CLINICAL Endocrinology
Volume 50, Number 1, January 1999
Contents
Review
1 Cardiovascular disease and risk factors in adults with
hypopituitarism: s. A. BESHYAH AND D. G. JOHNSTON
Commentary
17 Y-chromosomemosaicism in girls with Turner's syndrome:
c. CHU (see page 19)
Original papers
19 Y-chromosome identification by PCR and gonadal histopathology
m Turner's syndrome without overt Y-mosaicism: J. R. T. MENDES,
M. W. L. STRUFALDI, R. DELCELO, R. C. M. S. MOISTS, J. G. VIEIRA,
T. S. KASAMATSU, M. F. GALERA, J. A. D. ANDRADE AND
i. T. N. VERRESCHI (see commentary page 17)
27 Recent primary transnasal surgical outcomes associated with
intraoperative growth hormone measurement in acromegaly:
T. ABE AND D. K. LÜDECKE
37 The effects of interleukin-2 treatment on endothelin and the
activation of the hypothalamic-pituitary-adrenal axis: c. RAAB,
E. WEIDMANN, A. SCHMIDT, L. BERGMANN, K. BADENHOOP,
K. H. USADEL AND T. HAAK
45 A low individualized GH dose in young patients with childhood
onset GH deficiency normalized serum IGF-I without significant
deterioration in glucose tolerance: B. BÜLOW AND E. M. ERFURTH
57 Experience with transdermal testosterone replacement therapy
for hypogonadal men: s. PARKER AND M. ARMITAGE
63 An in vivo study of the cortisol-cortisone shuttle in subcutaneous
abdominal adipose tissue: J. R. KATZ, v. MOHAMED-ALI, p. J. WOOD,
J. S. YÜDKIN AND S. W. COPPACK
69 Novel DAX I m,utations in X-linked adrenal hypoplasia congenita
and hypogonadotrophic hypogonadism: J. H. D. BASSETT,
D. J. O,HALLORAN, G. R. WILLIAMS, C. G. BEARDWELL, S. M. SHALET
AND R. V. THAKKER
77 The effect of chronic hexarelin administration on the
pituitary-adrenal axis and prolactin: A. RAHIM, P. A. O'NEIL AND
S. M. SHALET
85 High precursor level in maternal blood results from the alternate
mode of proopiomelanocortin processing in human placenta:
M. L. RAFFTN-SANSON, J. F. MASSIAS, A. ANKOTCHE, J. COSTE,
Y. DE. KEYSER, C. OLIVER, C. DUMONT, D. CABROL, F. FERRE AND
X. BERTAGNA
95 Recombinant interferon (x (rlFN-(x) does not potentiate the
effect of iodine excess on the development of thyroid
abnormalities in patients with HCV chronic active hepatitis:
R. MINELLI, L. E. BRAVERMAN, M. A. VALLI, C. SCHIANCHI,
M. PEDRAZZONI, F. FIACCADORI, M. SALVI, M. G. MAGOTTI AND
E. ROTI
101 Serum vascular endothelial growth factor (VEGF) in the normal
menstrual cycle: association with changes in ovarian and uterine
Doppier blood flow: R. AGRAWAL, G. s. CONWAY, P. SLADKEVICIUS,
N. N. PAYNE, J. BEKIR, S. CAMPBELL, S. L. TAN AND H. S. JACOBS
107 Urocortin expression in the human central nervous system:
K. UNO, H. SASANO, Y. OKI, N. ANDOH, R. W. SHIN, T. KITAMOTO,
K. TAKAHASHI, H. SUZUKI, F. TEUKA, T. YOSHIMI AND H. NAGURA
115 Addison's disease in Africa - a teaching hospital experience:
s. SOULE
121 Laparoscopic adrenalectomy for phaeochromocytoma:
endocrinological and surgical aspects of a new therapeutic
approach: v. COL, L. DE CANNIERE, E. COLLARD, L. MICHEL
AND J. DONCKIER
127 Antithyroid drugs and Graves' disease - prospective randomized
assessment of long-term treatment: D. MAUGENDRE, A. GATEL,
L. CAMPION, C. MASSART, 1. GUILHEM, Y. LORCY, J. LESCOUARCH,
J. Y. HERRY AND H. ALLANNIC
Case report
133 Rosai-Dorfman disease presenting as a pituitary tumour:
W. F. KELLY, N. BRADEY AND D. SCOONES
139 Book reviews
Author's Declaration
_____________________________________________
Clinical Endocrinology
Vol.50, NO.2, February 1999
Contents
Review
141 Investigation protocol: adrenal enlargement: F. MANTERO AND
G. ARNALDI
Commentary
147 Thyroid hormones and neurodevelopment: J. H. LAZARUS
(see page 149)
Original papers
149 Low maternal free thyroxine concentrations during early
pregnancy are associated with impaired psychomotor development
in infancy: v. J. POP, J. L. KUIJPENS, A. L. VAN BAAR, G. VERKERK,
M. M. VAN SON, J. J. DE VIJLDER, T. VULSMA, W. M. WIERSINGA,
H. A. DREXHAGE AND H. L. VADER (see commentary page 147)
157 An atypical contiguous gene syndrome: molecular studies in a
family with X-linked Kallmann's syndrome and X-linked
ichthyosis: G. MAYA-NUNEZ, L. TORRES, A. ULLOA-AGUIRRE,
J. C. ZENTENO, S. CUEVAS-COVARRUBIAS, D. SAAVEDRA-ONTIVEROS,
S. KOFMAN-ALFARO AND J. P. MENDEZ
