Vol. 57, No. 1 JOURNAL OF CONTROLLED RELEASE 4 JANUARY 1999 CONTENTS
Abstracted/indexed in: Biosciences Information Service; Chemical Abstracts; Current Contents: Life Sciences; Exceipta Medica; International Pharmaceutical Abstracts; Polymer Contents; Current Awareness in Biological Sciences (CABS); CABS Abstracts; Index Medicus/Medline
Natural rubber base matrix containing Calendula officinalis plant as a source of molluscicdal saponin F.M. Helaly, A.A. Ahmed and M.A. Abd EI-Ghaffar (Cairo, Egypt) 1
Encapsulation of plasmid DNA in biodegradable poly(D,L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery
D. Wang, D.Ff. Robinson (Edmonton, Canada) G.S. Kwon (Edmonton, Canada and Madison Wi, USA) and J. Samuel (Edmonton, Canada) 9
Evaluation of a positively charged submicron emulsion of piroxicam on the rabbit corneum healing process following alkali bum S.H. Klang, C.S. Siganos, S. Benita and J. Frucht-Pery (Jerusalem, Israel) 19
Improved stability of highly fluorinated phospholipid-based vesicles in the presence of bile salts C. Gadras, C. Santaella and P. Vierling (Nice, France) 29
Evaluation of mitoxantrone-loaded albumin microspheres following intraperitoneal administration to rats C.P. Luftensteiner, 1. Schwendenwein, B. Paul, H.G. Eichlerand H. Viemstein (Vienna, Austria) 35
In vivo drug release behavior in dogs from a new colon-targeted delivery system T. lshibashi, H. Hatano, M. Kobayashi, M. Mizobe and H. Yoshino (Osaka, Japan) 45
Asymmetric membrane capsules for osmotic drug delivery. 1. Development of a manufacturing process A.G. Thombre, J.R. Cardinal, A.F{. DeNoto (Groton, CT, USA), S.M. Herbig and K.L. Smith (Bend, OR, USA) 55
Asymmetric membrane capsules for osmotic drug delivery II. In vitro and in vivo drug release performance A.G. Thombre, J.P. Cardinal, A.R. DeNoto and D.C. Gibbes (Groton, CT, USA) 65
Influence of drug:hydroxypropylmethylcellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets M.V. Velasco, J.L. Ford, P. Fiowe and A.R. Rajabi-Siahboomi (Liverpool, UK) 75 Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate
H. Yura, N. Yoshimura, T. Hamashima, K. Akamatsu, M. Nishikawa, Y. Takakura and M. Hashida (Kyoto, Japan) 87
Book Reviews 101 Instructions to Authors 105
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JOURNAL OF CONTROLLED RELEASE
Vol. 57, No. 2, FEBRUARY 1999
Review
Issues and perspectives on the biocompatibility and immunotoxicity evaluation of implanted controlled
release systems
J.M. Anderson (Cleveland, OH, USA) and J.J. Langone (RockvHle, MD, USA) 107
Incorporation of polymeric nanoparticles into solid dosage forms
C. Schmidt, R. Bodmeier (Berlin, Germany) 115
Spectrophotometric analysis of molecular transport in gels
E.N. Dunmire, A.M. Plenys and D.F. Katz (Durham, NC, USA) 127
Drug release from drug-polyanion complex tablets: poly(acrylamido-2-methyl-1-propanesulfonate sodium
-co- methyl methacrylate)
N. Konar, C.-j. Kirn (Philadelphia, PA, USA) 141
Effectiveness of ciprofloxacin microspheres in eradicating bacterial biofilm
G. Owusu-Ababio (Tallahassee, FL, USA) and J. Rogers, H. Anwar (Edmonton, Canada) 151
Cholephilic characteristics of a new cytostatic complex of cisplatin with glycocholate (Bamet-R2)
R.I.P. Macias, M.Y. EI-Mir, M.J. Monte, M.A. Serrano, M.J. Garcia and J.J.G. Marin (Salamanca,
Spain) 161
PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble
drug
T. Govender, S. Stolnik, M.C. Garnett, L Ilium and S.S. Davis (Nottingham, UK) 171
Macromolecular derivatives of N, /V-di-(2-chloroethyl)-4-phenylene diamine mustard. 2. In vitro cytotoxicity
and in vivo anticancer efficacy
H. Soyez (Gent, Belgium), L.W. Seymour (Birmingham, UK) and E. Schacht (Gent, Belgium) 187
Studies on drug release kinetics from ibuprofen-carbomer hydrophilic matrix tablets: influence of co-
excipients on release rate of the drug
G. Majid Khan (Dera lsmail Khan, Pakistan) and J.-B. Zhu (Nanjing, PR China) 197
The effect of methylated p-cyclodextrins on the tight junctions of the rat nasal respiratory epithelium.
