Metabolism
Vol 48, No I, January 1999

CONTENTS

Preliminary Report: Relationships Between Apolipoprotein(a) Phenotype and Increase of Lipoprotein(a) by
Troglitazone
Kazunari Matsumoto, Seibei Miyake, Mayumi Yano, Yukitaka Ueki, and Yuko Tominaga 1


Insulin Secretion and Biosynthesis by the Perfused Pancreas of Spontaneously Hypertensive Rats
Keiichiro Tanigawa, Yasushi Inoue, and Katsuhiro Tamura 3

Carbohydrate and Lipid Metabolism During Various Growth Hormone Dosing Regimens in Girls With
Turner Syndrome
A. van Teunenbroek. S.M.P.F. de Muinck Keizer-Schramcl, H.J. Aanstoot, T. Stijnen, N. Hoogerbrugge,
S.LS. Drop, and the Dutch Working Group on Growth Hormone 7


Effect of Exercise Training on Long-Term Weight Maintenance in Weight-Reduced Men
WilrikeJ. Pasman, WimH.M, Saris, ErikMuls, Greet Vansant, andMargrietS. Westerterp-Plantenga 15


Differential Effects of Cis and Trans Fatty Acids on Insulin Release From Isolated Mouse Islets
Kirsten Kudahl Alstrup, Soren Gregersen, Heidi Majgaard Jensen, Janus Laust Thomson, and Kjeld Hermansen 22


Diabetes Mellitus: Polymorphonuclear Leukocyte (PMN) Filtration Parameters and PMN Membrane Fluidity
After Chemotactic Activation
Rosalia LoPresti, Maria Montana, Baldassare Canino, Giuseppe Ventimiglia, Anna Catania, and Gregorio Caimi 30


BM 17.0744: A Structurally New Antidiabetic Compound With Insulin-Sensitizing and Lipid-Lowering Activity
Johannes Pill and Hans-Frieder KUhnle 34


lmrnunoblockade of Endogenous Glucagon-Like Peptide-I by Monoclonal Antibodies in Conscious Rats:
Effect on the Insulin Response to Intragastric Glucose
Jozefvan Delft, Otto Vttenthal, Claus Koch, and Margarita Ghiglione 41


Randomized Crossover Study ofGemfibrozil Versus Lovastatin in Familial Combined Hyperlipidemia: Additive
Effects of Combination Treatment on Lipid Regulation
Daniel Zambdn, Emilia Ros, CaminoRodriguez.-Villar, Juan Curios Luguna, Manuel Vaz.quez., Carolina Sanllehy,
Elena Casals, Josep M. Sol, and Gonzalo Hernandez. 47


Stiffness of the Aortic Wall in Hypercholesterolemic Children
Arcangelo lannuzzi, Paolo Rubba, Paolo Pauciullo, Egidio Celentano, Guglielmo Capano, Renata Sartorio,
Michele Mercuri, and M, Gene Bond 55

Interrelationships Between Postprandial Lipoprotein B:CIII Particle Changes and High-Density Lipoprotein
Subpopulation Profiles in Mixed Hyperlipoproteinemia
YoussefSaidi, Didier Sich, Anne Camproux, Monique Egloff, Marie-Christine Federspiel, Valeric Gautier,
Alain Raisonnier, Gerard Turpin, and Isabel Beucler 60


Effet of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor on Sterol Absorption in
Hypercholesterolemic Subjects
Fady Y. Ntanios, Peter J.H. Jones, and Jiri J. Frohlich 68


Effect of Long-Term Valproic Acid Administration on the Efficiency of Carnitine Reabsorption in Humans
Diane D. Stadler, James F. Bale Jr, Catherine A. Chenard, and Charles J. Rebouche 74


Peripheral Tissue Glucose Uptake Is Not Reduced After an Oral Glucose Load in Southern Italian Subjects at Risk
of Developing Non-Insulin-Dependent Diabetes Mellitus
Anne W. Thorburn and Joseph Proietto 80


Vitamin E Status in Patients With Liver Cirrhosis: Normal or Deficient?
Markus P. Look, Christoph Reichel, Marcus van Falkenhausen, Corinna Holm, Klaus Stockinger,
Klaus von Bergmann, Govind S. Rao, Ulrich Spongier, and Tilman Sauerbruch 86


