IMMUNOLOGIC RESEARCH

IMMUNOLOGY RESEARCH

VOL. 19 , NO. 2-3 , 1999

Contents Immunology at Yale
Charles A. Janeway, Jr. and Richard A. Flavell ....................................................................... 105 The Role of Self-Recognition in Receptor Repertoire Development
Charles A. J oneway, Jr. and Members ofthe Janeway Laboratory ......................................... 107 Lymplioid Neo-organogenesis: Lymphotoxin's Role m Inflammation and Development
Nancy H. Ruddle ......................................................................................................................... 119 Function and Regulation of Memory CD4 T Cells
Daniela P. MetZ and Kim Dottomly ............................................................................................ 127 Death and Destruction of Activated T Lymphocytes
I. Nicholas Crispe ....................................................................................................................... 143 The Molecular Basis of T Cell Differentiation
Richard A. Flavell....................................................................................................................... 159 Transposition Mediated by RAG I and RAG2 and the Evolution ofthe Adaptive Immune System
David G. Schatz........................................................................................................................... 169 Regulation of Inducible Gene Expression by the Transcription Factor NF-KB
Sankar Gllosh.............................................................................................................................. 183 Thiol Oxidation and Reduction in MHC-Restricted Antigen Processing and Presentation Peter Cresswell, Balasubrama
nian Arunachalarn, Naveen Bangia, Tobias Dick,
Gundo Diedrich, Eric Hughes, and Maja Maric........................................................................... 191 Molecular Analysis of Protein Interactions Mediating the Function of the
Cell Surface Protein CD8
Lesley Devine and Paula B. Kavathas ......................................................................................... 201 MHC Class I Restricted T Cell Responses to Listeria monocytogenes,
an Intracellular Bacterial Pathogen Alyce Finelli, Kristen M. Kerksiek, S. Elise Alien, Natalia Marshall, Roberta Mercado, lngrid Pilip, Dirk H. Busch, and Eric G. Pamer,........................................................................... 211 Immuno
biology of Human Vascular Endothelium
Jordan S. Pober........................................................................................................................... 225 Characterization of the Human Antiporcine Immune Response:
A Prerequisite to Xenotransplantation Alfred L M. Bothwell.................................................................................................................. 233 Autoreactive T Cells in Murine Lupus: Origins and Roles in Autoantibody Product
ion
Joe Craft, Stanford Peng, Takao Fujii, Masato Okada, and Saeed Fatenejad........................ 245 Regulation of Autoreactive Anti-IgG (Rheumatoid Factor) B Cells
in Normal and Autoimmune Mice Haowei Wang and Mark J. Shlomchik ....................................................................................... 259 Author Index........................................................................................
......................................... 271 Subject Index.................................................................................................................................. 273

IMMUNOLOGYIC RESEARCH

Vol. 20, No. 1, 1999

Contents
Dominant Regulation: A Common Mechanism oj'Monoclonal Antibody Induced Tolerance? Karen Honey, Stephen P. Cobbold, and Herman Waldmann ....................................................... 7
Role of Cytokines in Pulmonary Antimicrobial Host Defense Borna Mehrad and Theodore J. Standiford................................................................................. 15
Small GTPascs in Lymphocyte Biology: Rho Proteins Take Center Stage Stefan Henning and Steve Cleverly .............................................................................................. 29
Developmental Regulation oflmmunoglobulin mRNA Processing and IgA Response:
Establishing a Paradigm Deborah A. Lebrnan and John H. Coyle ...................................................................................... 43
The Development ofCD4+ T Effector Cells During the Type 2 Immune Response William C. Cause, Melinda Ekkens, Die? Nguyen, Velia Mitro, Qian Liu, Frederick D. Finkelman, Rebecca J. Green\vald, and Joseph F. Urban.................................... 55
Murine Mercury-Induced Autoimmunity: A Model of Chemically Related Autoimmunity in Humans Lee M. Bagenstose, PadminiSalgame, and Marc Monestier....................................................... 67