Electron microscopic and confocal laser scanning microscopic visualization studies
E. Marttin, J.C. Verhoef, F. Spies, J. van der Meulen, J.F. Nagelkerke, H.K. Koerten and F.W.H.M.
Merkus (Leiden, The Netherlands) 205
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JOURNAL OF CONTROLLED RELEASE
Vol. 57, No. 3, february 1999
A new intragastric delivery system for the treatment of Helicobacter pylori associated gastric ulcer: in
vitro evaluation
L Yang, J. Eshraghi, R. Fassihi (Philadelphia, PA, USA) 215
Evaluation of parameters involved in preparation and release of drug loaded in crosslinked matrices of
alginate
S. AI-Musa (Naor, Jordan), D. Abu Fara (Amman, Jordan) and A.A. Badwan (Naor, Jordan) 223
Controlled release of insect sex pheromones from paraffin wax and emulsions
C.A. Atterholt, M.J. Delwiche, R.E. Rice, J.M. Krochta (Davis, CA, USA) 233
In vitro release of 5-fluorouracil with cyclic core dendritic polymer
Ft.X. Zhuo, B. Du, ZR Lu (Wuhan, PRC) 249
Lidocaine-loaded biodegradable nanospheres. 1. Optimization of the drug incorporation into the polymer
matrix
T. Gorner, R. Gref, D. Michenot (Nancy, France), F. Sommer (Marseille, France), M.N. Tran
(Villeurbanne, France) and E. Dellacherie (Nancy, France) 259
Conjugation of drug to poly(D,L-lactic-co-glycolic acid) for controlled release from biodegradable
microspheres
J.E. Oh (Kyunggido, South Korea), Y.S, Nam (Taejon, South Korea), K.H. Lee (Kyunggido, South
Korea) and T.G. Park (Taejon, South Korea) 269
Preliminary clinical study of the distribution of HPMA copolymers bearing doxorubicin and galactosamine
P.J. Julyan, L.W. Seymour, D.R. Ferry, S. Daryani, C.M. Boivin, J. Doran, M. David, D. Anderson,
C. Christodoulou, A.M. Young, S. Hessfewood, D.J. Kerr (Birmingham, UK) 281
Photopolymerization of multilaminated poly(HEMA) hydrogels for controlled release
S. Lu, K,S. Anseth (Boulder, CO, USA) 291
Determination of the internal morphology of poly (D,L-lactide) microspheres using stereological methods
T. Ehtezazi, C. Washington, C.D. Melia (Nottingham, UK) 301
Author Index Volume 57 315
Subject Index Volume 57 317
Contents Volume 57 319
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JOURNAL OF CONTROLLED RELEASE
Vol. 58, No. 1, 8 MARCH 1999
CONTENTS
Polymer water-soluble derivatives of polypeptide antibiotic, gramicidin-S based on reactive copolymers of
/\/-(2-hydroxypropyl) methacrylamide
M. Solovskij, E. Panarin (St. Petersburg, Russian Federation) 1
Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-
oil emulsion technique
N.B. Viswanathan, P.A. Thomas (Pune, India), J.K. Pandit (Varanasi, India), M.G. Kulkami (Pune,
India) and Fi.A. Mashelkar (New Delhi, India) 9
Effect of Ca(2+)-alginate gel dissolution on release of dextran with different molecular weights
A. Kikuchi, M. Kawabuchi, A. Watanabe, M. Sugihara, Y. Sakurai and T. Okano (Tokyo, Japan) 21
Release of testosterone from an osmotic pump tablet utilizing (SBE)(7m)-p-cyclodextrin as both a
solubilizing and an osmotic pump agent
K. Okimoto (Osaka, Japan), Ff.A. Rajewski and V. J. Stella (Lawrence, KS, USA) 29
Buccal mucosa in vitro experiments. 1. Confocal imaging of vital staining and MTT assays for the
determination of tissue viability
D. Imbert and C. Cullander (San Francisco, CA, USA) 39
Absorption and biodistribution of '''indium-labelled desferrioxamine ('''In-DFO) after subcutaneous
injection of '''In-DFO liposomes
N.S. Postma (Utrecht, The Netherlands), O.C. Boerman, W.J.G. Oyen, J. Zuidema (Nijmegen, The
Netherlands) and G. Storm (Utrecht, The Netherlands) 51
Synthesis and characterisation of poly(D,L-lactic acid)-idoxuridine conjugate
M.G. Pimoli, L. Avallone (Naples, Italy), P. de Caprariis (Sassari, Italy), A. Galeone (Naples, Italy), F.
