LEUKEMIA

HW Findley & M Zhou

ORIGINAL MANUSCRIPTS
THERAPY

Major vascular complications in essential 150
thrombocythemia: a study of the predictive factors in a
series of 148 patients

C Besses, F Cervantes, A Pereira, L Florensa, F Sole,
JC Hemandez-Boluda, S Woessner, J Sans-Sabrafen,
C Rozman & E Montserrat

Unexpected mortality from the use of E. coli 155
L-asparaginase during remission induction therapy
for childhood acute lymphoblastic leukemia: a report
from the Taiwan Pediatric Oncology Group
D-C Liang, I-J Hung, C-P Yang, K-H Lin, J-S Chen,
T-C Hsiao, T-T Chang, C-H Pui, C-H Lee, K-S Lin and
the Taiwan Pediatric Oncology Group

Carboplatin plus cytarabine in the treatment of high-risk 161
acute myeloblastic leukemia

L Larrea, JA Marti'nez, GF Sanz, G Marti'n, J de la Rubia,
C Jimenez, I Jarque, A Cid, A Lopez & MA Sanz

IMMUNOTHERAPY

Generation of bcr-abi specific cytotoxic T-lymphocytes by 166
using dendritic cells pulsed with bcr-abi (b3a2) peptide:
its applicability for donor leukocyte transfusions in
marrow grafted CML patients

Y Osman, M Takahashi, Z Zheng, T Koike, K Toba, A Lili,
T Furukawa, S Aoki & Y Aizawa

NOSOLOGY

Genetic, phenotypic and clinical fcatur<;.s nt ai.utfc 175
lymphoblastic leukemias expressing myeloperoxiclase
mRNA detected by RT-PCR

J Serrano, J Roman, A Jimenez, JA Castillejo, JA Navarro,
I Sanchez, JM Garci'a-Castellanos, C Martm, J Maldonado
fe A Torres

CLINICAL-LABORATORY CORRELATES IN
CHILDHOOD ALL

enhanced expression of p 16'"^ is associated with a poor 181
irognosis in childhood acute lymphoblastic leukemia
Y Mekki, R Catallo, Y Bertrand, AM Manel, P Ffrench,
Baghdassarian, P Duhaut, PA Bryon & M Ffrench

Clonal stability in children with acute lymphoblastic 190
leukemia (ALL) who relapsed five or more years after

diagnosis

L Lo Nigro, G Gazzaniga, A Di Cataldo, A Pannunzio,
E D'Aniello, G Masera, G Schiliro & A Biondi

T CELL RECEPTOR GENE REARRANGEMENT

Cross-lineage T cell receptor gene rearrangements occur 196

in more than ninety percent of childhood precursor-B
acute lymphoblastic leukemias: alleriiative PCH targets
for detection of minimal residual disease
T Szczepariski, A Beishnizeii, MJ Pongers-Willernse,
K Hahlen, ER Van Wering, AJM WijkhLiijs, GJM Tibbe,
MAC De BrLiijn & JJM Van Dongen

Immunopbeiiotypic and immimogenotypic characteristics 206
of TCH-Yfi' T cell acute lymphoblastic leukemia
AW Langerak, ILM Wolvers-Tettero,
MWM van den Beemd, ER van Wering, W-D Ludwig,
K Hahlen, A Necker & JJM van Dongen

T CELL LEUKEMIAS: ATL AND T-LGL

Multi-clonal expansion of unique human T-lymphotropic 215

virus type-l-infected T cells with high growth potential in
response to interleukin-2 in prodromal phase of adult T
cell leukemia

T Hata, T Fujimoto, H Tsushima, K Murata, K Tsukasaki,
S Atogami, H Sohda, S Honda, M Mine, Y Yamada,
S Ikeda, S Karnihira & M Tomonaga

In vitro infection of CD4+ T lymphocytes with HTI.V-I 222
generates immortalized cell lines coexpressing lymphoid
and myeloid cell markers

M Tricarico, B Macchi, S D'Atri, S Morrone, E Bonmassar,
MP Fuggetta & G Graziani

"> t.wlitink C.h.i' \.{,\. .sh.iu- tuintihnut fnofn-tthfi with iW

their CU8'CI)57* cell counterpart expanded after BMI
L Mollct, B Fautrel, V Leblond, F Bergeron, 11 McrIe-Beiul,
E Baumelou, P Hubert, P Debre & B Autran

