37, NO. 4, 1999


Reviews
Toshiyuki Yamada
Serum Amyloid A (SAA): a Concise Review of
Biology, Assay Methods and Clinical Usefulness 381

Else Randers and Eriand J. Eriandsen
Serum Cystatin C as an Endogenous Marker
of the Renal Function - a Review............ 389

Clinical and Experimental Research
Claude Houdayer, Alban Lemon nier, Marion
Gerard, Corinne Chauve, Mohammed Tredano,
Thierry Billette de Villemeur, Pierre Ayrnard,
Jean-Paul Bonne font and Delphine Feidmann
Improved Fluorescent PCR-Based Assay for
Sizing CGG Repeats at the FRAXA Locus...... 397

Jens J. Froelich, Folker R. G. Schneller and
FfudolfK. Zahn
The Influence of Radiation and Chemotherapy-
Related DNA Strand Breaks on Carcinogenesis:
An Evaluation.......................... 403


Gernot Seebacher, Gunter Weigel, Ernst Wolner,
Robert Mallinger, Michael Grimm, Gunter Laufer,
lbrahim El Menyawi, Andrea Griesmacher and
Mathias M. Muller
A Simple HPLC Method for Monitoring
MycophenolicAcid and Its Glucuronidated
Metabolite in Transplant Recipients. ......... 409


Lech Romanowicz, Edward Bankowski and
Stefan Jaworski
The Activities of Some Glycosaminoglycan-
Degrading Enzymes in the Wall of the Umbilical
Cord Artery and Their Alteration in Edema,
Proteinuria, Hypertension (EPH)-Gestosis . .... 417

Jens Lutz, Matthias Gorenflo, Matthias Habighorst,
Martin Vogel, Peter E. Lange and Berthold Hocher
Endothelin-1- and Endothelin-Receptors in Lung
Biopsies of Patients with Pulmonary Hypertension
due to Congenital Heart Disease ............ 423


Epidemiology and Evaluation

Fried rich Lebihuber, Johannes Walli, Ulrike Demel,
Gernot P. 77/z, Bernhard Widner and Dietmar Fuchs
Increased Serum Neopterin Concentrations in
Patients with Aizheimer's Disease ........... 429

Mohamed Shaarawy, Abdel-Salam EI-DawakhIy,
Medhat Mosaad and Mostafa Mohamed EI-Sadek
Biomarkers of Bone Turnover and Bone Mineral
Density in Hyperprolactinemic Amenorrheic
Women............................... 433

Martin Hill, Dusan Lukac, Oldrich Lapcik, Jarmila
Sulcova, Richard Hampi, VladimfrPouzarand
Luboslav Starka
Age Relationships and Sex Differences in Serum
Levels of Pregnenolone and 17-Hydroxypreg-
nenolone in Normal Subjects .............. 439

Martin Crook

A Study of Hypermagnesaemia in a Hospital
Population ............................ 449

Steven C. Kazmierczak, Paul G. Catrou, Ann E.
Best, Steven W. Sullivan and Kimberly P. Briley
Multiple Regression Analysis of Interference
Effects from a Hemoglobin-Based Oxygen
Carrier Solution......................... 453

HenkJ. Huijgen, Renata Sanders, StaceyA.
Cecco, Nadja N. Rehak, Gerard T. Sanders and
Ronald J. Elin
Serum Ionized Magnesium: Comparison of
Results Obtained with Three Ion-Selective
Analyzers ............................. 465

Kornel Papik, Beta Molnar, Peter Fedorcsak,
Rainer Schaefer, Fridi Lang, Lydia Sreter,
Janos Feher and Zsolt Tulassay
Automated Prozone Effect Detection in Ferritin
Homogeneous Immunoassays Using Neural
Network Classifiers...................... 471



IFCC, FESCC and EC4 Papers
Gerard T. Sanders, Rob T. Jansen, Graham Beastall,
Eberhard Gurr, Desmond Kenny, Klaus P. Kohse
and Simone Zerah
Recent Activities of EC4 in the Harmonization
of CNnical Chemistry in the European Union . . . 477

Book Reviews
Preventing Coronary Artery Disease.
Cardioprotective Therapeutics in Practice.
Edited by M. J. Kendall and R. C. Horton . . . . . . 481


Will Medical Schools Remain what They Are?
Medical Education in the Millennium.
Edited by Brian Jolly and Lesley Rees ........ 482


IFCC News
Meetings and Awards

_______________________________________

_______________________________________

CLINICAL CHEMISTRY & LABORATORY MEDICINE

VOL. 37, NO. 6,JUNE 1999


Editorial
Marcello Galvani
Are Cardiac Troponins the Myocardial Markers
for the New Millenium?................... 605

