JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 91, Number 4 , February 1999



In This Issue 297




EDITORIALS Molecular Detection of Early Lung Cancer, A. F. Gaidar, J. D. Minna 299

Curreni Status of Sentinel Lymph Node Surgery for Breast Cancer, D. Kmg 302

Skewed X-Chromosome Tnactivation: Cause or Consequence? C J. Brown 304



NEWS Hughes' Unexpected legacy: a Thriving Research Knterprisc, N. Volkers 306

Cancer Vaccine Competition Wide Open as Agents Move Uapidly Into Clinical Arena, 309
T. Reynolds


Stat Bite: Lung Cancer Incidence in LLS. Males, hy Race/Ethnicity 311

NCI Overhauls Clinical Trials System 312

Jeffrey White Directs NCVs New Office of Alternative Medicine 313

Awards, Appointments, Announcements 314

Campaign Targets Oral Health During Cancer Treatment, K. Arnold 316

REVIEW Tomatoes, Tomato-Based Products, Lycopene, and Cancer: Review of the Epidemiologic 317
Literature, E. Giovannucci


ARTICLES Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With 332
Early Stage Lung Cancer, S. A. Ahrendt, J. T. Chow, L.-H. Xu, S. C. Yang, C F. Eisenherger,
M. Esteller, J. G. Herman, L. Wu. P. A, Decker, J. Jen, D. Sidransky


Association Between Nonrandom X-Chromosome Inactivation and BRCAI Mutation in 339
Germime DNA of Patients With Ovarian Cancer, R. E. Bulier, A. K. Sood, T. Lallas,
T. Buekers, J. S. SkilUng


Protective Alterations in Phase 1 and 2 Metabolism of Aflatoxin B, hy Oltipraz in Residents 347
of Qidong, People's Republic of China, J.-S. Wang, X. Shen. X. He. Y.--R. Zhu. B.-C. Zhang,
J.-B. Wang, G.-S. Qum, S.-Y. Kiumg, A, Zarba, P. A. Egner, L P. Jacohson, A. Munoz, et aL


Influence ofTangerctin on Tamoxifen's Therapeutic Benefit in Mammary Cancer, 354
M. E. Bmcke, H. T. Depypere, T. Boferberg, K L Van Marck, K. M. Vennekens, et aL

Microvascular Loops and Networks as Prognostic Indicators in Choroidal and Ciliary Body 359
Melanomas, T. Makitie, P. Summanen, A. Tarkkanen. T. Kivela


REPORTS Sentinel Lymph Node Biopsy and Axillary Dissection in Breast Cancer: Results in a Large 368
Series, U. Veronese G. Paganelli, G, Vuile. V, Galimberti, A, Luini, S. Zan-ukl, C. Robertson.
V. Sacchini, P. Veronesi, E. Orvieto, C De Cicco. M. Intra, G. Tosi. D. Scarpa


Cyclin D1 Proteolysis: a Retinoid Chemoprevention Signal in Normal, Immortalized, and 373
Transformed Human Bronchial Epithelial Cells, J. 0. Boyle, J. Lan^enfeid. F. Lonardo,
D. Sekula, P. Reciek, V, Rusch, M. L Dawsim, E, Dmitrovsky


CORRESPONDENCE Re: Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal 380
Women, J, F. Dorgan. C Longcope, F. Z. Stanczyk, H. E. Stephenson. Jr., R. N. Hoover


Re: Quality of Life in Advanced Prostate Cancer: Results of a Randomized Therapeutic 381
Trial, J.-F. Caubet • Response, C M. Moinpour, A. Troxel, L. C. Lovato, M. Eisenberger.
B. A. Blamenstein, E, D. Crawford


Re: Benefits and Risks of Screening Mammography for Wonien in Their Forties: a Statistical 382
Appraisal, A B. Kopans, E. Halpern • Response, D, A. Berry

Calendar of Eveiils 386


Classified Advertising 388

Information for Authors 392

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 91 , Number 5, March 1999



In This Issue 395

EDITORIALS Colorectal Cancer Screening: Sifting Through the Evidence, B, Levin 399


Searching for Evidence of Altered Gene Expression: a Comment on Statistical Analysis of 400
Microarray Data, J, Wines, H. P. Friedman


NEWS As Easy as ABC: Scientists Fish Out Another Drug Hesistance Cvnc, B. Kuska 402

Treating the Most Intractable Cancers Progresses Slowly, T. Reynolds 404

Sfaf Bite: Trends in Prevalence of Cigarette Smoking Among U.S. Adults 405

Panel Finds In Utero Gene Therapy Proposal Is Premature, G. Moulton 407


NCAB Expresses Concern About FY2000 Budget Request for NCI 408

Designing Ways: Computer Animators Illustrate Cancer Research in 3-D Imagery, M, Miller 409


How to Divvy Up NIH's Research Pie Sparks Debate, J. Randal 410

Awards, Appointments, Announcements 412

NCAB Passes Resolution on Access to Grantee Data 413


REVIEW Dietary Fat and Prostate Cancer: Current Status, L N. Kolone, A, M, K Nomum. R. V. Cooney 414


ACCELERATED Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA 429
DISCOVERY Expression in Mitoxantrone-Sclected Cell Lines, D. D. Ross, W, Yang, L V. Abruzzo.
W, S. Dalton, E. Schneider, H. Lage, M. Dietel. L Greenberger, S. P. C. Cole, L A. Doyle


ARTICLES Colorectal Cancer Mortality: Effectiveness of Biennial Screening for Fecal Occult Blood, 434
J. S. Mandel. T. R. Church. F. Eiferer, J. H. Bond


Effect of In Situ Retroviral lntcrleukin-4 Transfer on Established Intracranial Tumors, 438
M, Saleh, A. Wiegmans, Q, Maione, S, S. Stylli. A. H. Kaye


CDKN2A Variants in a Population-Based Sample of Queensland Families With Melanoma, 446
J. Ailken, J. Welch, D. Duffy, A, Milligan, A. Green, N, Martm. N. Hayward


REPORTS Statistical Analysis of Array Expression Data as Applied to the Problem ofTamoxifen 453


Resistance, S. G. HUsenbeck. W. E. Fnedrichs, R. Schiff, P. O'Conneih R. K. Himsen. C K. Oshome.
S. A. W. Fuquu


Mctabolites of a Tobacco-Specific Carcinogen in Urine From Newborns, G, M. Lackmann, 459
U. Salzberger, U. ToUner. M. Chen, S. G. Cannella. S, S. Hecht


High Seroprevalence of Antibodies to Human Herpesvirus-8 in Egyptian Children: Evidence 465
of Nonsexual Transmission, M. Andreorn, G. El-Sawaf, G. Rezza, B, Ensoli, E, Nicasm. L Ventuirn,
L. Ercoli, L. Sarmati, G. Rocchi


Frequency of p53 Mutations in Breast Carcinomas From Ashkeiiazi Jewish Curners of 469
BRCA1 Mutations, K.-A. Phillips. K. Nichoi, K. Nichol, J. Knight. S. J. Doue. P. J. Goodwin.
I. L. Andndis


CORRESPONDENCE Re: Effects of the Antiestrogens Tainoxifen, Toremifene, and ICI 182J80 on Fndonietrial 474
Cancer Growth,M. W, DeGregorio . Response, R. O'Regan, V, C. Jordan

CORRESPONDENCE Re: Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an 475
Inhibitor of Histone Deacetylase, D. Samid . Response, R. P. Warrell, Jr.