Forni and M.A. Vandelli (Modena, Italy) 61
Short term stability of freeze-dried, lyoprotected liposomes
E.C.A. van Winden and D.J.A. Crommelin (Utrecht, The Netherlands) 69
Control of medicine release from solid dispersion composed of the poly(ethylene oxide)-
carboxyvinylpolymer interpolymer complex by varying molecular weight of poly(ethylene oxide)
T. Ozeki, H. Yuasa,Y. Kanaya (Tokyo, Japan) 87
In vivo human skin permeability enhancement by oleic acid: a laser Doppler velocimetry study
H. Tanojo (San Francisco, CA, USA), E. Boelsma, H.E. Junginger, M. Ponec and H.E. Bodde
(Leiden, The Netherlands) 97
Book Reviews 105
Award News 109
Calendar 119
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JOURNAL OF CONTROLLED RELEASE
Vol. 58, No. 2, MARCH 1999
CONTENT
Optimization of preparative conditions for poly-DL-lactide-polyethylene glycol microspheres with entrapped
Vibrio Cholera antigens
X.M. Deng, X.H. U, M.L. Yuan, C.D. Xiong (Chengdu, P.P. China), Z.T. Huang (Beijing, P.P. China)
and W.X. Jia, Y.H. Zhang (Chengdu, P.P. China) 123
Modification of release rates of cyclosporin A from polyl(L-lactic acid) microspheres by fatty acid esters
and in-vivo evaluation of the microspheres
T. Urata, K. Arimori, M. Nakano (Kumamoto, Japan) 133
Stabilization of proteins against methylene chloride/water interface-induced denaturation and aggregation
H. Sah (Memphis, TN, USA) 143
Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle
structure and ultrasound on the intracellular drug uptake
N.Y. Papoport, J.N. Herron (Salt Lake City, UT, USA), W.G. Pitt (Provo, UT, USA) and L. Pitina (Salt
Lake City, UT, USA) 153
Structural parameters involved in the permeation of propranolol HCI by iontophoresis and enhancers
S. Chesnoy (Chatenay-Malabry, France), D. Durand, J. Doucet (Orsay, France) and G. Couarraze
(Chatenay-Malabry, France) 163
Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs
M.P. Youenang Piemi (Chatenay-Malabry, France), D. Korner, S. Benita (Jerusalem, Israel) and Jean-
Paul Marty (Chatenay-Malabry, France) 177
Biodegradable cross-linked prodrug of the bronchial dilator Vephylline®. 2. Kinetics and quantum chemical
studies on the release mechanism
G. Heun (Muenster, Germany) and N. Lambov, A. Zlatkov, P. Peikov, 1. Doytchinova, K. Gesheva
(Sofia, Bulgaria) 189
Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy
F. Kedzierewicz, P. Thouvenot, J. Lemut (Nancy, France), A. Etienne (Labege, France) and M.
Hoffman, P. Maincent (Nancy, France) 195
Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers
M. Kirj'avainen, J. Monkkonen, M. Saukkosaari (Kuopio, Finland), P. VaIjakka-Koskela, J. Kiesvaara
(Turku, Finland) and A. Urtti (Kuopio, Finland) 207
A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers. l.
Manipulation of drug release using Eudragit® LI 00-55 and Eudragit® SI 00 combinations
M.Z.I. Khan, Z. Pmbeg, N. KurJ'akovic (Zagreb, Croatia) 215
Biodegradable microparticles of influenza viral vaccine: comparison of the effects of routes of
administration on the in vivo immune response in mice
S.C. Chattaraj, A. Pathinavelu, S.K. Das (Ft Lauderdale, FL, USA) 223
Phase inversion dynamics of PLGA solutions related to drug delivery
P.O. Graham, K.J. Brodbeck, A.J. McHugh (Urbana, IL, USA) 233
Book Reviews 247
Acknowledgement to Reviewers 249
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JOURNAL OF CONTROLLED RELEASE
Vol. 58, No. 3, APRIL 1999
Synthesis of theophylline-polyrotaxane conjugates and their drug release via supramolecular dissociation
T. Ooya, N. Yui (Ishikawa, Japan) 251
Development of nonionic surfactant/phospholipid o/w emulsion as a paclitaxel delivery system
P. Kan, Z.-B. Chen, C.-J. Lee, I.-M. Chu (Hsmchu, Ft.O.C.) 271
Release of 5-amino salicylic acid from acrylic type polymeric prodrugs designed for colon-specific drug
delivery
S. Davaran, J. Hanaee, A. Khosravi (Tabriz, Iran) 279
Flow cytometric and optical microscopic evaluation of poly(D,L-lactide-co-glycolide) microspheres
phagocytosis by pig alveolar macrophages
A.-M. Torche (Rennes, France), E. Albina (Ploufragan, France), P. Le Corre (Rennes, France), A.