IMMUNOBIOLOGY

Influence of cytotoxicity enhancers in combination with 241
human serum on the activity of CD22-recomhinant ricin
A against B cell lines, chronic ami acute lymphocytic
leukemia cells

MYBLOUYSPLASIA

Therapy-related myelodysplastic syndrome and acute 250
myeloid lcukemia with 17p deletion. A report on 25 cases
A Merlat, JL Lai, Y Sterkas, JL Demory, F Baulers,
C Preutihomine & P Fenaux

HJ Broxterman, P Sonneveld, R Pieters, J Lankelma,
CA Eekrnan, AH Loonen, M Schoester, GJ Ossenkuppele,
B Lowenberg, HM Pinedo & GJ Schuurhliis

APOPTOSIS

Fibronectin interaction with «4<31 integrin prevents 266
apoptosis in B cell chronic lymphocytic leukemia:
correlation with Bcl-2 and Bax
M-T de la Fuenie, B Casanova, M Garcia-Gila, A Silva
& A Garcia-Pardo

DIFFERENTIATION

LYMPHOMA

I Planlier-Colcher, B Duprie?., M Simon. L Detolirmignies,
JP Jouet, P Fenaux, F Bauters and P Morel

MYELOMA

D Puthier, C Pellal-Deceunynck, S Barille N Robillai-d,
M-J Rapp, N Juge-Morineau, J-L Harousscan, R Bataille
& M Amiot

BRIEF COMMUNICATIONS

M Buisson, P Morand, M Peoc'h, 0 Bouchard,
M-J Bourgeat & J-M Seigneurin

M Busson-Le-Coniat, F Salomon-Nguyen, J Hillion,
OA Bernard & R Berger

CORRESPONDENCE

X Leteu, JP Jouet, I Plantier, M Zandecki, JL Lai',
D Mucha, JP Lejeune, F Bauters & T Facon

A novel method for prognostic evaluation of childhood 3W
acute lymphoblastic leukemia
D Sinha, C Mandal, DK Bhattacharya

Spontaneous remission of large granular lymphocyte T 31
cell leukemia
M Takeuchi, A Tamaoki, R Soda & K Takahashi

COMMENT ON PUBLISHED PAPER
The TCLI oncogene is not overexpressed in patients with 31
adult T cell leukemia
J Takizawa & M Seto

CORRIGENDUM

LEUKEMIA


Volume 13, Supplement I , April 1999


PREFACE

XIX Symposium of the International Association for S1
Comparative Research on Leukemia and Related
Diseases
R Hehlmann
(published in J Mol Med 1997)

MEMORIAL LECTURES

Yohei lto Memorial Lecture: Papillomaviruses in human S3
cancers
H zur Hausen

The Charlotte Friend Memorial Lecture. The role of S8
hematopoietic growth factors in the development and
suppression of myeloid leukemias
D Metcalf

Megakaryocytic growth factors: is there a new approach S 14
for management of thrombocytopenia in patients with
malignancies?
WK Hofmann, OG Ottmann & D Hoelzer

IN-DEPTH REVIEWS

Comparative research in leukemia and related diseases. S 19
An introduction to a scientific approach
R Hehlmann & M Essex
(published in J Mol Med 1997; 75: 528-538)

Dissection of signaling pathways and cloning of new S29
signal transducers in tyrosine kinase-induced pathways
by genetic selection
S Mahlmann, J McLaughlin, DEH Afar, R Mohr, RJ Kay
& ON Witte

Dioxin exposure and human leukemias and lymphomas. S72
Lessons from the Seveso accident and studies on
industrial workers
PA Bertazzi, AC Pesatori, I Bemucci, MT Landi
& D Consonni

The effect of Bcl-2 on Apoptin in normal ' vs S75
transformed human cells

AAAM Danen-Van Oorschot, Y Zhang, SJ Erkeland,
DF Fischer, AJ van der Eb & MHM Noteborn

A novel mouse model of HIV-I disease S78
P Jolicoeur, DG Kay, M Cool, S Jothy, N Rebai
& Z Hanna

Phosphorylation substrates and altered signalling in S81
leukemias caused by BCR/ABL
J Groffen, R de Jong, L Haataja, V Kaartinen
& N Heisterkamp

Identification of murine CBFal, a runt domain S83
transcription factor, as a putative Myc collaborator in
T cell lymphoma