Calendar of Events 478

Classified Advertising 480

Information for Authors 484

Journal Order Form Inside Front Cover

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 91, Number 6, March 1999


In This Issue 487

EDITORIALS Dietary Fat, Calories, and Prostate Cancer Risk, M. C Borland, I. Oakley-Girvan, 489
A. S.Whinemore

Dietary Fat, Scrum Estrogen Levels, and Breast Cancer Risk: a Multifaceted Story, 492
R. Baliard-Barbash, M. R. Fonmin, V. Kipnh

Measure Once or Twice—Does It Ideally Mutter? S. G. Hilsenbeck .D.D. Von Hoff 494

NEWS Beans and Bran—Fiber Data Come Under rire, N, Voters 496

Esophageal Cancers: Changing Character, Increasing Incidence, J. McCann 497

Cancer Strikes the Comic Pages, K. Amoid 499

New Standard of Care for Cervical Cancer Sets Stage for Next Questions' C McNeii 500

Safe Cigarette Alternatives? Industry Critics Say "Not Yet," D. Holzman 502

Stat Bite: Cancer in Children Under 15 503

Awards, Appointments, Announcements 504

World Conference in May 505

COMMENTARY Epidemiologic Evidence and Human Papillomavinis Infection as a Necessary Cause of 506
Cervical Cancer, E. L Franco. T. E. Rohan. L L Villa


ARTICLES Energy Intake and Prostate Tumor Growth, Angiogenesis, and Vascular Endothelial Growth 512
Factor Expression, P. Makherjee, A. V. Sotnikov, H. I Mangian, J.-R, Zhou, W, J, Visek, S, K, Cirnton


Measuring Response in Solid Tumors: Unidimensional Versus Bidimensional Measurement, 523
K. James, E. Eisenhauer, M. Christian. M, Terenuam. D. Vena, A. Mlihhd, P. Therasse


REPORTS Meta-analysis: Dietary Fat Intake, Serum Estrogen Levels, and the Risk of Breast Cancer, 529
A. H. Wu. M. C. Pike. D. 0. Stram


Pancreatic Cancer Risk and Nutrition-Related Methyl-Group Availability Indicators in Male 535
Smokers, R. Z Stohenberg-Sohmon, D. Albanes, F. J. Niefo, T. J. Hartman, J. A. Tangrca.
M. Routalahn, J. Sehlub, J. Virtamo, P. R. Taytor


Prospective Study of Adult Onset Diabetes Mellitus (Type 2) and Risk of Colorectal Cancer 542
in Women, F. B. Hu, J. E. Mamso, S. Liu 0. Himter, G. A. Colditz, K. B. Micheh, F. E. Spelter
E, Giovannucci


Dietary Carotenoids and Vitamins A, C, and K and Risk of Breast Cancer, S, Zhang, 547
D. J. Hunter, M. R. Format B. A. Rosner. F. E. Speizer, G, A, Colditz, J. E. Manson. efal.

BRIEF p53 and Genetic Susceptibility to Cervical Cancer, K Sonoda. P. E. Saigo, J. Boyd 557
COMMUNICATION


BOOK REVIEW Be a Survivor: Your Guide to Breast Cuncer Treatment, M. 0'R. Thomson 558
Books Received


CORRESPONDENCE Re: Multicenter Case-Control Study of Exposurc to Knvironmental Tobacco Smoke and 560
Lung Cancer in Europe, P, N. l.ee. B. A. Forey . Response, P.Boffetta. F. Nyberg. R. Saracci

CORRESPONDENCE Re: Autofluorvscence Uronchoscopy m the Detection of Squamous Metaplasia and Dysplasia 561
in Current and Former Smokers, S. Lam,,B. Palcic B. J. Venmans, E. F. Smit, P. E. Postmus,
T. G. Suiedja . Response, J, M. Kurie, J. S. Lee, R. C. Morice, W. K. Hong


Re: Cancer Chemoprevention: Progress and Promise, F. L. Meyskens, Jr. . Response, 563
S. M. Lippman, J. J. Lee, A, L Sahichi


Re: Nonmelanomatous Skin Cancer Following Cervical Vaginal, and Vulvar Neoplasms: 565
Etiologic Association, M. Fnsch. H. Hjalgrim . Response, F. Levi, L Randimbison,
C, La Veccfim


Calendar of Events 567

Classified Advertising 569

Information for Authors 572

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 97, Number 7, April 7999



In This Issue 575

EDITORIALS Molecular Dosimeters of Smoking Damage in the Lung, M, R. Spitz M. de Afulmde, 578
J. Di Ciiovanni

Insulin-Like Growth Factor-I: a Key Regulator of Human Cancer Risk? K. D. Burroughs 579
S. E. Dunn, J. C. Barren, J. A. Taylof

NEWS Endoscopy Removal of Axillary Nodes Gains Ground Abroad, Toehold in U.S., C McNeil 582

Will Spain's First National Cancer Center Boost Research? S. Steimle 584

Bullish Sentunent Stays (Mostly) High for Investments in Cancer Drugs and Biotechnology, 585
J, Roemer


Stat Bite: Race and Sex Differences in LLS. Cancer Rates 586

Diagnosis, Tibetan Style, Underlies Small ITerhal Study of Advanced Breast Cancer, J. Randal 587


Werner's Syndrome: What Does an Aging Syndrome Gene Reveal About Cancer? M. Miller 589

Survivorship Group Eyes Future Research Goals, K. Arnold 590

Awards, Appointments, Announcements 592


REVIEW The Emerging p53 Gene Family, W. G. Kaelin,Jr 594

ACCELERATED Unknown Primary Head and Neck Squamous Cell Carcinoma: Molecular Identification of 599
DISCOVERY the Site of Origin, J. Califuno, W. H. Westra. W. Koch. G. Meininger ,A. Reed. L Yip. J. O. Boyle.
F. Lonardo, D. Sidransky


ARTICLE Fruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort, 605
D. S. Michaud. D. Spiegelman. S. K. Clinton. E. B. Rimm. W. C, Willed E. L Giovannucci


REPORTS Early Age at Smoking Initiation and Tobacco Carcinogen DNA Damage in the Lung, 614
J. K. Wiencke. S. W. Thurston. K, T. Keisey. A. Vm-konyi. J. C Wain, et.al


Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like 620
Growth Factor (IGF)-I and IGF-Binding Protcin-3, J, Ma. M. N. PoUak. E, C/tovannucci,
J. M. Chan, Y. Too, C. H. Hennekens, M. J. Stampfer


Comparison of Prophylactic Oophorectomy Specimens From Carriers and Noncarriers of a 626
BRCAI or BRCA2 Gene Mutation, 7. F, Stratton, C. H. Buckley. D. Lowe. B, A, J. Ponder, etui.