Review
Jose Antonio Viedma Contreras
Leukocyte Activation Markers in Clinical Practice 607

Clinical and Experimental Research
Rei nhard H. Dennin, Jianer Wo and Zhi Chen
Hepatitis C Virus-Specific DNA Sequences
in Human DNA: Differentiation by Means of
Restriction Enzyme Analysis at the DNA Level
of Healthy, Anti-HCV-Negative Individuals. . ... 623

Tetsuji Yamaguchi, Toshiyuki Yamada, Ryuta
Okutani, Noriharu Shijubo, Gurmukh Singh and
Yoshihisa ltoh
Characterization of Monoclonal Antibodies to
Human Protein I/Clara Cell 10 Kilodalton Protein 631


Frank Musshoff^ Heike Junker and Burkhard
Madea
Rapid Analysis of Parathion in Biological Samples
Using Headspace Solid-Phase Micro-Extraction
(HS-SPME) and Gas Chromatography/Mass
Spectr ometry (GC/MS)................... 639


Bernd Noll, RolfHackler, Mirko Pelzer, Sabine
Pelzer, Petra Nusser, Bernhard Maisch, Juergen R.
Schaefer and Armin Steinmetz
S emi-Automated Rapid Isoelectric Focusing of
Apolipoproteins C from Human Plasma Using
PhastSystem^ and Immunofixation ......... 643

Giovanna Vona, Anna Caldini, Roberta Sestini ,
Stefano Rap!, Simonetta Bianchi, Alessandra
Fanelli, Mario Pazzagli and Claudio Orlando
The c-erbB-2 Oncogene Amplification by
Competitive PCR in Aneuploid Cell Clones
Flow Sorted from Breast Cancer Samples ..... 649

Epidemiology and Evaluation

Per Hyftoft Petersen, CaHum G. Fraser,
Sverre Sandberg and Henk Goldschmidt
The index of Individuality Is Often a Misinter-
preted Quantity Characteristic.............. 655

Sandra Secchiero, Laura Sciacovelli, Piero
Bonvicini, Martina Zaninotto and Mario Plebani
Assessment of Package Inserts for Diagnostic
Kits............................. ..... 663

Dubravka Juretic, lvana Cepelak and Zlata
Flegar-Mestric
External Quality Assessment in Clinical Chemistry:
Review of the Situation in Croatia wi th Particular
Reference to Equipment .................. 667

Hans W. Janssen, Hans Bookelman, Jan L. S. Do/s,
Wiveka E. Elion Gerritzen and Pies H. de Keyzer
Point-of-Care Testing: the Views of the Working
Group of the Dutch Association of Clinical
Chemistry............................. 675


Fran^oise Picard, Catherine Gicquel, Laurence
Marnet, Martine Guesnu and Jean P. Levy
Preliminary Evaluation of the New Hematology
Analyzer COULTER® GEN*S(tm)in a University
Hospital .............................. 681


IFCC, FESCC and EC4 Papers
Mauro Panteghini, Fred S. Apple, Robert H.
Christenson, Francesco Dati, Johannes Mair
andAlan H. Wu
Use of Biochemical Markers in Acute Coronary
Syndromes. IFCC Scientific Di vision, Committee
on Standardization of Markers of Cardiac
Damage .............................. 687


Book Reviews

Oxidative Stress in Skeletal Muscle.
A.E. Rezuick, L. Packer, C.K. Sen. J.O. Hollosey
and M.J. Jackson, editors ................. 695


Handbook of Lipoprotein Testing. IFCC News
N. Rifai, C.G. Warnick and M.H. Dominiczak,
editors ............................... 696 Meetings and Awards


Erratum
Matthias Oberhoffer, Hein z Vogelsang, Stefan
RuRwurm, Thomas Hartung and Konrad Reinhart
Outcome Prediction by Traditional and New
Markers of Inflammation in Patients with Sepsis 697

_______________________________________

CLINICAL CHEMISTRY & LABORATORY MEDICINE

VOL. 37, NO. 7, JULY 1999


Review

Esa Tahvanainen
Development of Molecular Genetics ......... 699


Opinion Paper

Mario Plebani
The Changing Face of Clinical Laboratories. . . . 711


Clinical and Experimental Research
AndreasAmbrosch, Ralf Lobmann, Jutta Dierkes,
Wolfgang Konig, Claus Luley and He ndrik Lehnert
Analysis of the Gly40Ser Polymorphism in the
Glucagon Receptor Gene in a German Non-Insu-
lin-Dependent Diabetes Mellitus Population ... 719