J Nell, M Stewart, A Terry, M O'Hara, M Hu, K Blyth,
E Baxter, D Onions & E Carneron

Immunophenotypic and functional characterization of S87
human umbilical cord blood mononuclear cells
K Paloczi

Genotypic classification of childhood acute lymphoid S90
leukemia
D Pinkel

Stem cell engraftment and cell cycle phenotype S92
P Quesenberry, P Becker, S Nilsson, M Stewart, S Zhong,
C Grirnaldi, J Reilly, H Hababian, M Dooner, S Peters
& H Ramshaw

Vaccine protection by subinfectious doses of a live
murine leukemia virus
RA Rasmussen, PL Sharma, Y Hu & RM Ruprecht S94

BCR/ABL rearrangement and leukemia phenotype
G Saglio, F Pane, G Martinelli & A Guamsio S96

Impact of human endogenous retroviral elements on
cellular genes: strategy for isolation of LTR-driven
chimeric transcripts S97
W Seifarth, F Krieg-Schneider, H Skladny, A Marachelian,
H Germaier, R Hehlmann & C Leib-Mösch

Modulation of cell surface protein expression by infection
with HIV-I
C Speth & MP Dierich S99

Bovine immunodeficiency virus and analogies with
human immunodeficiency virus
OC Sträub & D Levy S106

Human herpcsvirus-8 (HHV-8) gene expression in
Kaposi's sarcoma (KS) primary lesions: an in situ
hybridization study S110
Stürzi, A Wunderlich, G Ascherl, C Hohenadi, P Monini,
C Zietz, PJ Browning, F Neipel, P Biberfeld & B Ensoli

Effect of mutations in NC7 on endogenous reverse
transcription in HIV-I S113
M Hsu, E Cherry, Y Quan, N Richard, L Kleiman
& MA Wainberg

Alteration of proteolytic processing of c-Myb as a
consequence of its truncation in murine myeloid
Jeukemia S116
J Bies, V Nazarov & L Wolff

LEÜKEMIA

Volume 13, Number 3 , March 1999

EDITORIAL

Infantile leukemia and soybeans - a hypothesis 317
T Abe

MINI-REVIEW

Post-transplant acute myeloid leukemia (PT-AML) 321
R Thalhammer-Scherrer, G Wieselthaler, P Knoebl,
l Schwarzinger, l Simonitsch, G Mitterbauer,
GA Beriakovich, Ch Mannhalter, OA Haas, G Mayer,
F Muehlbacher, E Wolner, W Klepetko, K Lechner
& U Jaeger

ORIGINAL MANUSCRIPTS
THERAPY AND CLINICAL TRIALS
, Polycythemia vera megakaryocytes but not 327
megakaryocytes from normal controls and patients with
smokers polyglobuly spontaneously express IL-6 and IL-
6R and secrete IL-6
C Wickenhauser, J Thiele, J Lorenzen, B Schmilz,
S Frimpong, K Schramm, l Neurnann, R Zankovich
& R Fischer

Intensive high-dose asparaginase consolidation improves 335
survival for pediatric patients with T cell acute
lymphoblastic leukemia and advanced stage
lymphoblastic lymphoma: a Pediatric Oncology Group
Study
MD Amylon, J Shuster, J Pullen, C Berard, MP Link,
M Wharam, J Katz, A Yu, J Laver, Y Ravindranath,
J Kurtzberg, S Desai, B Camitta & SB Murphy

Phase I trial of sequential topotecan followed by 343
etoposide in adults with myeloid leukemia: a National
Cancer Institute of Canada Clinical Trials Group Study
M Crump, J Lipton, D Hedley, D Sutton, F Shepherd,
M Minden, K Stewart, S Beare & E Eisenhauer

PHYSIO-PATHOLOGICAL MECHANISMS IN
LEUKEMIA

MDSI/EVII enhances TGF-J31 signaling and strengthens 348
its growth-inhibitory effect, but the leukemia-associated
fusion protein AMLI/MDSI/EVII, product of the t(3;21),
abrogates growth-inhibition in response to TGf-ßl
R Sood, A Talwar-Trikha, SR Chakrabarti & G Nucifora