Plasma Prolactin Levels and Subsequent Risk of Breast Cancer in Postmenopausal Women, 629
S. E. Hankinson. W. C. Willrtt, D. S, Michaud, J. E. Manson. G. A. Coldiu. C Umgcope. et aL

Oral Contraceptive Use and Risk of Gestational Trophoblastic Tumors, ./ R. Palmer, 635
S, G. Drhcoil, L Rosenberg, R. S. Berkowitz, J. R. Lunnn, J. Soper, L B. Twiggy etaL


Brief P(53) Mutation as a Genetic Trait of Typicul Medullary Breast Carcinoma, P. de Cremoux. 641
COMMUNICATION A. V. Salomon. S. Liva, R. Dendale. B. B(ntchmd'homme, E. Mamn. X. Sastre-Gamu. et. aL


BOOK REVIEWS Pancreatic Cancer: Pathogenesis, Diagnosis, and Treatment, J. L Abbruzzese 644

Medical Management of Chronic Myelogenous Leukemia, D.E. Gladstone 645

CORRESPONDENCE Re: Quality of Lite in Advanced Prostate Cancer: Results of a Randomized Therapeutic 646
Trial. P. C Albertsen . Response, C M. Moinpour, A. Troxel, L C. Lovato, M. Eisenberger,
B. A, Biumenstein, E. D. Cmwford


Irinotecan-induced Central Nervous System Toxicity: a Case Report, I, S. Garcia, A. Rueda, 647
E. Alba


Revisiting: Involuntary Smoking and Lung Cancer: a Case-Control Study, P. N. Lee 647


Re: Trends in Reported Incidence of Primary Malignant Brain Tumors in Children in the 648
Lnifed States, A, D. Fonmm • Responses, W. C Biack • M. A, Smith, B. Freidim,
L A. Gloeckler Ries, R. Simon


Re: Diagnostic Testing Following Screening Mammography in the Elderly, R. Clark 649


Re: Hormonal Etiology of Epithelial Ovarian Cancer, With a Hypothesis Concerning the 650
Role of Androgens and Progesteron, T. C. Hamilton . Response, H. A. Risch


Calendar of Events 652

Classified Advertising 654

Information for Authors 656

Journal Order Form Inside Front Cover

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 91, Number 8 , April 1999



In This Issue 659


EDITORIAL The End of the "Tobacco and Cancer" Century, H. K. Koh 660


NEWS SV40 Bugaboo: Spinning the News, B. Kusha 662

Cell Death Genes May Hold Clues to Preserving Fertility After Chemotherapy, T. Reynohh 664

New Project Targets Minority Populations 666

Venom Anyone? Researchers Tweak "Bad" Compounds Into Good Medicines, N. Volkers 667

For Advanced Cancer, Intraoperative Radiation Garners Mixed Reviews, J. McCann 668

Bristol Award: Fidler Honored for Metastasis Research, C Bankhcad 670

Surveillance Data Take on a New Statistical Dimension, G. Moahon 671

Stat Bite: Recent U.S. Cancer Rates hy Race/Ethnicity, 1990-1996 672

Awards, Appointments, Announcements 673


SPECIAL ARTICLE Annual Report to the Nation on the Status of Cancer, 1973-1996, With a Special Section on 675
Lung Cancer and Tobacco Smoking, P. A. Wingo. L A. G, Ries, G. A. Giovino. D, S. Miller,
H. M. Rosenberg, D. R. Shophtnd, M. J. Than, B. K. Edwards


ARTICLE Sex-Related Differences in Bronchial Epilhelial Changes Associated With Tobacco Smoking, 691
S, lam, J. C. leRiche, Y.Zheng, A. Coldman, C. MacAulay, E. Hawk, G. Kelloff. A. F. Gazdar


REPORTS Cigar and Pipe Smoking and Lung Cancer Risk: a Multicenter Study From Europe, 697
P. Boffetta, G. Pershagen, K.-H. Jockel, F. Forastiere, V, Gahoneau, J, Hemrich, etaL


Screening for Breast Cancer: Time, Travel, and Out-of-Pocket Expenses, R. H. Secker-Walker, 702
P. M. Vacek, G. I Hooper. D. A. Plante, A. S. Detsky


Tobacco Smoking as a Risk Factor jn Anal Carcinoma: an Antiestrogenic Mechanism? 708
M. Friscch, B. Glimelius, J. Wohlfahrt, H.-O. Adami,M. Melbye


BRIEF Somatostatin Receptor Expression in Primary dastric Versus Nongastric Extranodal B-Cell 716
COMMUNICATIONS Lymphoma of Mucosa-Associatcd lymphoid Tissue Type, M. Raderer. J. Vulencak. F. Pfeffel
J. Drach, T. Pangeri, A. Kurtaran, M. Hejna, F. Vorheck, A. Chon, A Virgolini


Alterations in NFkB Activation in T Lympliocytes of Patients With Renal Cell Carcinoma, 718
R. G. Uzzo, P. E. Chirk, P. Rayman, T, Bloom, L. Rybicki, A. C. Novick, et aL


CORRESPONDENCE Re: Effects of the Antiestronens Tamoxifen, Toreinifene, and ICI 182,780 on Endometrial 723
Cancer Growth, G. M. Williams . Response, R. M. O'Regan, V. C. Jordan


Maternal Inheritance Pattern of Hereditary Pancreatilis in Patients With Pancreatic 723
Carcinoma, M. M, Lerch, I.Ellis,D.C. Whitcomh. V. Keim, P. Simon. N. Howes. S. Rutherford,
W. Domschke, C hnne, J. P. Neoptoiemos


Re: Plasma Sex Steroid Hormone Levels and Risk of Tircast Cancer in Postmenopmisal 724
Women, N. S. Chobimyan