Martin Beranek, Jan Bures, Vladimir Palicka,
Pave l Jandik, Frantisek Langr and Eliska Nejedia
A Relationship between K-rasGene Mutations
and Some Clinical and Histologic Variables in
Patients with Primary Colorectal Carcinoma . . . 723


Laurence M. Galan ti, Juliette DeU'Omo, Danielle
Vanbeckbergen, Pierre Dubois, Pierre L Masson
and Cesar L. Cambiaso
Particle Counting Immunoassay for Urinary
Cotinine. Comparison with Chromatography,
Enzyme-linked Immunoassay and Fluorescence
Polarization Immunoassay ................ 729


P. Marchetti, J. Gutierrez, P. Velia, J.-L. Faucompre,
B. Onraed, P. Formstecher and B. Hennache
Identification of lgG-specific Oligoclonal Banding
in Serum and Cerebrospinal Fluid by Isoelectric
Focusing: Description of a Simplified Method for
the Diagnosis of Neurological Disorders ...... 735


Epidemiology and Evaluation
Angelika Schmi edl, Paul Otto Schwille, Christine
Stuhler, Jonas Gohl and Gerhard Rumenapf
Low Bone Mineral Density after Total Gastrectomy
in Males: a Preliminary Report Emphasizing the
Possible Significance of Urinary Net Acid
Excretion, Serum Gastrin an d Phosphorus . ... 739


Markus S. Nauck, Matthias A. Nauck, Michael A.
Nauck, Winfried Marz and Heinrich Wieland
Six Methods for the Determination of C-Peptide
Evaluated................. ............ 745


Kurt Hannemann-Pohl and Sieghard Carsten Kampf
Automation of Urine Sediment Examination: a
Comparison of the Sysmex UF-100 Automated
Flow Cytomet er with Routine Manual Diagnosis
(Microscopy, Test Strips, and Bacterial Culture) . 753


Luis F. Perez, M. Isabel Martinez, Helena M.
Ribeiro, Ftui A. Pinto, M. Clara Sa Miranda and
J. Carlos Tutor
Characterisation of the Isoenzyme Profile of
p-/V-Acetylhexosaminidase in the Urine of
Newborns............................. 765


Book Reviews
Clinical La boratory Diagnostics. Thomas Lothar,
editor
Reviewed by Marie-MadelaineGalteau .......... 771


Structure-based Ligand Design. Klaus Gubernator
and Hans-J. B6hm, editors
(Methods and Principles in Medicinal Chemistry,
vol. 6. )
Reviewed by John W. Baynes. ................ 772


IFCC News
News of the Scientific Division
- Activities of IFCC Working Group ..C alibrators
in Clinical Enzymology" (WG-CCE)

Call for Nominations

- Committee on Plasma Proteins (C-PP) ...... 773

IFCC Visiting Lecturer Programme (VLP) ...... 775


_______________________________________

CLINICAL SHEMISTRY & LABORATORY MEDICINE

VOL. 37, NO. 1, SPECIAL SUPPLEMENT , JANUARY 1999

Contents
Plenary Lecture Abstracts
Apoptosis ........................................................S9

From Gene Sequence to Protein Functions................... S9

Geneticsand Environment ..........................................S9

TheTh1/Th2ParadigminDisease ................................ S10


Proteome Research and its Impact on
LaboratoryMedicine................................................S10


Symposium Abstracts
NewTrendsinDiabetesandObesity........................... S13


Gene Therapy: Promise and Reality .............................. S 15


Advanced Mass Spectrometry as a Diagnostic Tool .... S 17


Novel Aspects of Haemostasis and Thrombosis .......... S19


The Role of the Laboratory in
Evidence-Based Medicine ....................................... S21


From Genotype to Phenotype ....................................S23


Animal Models on Human Diseases .............................. S25


Molecular Diagnostic and Prognostic Markers in
Haematological Malignancies.....................................S27


Biosensors and Non-Invasive Technology.................... S29

The Laboratory Influencing Clinical Practice-
Past, Present and Future............................................... S 31

BiochemicalandGeneticTumorMarkers...................... S32
Standardization and Quality Control of Molecular
BiologicalTechniquesinClinical Laboratory................... S35

Biochemical and Genetic Markers of Atherosclerosis .. S 38

Therapeutic Drpg Monitoring and Clinical Toxicology..... S40

The Changing Face of Laboratory Medicine ................. S43

New Tools in Genetic Analysis: the Emerging
Biochip Technologies..................................................... S 45