Jestin (Ploufragan, France) and R. Le Verge (Fiennes, France) 289
The potential use of mixed films of pectin, chitosan and HPMC for bimodal drug release
G.S. Macleod, J.H. Collett, J.T. Fell (Manchester, UK) 303
Modulated release of ldUrd from poly (D,L-lactide-co-glycolide) microspheres by addition of poly (D,L-
lactide) oligomers
A. Geze, M.-C. Venier-Julienne, P. Saulnier (Angers, France), P. Varlet, C. Daumas-Duport (Paris,
France), P. Devauchelle (Maisons Alfort, France) and J.-P. Benoit (Angers, France) 311
An analysis of solute structure-human epidermal transport relationships in epidermal iontophoresis using
the ionic mobility: pore model
P.M. Lai, M.S. Roberts (Brisbane, Australia) 323
Adsorption of serum albumin to thin films of poly(lactide-co-glycolide)
S.M. Butler (Pittsburgh, PA, USA), M.A. Tracy (Cambridge, MA, USA) and R.D. Tilton (Pittsburgh,
PA, USA) 335
The percutaneous penetration of prostaglandin E(1) and its alkyl esters
H.-O. Ho, M.-C. Hwang, S.-L. Tseng, L.'H. Lin, K.-T. Chen, H.-S. Chiang (Taipei, R.O.C.), B.W. Spur,
P.Y.-K. Wong (Stratford, NJ, USA) and M.-T. Sheu (Taipei, R.O.C.) 349
FTIR characterization of the secondary structure of proteins encapsulated within PLGA microspheres
K. Fu (Cambridge, MA, USA), K. Griebenow (San Juan, Puerto Rico) and L. Hsieh, A.M. Klibanov,
R. Langer (Cambridge, MA, USA) 357
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JOURNAL OF CONTROLLED RELEASE
Vol. 59, No. 1, MAY 1999
CONTENT
Review
Controlled release opportunities for oral peptide delivery in aquaculture
L.J. Schep, I.G. Tucker, G. Young, R. Ledger and AG. Butt (Dunedin, New Zealand) 1
Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution
K.-i. Ogawara, M. Yoshida, K. Higaki, T. Kimura (Okayama, Japan), K. Shiraishi, M. Nishikawa, Y.
Takakura and M. Hashida (Kyoto, Japan) 15
Tetracycline-HCl-loaded poly(DL-lactide-co-glycolide) microspheres prepared by a spray drying technique:
influence of -y-irradiation on radical formation and polymer degradation
B. Bittner, K. Mader (Marburg, Germany), C. Krotl, H.-H. Borchert (Berlin, Germany) and T. Kissel
(Marburg, Germany) 23
The application of an artificial neural network and pharmacokinetic simulations in the design of
controlled-release dosage forms
Y. Chen (Memphis, TN, USA), T.W. McCall, A.FI. Baichwal (Patterson, NY, USA) and M.C. Meyer
(Memphis, TN, USA) 33
Stealth monensin liposomes as a potentiator of adriamycin in cancer treatment
M. Singh, A.J. Ferdous and T.L. Jackson (Tallahassee, FL, USA) 43
One-month sustained release microspheres of (125) I-bovine calcitonin. In vitro—in vivo studies
R.V. Diaz, M. Uabres and C. Evora (La Laguna, Spain) 55
Improvement of temperature-sensitivity of poly(/V-isopropylacrylamide)-modified liposomes
K. Kono, A. Henmi, H. Yamashita (Osaka, Japan), H. Hayashi (Shiga, Japan) and T. Takagishi
(Osaka, Japan) 63
Hyaluronic acid grafted with poly(ethylene glycol) as a novel peptide formulation
K. Moriyama, T. Ooya and N. Yui (Ishikawa, Japan) 77
Liposomes as a topical delivery system: the role of size on transport studied by the EPR imaging
method
M. Sentjurc, K. Vrhovnik and J. Kristl (Ljubljana, Slovenia) 87
Transdermal iontophoretic delivery of bovine insulin and monomeric human insulin analogue
N. Kanikkannan, J, Singh and P. Ramarao (Varanasi, India) 99
Cyclodextrins as permeation enhancers: some theoretical evaluations and in vitro testing
M. Masson, T. Loftsson (Reykjavik, Iceland), G. Masson (Stockholm, Sweden) and E. Stefansson
(Reykjavik, Iceland) 107
Short Communication
A recombinant prodrug type approach for triggered delivery of streptokinase
H. Wang, H. Song and V.C. Yang (Ann Arbor, MI, USA) 119
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JOURNAL OF CONTROLLED RELEASE
Vol. 59, No. 2, MAY 1999
CONTENTS
Quantitative analysis of polyvinyl alcohol on the surface of poly(D,L-lactide-co-glycolide) microparticles
prepared by solvent evaporation method: effect of particle size and PVA concentration
S.C. Lee, J.T. Oh, M.H. Jang and S.I. Chung (Yongin city, Kyonggi-do, Republic of Korea) 123
Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a
human ovarian carcinoma cell line
T. Minko, P. Kopeckova, J. Kopecek (Salt Lake City, UT, USA) 133
Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations
T. Marjukka Suhonen (Kuopio, Finland and Salt Lake City, UT, USA), J. A. Bouwstra (Leiden, The
Netherlands) and A. Urtti (Kuopio, Finland) 149
Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the
rectum
J.-M. Ryu, S.-J. Chung, M.-H. Lee, C.-K. Kirn and C.-K. Shim (Seoul, Korea) 163
Determining the absolute surface hydrophobicity of microparticulates using thin layer wicking
D.A. Norn's (Piscataway, NJ, USA and Sparks, NV, USA), N. Puri (Piscataway, NJ, USA), M.E. Labib
(Newark, NJ, USA) and P.J. Sinko (Piscataway, NJ, USA) 173
Targeting of tumor necrosis factor to tumor by use of dextran and metal coordination
Y. Tabata, Y. Noda, Y. Matsui and Y. lkada (Kyoto, Japan) 187
Nonparametric analysis of the absorption profile of octre.otide in rabbits from long-acting release
formulation OncoLAR
E Comets, F. Mentre (Paris, France ), F. Nimmerfall, R. Kawai, 1. Mueller, P. Marbach and J.