Re: Nutritional and Socioeconomic Factors in Relation to Prostate Cancer Mortiilhy: 725
a Cross-national Study, P. K. Mills. Response, J. R. Hebert, T, G, Hurley. H. C. Olendzki
J. Teas. Y. Ma

CORRESPONDENCE Time Since Stopping Smoking and the Risk of Oral and Pharyngeal Cancers, C La Vecchia. 726
S.Franceschi, C, Bosctti, F. Levi, R. Talamini, E. Negri


Re: erbB-2, p53, and Efficacy of Adjuvant Therapy in Lymph Node-Positive Breast Cancer, 728
D. A. Cameron. R. C F. Leonard . Response, D. A. Berry, A. D. Thor


Re: Tanioxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant 730
Breast and Howel Project P-1 Study, T. J, Powles


Erratum: P:incieatic Cancer Risk and Nutrition-Related Methyl-Group Availability 730
Indicators in Male Smokers, R. Z. Stozenberg- Solomon, D. Alhanes, F. J. Nieto, T. J. Hartman,
J. A. Tangrea, M. Rautalahita, J. Sehlub. J. Virtamo, P. R. Taylor


Calendar of Events 731

Classified Advertising 733

Information for Authors 736

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 91, Number 9, May 1999



In This issue 739


EDITORIALS Arsenic Trioxide, a Novel Mitochonciriotoxic Anticancer Agent? G. Kroemer. H. dc The 743

Dioxin Dilemmas, R. N. Hoover 745

The Rising Incidence of Gastric Cardia Cancer, S. S. Devesa, J. F. Fraumeni, Jr. 747


NEWS Declining Breast Cancer Mortality: What's Behind It? T. Reynakh 750

Stat Bite: Breast Cancer Mortality Rules: U.K., Canada, and U.S., 1950-1994 752

Can Guidelines Be Integrated Into Everyday Practice? The NCCN in Year 4, C McNeil 753

Purple Carrots, Margarine Laced With Wood Pulp? Nlitraceuticals Move Into the 755
Supermarket, N. J. Nelson

Whatever Happened to..... ? Looking Hack 10 Years, K. Amold 758

Cancer Imaging: Changing Focus in the 21st Century, M. Miller 759

IOM Report on Quality of Cancer Care Highlights Need for Research, Data Expansion, 761
G. Mottlton

Awards, Appointments, Announcements 762


ARTICLE Adenovirus-Mediated p53 Gene Transfer in Advanced Non-Small-Cell Lung Cancer, 763
S. G. Swisher, J, A. Roth, J. Nemunaith, D. D. Lawrence. D. L Kemp, C. H. Carrasco et aL.

REPORTS Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic 772
Trioxide at Clinically Achievable Concentrations, X. -H. Zhu, Y.-L Shen. K Jing. X. Cai.
P.-M, Jia, Y, Haang, W. Tang, G.-Y. Shi. Y.-P. Sun, J. Dai, Z.-Y. Wang, S.-J. Chen. et aL


Cancer, Heart Disease, and Diabetes in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-(rho)- 779
dioxin, K. Steenland, L Piacitelli, J. Deddens, M. Fingerhut, L A Chang

Evaluating Gastric Cancer Misclassification: a Potential Expianation for the Rise in Cardia 786
Cancer Incidence, A. M. Ekstrom, L. B. Signorello, L.-E. Honsson, R. Bergstrom, A. Lindgren.
O. Nyren


Possible Role of Calponin h 1 as a Tnnior Suppressor in Human Uterine Leicniyosarcoma, 790
A. Horiuchi, T. Nikaido, S. Taniguchi, S. Fujii


Nasopharyngeal Brush Biopsies and Detection of Nasopharyngeal Cancer in a High-Kisk 796
Population, C E. Tune. P.-G. Liavaag, J. L. Freeman, M. W, M. van den Breket. T, Shpitzer,
I D. F, Kerrebijn, D, Payne, I C. lrish, R. Ng, R. K. Cheimg, H.-M. Dosch


CORRESPONDENCE Re: Race, Prostate Cancer Survival, and Membership in a Large Health Maintenance 801
Organization, M. Roach III, A Forte, M, Alexander, Response, A. S. Robbing A. S. Whittemore,
S, K, Van Oen Eeden


Re: Multiventer Case-Control Study of Exposure to Environmental Tobacco Smoke and 803
Lung Cancer in Europe, K, W, E. Denson . Response, P. Boffetta, F. Nyberg


Re: Depression as a Risk Factor for Cancer: Renewing a Ochute on the Psychobiology of 804
Disease, D. S. David. Response, R, W. J. H. Pemunx. J. M. Gundnik


Re: Macrophage Role in the Anti-Prostate Cancer Response to One Class of Antiangiogenic 804
Agents, A. Dabrowska, J. Golab. A. Giermasz,M. Marczak. M. Jakobisiak • Response,
I. B. J. K. Joseph, J. T. Isaacs

Calendar of Events 807

Classified Advertising 809

Information for Authors 812

Journal Order Form Inside Front Cover

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTR
Volume 91, Number 10, May 1999



In This Issue 815

EDITORIALS Does Size Matter? Association Between Number of Patients Treated and Patient Outcome in 816
Metastatic Testicular Cancer, E. J. Feuer, J. ShewJeid, G. L Bosl


Cancer Patient Care in Clinical Trials Sponsored by the National Cancer Institute: What 818
Does It Cost? M, L Brown


NEWS Angiogenesis Research Is on Fast Fonvard, N. J. Nelson 820

Americans With Disabilities Act: Do Cancer Patienis Qualify as Disabled? K. Arnohl 822

Exercise and Breast Cancer Risk: Lacking Consensus, L Fmior 825

New Structure for Trish Cancer Kesearch, NCI Asreeincnt Planned, S, Steimle 827

Stat Bite: Cancer Incidence in Ireland 828

In Utero Gene Therapy Is Still a Distant Promise, S. Jenks 829

Awards, Appointments, Announcements 830


COMMENTARY A Tangled Web: Factors Likely to Affect the Efficacy of Screening Mammography, 833
C L Baines, R, Dayan


ARTICLES Impact of the Treating Institution on Survival of Patients With "Poor-Prognosis" Metastatic 839
Nonseminoma, L. Coliette, R. J. Sylvester, S. P. Stenning, S, D, Fossa, G. M. Mead, R. de Wit.
A N. M. de Midder, N. Neymurk, E. lMlkmand. S. B. Kaye


Incremental Costs of Enrolling Cancer Patients in Clinical Trials: a Population-Based Study, 847
J. L. Wagner, S. R. Alberts. J. A. Sloan, S. Cha. J. KilUan. M. L O'Conneit, etaL