Genetic-Based Drug Responses .................................. S47

MolecularMarkers in SolidTumors................................ S49

The Role of the Endocrine Laboratory in
Medical-Assisted Fertilization........................................ S51

ExtemalQualityAssessmentProgrammes................... S53

Robotics, Automation and the Virtual Laboratory ......... S55

Genetic Analysis of Common Diseases........................ S57

Standardization in Clinical Chemistry ............................ S59

• Critical Care (AVL Awards Session) ............................ S62

• Accreditation in Clinical Chemistry ................................ S63

• Public Understanding of Science and Health
(PUSH)andClinicalChemistry....................................... S65

Computer-Assisted Decision-Making
Activated by Clinical Laboratory Findings ..................... S66

Environmental Risks for the Human
EndocrineSystem......................................................... S68

Diagnostic Molecular Microbiology: Current and
FutureTrends ............................................................... S69

ReceptorsandOtherSurfaceMarkers........................ S71

The Human Genome Project: a Revolution in
Biomedical Research .................................................... S73

Ageing and Neurological Diseases ............................... S75

Endothelial Cells-Functional and Diagnostic Aspects ..... S78

High Sensitivity and Multianalyte
Immunochemical Methods ............................................. S81

Regulation of Gene Expression in Inflammation:
Tool and TargetforTherapeuticApplications ............... S83

Organizational Structure of Laboratories in Europe ......... S85

Microbial Agents and Coronary Diseases..................... S87

Assessment of Micronutrient Status-Biochemical
Techniques orTissue Function ..................................... S89

lonChannel Diseases ................................................... S91

Projects for Quality Improvement in
DevelopingCountries.................................................... S93

Standardization and Reference
Materialsforimmunoassays......................................... S 95

Oxidants and Antioxidants in Clinical Biochemistry....... S97

Electrophoresis and High Resolution
SeparationTechniques ................................................. S99


Assessment of Male Fertility and Infertility ................... S 101


Improving Patient Safety and Security .......................... S 103

Poster Abstracts
Poster display: Monday through Thursday code page
IFCCandFESCC .......................... 1420-1450 S 107-116


Poster display: Monday, 7 June
ClinicalMolecularBiology............. M001-M173 S117-160

Coagulation-Fibrinolysis ............... M174-M213 S 161-170

Endocrinology............................... M214-M328 S 171-199

Hematology ................................... M329-M394 S 200-216


Poster display: Tuesday, 8 June
Bone .......................................... T001-T111 S217-244

Computer Applications-
Laboratory Information Systems... T112-T135 S 245-250

HistoryotClinicalChemistry......... T136-T138 S251

Lipids-Upoproteins..................... T139-T246 S252-278

Quality Assurance - Management -
Analytical Techniques .................. T247-T344 S 279-303

TDM-Toxicology-Environment ..... T345-T418 S 304-322

Poster display: Wednesday, 9 June

Clinical Studies - Test Utilization -
Outcomes.................................. W001-W188 S323-369

Instruments and Product
Evaluation ..................................... W189-W327 S 370-404

Laboratory Design - Automation..... W328-W360 S 405-412

PediatricClinicalChemistry ........... W361-W412 S413-425

Posterd is play: Thursday, IOJune
Cancer-TumorMarkers .............. H001-H047 S426-437

CardiacMarkers........................... H048-H142 S438-461

Enzymes-Isoenzymes................ H143-H204 S 462-477

Immunology-Infectious Diseases.... H205-H280 S 478-496

Nutrition-Trace Elements-
Vitamins ........................................ H281-H345 S497-512

Proteins ........................................ H346-H419 S 513-531

Authors Index......................................................... S533


_______________________________________

CLINICAL CHEMISTRY & LABORATORY MEDICINE

VOL. 37, SPECIAL SUPPLEMENT 2, 1999



A.M. Scanu
Metalloproteinases, lipoproteins, proteoglycans
and the atherosclerotic process ............ Sil 1


F. Cimino, F. Espos'rto, Ft. Ammendola, T. Russo
Regulation of gene expression by oxidative stress
and in cellular senescence ............... Sil 1


Kelvin J, A. Davf'es
Stress responses and the free radical theory of aging . Sll 1


B. Tadolini
Evaluation of oxidative stress ............. Sil 1


John W. Baynes & Suzanne R. Thorpe
Biomarkers of oxidative stress in aging and age-related
diseases ........................ Sll 2


S.Bertolini, A. Cantafora, L. Deiana, M. Avema,
S. Martini, C. Cortese, S. Calandra
Familial hypercholesterolemia: from single mutations to
clusters and genotype-phenotype relationship . . . . . Sll 2