Vonderscher (Basel, Switzerland) 197
Antibiotic release from biodegradable PHBV microparticles
D. Sendil, 1. Gursel (Ankara, Turkey), D.L. Wise (Boston, MA, USA) and V. Hasirci (Ankara, Turkey) 207
Controlled release of a model protein from enzymatically degrading dextran microspheres
0. Franssen, R.J.H. Stenekes and W.E. Hennink (Utrecht, The Netherlands) 219
In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal
tract. 1. Comparison of pH-responsive drug release and associated kinetics
V. Pillay and Ft. Fassihi (Philadelphia, PA, USA) 229
In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal
tract. II. Physicochemical characterization of calcium-alginate, calcium-pectinate and calcium-
alginate-pectinate pellets
V. Pillay and P. Fassihi (Philadelphia, PA, USA) 243
Calendar of Events 257
_______________________________________________________________________
JOURNAL OF CONTROLLED RELEASE
Vol. 59, No. 3, JUNE 1999
CONTENT
Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable
nanospheres using SSIMS and XPS
P.O. Scholes, A.G.A. Coombes, L ilium, S.S. Davis (Nottingham, UK), J.F. Watts (Guild ford, UK), C.
Ustanz, M. Vert (Montpelier, France) and M.C. Davies (Nottingham, UK) 261
Microporous membrane drug delivery system for indomethacin
P. A. Elchidana, S.G. Deshpande (Mumbai, India) 279
Modulating insulin-release profile from pH/thermosensitive polymeric beads through polymer molecular
weight
C. Rarnkissoon-Ganorkar, F. Liu, M. Baudys, S.W. Kirn (Salt Lake City, UT, USA) 287
Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect
on brain
S.C. Yang, L.F. Lu, Y. Cai, J.B. Zhu, B.W. Liang, C.Z. Yang (Nanjing, People's Republic of China) 299
Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-
branched block copolymers: Influence of encapsulation technique and polymer composition on particle
characteristics
K.F. Pistol, B. Bittner (Marburg, Germany), H. Koll, G. Winter (Penzberg, Germany) and T. Kissel
(Marburg, Germany) 309
Identification of critical formulation and processing variables for metoprolol tartrate extended-release (ER)
matrix tablets'
G.S. Rekhi (Gainesville, GA, USA), R.V. Nellore (Palo Alto, CA, USA), A.S. Hussain (Rockvnie, MD,
USA), L.G. Tillman (Carlsbad, CA, USA), H.J. Malinowski (Rockville, MD, USA) and LI. Augsburger
(Baltimore, MD, USA) 327
Mathematical modelling of drug permeation through a swollen membrane
M. Grassi, I. Colombo (Trieste, Italy) 343
Evaluation of coionic absorbability of drugs in dogs using a novel colon-targeted delivery capsule (CTDC)