Trichloroethylene Exposure and Specific Somatic Mutations in Patients With Renal Cell 854
Carcinoma, H. Brnuch, G, Wchich, M. A. Honumer, S. Storkel, T. Wohl, T. Bmmng


Chemotherapeutic Options in Chronic Lymphocytic l.cukemia: a Meta-analysis of the 861
Randornized Trials, CLL Trialists Collaborative Group


REPORTS Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to 869
Prognosis, R. W. Stephens, H. J. Nielsen, I. J. Chrisrensen, O. Thorheius-Ussing, S. Sorensen,
K. Dano, N. BrUnner


Prognostic Significance of Transcription Factor E2F-1 in Bladder Cancer: Genotypic and 874
Phenotypic Characterization, F. Rabhani, V. M. Richon. L Orhw. M.-L. Lu, M. Drobnjak,.
M. Dudas, E. Charytonowicz, G, Dalbagni, C. Cordon-Cardo


BRIEF Prevalence of Mutations in the BRCAI Gene Among Chinese Patients With Breast Cancer, 882
COMMUNICATION N. L. S. Tang. C.-P. Pang. W. Yeo. K.-W. Choy. P. K. Lam, M. Suen. L. K. Law, et al.


BOOK REVIEW Breast Imaging,R.F. Brem 886

Books Received 887

CORRESPONDENCE Re: Characterization of MOAT-C and MOAT-D, New Members of the MHP/cMOAT 888
Subfamily of Transporter Proteins, S. P.C. Cole . Response, G. D. Kruh,M. G. Belinsky

Journal Order Form 890

Calendar of Events 891


Classified Advertising 893

Information for Authors 896

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 91, Number 11, June 1999


In This Issue 899

EDITORIALS Taxing the Cellular Capacity for Repair: Human T-Cell Leukemia Virus Type 1, DNA 903
Damage, and Adult T-Cell Lcukemia, K, V, Kibler, K.-T. Jeang


BRCAI and BRCA2: a Small Part of the Puzzle, VK Burke. N, Press, L. Pinsky 904

NEWS Hepatitis C Vaccine Hampered by Viral Complexity, Many Technical Restraints' Randal 906

Researchers Use Radiofrequency Ablatmn to "Cook" and Destroy Human Tumors, 909
T. Reynolds

Hornional Manipulations May Also Reduce Breast Cancer Risk, N. J. Nelson 910

Can Skin Cancers Be Minimized or Prevented in Organ Transplant Patients? J. McCann 91 I

Stat HUe: Melanoma Incideuce in U.S. Whites 912

Awards, Appointments, Announcements 913


REVIEW Colorectal Cancer: Molecules and Populalious, J. D. Potter 916


ARTICLES Defective DNA Repair in Cells With Human T-Cell Leukemia/Bovine Leukemia Viruses: 933
Role of tax Gene, S, M. Philpott, G. C Buehring


Prevalence of BRCAI and BRCA2 Gene Mutations in Patients With Early-Onset Breast 943
Cancer, J. Peto, N. Colims, R. Barfoof. S. Seal, W. Warren, N. Rahman. D. F. Easton, C Evans,
J. Deacon, M. R, Strait on


REPORTS Physical Activity, Body Mass Index, and Prostaglandin E(2) Levels in Rectal Mucosa, 950
M. E. Martinet D, Heddens, D. L. Earner C. L Bogerf, D, Roe, J, Einspahr, et aL

Detection of Human Papillomavinis DNA in Cytologically Normal Women and Subsequent 954
Cervical Squamous Intraepithelial Lesions, K.-L Liaw, A. G. Glass, M. M. Manos, C E, Greer,
D. R. Scott, M. Sherman, R, D. Burk. R. J, Kumum. S. Wacholder, B. B. Rush, et aL


Androgen Receptor Exon I CAG Repeat Lenuth and Breast Cancer in Women Before Age 961
Forty Years, A. B, Spurdle. G, S. DUc, X. Chen. C. J. Mayne. M. C. Southey. L. E. Batten. H. Chy,
L. Trute. M. R. E. McCredie, G. G. Giles, L Annes, D. J, Venter et al.


BRIEF Chemical Carcinogen-induced Tliniorigenesis in Parous, Involuted Mouse Mammary Glands, 967
COMMUNICATION A Medina, G. H. Smith


BOOK REVIEW Cutaneous Melanoma, M. H. Atkins,M. Stone 970


CORRESPONDENCE Re: Effects of the Antiestrogens Tamoxifen, Toremifene, and JCI 182,780 on Endometrial 972
Cancer Growth, J. Maenpaa,J. Ellmen. T. Pasane, M. Kaukonen • Response, R. O' Regan,
V.C. Jordan


Re: Trends m Reported Incidence of Primary Malignant Brain Tumors in Children in the 973
United States, A. Varner, Response, M. A. Smith, H. Freidlin. L. A. Gloeckler Ries, R. Simon

A Novel Fusion Gene, SYT-SSX4, in Synovial Sarcoma, B, Skytting, G. Nihson. B, Brodin, 974
Y. Xie, J. Lundeberg, M, Uhlen. O. Larsson

Calendar of Events 977

CItissHled Advertising 979

Information for Authors 984

Journal Order Fonn Inside Front Cover

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 91, Number 12, June 1999



In This Issue 987

EDITORIAL Aberrant Expression of Retinoid Receptors and Lung Carcinogenesis, R. Lotan 989

NEWS High-Dose Chemo and Breast Cancer: Karly Results Spark Dehate, K. Arnold 992

Breast Cancer Increases on Vaplia New Guinea, R, Kaska 994

Managed Care "De-Skills" the Oncology Nurse, ONS Says, N. Volkers 997

Second Line Therapies Move to the Forefront in Colorectal Cancer, M. Miller 998

Stat Bite: U.S. Cancer Death Rates With and Without Lung Cancer 999

Traditional Chinese Medicine Taps "Qi" for Health, J. Ziegler 1000

Awards, Appointments, Announcemeuts 1002

COMMENTARY Cancer Surveillance Series: Inauguration, J, F. Fraumetu, Jr, B. K. Rimer 1004

REVIEW Analyzing Health Surveys for Cancer-Related Objectives, B. L Graubard, E. L Kom 1005

ARTICLES Cancer Surveillance Series: Interpreting Trends in Prostate Cancer—Part 1: Evidence of the 1017
Effects of Screening in Recent Prostate Cancer Incidence, Mortality, and Survival Rates,
B. F. Hankey. K J. Feuer. L X Clegg, R. B. Hayes, J. M. Letter. P. C Prorok. L A, Ries, et aL