163 Hyperleptinaemia in young adults following cranial irradiation
in childhood: growth hormone deficiency or leptin
insensitivity?: B. M. D. BRENNAN, A. RAHIM, w. F. BLUM,
J. A. ADAMS, 0. B. EDEN AND S. M. SHALET
171 Bone turnover and cortical bone mineral density in the distal
radius in patients with hyperthyroidism being treated with anti-
thyroid drugs for various periods of time: M. OIKAWA, K. KUSHIDA,
M. TAKAHASHI, T. OHISHI, H. HOSHINO, M. SUZUKI, H. OGIHARA,
J. ISHIGAKI AND T. INOUE
177 Cord blood leptin concentrations in relation to intrauterine
growth: A. VARVARIGOU, C. S. MANTZOROS AND N. G. BERATIS
185 Comparison of serum thyrotrophin concentrations determined
by a third generation assay in patients with various types of overt
and subclinical thyrotoxicosis: K. KASAGI, T. KOUSAKA, T. MISAKI,
M. IWATA, M. S. ALAM AND J. KONISHI
191 Genetic studies of a family with hereditary hyperparathyroidism-
jaw tumour syndrome: w. s. WASSIF, F. FARNEBO, B. T. TEH,
C. F. MONIZ, F. Y. LI, J. D. HARRISON, T. J. PETERS, C. LARSSON
AND P. HARRIS
197 Long-term effect of radioactive iodine on thyroid function and
size in patients with solitary autonomously functioning toxic
thyroid nodules: B. NYGAARD, L. HEGEDUS, K. G. NIELSEN,
P. ULRIKSEN AND J. M. HANSEN
203 Serum prostate specific antigen, sex hormone binding globulin
and free androgen index as markers of pubertal development in
boys: M. R. KIM, M. K. GUPTA, S. H. TRAVERS, D. G. ROGERS,
F. VAN LENTE AND C. FAIMAN
211 Serum leptin levels in women throughout pregnancy and the
postpartum period and in women suffering spontaneous
abortion: M. LAGE, R. c. GARCIA-MAYOR, M. A. TOME, F. CORDIDO,
F. VALLE-INCLAN, R. V. CONSIDINE, J. F. CARO, C. DIEGUEZ AND
F. F. CASANUEVA
217 The prevalence of subclinical hypothyroidism at different total
plasma cholesterol levels in middle aged men and women: a
need for case-finding?: A. J. G. H. BINDELS, R. G. J. \VESTENDORP,
M. FROLICH, J. C. SEIDELL, A. BLOKSTRA AND A. H. M. SMELT
221 InInsulin-like growth factor binding protein-1 in NIDDM:
relationship with the insulin resistance syndrome:
V. MOHAMED-ALI, J. H. PINKNEY, A. PANAHLOO,
S. CWYFAN-HUGHES, J. M. P. HOLLY AND J. S. YUDKIN
229 Functional hypothalamic amenorrhoea: a partial and reversible
gonadotrophin deficiency of nutritional origin: B. COUZINET,
J. YOUNG, S. BRAILLY, Y. LE BOUC, P. CHANSON AND G. SCHAISON
237 Bone mineral density and markers of bone turnover in young
adult survivors of childhood lymphoblastic leukaemia:
J. J. G. HOORWEG-NUMAN, G. KARDOS, J. C. ROOS, H. J. VAN DIJK,
C. NETELENBOS, C. POPP-SNIJDERS, C. M. DE RIDDER AND
H. A. DELEMARRE-VAN DE WAAL
245 Comparison of monthly intramuscular injections of Sandostatin
LAR with multiple subcutaneous injections of octreotide in the
treatment of acromegaly; effects on growth hormone and other
markers of growth hormone secretion: s. J. HUNTER,
J. A. M. SHAW, K. 0. LEE, P. J. WOOD, A. B. ATKINSON AND
J. S. BEVAN
253 Plasma oestrone-fatty acid ester levels are correlated with body
fat mass in humans: J. M. FERNANDEZ-REAL, D. SANCHIS,
W. RICART, R. CASAMITJANA, F. BALADA, X. REMESAR AND
M. ALEMANY
261 A comparison of the naxioxone test with the insulin stress test
in patients following transsphenoidal surgery: A. s. MCALLISTER,
D. R. MCCANCE, D. R. HADDEN, P. M. BELL, H. LESLIE, B. SHERIDAN
AND A. B. ATKINSON
Case report
267 Apparent cure of Graves-Basedow disease after sibling allogeneic
bone marrow transplantation: s. DIEZ, H. BANIAS,
J. L. DI'EZ-MARTIN, M. BRIZ, J. ESTRADA AND B. BARCELO
271 Letters to the Editors
273 Book reviews
______________________________________________
Clinical Endocrinology
Vol.50, NO. 3, March 1999
Contents
Review
275 Congenital growth hormone insensilivity syndromes and their
relevance to idiopathic short stature: p. E. CLAYTON, J. s. FREETH
AND M. R. NORMAN
285 Investigation protocol: Acromegaly and its investigation:
E. DUNCAN AND J. A. H. WASS
Original papers
295 Clinical and biochemical response following withdrawal of a
long-acting, depot injection form of octreotide (Sandostatin-
LAR®): P. M. STEWART, S. E. STEWART, P. M. S. CLARK AND
M. C. SHEPPARD
301 Peak and trough growth hormone (GH) concentrations influence
growth and serum insulin like growth factor-1 (IGF-I)