T. Ishibashi, K. Ikegami, H. Kubo, M. Kobayashi, M. Mizobe, H. Yoshino (Osaka, Japan) 361
Encapsulation of rotavirus into poly(lactide-co-glycolide) microspheres
C. Sturesson (Stockholm, Sweden), P. Artursson, R. Ghaderi (Uppsala, Sweden), K. Johansen, A.
Mirazimi (Stockholm, Sweden), I. Uhnoo (Uppsala, Sweden), L. Svensson, .-C. A. Ann-Christine
Albertsson (Stockholm, Sweden) and J. Carifors (Uppsala, Sweden) 377
How interactions between drugs and agarose-carrageenan hydrogels influence the simultaneous transport
of drugs
H. Sjoberg, S. Person, N. Caram-Lelham (Uppsala, Sweden) 391
Book Review 401
Author Index Volume 59 403
Subject Index Volume 59 407
Contents Volume 59 409
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JOURNAL OF CONTROLLED RELEASE
VOL. 60, NO. 1, JUNE 1999
Transdermal iontophoretic delivery of enoxacin from various liposome-encapsulated formulations
J.-Y. Fang (Taipei, Taiwan), K.C. Sung, H.-H. Un (Tainan Hsien, Taiwan) and C.-L. Fang (Taipei, Taiwan) 1
Poly(fumaric-co-sebacic anhydride). A degradation study as evaluated by FTIR, DSC, GPC and X-ray diffraction
C.A. Santos, B.D. Freedman, K.J. Leach, D.L. Press, M. Scarpulla and E. Mathiowitz (Providence, Rl, USA) 11
Factors influencing nonoxynol-9 permeation and bioactivity in cervical mucus
D.H. Owen, E.N. Dunmire, A.M. Plenys and D.F. Katz (Durham, NC, USA) 23
Comparison of the effects of short, high-voltage and long, medium-voltage pulses on skin electrical and transport
properties
R. Vanbever (Cambridge, MA, USA and Brussels, Belgium), U.F. Pliquett (Cambridge, MA, USA and Bielefeld,
Germany), V. Preat (Brussels, Belgium) and J.C. Weaver (Cambridge, MA, USA) 35
Evaluation of the use of xanthan as vehicle for cationic antifungal peptides
A.L.A. Ruissen, W.A. van der Reijden, W. van't Hof, E.C.I. Veerman and A.V. Nieuw Amerongen (Amsterdam, The
Netherlands) 49
Sol-gel composite films with controlled release of biocides
H. Böttcher, C. Jagota, J. Trepte, K.-H. Kallies (Sebnitz, Germany) and H. Haufe (Halle, Germany) 57
Percutaneous absorption of sunscreens from liquid crystalline phases
L Brinon, S. Geiger (Chatenay-Malabry, France), V. Alard (Saint Jean de Braye, France), J. Doucet (orsay,
France), J.-F. Tranchant (Saint Jean de Braye, France) and G. Couarraze (Chatenay-Malabry, France) 67
Thermodynamic prediction of active ingredient loading in polymeric microparticles
G. Tse, D. Blankschtein (Cambridge, MA, USA), A. Shefer and S. Shefer (Union Beach, NJ, USA) 77
Spatially constrained localized transport regions due to skin electroporation
T.R. Gowrishankar (Cambridge, MA, USA), T.O. Herndon (Lexington, MA, USA), T.E. Vaughan and J.C. Weaver
(Cambridge, MA, USA) 101
A dose-response study of epidural liposomal bupivacaine in rabbits
J.-M. Malinovsky (Nantes, France), P. Le Corre (Rennes, France), J.-F. Meunier (Nantes, France), F. Chevanne
(Rennes, France), M. Pinaud (Nantes, France), Ff. Leverge (Fiennes, France) and F. Legros (Bruxelles, Belgium) 111
Stealth® PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting
M.T. Peracchia, E. Fattal, D. Desmaole, M. Besnard (Chatenay-Malabry, France), J.P. Noel, J.M. Gomis (Saclay,
France), M. Appel, J. d'Angelo and P. Couvreur (Chatenay-Malabry, France) 121
Perivascular delivery of heparin for the reduction of smooth muscle cell proliferation after endothelial injury
D. Teomim, 1. Fishbien and G. Golomb (Jerusalem, Israel), L . Orloff (Seattle, WA, USA), M. Mayberg (San Diego,
CA, USA), A.J. Domb (Jerusalem, Israel) 129
Book Reviews 143
Calendar 145
JOURNAL OF CONTROLLED RELEASE
Vol. 60, Nos 2-3, AUGUST 1999
Review
Poly(ethylenimine) and its role in gene delivery
W.T. Godbey, K.K. Wu and A.G. Mikos (Houston, TX, USA) 149
Cross-linked amylose tablets containing (x-amylase: an enzymatically-controlled drug release system
K Dumoulin, L.H. CartHieranci M.A. Mateescu (Montreat, Canada) 161
Udocaine loaded biodegradable nanospheres, II. Modelling of drug release
M, Poiakovic (Bratislava, Slovak Republic), T Gorner, R. Gref and E. Dellacherle (Nancy, France) 169
Preparation and characterization of protein C-loaded PLA nanoparticles
M.F, Zambaux, F, Bonneaux (Nancy, France) R. Gref (Nancy and Chatenay-Malabry, France), 5,