MOLECULAR CYTOGENETICS

Low BCL-2 expression in acute leukemia with t(8;21) 358
chromosomal abnormality

M Shikami, H Miwa, K Nishii, T Takahashi, T Sekine,
N Mahmud, M Nishikawa, H Shiku, N Kamada & K Kita
Identification of a novel molecular partner of the E2A 369
gene in childhood leukemia
F Brambillasca, G Mosna, M Colombo, A Rivulla,
C Caslini, M Minuzzo, G Giudici, L Mizzi, A Biondi
& E Privitera

NOSOLOGY

Myelodysplastic syndrome, juvenile myelomonocytic 376
leukemia, and acute myeloid leukemia associated with
complete or partial monosomy 7
H Hasle, M Arico, G Basso, A Biondi, A Cantu Rajnoldi,
LI Creutzig, S Fenu, C Fonatsch, OA Haas, J Harbott,
G Kardos, G Kemdrup, G Mann, CM Niemeyer,
H Ptoszkova, J Ritter, R Slater, J Stary,
B Stollmann-Gibbels, AM Tesli, ER van Wering
& M Zimmermann for the European Working Group on
MDS in Childhood (EWOG-MDS)

CLONALITY STUDIES

Clonal chromosomal abnormalities in the stem cell 386
compartment of patients with acute myeloid leukemia in
morphological complete remission
M Feuring-Buske, D Haase, C Buske, W Hiddemann
& B Wörmann

MDS

The Wilms' tumor gene WTI is a good marker for 393
diagnosis of disease progression of myelodysplastic
syndromes
H Tarnuki, H Ogawa, K Ohyashiki, JH Ohyashiki, H Iwama,
K Inolie, T Soma, Y Oka, T Tatekawa, Y Oji, A Tsuhoi,
EH Kim, M Kawakami, K Fuchigami, M Tomonaga,
K Toyama, K Aozasa, T Kishiniolo & H Sligiyama

APOPTOSIS

Chemotherapeutic drugs sensitize pre-B ALL cells for 400
CD95- and cytotoxic T-lymphocyte-mediated apoptosis
C Posovszky, C Friesen, l Herr & K-M Debatin

SENSITIVITY AND RESISTANCE TO THERAPY
Decreased sensitivity of drug-resistant cells towards T 410
cell cytotoxicity
CF Classen, S Fulda, C Friesen & K-M Debatin

• IMMUNOBIOLOGY

Flow cytometric analysis of normal B cell differentiation: 419
a frame of reference for the detection of minimal
residual disease in precursor-B-ALL
P LUdo, A Pari-eira, MWM van den Bccmd,
EG van Lochein, ER van Wering, E Baurs,
A Porwit-MacDonald, E Bjorklund, G Gaipa, A Biondi,
A Orfao, G Janossy, JJM van Dongen & JF San Miguel

LEÜKEMIA

Volume 13, Number 4 , April 1999


EDITORIAL

Cell division tracking and expansion of hematopoietic 499
long-term repopulating cells
RAJ Oostendorp, J Audet, C Miller & CJ Eaves

REVIEW

Modulation of the immune response and tumor growth 502
by activated Ras
S Weijzen, MP Velders & WM Käst

ORIGINAL MANUSCRIPTS
THERAPY

Outpatient management of acute promyelocytic leukemia 514
after consolidation chemotherapy
C Girmenia, R Latagliata, S Tosti, SG Morano, F Celesti,
L Coppola, A Spadea, M Breccia, R Battistini, A Tafuri,
G Cimino, F Mandelli & G Alimena

2-Chlorodeoxyadenosine (Cladribine) in the treatment of 518
patients with chronic lymphocytic leukemia 55 years old
and younger
T Robak, JZ Blonski, H Urbanska-Rys,
M Blasiriska-Morawiec & AB Skotnicki

A prospective study of autologous bone marrow or 524
peripheral blood stem cell transplantation after intensive
chemotherapy in myelodysplastic syndromes
E Wattel, E Solary, X Leieu, F Dreyfus, A Brion, JP Jouet,
L Hoang-Ngoc, F Maloisel, A Guerci, H Rochant,
N Gratecos, P Casassus, M Janvier, P Brice, P Lepelley,
P Fenaux, Groupe Fran^ais des Myelodysplasies (GFM) and
Groupe Ouest-Est d 'etude des Leucemies aigues myeloi'des
(GOELAMS)

CLINICAL LABORATORY CORRELATES
Cell lineage specificity in G-CSF receptor gene 530
methylation
J Feigner, K Heidom, D Körbächer, SO Frahm
& R Parwaresch