concentrations in short children: J. c. ACHERMANN,
C. G. D. BROOK, 1. C. A. F. ROBINSON, D. R. MATTHEWS AND
P. C. HINDMARSH
309 Multiple endocrine neoplasia type I (MEN 1): clinical
heterogeneity in a large family with a nonsense mutation in the
MEN I gene (Trp471 Stop): N. VALDES,
G. PEREZ DE NANCLARES, V. ALVAREZ, L. CASTANO,
F. DfAZ-CADORNIGA, J. ALLER AND E. GOTO
315 Life expectancy following surgery for pituitary tumours:
A. S. BATES, B. BULLIVANT, M. C. SHEPPARD AND P. M. STEWART
321 Left ventricular hypertrophy in primly hyperparathyroidism.
Effects of successful parathyroidectomy: A. PIOVESAN,
N. MOLINERI, F. CASASSO, 1. EMMOLO, G. UGLIENGO, F. CESARIO
AND G. BORRETTA
329 Dose response with fluticasone propionate on adrenocortical
activity and recovery of basal and stimulated responses after
vstopping treatment: A. M. WILSON, E. J. SIMS AND B. J. LIPWORTH
337 Rapid leptin decrease in immediate post-exercise recovery:
M. DUCLOS, J. B. CORCUFF, A. RUFFIE, P. ROGER AND G. MANIER
343 No overrepresentation of congenital adrenal hyperplasia in
patients with adrenocortical tumours: M. KJELLMAN, M. HOLST,
M. BACKDAHL, C. LARSSON, L. 0. FARNEBO AND A. WEDELL
347 High prevalence of osteoporosis in cardiac transplant recipients
and discordance between biochemical turnover markers and
bone histomorphometry: p. GLENDENNING, G. N. KENT,
B. D. ADLER, L. MATZ, 1. WATSON, G. J. O'DRISCOLL AND
D. M. HURLEY
357 Diagnosis and treatment of the solitary thyroid nodule. Results
of a European survey: F. N. BENNEDB^EK, H. PERRILD AND
L. HEGEDUS
365 Detection of thyroid stimulating (TSAB)- and thyrotropin
stimulation blocking (TSBAB) antibodies with CHO cell lines
expressing different TSH-receptor numbers: H. WALLASCHOFSKI
AND R. PASCHKE
373 Octreotide-scintigraphy is a disease-activity parameter in Graves'
ophthalmopathy: M. N. GERDING, F. M. VAN DER ZANT,
E. A. VAN ROYEN, L. KOORNNEEF, E. P. KRENNING, W. M. WIERSINGA
AND M. F. PRUMMEL
381 Inhibin forms in serum from postmenopausal women with
ovarian cancers: D. M. ROBERTSON, N. CAHIR, H. G. BURGER,
P. MAMERS AND N. GROOME
387 Oestrogen has no short-term effect on intestinal strontium
absorption in healthy postmenopausal women: M. TEN BOLSCHER,
G. W. DE VALK-DE ROO, R. BARTO, W. J. F. VAN DER VIJGH AND
J. COEN NETELENBOS
393 Do some men with acne vulgaris have raised levels ofLH?:
A. FARRELL, J. ALAGHBAND-ZADEH, G. CARTER, R. B. NEWSON
AND J. J. CREAM
Case report
399 Relapsing Whipple's disease presenting with hypopituitarism:
M. BRANDLE, P. AMMANN, G. A. SPINAS, F. DUTLY, R. L. GALEAZZI,
C. SCHMID AND M. ALTWEGG
405 Letters to the Editors
409 Book reviews
410 Notices
Author's Declaration
________________________________________
Clinical Endocrinology
Vol. 50, NO. 4, April 1999
Contents
Review
411 The effects of testosterone on osteoporosis in men: R. M. FRANCIS
Commentary
415 The growth hormone IGF-I axis in dilated cardiomyopathy:
R. C. JENKINS AND R. J. M. ROSS (See page 417)
Original papers
417 Activity of GH/IGF-I axis in patients with dilated cardio-
myopathy: F. BROGLIO, A. FUBINI, M. MORELLO, E. ARVAT,
G. AIMARETTI, L. GIANOTTI, M. F. BOGHEN, R. DEGHENGHI,
L. MANGIARDI AND E. GHIGO (see commentary page 415)
431 Prevalence, predictors and patterns of postoperative polyuria
and hyponatraemia in the immediate course after transsphenoidal
surgery for pituitary adenomas: J. HENSEN, A. HENIG,
R. FAHLBUSCH, M. MEYER, M. BOEHNERT AND M. BUCHFELDER
441 Evaluation of free insulin-like growth factor-I measurement on
the diagnosis and follow-up treatment of growth homone-deficient
adult patients: N. R. c. MUSOUNO, M. B. DA CUNHA NETO,
R. MARINO, D. GIANNELLA-NETO AND M. D. BRONSTEIN