DeUachene and C- Vigneron (Nancy, France) 179
Folic acid-PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents
K.E. Anderson, B.R. Stevenson and J.A. Rogers (Edmonton, Canada) 189
Mechanism of drug release from poly(L-lactic add) matrix containing acidic or neutral drugs
M. Mfyajima, A. Koshika, J. Okada and M, ikeda (Tokyo, Japan) 199
Degradable dextran hydrogels: controlled release of a model protein from cylinders and microspheres
O, Franssen, L Vandervennet, P. Roders and W,E, Hennink (Utrecht The Netherlands) 211
TR146 cells grown on filters as a model of human buccal epithelium: permeability of fluorescein
isothiocyanate-labelleddextrans in the presence of sodium glycocholate
H.M. Nieisen (Copenhagen, Denmark), J.C. Verhoef, M. Ponce (Leiden, The Netherlands) and
M.R. Passing (Copenhagen, Denmark) 223
Alkylated poly(L"lysine citramide) as models to investigate the ability of amphiphilic macromolecuiar drug
carriers to physically entrap lipophilic compounds in aqueous media
S. Gauffer (Uege, Belgium), M. Boustfa and M. Vert (Montpelfier, France) 235
Thermosensitive polymers as carriers for DNA delivery
W.L.J. Hinrichs, NM.E. Schuurmans-Nieuwenbroek, P van de Wetering and W.E. Hennink (Utrecht,
The Netherlands) 249
Distribution of khellin in excised human skin following iontophoresis and passive dermal transport
B. Marconi) F. Mancinh P. Colombo, F. Megra, F. Giordano (Parma, Italy), A. Gazzaniga (Milan,
ftaiy). G. Orecchia (Pavia, ftaiy) and P. Santi (Parma, Italy) 261
Sustained release of heparin from polymeric particles for inhibition of human vascular smooth muscle cell
proliferation
Z, Yang, P. Birkenhauer (Zurich, Switzerland), F. Juimy (Bern, Switzerland), D. Chickering,
J.R Ranieri (Austin, T X, USA). H.P, Merkle, T.F. LuscherandB. Gander (ZOrich, Switzerland) 269
Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres
containing poly(L-lysine) complexed plasmid DNA
K Capan (Ankara, Turkey), B.H. Woo, S. Gebrekidan, S. Ahmed and P.P. DeLuca (Lexingfon, KY,
USA) 279
In situ-gelling gellan formulations as vehicles for oral drug delivery
S. Miyazaki, H. Aoyama, A/. Kawasaki, W. Kubo (Hokkaido, Japan) and D. Attwood (Manchester, UK) 287
Degradation and protein release properties of microspheres prepared from biodegradable poly(lactlde-co-
glycolide) and ABA triblock copolymers: influence of buffer media on polymer erosion and bovine
serum albumin release
B. Bittner, C. Witt, K. Mader and T. Kissef (Marburg, Germany) 297
Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE)(7m)
(beta)CD as both a solubilizer and osmotic agent
K. Okimoto, A. Ohike. R. lbuki, O. Aoki, N. Ohnishi (Osaka, Japan), R.A. Rajewski, V.J. Stella
(Lawrence, KS, USA), T. inc and K. Uekama (Kumamoto, Japan) 311
High-molecu!ar weight HPMA copolymer-adriamycin conjugates
M. Dvorak. P. Kopeckova and J. Kopecek (Salt Lake City. UT, USA) 321
Delivery of glipizide from asymmetric membrane capsules using encapsulated excipients
AG. Thombre, Afl. DeNoto and D.C. Gibbes (Groton, CT, USA) 333
Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-
plasmid complexes
J.-Y. Chemg, N.M.B. Schuurmans-Nieuwenbroek, W. Jiskoot, H. Talsma, N,J. Zuldam, W.E. Hennink
and D.J.A, Crommelin (Utrecht The Netherlands) 343
Gelatin-stabilised microemutsion-based organogels: rheology and application in iontophoretic transdermal
drug delivery
S. Kantaria, G.D. Rees and M.J. Lawrence (London, UK) 355
Novel hydrogel system from scleroglucan: synthesis and characterization
T. Covielio (Rome, Italy), M. Grassi (Trieste, Italy), G. Rambone, E. Santucci, M. Carafa, E, Murtas
F.M. Hiccien anc) F. Afhaique (Home, Italy) 367
Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired
release profiles
J. Siepmann, F, Lecornte and R. Bodmeler (Berlin, Germany) 379
Extrusion of niosomes from capillaries: approaches to a pulsed delivery device
P. Arunothayanun, T. Sooksawate and AT. Florence (London. UK) 391
Influence of phase transformation on indomethacin release from microemutsions
M. Trotta (Tonno, Italy) 399
Book Reviews 407
Erratum 411
Instructions to Authors 413
Author Index Volume 60 417
Subject Index Volume 60 421
Contents Volume 60 423
JOURNAL OF CONTROLLED RELEASE