The TGV-ß type II receptor in chronic myeloid 535
leukemia: analysis of microsatellite regions and gene
expression
HM Rooke, MR Vitas, PS Crosier & KE Crosier

a!imple and reliably sensitive diagnosis and monitoring of 542
Philadelphia chromosome-positive cells in chronic
nyeloid leukemia by interphase fluorescence in situ
iybridization of peripheral blood cells
M Yanagi, K Shinjo, A Takeshita, T Tobita, K Yano,
M Kobayashi, H Terasaid, T Naoe, K Ohnishi & R Ohno

Endogenous FLT-3 ligand serum levels are associated 553
with disease stage in patients with myelodysplastic
syndromes
H Zwierzina, JE Anderson, I Rollinger-Holzinger,
B Torok-Storb, V Nuesslei- & SD Lyman

MINIMAL RESIDUAL DISEASE
A limited antibody panel can distinguish B-precursor 558
acute lymphoblastic leukemia from normal B precursors
with four color flow cytometry: implications for residual
disease detection
EG Weir, K Cowan, P LeBeau & MJ Borowitz

Quantitation of minimal residual disease in acute 568
myelogenous leukemia and myelodysplastic syndromes in
complete remission by molecular cytogenetics of
progenitor cells
H Engel, J Drach, A Keyhani, S Jiang, NT Van, M Kimmel,
G Sanchez-Williams, A Goodacre & M Andreeff

SENSITIVITY AND RESISTANCE TO THERAPY
Role of MRPI in multidrug resistance in acute myeloid 578
leukemia
O Legrand, R Zittoun & J-P Marie

SIGNAL TRANSDÜCTION

Lack of constitutive activation of MAP kinase pathway in 585
human acute myeluid leukemia cells with N-Ras mutation
M lida, M Towatari, A Nakao, H lida, H Kiyoi, Y Nakano,
M Tanimoto, H Saito & T Naoe

NORMAL HEMOPOIESIS AND
STEMCELLOLOGY

In vivo and in vitro effects of cytokines and the 590
hemoregulatory peptide dimer (pEEDCK)2 (pyroGlu-
Glu-Asp-Cys-Lys)2 on Gal6-positive hematopoiesis
M Pfeilstöcker, H Karlic, J Paukovits, G Anzenberger,
N Louda, J Salamon, H Mühlberger, H Strobi, E Pittermann
& R Heinz

CELL BIOLOGY

Expressions of four major protein Ser/Thr phospliatases 595
in human primary leukemic cells
M Yamamoto, Y Suzuki, H Kihira, H Miwa, K Kita,
M Nagao, S Tamura, H Shiku & M Nishikawa

IMMUNOBIOLOGY

Selection of iinmunoglobulin diversity gene reading 601
frames in B cell lymphoproliferative disorders
K Stamatopoulos, C Kosinas, N Stavroyianni, C BeJessi
& T Papadaki

Efficient detection and selection of immature rhesus 605
monkey and human CD34^ hematopoietic cells expressing
the enhanced green fluorescent protein (EGFP)
MFA Bierhuizen, Y Westerman, SCC Hartong, TP Visser,
AW Wognum & G Wagemaker

A classification based on T cell selection-related 614
phenotypes identifies a subgroup of childhood T-ALL
with favorable outcome in the COALL studies
T Niehues, P Kapaun, DO Harms, S Burdach, C Krarnrn,
D Körholz, G Janka-Schaub & U Göbel

ANIMAL MODELS

Multilineage outgrowth of both malignant and normal 618
hemopoietic progenitor cells from individual chronic
myeloid leukemia patients in immunodeficient mice
MMA Verstegen, JJ Comelissen, W Terpstra,
G Wagemaker & AW Wognum

DT388-GM-CSF, a novel fusion toxin consisting of a 629
truncated diphtheria toxin fused to human granulocyte-
macrophage colony-stimulating factor, prolongs host
survival in a SCID mouse model of acute myeloid
leukemia
PD Hall, MC Willingham, RJ Kreitman & AE Frankel

LYMPHOMA

Constitutive cytokinc production by primary effusion 634
(body cavity-based) lymphoma-derived cell lines
HG Drexler, C Meyer, G Gaidano & A Carbone