Cancer Surveillance Series: Interpreting Trends in Prostate Cancer—Part II: Cause of 1025
Death Misclassification and the Recent Rise and Fall in Prostate Cancer Mortality,
E. J. Feuer, R. M. Merrill, B. F. Hankey


Cancer Surveillance Series: Interpreting Trends in Prostate Cancer—Part III: Quantifying 1033
the Link Between Population Prostate-Specific Antigen Testing and Recent Declines in
Prostate Cancer Mortality, R, Etuoni, J, M, Legier, E. J. Feuer. R. M. Merrill, K. A. Cronin.
B. F. Hankey


Cancer Surveillance Series: Changing Geographic Patterns of Lung Cancer Mortality in the 1040
United States, 1950 Through 1944, S. S. Devesa, D.J. Grauman. W. J. Blot, J. F. Fraumeni. Jr

REPORTS Cancer Surveillance Series: Recent Trends in Childhood Cancer Incidence and Mortality in 1051
the United States, M. S. Linet. L. A, G. Ries, M. A. Smith, R. E. Tarone. S. S. Devesa


Expression of Retinoid Receptor Genes and Proteins in Non-Sniall-Cell l.ung Cancer, 1059
E. Picard. C Segam. N. Monhoven. C. Rochette-Egly, J. Siat. L Borrelly. Y. Martinet. etaL


Urinary 2-Hydroxyestrone/16(alfa)Hydroxyestrone Ratio and Risk of Breast Cancer in 1067
Postmenopausal Women, G, Ursin, S. London,F. Z. StanczYk, E. Gentzchem, A, Paganini-Hill,
R. K. Ross. M. C Pike


BOOK REVIEWS Social Inequalities and Cancer, J. Swan, N. Breen 1073

Current Cancer Therapeutics, D. A. Laheru 1074


CORRESPONDENCE Re: Statewide Study of Diagnostic Agreement in Breast Pathology, A, Parade C. Guirdina. 1076
J. S. Meyer. Response, W. A. wells, P. A. Carney, M. S. Eliassen

Continuing: Biology of Cachexia, F. Bozzetti.J. Gold • Response, B, M. Wheeler 1077

Re: Sunscreen Use, Wearing Clothes, and Number of Nevi in 6- to 7-Year-Old European 1078
Children, F, P. Gasparro, M. Berwick . Response, P. Antier, J.-F. Dore

CORRESPONDENCE Re: ChrmucaHy Depressed Mood and Cancer Risk in Older Persons, D. Serraino. P. Pezzotti. 1080
L. Fratino. V. Zagonel, S. Franceschi . Response, B. W. J. H. Penning J. M. Guralnik


Revisiting: Involuntary Smoking and Lung Cancer: a Case-Control Sludy, A. L Wells, 1081
S. J. Henley


Erratum: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic 1082
Variant in CYP3A4, T. R, Rebbeck. J. M, Jaffe, A. H. Walker A. J. Wein. S, B. Malkowicz


Calendar of Events 1084


Classified Advertising 1086

Inforniation for Authors 1090

_______________________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE


JULY 7, 1999
VOLUME 91, NUMBER 13

CONTENTS

In This Issue 1093


EDITORIALS Genetics of Smoking-Related Cancer and Mutagen Sensitivity, N. Caporaso 1097
Fenretinide: the Death of a Tumor Cell, J. C. Reed 1099


NEWS Prevention Study Turns Spotlight on Bladder Cancer, T. Reynolds 1102
Alternative Medicines Gain in Popularity, Merit Closer Scrutiny, K. Arnold 1104
The Euro: Single Currency Brings Little Change to Cancer Research, S. Steimle 1105
General Motors Cancer Research Foundation Awards Honor Top Cancer Innovators, 1107
N. Volkers

PSA as a Treatment Marker for Prostate Cancer? M. Miller 1 108
Stat Bite: U.S. Non-Hodgkin's Lymphoma Incidence, 1973-1996 1109
Snipping "SNPs": a New Tool for Mining Gene Variations, B. Kuska 1110
Awards, Appointments, Announcements 1110


REVIEW Detection and Clinical Importance of Micrometastatic Disease, K. Pantel, R. J. Cote, 1113
O. Fodstad

ARTICLES Inherited Susceptibility to Bleomycin-induced Chromatid Breaks in Cultured Peripheral 1125
Blood Lymphocytes, J. Cloos, £. J. C. Nieuwenhuis, D. 1. Boomsma, Z). J. Kuik,
M. L. T. van der Sterre, F. Arwert, G. B. Snow, B. J. M. Braakhuis

Risk of Endometrial Cancer Following Estrogen Replacement With and Without Progestins, 1131
E. Weiderpass, H.-O. Adami, J. A. Baron, C. Magnusson, R. Bergstrom, A. Lindgren, et al.

REPORTS Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by ^V-(4-Hydroxyphenyl)- 1138
retinamide in Neuroblastoma Cell Lines, B. J. Maurer, L S, Metelitsa, R. C. Seeger, M. C. Cabot,
C. P. Reynolds
Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer, 1147
R. E. Schoen, C. M. Tangen, L H. Kuller, G. L. Burke, M. Cushman, R. P. Tracy, et al.

Expression of p73 and Its Relation to Histopathology and Prognosis in Hepatocellular 1154
Carcinoma, A. Tannapfel, M. Wasner, K. Krause, F. Geissler, A. Katalinic, J. Hauss, J. Mossner,
K. Engeland, C. Wittekind

BRIEF Renal Cell Cancer: Chromosome 3 Translocations as Risk Factors, A. Courts van Kessel, 1159
COMMUNICATIONS H. Wijnhoven, D. Bodmer, M. Eleveld, L Kiemeney, P. Mulders, M. Weterman, et al.