451 Discrepancy between serum leptin values and total body fat in
response to the oral growth hormone sdcretagogue MK-677:
J. SVENSSON, B. CARLSSON, L. M. S. CARLSSON, J. 0. JANSSON AND
B. A. BENGTSSON
457 Endothelial dysfunction in hypopituitary adults with growth
hormone deficiency: L. M. EVANS, J. s. DAVIES, J. GOODFELLOW,
J. A. E. REES AND M. F. SCANLON
465 Evaluation of adrenal function in patients with hypothalamic
and pituitary disorders: comparison of serum cortisol, urinary
free cortisol and the human-corticotrophin releasing hormone
test with the insulin tolerance test: R. p. F. DULLAART,
S. H. PASTERKAMP, J. A. M. BEENTJES AND W. J. SLUITER
473 Circadian variation of plasma cortisol in prepubertal children
with normal stature, short stature and growth hormone
deficiency: R. c. HERMIDA, L. GARcfA, D. E. AYALA AND
J. R. FERNANDEZ
481 Kallmann's syndrome: is it always for life?: R. QUINTON,
H. K. CHEOW, D. J. TYMMS, P. M. G. BOULOUX, F. C. W. WU AND
H. S. JACOBS
487 Effect of acute high dose dobutamine administration on serum
thyrotrophin (TSH): E. LEE, p. CHEN, H. RAO, J. LEE AND
L. A. BURMEISTER
493 The HLA-DQ association with Graves' disease in Chinese
children: G. w. K. WONG, s. H. CHENG AND J. s. DORMAN
497 Cardiac function at rest in hypothyroidism evaluated by
equilibrium radionuclide angiography: E. T. TIELENS, M. PILLAY,
C. STORM AND A. BERGHOUT
503 Prevalence and significance of thyroid autoantibodies in patients
with chronic hepatitis C virus infection: a prospective controlled
Study: M. J. HUANG, S. L. TSAI, B. Y. HUANG, 1. S. SHEEN,
C. T. YEH AND Y. F. LIAW
511 Female sex hormone replacement therapy increases serum free
1,25-dihydroxyvitamin Dy a I year prospective study:
H. J. C. VAN HOOF, M. J. VAN DER MOOREN, L. M. J. W. SWINKELS,
C. G. J. SWEEP, J. M. W. M. MERKUS AND T. J. BENRAAD
517 The natural history of the metabolic syndrome in young women
with the polycystic ovary syndrome and the effect of long-term
oestrogen-progestagen treatment: R. PASQUALI, A. GAMBINERI,
B. ANCONETANI, V. VICENNATI, D. COLITTA, E. CARAMELLI,
F. CASIMIRRI AND A. M. MORSELLI-LABATE
529 Prevalence of Ras mutatons in thyroid neoplasia: C.T. ESAPA,
S. J. JOHNSON, P. KENDALL-TAYLOR, T. W. J. LENNARD AND
P. E. HARRIS
Case report
537 An adult patient with severe hypercalcaemia and hypocalciuria
due to a novel homozygous inactivating mutation of the calcium-
sensing receptor: N. CHIKATSU, s. FUKUMOTO, M. SUZAWA,
Y. TANAKA, Y. TAKEUCHI, S. TAKEDA, Y. TAMURA, T. MATSUMOTO
AND T. FUJITA
545 Letters to the Editors
Author's Declaration
_______________________________________
Clinical Endocrinology
Vol. 50, NO. 5, May 1999
Contents
Review
547 Can GHRH or GH secretagoges re-initiate pituitary GH
pulsatility?: s. CHAPPEL
Commentary
557 How many surgeons to operate on acromegalic patients:
R.N. CLAYTON (see page 561)
Original papers
561 Outcome of transphenoidal surgery for acromegaly and its
relationship to surgical experience: s. AHMED,
M. ELSHEIKH, 1. M. STRATTON, R.C.L. PAGE, C.B.T. ADAMS
AND J.A.H. WASS (see commentary page 557)
569 Insulin regulation of leptin synthesis and secretion in
humans: the model ofmyotonic dystrophy: J.M. GOMEZ,
A. MOLINA, M. FERNANDEZ-CASTANER, R. CASAMITJANA,
J.A. MARTI'NEZ-MATOS AND J. SOLER
577 A trial of growth hormone therapy in well-controlled
hypophosphataemic rickets: F.J. CAMERON, E.B. SOCHETT,
A. DANEMAN AND S.W. KOOH
583 Parathyroid hormone gene polymorphisms in primary
hyperparathyroidism: M. KANZAWA, T. SUGIMOTO,
T. KOBAYASHI. A. KOBAYASHI AND K. CHIHARA
589 Familial non-medullary thyroid carcinoma: pathology
review in 27 affected cases from 13 French families:
F. LEPRAT, F. BONICHON, M. GUYOT, H. TROUETTE,
M. TROJANI, V. VERGNOT, M. LONGY, G. BELLEANNEE.
A. DE MASCAREL AND P. ROGER
595 Relationships between dehydroepiandrosterone-sulphate
and anthropometric, metabolic and hormonal variables in
a large cohort of obese women: M. MACCARIO, E. MAZZA,
J. RAMUNNI, S.E. OLEANDRI, P. SAVIO, S. GROTTOLI,
R. ROSSETTO, M. PROCOPIO, C. GAUNA AND E. GHIGO
601 Circulating levels of human insulin-like growth factor
binding protein-6 (IGFBP-6) in health and disease as
determined by radioimmunoassay: J. VAN DOORN,
A.M. RINGELING, S.S. SHMUELI, M.C. KUIJPERS,
A.C.S. HOKKEN-KOELEGA, S.C. VAN BUUL-OFFERS AND
M. JANSEN
611 Relationship between serum and urinary insulin-like
growth factor-I through childhood and adolescence: their
use in the assessment of disordered growth: C.M. HALL,
M.S. GILL, P. FOSTER. L. PENNELLS, V. TILLMANN,
J. JONES. D.A. PRICE AND P.E. CLAYTON
619 Acidic isoforms of chorionic gonadotropin in European
and Samoan women are associated with hyperemesis
gravidarum and may be thyrotrophic: v. JORDAN,
S.K.G. GREBE, R.R. COOKE. H.C. FORD, P.D. LARSEN,
P.R. STONE AND C.E. SALMOND
629 Long-term substitution therapy of hypogonadal men with
transscrotal testosterone over 710 years: H.M. BE H RE,
S. VON ECKARDSTEIN, S. KLIESCH AND E. NIESCHLAG
637 Expression of the androgen metabolizing enzyme
UGT2B15 in adipose tissue and relative expression
measurement using a competitive RT-PCR method:
A. TCHERNOF, E. LEVESQUE, M. BEAULIEU, P. COUTOURE,
J.P. DESPRES, D.W. HUM AND A. BELANGER
643 Differentiated thyroid cancer: a retrospective analysis of
832 cases from Greece: i. TZAVARA, B. VLASSOPOULOU,
C. ALEVIZAKI, G. KOUKOULIS, M. TZANELA,
P. KOUMOUSSI, F. SOTSIOU AND N. THALASSINOS
655 Disturbances of menstruation in hypothyroidism:
G.E. KRASSAS, N. PONTIKIDES, T. KALTSAS,
P. PAPADOPOULOU, J. PAUNKOVIC, N. PAUNKOVIC AND
L. H. DUNTAS
661 Adrenal and gonadal contributions to urinary excretion
and plasma concentration of epitestosterone in men effect
of adrenal stimulation and implications for detection of
testosterone abuse: A. T. KICMAN. S.B. COUTTS,
D.A. COWAN, D.J. HANDELSMAN, C.J. HOWE, S. BURRING
AND F.C.W. WIJ
669 Amniotic fluid levels of dimeric inhibins, pro-aC inhibin,
activin A and follistatin in Down's syndrome:
E.M. WALLACE, D. D'ANTONA, C. SHEARING. L.W. EVANS,
P. THIRUNAVUKARASU, J.P. ASHBY, M. SHADE AND
N.P. GROOME
Case report
675 Gushing's syndrome secondary to ectopic ACTH secretion
from metastatic breast carcinoma: S.J. WIGG, A.R. EHRLICH
AND P.J. FULLER
679 Letters to the Editors
682 Notices
Author's Declaration
_______________________________________
Clinical Endocrinology
Vol. 50, NO. 6, June. 1999,
Contents
Review
683 Growth hormone and exercise: p. J. JENKINS
Commentary
691 Casting new light on the clinical spectrum of neonatal severe
hyperparathyroidism: s. PEARCE AND B. STEINMANN (see Clinical
Endocrinology, 50,537-543)
original papers
695 Inhibin B levels in azoospermic subjects with cytologically
characterized testicular pathology: c. FORESTA, A. BETTELLA,
F. PETRAGLIA, M. PISTORELLO, S. LUISI AND M. ROSSATO
703 GH replacement in 1034 growth hormone deficient hypopituitary
adults: demographic and clinical characteristics, dosing and
safety: R. ABS, B. A. BENGTSSON, E. H. HERNBERG-STAHL,
J. P. MONSON, J. P. TAUBER, P. WILTON AND C. WUSTER
715 Correlation between urinary cortisol and 6-sulphatoxymelatonin
rhythms in field studies of blind subjects: D. J. SKENE,
S. W. LOCKLEY, K. JAMES AND J. ARENDT
721 Constitutional delay in growth and puberty (CDGP) is associated
with hypoleptinaemia: M. s. GILL, c. M. HALL, v. TILLMANN AND
P. E. CLAYTON
727 Increased MEN I mRNA expression in sporadic pituitary tumours:
C. J. MCCABE, N. J. L. GITTOES, M. C. SHpPPARD AND J. A. FRANKLYN
735 Reduced fetal growth and growth hormone secretion in adult
life: D. E. FLANAGAN, V. M. MOORE, 1. F. GODSLAND,
R. A. COCKINGTON, J. S. ROBINSON AND D. 1. W. PHILLIPS
741 Hypothalamic derangement in traumatized patients: growth
hormone (GH) and prolactin response to thyrotrophin-releasing
hormone and GH-releasing hormone: L. DE MARINIS, A. MANCINI,
D. VALLE, A. BIANCHI, R. GENTILELLA, 1. LIBERALE, V. MIGNANI,
M. PENNISI AND F. DELLA CORTE