G.M. Kostner, S. Frank, KM Kostner, A, Hrzenjak
Clinical biochemistry and molecular gene-tics of
lipoprotein(a) ...................... Sll 3


AL Catapano, A. P'rnilo, T. ZaneHi, G.D. Norata, P. Roma
Modified lipoproteins and atherosclerosis . ...... Sll 3


G. Baggio, L. Deiana, G.M. Pes, C. Carru,
L Ferrucci, C. Franceschi
The Sardinian centenarian study: the contribution
of mediterranean sea to longevity . ...... .... Sll 3


G. DG Benedictis
Mitochondrial genomes in multifactorial traits: longevity
or disease? ................ ....... Sll 4


B. Jeune
Biological and genetic markers in danish centenarians . Sll 4


Jan Vijg
Two-dimensional gene scanning of centenarians . . . Sll 4


M. Bonafe, G. DQ Benedictis, C. Franceschi
Longevity genes: how many? how many strategies to
catch them? ... .......... ...... ... Sll 5


C. Carru, GM Pes, A. Zinellu, F. Galistu, M. Barca,
V. Pasciu, F. Lumbau, L. Deiana, B. Tadolini
Comparison between a capillary electrophoresis
and a spectrophotometric method for the evaluation
of "mvitro" oxidation of LDL . .... ..... .... SII 5


M. Formato, P. Demuro, M. Farina, A. Zinellu, G.M. Cherchi
Human Idl binding to plasma high-charge
glycosaminoglycan-protein complexes . ...... .. Sll 6


B. Marchetti, M.C. Morale, F. Gallo, Z Farinella,
N. Testa, C. Tirolo
impact of gender on longevity?: estrogens modulation of
neuroendocrine-immune axis and their possible role in
aging pathologies ................... Sll 6


G. Tonolo, M.G. Metis, M. Formato, M.F. Angius,
A. Carboni, P. Brizzi, M. Ciccarese, G. Dachena,
G.M. Cherchi, M. Maioli
Simvastatin reduces cardiovascular risk factors
independently from its effects on LDL-cholesterol . . Sll 6


L. Puddu, G. Tonolo, P. Brizzi, G. Dachena, S. Milia,
M. Maioli, S. Dessole
Effects of hormone replacement therapy on lipid profile
in menopausa..................... Sll 7


P. Brizzi, G. Tonolo, A.M. Asara, F. Esposito,
L. Puddu, S. Dessole, G. Dachena, M. Maioli,
S. Milia
Upoprotein metabolism during normal pregnancy . . Sll 7


M. Ciccarese, A. Pacifico, G. Tonolo, P. Pintus,
A. Nikoshkov, G. Zuliani, R. Fellin, H. Luthman,
M. Maioli
A new form of monogenic hypercholesterolemia
localized to human chromosome 15Q25-Q26 . . . . Sll 7


F. Turrini, F. Mannu, P. Arese
Erythrocyte aging a model of auto-immune cell death Sll 8


C. Carru, A. Errigo, M.L. Prof Hi, A. Petrazzini,
S. Cau, R. Spissu, S. Manca, G.F. Meloni,
L. Deiana
Point mutations in the Idl receptor gene causing familial
hypercholesterolemia in northern Sardinia ...... Sll 8


M.P. Simula, M.G. Perino, G.M. Pes, C. Carru,
G. Baggio, C. Franceschi, L. Deiana
Diallelic polymorphisms of apolipoprotein b gene in
Sardinian centenarians and their influence on plasma
lipid levels ....................... SlI 8


A. Cadoni, S. Milia, A. Piras, M.F. Puggioni,
G.M. Pes, C. Carru, L. Deiana, L. Ferrucci,
C. Franceschi, G. Baggio
Is "centenariety" familial or sporadic? preliminary
insights from the Sardinia centenarian study . . . . . Sll 9


L. Deiana, G.M. Pes, A. Mura, A. Errigo, C. Carru,
S. Manca, S. Pettinato, R. Ginanneschi,
S. Magliona, C. Franceschi, G. Baggio
Influence of ACE, MTHFR, and apolipoprotein e gene
polymorphisms on longevity in Sardinia ....... Sll 9


Ft. Albertini, P.M. Abuja, G. Palladini, A. Passi,
G. DQ Luca, G. V. Meizi d'Eril
Assay of low density lipoprotein oxidation by low level
chemiluminescence.................. Sll 9


C. Franceschi, R.A. Rabini, Ft. Staffolani,
E. Salvolini, F. Cintolesi, L. Mazzanti
Modifications in the plasma membrane lipid composition
and properties in centenarians: a possible role in
successful ageing? .................. Sll 10

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