Mitotic Kinase Expression and Colorectal Cancer Progression, H. Katayama, T. Ota, F. Jisaki, 1160
Y. Ueda, T. Tanaka, S. Odashima, F. SuZuki, Y. Terada, M. Tatsuka

BOOK REVIEW Textbook of Radiation Oncology, R. Abrams 1163

CORRESPONDENCE Fruits, Vegetables, and Cancer Prevention Trials, N. J. Temple \ 164

More About: Sunscreen Use, Wearing Clothes, and Number of Nevi in 6- to 7-Year-Old 1164
European Children, J. M. Elwood, R. P. Gallagher* Response, P. Autier, J.-F. Dore, G. Severi

CORRESPONDENCE Delayed Adjuvant Tamoxifen in Postmenopausal Women With Axillary Node-Negative 1167
(Continued) Breast Cancer: Mortality Over 10 Years, R. R. Love, M. R. Olsen, T. C Havighurst

Calendar of Events 1169
Classified Advertising 1171

Information for Authors 1174
Journal Order Form Inside Front Cover

Re: Cell and Molecular Biology of Simian Virus 40: Implications for Human Infections and 1166
Disease, B. G. M. Durie, H. B. Urnovitz • Response, J. S. Butel, J. A. Lednicky

____________________________

____________________________

JOURNAL OF THE NATIONAl CANCER INSTITUTE

VOL. 91, NO. 16, AUGUST 1999

In this Issue 1347


EDITORIALS Breast Cancer: a New Epstein-Barr Virus-Associated Disease? /. Magrath, K. Bhatia 1349


What Defines a Useful Marker of Metastasis in Human Cancer? D. R. Welch, 1351
C. W. Rinker-Schaeffer


NEWS
Prioritize, Prioritize: WHO Campaigns for National Cancer Programs, C. McNeil 1354

Critics Feel States May Misspend Their Tobacco Windfall, L. Fintor 1356

Making Sense: Therapy Targeting RNA Continues to Advance, N. Volkers 1359

"Age of Possibility" Ushered in by Rapid Gene Discovery, B. Kuska 1360

DES Research Heats Up Again After Breast Cancer Finding, M. Miller 1361


Stat Bite: U.S. Urinary Bladder Cancer Death Rates 1362

HMO Research Network to Focus on Cancer Prevention and Control, G. Moulton 1363

Awards, Appointments, Announcements 1363

REVIEW
Cigarette Smoking, A. W. Bergen, N. Caporaso 1365


ARTICLES
Detection of Epstein-Barr Virus in Invasive Breast Cancers, M. Bonnet, J.-M. Guinebretiere, 1376
E. Kremmer, V. Grune\vald, E. Benhamoa, G. Contesso, I. Joab


Brain and Other Central Nervous System Cancers: Recent Trends in Incidence and 1382
Mortality, J. M. Legler, L. A. Gloeckler Ries, M. A. Smith, J. L. Warren, E. F. Heineman,
R. S. Kaplan, M. S. Linet


REPORTS Loss of Heterozygosity at D14S62 and Metastatic Potential of Breast Cancer, P. O'Connell, 1391
K. Fischbach, S. Hilsenheck, S. K. Mohsin, S. A. W. Fiiqiia, G. M. Chirk, el ill.


Induction of Prostaglandin G/H Synthase-2 in a Canine Model of Spontaneous Prostatic 1398
Adenocarcinoma, C. Tremblay, M. Dore, P. N. Bochsler, J. Sirois


Mammographic Densities and Risk of Breast Cancer Among Subjects With a Family History 1404
of This Disease, N. F. Boyd, G. A. Lockwood, L. J. Martin, J. A. Knight, R. A. Jong, E. Fishell,
J. W. Byng, M. J. Yaffe, D. L. Tritchler


Effects of Health Insurance and Race on Early Detection of Cancer, R. G. Roeuheim, N. Pal, 1409
C. Tennant, L. Voti, J. Z. Ayanian, A. Schwabe, J. P. Krischer


BRIEF Low-Dose Difluoromethylornithine and Polyamine Levels in Human Prostate Tissue, 1416
COMMUNICATION E. M. Messing, R. R. Love, K. D. Tutsch, A. K. Verma, J. Douglas, M. Pomplan, etaL


BOOK REVIEW Women's Cancers: How to Prevent Them, How to Treat Them, How to Beat Them, 1418
M. O'R. Thompson


CORRESPONDENCE Re: Natural History of Dysplasia of the Uterine Cervix, /. Nyirjesy • Response, P. Holowaty, 1420
A. B. Miller, T. Rohan, T. To

More About: Multifactorial Analysis of Differences Between Sporadic Breast Cancers and 1421
Cancers Involving BRCAI and BRCA2 Mutations, F. Eisinger, J. Jacquemier,
E. Charafe-Jauffret, M.-C. Rio, et al. • Response, D. L. Brown, B. F. Cole, B. A. Arrick


CORRESPONDENCE
Re: Early Age at Smoking Initiation and Tobacco Carcinogen DNA Damage in the Lung, 1423
J. H. Glaser • Response, J. K. Wiencke


Re: Thyroid Cancer Rates and (13)1 Doses From Nevada Atmospheric Nuclear Bomb Tests, 1423
V. E. Archer • Response, E. S, Gilbert, R. Tarone, A. Bouville, E. Ron


Re: Dose and Dose Intensity as Determinants of Outcome in the Adjuvant Treatment of 1425
Breast Cancer, W. Hryniuk. Response, D. A. Berry, D. R. Budman

Calendar of Events 1427

Classified Advertising 1430

Information for Authors 1434

_____________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE

VOL. 91, NO. 17, SEPTEMBER 1999


EDITORIALS
Human Herpesvirus 8 and Cancer, V. Beral, R. Newton, F. Sitas 1440


Bad News/Good News: Information About Breast Cancer Risk Following Prophylactic 1442
Oophorectomy, K. J. Hel^lsoaer


NEWS An End to Outpatient Chemotherapy? Medicare Takes Aim at Reimbursement, J. Roemer 1444

New Estrogen Receptor Adds Complexity, Recasts Drug Strategies, T. Reynolds 1445

Subtle Signs May Mask Cancer-Related Emergencies, J. McCann 1447

Stat Bite: Mouth and Throat Cancers in U.S. Males 1448

Whatever Happened to . . . ? Looking Back 10 Years, N. Gottlieb 1449

Awards, Appointments, Announcements 1451

NCI and DoD Agree to Expand Clinical Trials Coverage 1452

COMMENTARY Perspective on KaposFs Sarcoma: Facts, Concepts, and Conjectures, M. S. Rein, Jr., 1453
L. S. Nerurkar, R. C. Gallo

EVIEW Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer, R. B. Ness, C. Cottreau 1459

REPORTS Human Herpesvirus 8 Seropositivity and Risk of Kaposi's Sarcoma and Other Acquired 1468
Immunodeficiency Syndrome-Related Diseases, G. Rezza, M. Andreoni, M. Dorrucci, P. Pezzotti,
. Monini, R. Zerboni, B. Salussa, V. Colcmgeli, L. Sarmati, E. Nicastri, M. Barbanern, et al.


Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCAI Mutation Carriers, 1475
T. R. Rebbeck, A. M. Levin, A. Eisen, C. Snyder, P. Watson, L. Cannon-Albright, C. Isaacs, et al.