BRIEF COMMUNICATION

Evaluation of minimal residual disease by interphase 641
FISH in multiple myeloma: does complete remission
exist?
F Genevieve, M Zandecki, J-L La'i, B Hennache,
J-L Faucompre, L Stalnikiewicz, F Bauters & T Facon

CORRESPONDENCE

B2 exon of the BCR gene is also duplicated in some 645
patients with CML
TA Almeida, JC Cigudosa, A Otero & JL Garcia-Miranda

Fatal mycobacteremia caused by Mycobacterium 646
tuberculosis in a patient with acute leukemia
C-C Ker, C-C Hung, W-H Sheng, S-C Chang & K-T Luh

ALL-trans retinoic acid-induced vasculitis and 647
hemonecrosis of the ileum in a patient with acute
promyelocytic leukemia
K Yamada, K Sugimoto, T Matsumoto, K Narumi
& K Oshimi

Long-term molecular remission in promyelocytic 648
transformation of myeloproliferative disease
PN Mollee, KM Taylor, B Williams, D Taylor & R Rodwell

Mutational analysis of the Hel-NI gene in childhood 650
acute lymphoblastic leukemia with LOH at 9p21
C Takeuchi, S Takeuchi, T Ikezoe, CR Bartram,
HP Koeffler & H Taguchi

LEUKEMIA

Volume 13, Number 5 , May 1999

Dendritic cell-based vaccine: a promising approach for 653
cancer immunotherapy
K Tarte & B Klein

MINI-REVIEWS

Primary effusion lymphoma after heart transplantation: 664
a new entity associated with human herpesvirus-8
G Dotti, R Fiocchi, T Motta, B Facchinetti, B Chiodini,
GM Borieri, G Gavazzeni, T Barbui & A Rambaldi

Centric and pericentric chromosome rearrangements in 671
bematopoietic malignancies
R Berger & M Busson-Le Coniat

ORIGINAL MANUSCRIPTS
CLINICAL LABORATORY CORRELATES
Cytogenetic studies of infant acute lymphoblastic 679
leukemia: poor prognosis of infants with t(4;ll)-a
report of the Children's Cancer Group
NA Heerema, HN Sather, J Ge, DC Arthur, JM Hilden,
ME Trigg & GH Reaman

Expression of HOX genes, HOX-cofactors, and MLL in 687
phenotypically and functionally defined subpopulations of
leukemic and normal human hematopoietic cells
H Kawagoe, RK Humphries, A Blair, HJ Sutherland
& DE Hogge

MDS
Expression of inducible nitric oxide synthase (NOS) in 699
bone marrow cells of myelodysplastic syndromes
M Kitagawa, M Takahashi, S Yamaguchi, M Inoue,
S Ogawa, K Hirokawa & R Kamiyama

SECONDARY LEUKEMIA

Therapy-related adult acute lymphoblastic leukemia with 704
t(4;11)(q21;q23): MLLI rearrangement, p53 mutation and
multilineage involvement

R Bigoni, A Cuneo, M Grazia Roberti, S Moretti,
C De Angeli, M Dabusti, D Campioni, L del Senno,
A Biondi, T Chaplin, BD Young & G Castoldi

CYTOGENETICS

Discontinuous deletions at llq23 in B cell chronic 708
lymphocytic leukemia
Y Zhu, 0 Monni, W EI-Rifai, SM Siitonen, L Vilpo,
] Vilpo & S Knuutila
APOPTOSIS
Detection of inducible nitric oxide synthase (iNOS) 713
mRNA by RT-PCR in ATL patients and HTLV-I
infected cell lines: clinical features and apoptosis by NOS
inhibitor

T Sonoki, H Matsuzaki, A Nagasaki, H Hata, M Yoshida,
M Matsuoka, N Kuribayashi, T Kimura, N Harada,
K Takatsuki, H Mitsuya & M Mori

Cleavage of Bcl-2 is an early event in chemotherapy- 719
induced apoptosis of human myeloid leukemia cells
B Fadeel, Z Hassan, E HellsirOin-Lindberg, J-l Heiiter,
S Orrenius & B Zhivotovsky

Induction of apoptosis by bestatin (ubenimex) in human 729
leukemic cell lines
K Sekine, H Fuji) & F Abe

Inhibition of constitutively activated Stat3 correlates with 735
altered Bcl-2/Bax expression and induction of apoptosis
in mycosis fungoides tumor cells