VoL 61, Nos 1-2, AUGUST 1999
CONTENTS
Preparation and evaluation of double-phased mucoadhesive suppositories of lidocaine utilizing Carbopol
and white beeswax
R. Yahagi, K Onishi and K Machida (Tokyo, Japan) 1
Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long
circulating liposomes in mice using peritoneal P388
M. Tsuchfhashi, H. Harashima and H. Kiwada (Tokushima, Japan) 9
The delivery of BCNU to brain tumors
C.-H, Wang, J. U, C.S. Teo and T. Lee (Singapore, Singapore) 21
Development of a multifunctionai matrix drug delivery system surrounded by an impermeable cylinder
I. Krogel and P, Bodmeier (Berlin, Germany) 43
Bacterial ghosts as drug carrier and targeting vehicles
V. Huter, M.P, Szostak, J. Gampfer, S. Prethaier (Vienna, Austria), G. Wanner (Munich, Germany),
F. Gabor and W. Lubitz (Vienna, Austria) 51
Noninvasive sampling of phenylalanine by reverse iontophoresis
V. Merino, A. Lopez (Archamps, France, Geneva, Switzerland and Valencia, Spain), D, Hochstrasser
and R.H, Guy (Archamps, France and Geneva, Switzerland) 65
Optimization of a vehicle mixture for the transdermal delivery of melatonin using artificial neural networks
and response surface method
K.K. Kandimalfa, N. Kanikkannan and M. Singh (Talfahassee, FL, USA) 71
Observation of swelling process and diffusion front position during swelling in hydroxypropyl methyl
cellulose (HPMC) matrices containing a soluble drug
P. Colombo, R. Bettini (Parma, Italy) and /V-A Peppas (West Lafayette, W, USA) 83
Optimization of antitumor effect of liposomaly encapsulated doxorubicin based on simulations by
pharmacokinetic/pharmacodynamic modeling
H. Harashima, S. lida^ Y. Urakami, M. Tsuchthashi and H. Ktwada (Tokushima, Japan) 93
A method for the preparation of polymeric nanocapsules without stabilizer
Z Lu, J. Bei and S. Wang (Beijing, China) 107
Correlation of two bioadhesion assays: the everted sac technique and the CAHN microbalance
C.A Santos, J.S. Jacob, B.A. Hertzog, B.D. Freedman, D.L Press, P. Harnpichamchai and
5. Mathiowitz (Providence. Rf, USA) 113
Preparation and properties of glutaraldehyde cross-linked whey protein-based microcapsules containing
theophylline
S-J. Lee and M. Posenberg (Davis, CA, USA) 123
The design and synthesis of polymers for eukaryotic membrane disruption
N. Murlhy. J.R. Robichaud (Seattle WA. USA), D.A. Tirrelf (California, CA, USA), P.S- Stayfon and
A.S. Hoffman (Seattle. WA, USA) 137
Biodistribution of free and /\/-(2-hydroxypropyl)methacryiamide copolymer-bound mesochlorin e(6) and
adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts
J.-G. Shiah. Y. Sun, CM Peterson and I Kopecek (Salt Lake City, UT, USA) 145
Variation in the diffusion and release of ribonuclease through and from estenfied hyaluronic acid
membranes: Effect of changes in matrix characteristics
LD. Simon, V.I Stella (Lawrence, KS, USA), W.N. Charman and S.A. Charman (Parkville, Australia) 159
(3)He ion-beam analysis of water uptake and drug delivery
P,D. Piggs (London, UK), A.S, Clough, P.M. Jenneson, DM Drew (Guildford, UK), M. Braden and
M.P. Patel (London, UK) 165
An in vitro mucosal model predictive of bioadhesive agents in the oral cavity
0 Patei (Portsmouth. UK), AM Smithy N. Grist P. Bamett (Weybrfdge. UK) and J.D. Smart
(Portsmouth, UK) 175
Spatially constrained skin electroporation with sodium thiosulfate and urea creates transdermat
microconduits
L Hie, T-R. Gowrishankar, T.E Vaughan (Cambridge, MA, USA), T.O, Herndon (Lexington, MA, USA)
and J.C. Weaver (Cambridge, MA, USA) 185
Gamma irradiation for terminal sterilization of 17(beta)-estradiol loaded poly-(D,L-lactide-co-glycolide)
microparticles
D. Mohr, M. Wofff (Monheim, Germany) and T. Ktssel (Marburg, Germany) 203
Drug and excipient diffusion and solubility in acrylate adhesives measured by infrared-attenuated total
reflectance (IR-ATR) spectroscopy
A.S. Cantor (St. Paul, MU, USA) 219
Positively charged liposome functions as an efficient immunoadjuvant in inducing cell-mediated immune
response to soluble proteins
T. Nakanishi, J. Kunisawa, A. Hayashi, Y. Tsutsumi, K. Kubo, S. Nakagawa, M. Nakanishi, K, Tanaka
and T. Mayumf (Osaka, Japan) 233
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