Cancer Prevalence and Survivorship Issues: Analyses of the 1992 National Health Interview 1480
Survey, M. Hewitt, N. Breen, S. Devesa

Race and Differences in Breast Cancer Survival in a Managed Care Population, 1487
M. Ulcickas Yood, C. C. Johnson, A. Blount, J. Abrams, E. Wolman, B. D. McCarthy, et al.

Randomized Trial Testing the Effect of Peer Education at Increasing Fruit and Vegetable 1491
Intake, /). B. Buller, C. Momil, D. Taren, M. Aickin, L. Sennott-Miller, M. K. Bailer, L. Larkey,
C. Alatorre, T. M. WenUel


BRIEF Enhancement of Tumor Response to 'Y-RadiatJon by an Inhibitor of Cyclooxygenase-2 Enzyme, 1501
COMMUNICATION L. Milas, K. Kishi, N. Hunter, K. Mason, J. L. Masferrer, P. J. Tofilon

BOOK REVIEWS Tamoxifen for the Treatment and Prevention of Breast Cancer, A. M. Mondwc 1505

The Nazi War on Cancer, E. J. Seifter 1505

CORRESPONDENCE Re: Colorectal Cancer Screening: Sifting Through the Evidence, C. D. Atkins • Response, 1507
B. Levin

Re: Association Between Nonrandom X-Chromosome Inactivation and BRCAI Mutation in 1507
Germline DNA of Patients With Ovarian Cancer, J. Boyd, S. A. Narod • Response,
R. E. Buller, A. K. Sood, T. Lallas, T. Buekers, J. S. Skilling


CORRESPONDENCE
Re: Relationship Between p53 Mutations and Indudble Nitric Oxide Synthase Expression in 1509
Human Colorectal Cancer, 0. Gallo, /. Sardi, M. Masini, A. Franchi • Response, S. Ambs,
C. C. Harris


Re: Meta-analysis: Dietary Fat Intake, Serum Estrogen Levels, and the Risk of Breast 1511
Cancer, M. D. Holmes, E. F. Schisterman, D. Spiegelman, D. J. Hunter, W. C. Willett • Response,
A. H. Wit, D. 0. Straw, M. C. Pike


Antiquity ofEpstein-Barr Virus, Sjogren's Syndrome, and Hodgkin's Disease—Historical 1512
Concordance and Discordance, E. L. Altshuler


Microencapsulated NaCI for Oral Salt-Replacement Therapy in Infants, A. Clavier, R. Thies, 1513
P. Kleinebudde, M. Suttorp

Calendar of Events 1515

Classified Advertising 1518

Information for Authors 1522
Journal Order Form
Inside Back Cover

_____________________________

JOURNAL OF THE NATIONAL CANCER INSTITUTE

VOL. 91, NO. 18, SEPTEMBER 1999


EDITORIALS
Photoimmunotherapy and Ovarian Cancer: an Improbable Fiction or a Palpable Hit? 1526
Z. A. Tochner, S. Hahn, E. Glatstein


Closing in on Another Renal Cancer Suppressor Locus Near Chromosome 3pl4, F. J. Kaye 1528

NEWS Stem Cell Maneuvers Target Bone Marrow Toxicity, J. Randal 1530

Pancreatic Cancer Research: Putting All Their Ducts in a Row, B. Kaska 1532

Charity Volunteers Face Forward With a New Look, T. Reynolds 1534

Stat Bite: Age-Specific Incidence of Brain and Central Nervous System Tumors 1535

Incurable Childhood Cancers Pose Painful End-of-Life Issues, M. Miller 1537

Smokeless Cars: the Trend of the Future? N. Gottlieb 1538

Awards, Appointments, Announcements 1539

ARTICLES Validation Studies for Models Projecting the Risk of Invasive and Total Breast Cancer 1541

Incidence, J. P. Costantino, M. H. Gail, D. Pee, S. Anderson, C. K. Redmond, J. Benichou,
H. S. Wieand

Reversion of Human Glioblastoma Malignancy by Ul Small Nuclear RNA/Ribozyme 1548
Targeting of Scatter Factor/Hepatocyte Growth Factor and c-met Expression, R. Abounader,
S. Ranganathan, B. Lal, K. Fielding, A. Book, H. Dietz, P. Burger, J. Laterra

REPORTS Combination Photoimmunotherapy and Cisplatin: Effects on Human Ovarian Cancer 1557

Ex Vivo, L R. Duska, M. R. Hamblin, J. L. Miller, T. Hasan

Novel Tumor Suppressor Locus in Human Chromosome Region 3pl4.2, K. Jiilicher, 1563
G. Marquitan, N. Werner, W. Bardenheuer, L. Vieten, F. Brocket', H. Topal, S. Seeber, et al.

Biologic and Biochemical Analyses ofpl6^^* Mutations From Primary Tumors, 1569
W. G. Yarbrough, R. A. Buckmire, M. Bessho, E. T. Liu

Clinical Significance of Alterations of Chromosome 8 in High-Grade, Advanced, 1574
Nonmetastatic Prostate Carcinoma, K. Sato, J. Qian, J. M. Slewk, M. M. Lieber, D. G. Bostwick,
E. J. Bergstralh, R. B. Jenkins

BRIEF Clonal Loss ofHeterozygosity in Microdissected Hodgkin and Reed-Sternberg Cells, 1581
COMMUNICATION U. Hasse, M. Tinguely, E. 0. Leibundgut, J.-F. Cajot, A. M. Gurvin, A. Tobler, etal.

CORRESPONDENCE Re: Prognostic Importance of Low c-erbB2 Expression in Breast Tumors, M. Ferrero-PoUs, 1584
K. Hacene, et al. • Response, S. Koscielny, P. Terrier, et al.


Re: Evaluating Gastric Cancer Misclassification: a Potential Explanation for the Rise in 1585
Cardia Cancer Incidence, F. Levi, V.-C. Te, L. Randimbison, C. La Vecchia • Response,
A. M. Ekstrom, 0. Nyren


Re: Depression as a Risk Factor for Cancer: Renewing a Debate on the Psychobiology of 1586
Disease, R. FrenUel-Beyme

Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in 1587
CYP3A4, K Ando, T. Tateishi, Y. Sekido, T. Yamamoto, T. Satoh, Y. Hasegawa, S. Kobayashi,
Y. Katsumata, etal. • Response, B. Amirimani, A. H. Walker, B. L. Weber, T. R. Rebbeck


CORRESPONDENCE
Re: Maternal Inheritance Pattern of Hereditary Pancreatitis in Patients With Pancreatic 1590
Carcinoma, A. B. Low enf els, P. Maisonneuve • Response, M. M. Lerch, J. P. Neoptolemos

Calendar of Events 1592

Classified Advertising 1594

Information for Authors 1596

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