M Nielsen, CG Kastei, KW Eriksen, A Woetmann,
T Stokkedal, K Kaltoft, C Geisler, C Röpke & N 0dum


MOLECULAR BIOLOGY OF RETINOIDS

In acute promyelocylic leukemia NB4 cells, the synthetic 739
retinoid CD437 induces contemporaneously apoptosis, a
caspase-3-mediated degradation of PML/RARa protein
and the PMI. retargeting on PML-nuclear bodies
M Gianni & H de The


Chromatin structure and transcriptional regulation of the
stem cell leukaernia (SCL) gene in mast cells
JL Fordham, B Göttgens, F McLaughlin & AR Green 750

GROWTH FACTORS, CYTOKINES AND CELL
SIGNALLING
APS, an adapter protein containing Pleckstrin homology 760
(PJI) and Src hoinology-2 (SH2) domains inhibits the
JAK-STAT pathway in collaboration with c-Cbl
T Wakioka, A Sasaki, K Mitslii, M Yokouchi, A Inoue,
,S Komiya & A Yoshimura

SENSITIVITY AND RESISTANCE TO LEUKEMIA
Growth inhibition, cytokinesis failure and apoptosis of 768
multidrug-resistant leukemia cells after treatment with
P-glycoprotein inhibitory agents
G Lehne, P De Angelis, M den Boer & HE Rugstad
IMMUNOBIOLOGY

The KOR-SA3544 antigen predominantly expressed on 779
the surface of Philadelphia chromosome-positive acute
lymphoblastic leukemia cells in nonspecific cross-reacting
antigcn-50/90 (CD66c) and invariably expressed in
cytoplasm of human leukemia cells
K Sugita, T Mori, S Yokota, Ma Kuroki, T O-Koyama,
T Inukai, K lijima, K Goi, T Tezuka, S Kojika, K Shiraishi,
M Nakamura, N Miyamoto, N Karakida, K Kagami
& S Nakazawa

BONE MARROW TRANSPLANTATION
Early allogeneic transplantation for refractory or 786
relapsed acute leukaemia following remission induction
with FLAG
JL Byrne, E Dasgupta, M Pallis, J Turzanski, K Forman,
D Mitchell, AP Haynes & NH Russell

LYMPHOMA

Frequent chromosome arm 13q deletion in aggressive 792
non-Hodgkin's lymphoma
M Wada, T Okamura, M Okada, M Teramura, M Masuda,
T Motoji & H Mizoguchi

Gastric low-grade MALT lymphoma, high-grade MALT 799
lymphoma and diffuse large B cell lymphoma show
different frequencies of trisomy
MA Hoeve, IAM Gisbertz, HC Schouten, E Schuuring,
FJ Bot, J Hermans, A Hopman, PhM Kluin, J-W Arends
& JHJM van Krieken

Analysis of the INK4a/ARF locus in non-Hodgkin's 808
lymphomas using two new internal microsatellite
markers
M Herranz, M Urioste, J Santos, C Rivas, B Marti'nez,
J Benitez & J Fernändez-Piqueras
Profiles and prognostic values of LDH isoenzymes in 811
patients with non-Hodgkin's lymphoma
C Dumontet, J Drai, J Bienvenu, E Neidhardt Berard,
C Thieblemont, F Bouafia, F Bayle, l Moullet, G Salles
& B Coiffier

BIO-TECHNICAL METHODS SECTION (BTS)
Detection of BCR-ABL transcripts in chronic myeloid 818
leukemia (CML) using an in situ RT-PCR assay
C Preudhomme, L Chams-Eddine, C Rournier,
N Duflos-Grardel, C Denis, A Cosson & P Fenaux

CORRESPONDENCE

Bone marrow transplant and toxoplasmosis 824
AI Miles

A case of TCRr6+ T-ALL with cross-lineage CD19 824
expression
J Pereira, NB de Melo, V Buccheri, IE Tutiya, B Beitier,
PE Dorlhiac-Llacer & D Chamone

Hodgkin's disease type Richter's syndrome in chronic 826
lymphocytic leukemia
S Juneja, D Carney, D Ellis, EH Januszewicz, M Wolf &
HM Prince

Immunoglobulin light chain variable region genes in 827
multiple myeloma
C Kosmas & K Stamatopoulos

Reply: Review of the immunoglobulin light chain 829
variable region sequences from multiple myeloma cells
H Kiyoi & T Naoe