749 Dose titration and patient selection increases the efficacy of GH
replacement in severely GH deficient adults: R. D. MURRAY,
C. J. SKILLICORN, S. J. HOWELL, C. A. LISSETT, A. RAHIM AND
S. M. SHALET
759 The influence of hydrocortisone substitution on the quality of
life and parameters of bone metabolism in patients with secondary
hypocortisolism: M. WICHERS, w. SPRINGER, F. BIDLINGMAIER
AND D. KLINGMULLER
767 Correlation between cortisol and insulin-like growth factor-
binding proteins (IGFBPs) under physiological conditions in
children: c. E. MARTINELLI, M. E. YATEMAN, A. M. COTTERILL,
A. C. MOREIRA AND C. CAMACHO-HIJBNER
775 The impact of gender, puberty and body mass on reference
values for urinary growth hormone (GH) excretion in normally
growing non-obese and obese children: G. BONA, A. PETRI,
A. RAPA, A. CONTI AND A. SARTORIO
783 Determinants of longterm outcome of radioiodine therapy for
sporadic nontoxic goitre: R. LE MOLl, M. F. T. WESCHE,
M. M. C. TIEL-VAN BUUL AND W. M. WIERSINGA
791 Reduced androgen levels in adult Turner syndrome: influence
of female sex sleroids and growth hormone status: c. H. GRAVHOLT,
B. SVENSTRUP, P. BENNETT AND J. S. CHRISTIANSEN
801 Different immunohistochemical patterns ofTGF-pl expression
in benign and malignant adrenocortical tumours: A. BOCCUZZI,
M. TERZOLO, S. CAPPIA, P. DE GlULI, C. DE RISI, E. LEONARDO,
S. BOVIO, M. BORRIERO, P. PACCOTTI AND A. ANGELI
Case report
809 Fetal pituitary negative feedback at early gestational age:
Y. RAKOVER, E. WEINER, N. MOSH AND E. SHALEV
815 Letters to the Editors
821 Book reviews
823 Referees
825 Author index
835 Subject index
Author's Declaration
______________________________________
Clinical Endocrinology
Volume 51, Number 1, July 1999
Contents
Review
1 Apoptosis in neuroendocrine tumours: D. G. WANG
Commentary
11 Practice guidelines for the detection and management of thyroid
dysfunction. A comparative review of the recommendations:
J. E. ARBELLE AND A. PORAIH
19 Mapping of a novel tumour suppressor gene with a role in
neuroendocrine tumours: s. H. s. PEARCE (see page 27)
Rapid communication
21 Growth hormone replacement therapy in adults with growth
hormone deficiency improves vascular reactivity: E. R. CHRIST,
P. J. CHOWIENCZYK, P. H. SÖNKSEN AND D. L. RUSSEL-JONES
Original papers
27 Frequent loss of heterozygosity at chromosome 3pl4-2-3p21
in human pancreatic islet cell tumours: M. N. NIKIFOROVA,
Y. E. NIKIFOROV, P. BIDDINGER, D. R. GNEPP, L. A. GROSEMBACHER,
B. L. WAJCHENBERG, J. A. FAGIN AND R. M. COHEN (see commentary
page 19)
35 Evaluation of bone metabolism after the use of an inhaled
glucocorticoid (flunisolide) in patients with moderate asthma:
O. M. HAUACHE, E. C. J. AMARANTE, J. G. H. VIEIRA,
S. M. FARESIN, A. L. G. FERNANDES, J. R. JARDIM AND
M. LAZARETTI-CASTRO
41 Short-term leptin infusion does not affect circulating levels of
LH, testosterone or cortisol in food-restricted pubertal male
rhesus macaques: J. LADO-ABEAL, Y. o. LUKYANENKO, s. SWAMY,
R. C. HERMIDA, J. C. HUTSON AND R. L. NORMAN
53 Effects of growth hormone replacement on physical performance
and body composition in GH deficient adults:
J. RODRfGUEZ-ARNAO, A. JABBAR, K. FULCHER, G. M. BESSER
AND R. J. M. ROSS
61 Growth hormone status following treatment for Cushing's
syndrome: N. R. HUGHES, c. A. LISSETT AND s. M. SHALET
67 Salivary cortisol for screening of Cushing's syndrome in
children: c. E. MARTINELLI, s. L. SADER, E. B. OLIVEIRA,
J. C. DANELUZZI AND A. C. MOREIRA
73 Differences in the levels of TSH-binding inhibitor immuno-
globulins in goitrous and agoitrous autoimmune thyroiditis after
twelve months ofL-thyroxine therapy: D. H. c. KHOO,
P. H. K. ENG, S. C. HO AND A. C. K. FOK
81 Serum leptin levels in healthy ageing men: are decreased serum
testosterone and increased adiposity in elderly men the
consequence of leptin deficiency?: J. K. VAN DEN SAFFELE,
S. GOEMAERE, D. DE BACQUER AND J. M. KAUFMAN
89 Reduced human growth hormone (hGH) bioactivity without a
defect of the GH-1 gene in three patients with rhGH responsive
growth failure: G. BINDER, M. R. BENZ, M. ELMLINGER,
C. D. PFLAUM, C. J. STRASBURGER AND M. B. RANKE
97 Mutation screening and isoform prevalence of the follicle
stimulating hormone receptor gene in women with premature
ovarian failure, resistant ovary syndrome and polycystic ovary
syndrome: G. s. CONWAY, E. CONWAY, c. WALKER, w. HOPPNER,
J. GROMOLL AND M. SIMONI
101 Type I multiple endocrine neoplasia (MENI): contribution of
genetic analysis to the screening and follow-up of a large French
kindred: c. WATERLOT, N. PORCHET, C. BAUTERS, M. DECOULX,
J. L. WEMEAU, C. PROVE, P. M. DEGAND, J. P. AÜBERT, C. CORTET
AND D. DEWAILLY
109 Incidentally discovered pituitary lesions: high freqency of
macroadenomas and hormone-secreting adenomas — results
of a prospective study: J. FELDKAMP, R. SANTEN, E. HARMS,
A. AULICH, U. MODDER AND W. A. SCHERBAUM
115 Association of the large multifunctional proteasome (LMP2)
gene with Graves' disease is a result of linkage disequilibrium
with the HLAhaplotype DRB1*0304-DQB1*02-DQA1*0501:
J. M. HEWARD, A. ALLAHABADIA, M. C. SHEPPARD, A. H. BARNETT,
J. A. FRANKLYN AND S. C. L. GOUGH
119 Macroprolactinaemia: validation and application of the
polyethylene glycol precipitation test and clinical characterisation
of the condition: A. o. OLUKOGA AND J. w. KANE
Case report
127 Ovarian responses to hCG stimulation: insulin resistance/
hyperinsulinaemia vs. insulin deficiency: s. F. WITCHEL AND
S. ARSIANIAN
131 Letter to the Editors
137 Book review
137 Notices
_______________________________________
CLINICAL Endocrinology
Volume 51, Number 2, August 1999
Contents
Heview
139 Role ofFSH in the regulation of spermatogenesis: clinical
aspects: E. NIESCHLAG, M. SIMONI, J. GROMOLL AND
G. F. WEINBAUER
Commentary
147 Non-islet cell tumour hypoglycaemia: J. D. TEALE (see page 247)
149 The role of bilateral inferior petrosal sinus sampling in the
investigation ofACTH-dependent hypercortisolism:
A. B. ATKINSON (see page 255)
151 The short Synacthen test: is less best?: P. M. STEWART AND
P. M. s. CLARK (see page 153)
Original papers
153 Reproducibility of the cortisol response to stimulation with the
low dose (I ug) ofACTH: Y. J. PARK, K. s. PARK, J. H. KIM,
c. s. SHIN, s. Y. KIM AND H. K. LEE (see commentary page 151 )
159 Comparison of six months therapy with octreotide versus
lanreotide in acromegalic patients: a retrospective study:
P. RAZZORE, A. COLAO, R. BALDELLI, D. GAIA, P. MARZULLO,
E. FERRETTI, D. FERONE, M. L. JAFFRAIN-REA, G. TAMBURRANO,
G. LOMBARDI, F. CAMANNI AND E. CICCARELLI
165 A novel mutation in the TPO gene in goitrous hypothyroid
patients with iodide organification defect: c. L. s. SANTOS,
H. BIKKER, K. G. M. REGO, A. C. NASCIMENTO, M. TABASCIA,
J. J. M. DE VIJLDER AND G. MEDEIROS-NETO
173 Growth hormone (GH) replacement therapy reduces serum
sialic acd concentrations in adults with GH-deficiency: a
double-blind placebo-controlled study: E. R. CHRIST,
M. H. CUMMINGS, P. J. LUMB, M. A. CROOK, P. H. SONKSEN AND
D. L. RUSSELL-JONES
181 Classical pituitary apoplexy: clinical features, management and
outcome: H. s. RANDEVA, J. SCHOEBEL, J. BYRNE, M. ESIRI,
C. B. T. ADAMS AND J. A. H. WASS
189 Ontogeny of serum leptin concentrations in the human:
M. GEARY, R. HERSCHKOVITZ, P. J. PRINGLE, C. H. RODECK AND
P. C. HINDMARSH
193 The continuous 7-hour intravenous dexamethasone suppression
test in the differential diagnosis ofACTH-dependent Gushing's
syndrome: D. P. M. VAN DEN BOGAERT, w. w. DE HERDER,
F. H. DE JONG, P. BIEMOND, A. J. VAN DER LELY AND
S. W. J. LAMBERTS
199 Leptin serum concentrations in healthy neonates within the first
week of life: relation to insulin and growth hormone levels,
skinfold thickness, body mass index and weight: c. SCHUBRING,
T. SIEBLER, J. KRATZSCH, P. ENGLARO, W. F. BLUM, K. TRIEP AND
W. KIESS
205 Sleep deprivation effects on the activity of the hypothalamic-
pituitary—adrenal and growth axes: potential clinical implications:
A. N. VGONTZAS, Ci. MASTORAKOS, E. 0. BIXLER, A. KALES,
P. W. GOLD AND G. P. CHROUSOS
217 Vitamin D insufficiency increases bone turnover markers and
enhances bone loss at the hip in patients with established vertebral
osteoporosis: o. SAHOTA, T. MASLJD, p. SAN AND D. J. HOSKING
223 Syndrome of body fat redistribution in HIV-1 -infected patients:
relationships to cortisol and catecholamines: E. RENARD, J. FABRE,
K PARIS, J. REYNES AND J. BRINGHR
231 The effects of metformin on insulin resistance and ovarian
steroidogenesis in women with polycystic ovary syndrome:
K. UNLUHIZARCI, F. KELE^TIMUR, F. BAYRAM, Y.SAHIN AND
A. TUTLJS
237 Neuromusclilar symptoms and dysfunction in subclinical
hypothyroid patients: beneficial effect of L-T4 replacement
therapy: F. MONZANI, N. CARACCIO, p. DEL GUERRA, A. CASOLARO
AND E. FERRANNINI
243 Association of molecular variants of luteinizing hormone with
menstrual disorders: L. N. RAMANUJAM, w. x. LIAO, A. c. ROY,
A. LOGANATH, H. H. GOH AND S. C. NG
Case report
247 Hypoglycaemia associated with the production of insulin-like
growth factor II and insulin-like growth factor binding protein
6 by a haemangiopericytoma: K. HOEKMAN, J. VAN DOORN,
T. GI.OUDEMANS, J. A. MAASSEN, A. G. P. SCHULLER AND
H. M. PINEDO (see commentary page 147)
255 Letters to the Editors (see commentary page 149)
262 Book review
_______________________________________
Clinical Endocrinology
Volume 51, Number 3, September 1999
Contents
Editorial
263 Role of postoperative radiotherapy in the treatment of pituitary
tumours: A. B. GROSSMAN AND P. KENDALL-TAYLOR
Review
265 Pituitary adenoma radiotherapy -when and how?: P.N.PLOWMAN
Commentary
273 Toward better treatment of congenital adrenal hyperplasia:
p. w. SPEISER (see page 285)
Rapid communication
275 A comparison of lanreotide and octreotide LAR for treatment
of acromegaly: H. E. TURNER, A. VADIVALE, J. KEENAN AND
J. A. H. WASS
Original papers
281 Audit of selected patients with non-functioning pituitary adenomas
treated without irradiation - a follow-up study: H. E. TURNER,
I. M. STRATTON, J. V. BYRNE, C. B. T. ADAMS AND J. A. H. WASS
285 Effect of carbenoxolone on the plasma renin activity and
hypothalamic-pituitary-adrenal axis in congenital adrenal
hyperplasia due to 21-hydroxylase deficiency: i. IRONY AND
G. B. CUTLER (see commentary page 273)
293 Increased pressor response to noradrenaline in pituitary dependent
Cushing's syndrome: A. P. HEANEY, S. J. HUNTER, B. SHERIDAN
AND A. B. ATKINSON
301 The relationship among circulating insulin-like growth factor
components, biochemical markers of bone turnover and bone
mineral density in postmenopausal women under the age of 60:
J. G. KIM, C. S. SHIN, Y. M. CHOI, S. Y. MOON, S. Y. KIM AND
J. Y. LEE
309 Growth hormone (GH) status is an independent determinant of
serum levels ofcholesterol and triglycerides in healthy adults:
N. VAHL, I. KLAUSEN, J. S. CHRISTIANSEN AND J. 0. L. J0RGENSEN
317 pl6 (INK4^, MTS-1 ) gene polymorphism and methylation status
in human pituitary tumours: M. L. JAFFRAIN-REA, E. FERRETTI,
E. TONIATO, K. CANNITA, A. SANTORO, D. Dl STEFANO, E. RICEVUTO,
M. MARODER, G. TAMBURRANO, G. CANTORE, A. GULINO AND
S. MARTINOTTI
327 Splanchnic exchange of insulin-like growth factor binding
protein-1 (IGFBP-I), IGF-I and acid-labile subinit (ALS) during
normo- and hyper-insulinaemia in healthy subjects:
E. FERNQVIST-FORBES, K. EKBERG, B. F. LINDGREN AND K. BRISMAR
333 The quality of life of adults with growth hormone deficiency:
comparison with diabetic patients and control subjects:
M. WALLYMAHMED, P. FOY AND I. A. MACFARLANE
339 Serum IGF-I and IGFBP-3 concentrations do not accurately
predict growth hormone deficiency in children with brain tumours:
S. A. WEINZIMER, S. A. HOMAN, R. J. FERRY AND T. MOSHANG
347 Lipid profile, glucose tolerance and insulin sensitivity after more
than four years of growth hormone therapy in non-growth
hormone deficient adolescents: P. BAREILLE, C. AZCONA,
D. R. MATTHEWS, G. S. CONWAY AND R. STANHOPE
355 Mutations in intron 3 of GH-1 gene associated with isolated GH
deficiency type II in three Japanese families: T. KAMIJO,
Y. HAYASHI, A. SHIMATSU, E. KINOSHITA, M. YOSHIMOTO,
M. OGAWA AND H. SEO
361 The prevalence of thyroid dysfunction in a population with
borderline iodine deficiency: N. KNUDSEN, T. J0RGENSEN,
S. RASMUSSEN, E. CHRISTIANSEN AND H. PERRILD
369 Hexarelin as a test of pituitary reserve in patients with pituitary
disease: M. KORBONITS, G. KALTSAS, L. A. PERRY, A. B. GROSSMAN,
J. P. MONSON, G. M. BESSER AND P. J. TRAINER
Case report
377 Pituitary apoplexy following metastasis of bronchogenic
adenocarcinoma to a prolactinoma: F. w. F. H ANNA,
O. M. WILLIAMS, J. S. DAVIES, T. DAWSON, J. NEAL AND
M. F. SCANLON
383 Book reviews
Author's Declaration
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