Regression and Progression of Cardiac Sympathetic Dysinnervation Complicating Diabetes: An Assessment by
C-11 Hydroxyephedrine and Positron Emission Tomography
Martin J. Stevens, David M. Raffel, Kevin C. Allman, Markus Schwaiger, and Donald M. Wieland 92


Effects of Starvation and Diabetes on the Metabolism of [2,3-913)C] Succinic Acid Dimethyl Ester in
Rat Hepatocytes
Laurence Ladriere, Francine Malaisse-Lagae, Ingrid Verb rug gen, Rudolph Willem, and Willy J. Malaisse 102


Hyperinsulinism and Sex Hormones in Young Adult African Americans
Bonita Falkner, Katherine Sherif, Anne Sumner, and Harvey Kushner 107


Elevated Serum Semicarbazide-Sensitive Amine Oxidase Activity in Non-Insulin-Dependent Diabetes Mellitus:
Correlation With Body Mass Index and Serum Triglyceride
Zsuzsa Meszaros, Tamas Szombathy, Laura Raimondi, lstvan Karadi, Laszlo Romics, and Kalman Magyar 113


Association Between Low-Density Lipoprotein Composition and Its Metabolism in Non-Insulin-Dependent
Diabetes Mellitus
Patrick Deegan, Daphne Owens, Patrick Collins, Alan Johnson, and Gerald H. Tornkin 118


Troglitazone and Vascular Reactivity: Role of Glucose and Calcium
Syed S. Ali, Robert C lgwe, Mary F. Walsh, and James R. Sowers 125


Lipid Abnormalities in Taiwan Aborigines With Gout
C - 7: Chou and P. -M. Chao 131


Glucagon-Like Peptide-I Has No Insulin-Like Effects in Insulin-Dependent Diabetic Dogs Maintained
Normoglycemic and Normoinsulinemic
E

Metabolism: Clinical and Experimental

Vol 48, No 3, March 1999

CONTENTS

Preliminary Report: Effects of the Menstrual Cycle on Excess Postexercise Oxygen Consumption in Healthy
Young Women
Tatslthiro Matsuo, Shinichi Saitoh, and Masasahige Suwki 275

Thermogenic Effect of Slight Hyperglycemia During a Lipid Infusion
V. Rigalleau, M. Beylot, M. Laville, C. Pachiaudi, S. Normand, E. Nlend, and H. Gin 278

Apolipoprotein E Affects Serial Changes in Total and Low-Density Lipoprotein Cholesterol in Adolescent Girls:
Project HeartBeat!
Janet E. Fulton, Shifan Dai, JoAnne Grunbaum, Eric Boenvinkle, and Darwin R. Luburthe 285

Intralipid Infusion Combined With Propranolol Administration Has Favorable Metabolic Effects in Elderly
Malnourished Cancer Patients

Antonio Gambardella, Rosa Tortoriello, Laura Pesce, Maria Rosaria TagUamonte, Ginseppe Poolisso,
and Michele Varricchio 291

Renin-Angiotensin-Aldosterone System in Primary Hyperparathyroidism Before and After Surgery
Giampaolo Bernini, Angelica Moretti, Simone Lon^i, Cino Bendinelli, Paulo Miccoli, and Antonio Salvetti 298

Differences in Postprandial Concentrations of Very-Low-Density Lipoprotein and Chylomicron Remnants
Between Normotriglyceridemic and Hypertriglyceridemic Men With and Without Coronary Heart Disease
Fredrik Karpe, Mai-Lis Hellenius, andAnders Hamsten 301

Gender Differences in the Response of Growth Hormone (GH)-Deficient Adults to GH Therapy
Frances J. Hayes, Tarek M. Fiad, and T. Joseph McKennu 308

High-Affinity Growth Hormone (GH)-Binding Protein (GHBP), Body Fat Mass, and Insulin-Like Growth
Factor-Binding Protein-3 Predict the GHBP Response to GH Therapy in Adult GH Deficiency Syndrome
Come A.M. Roelen, Hans P.F. Koppeschaar, Wouter R. de Vries, Manorath E. Doerga, Yvonne E.M. Snef, Eduard Bol,
Pierre M.J. ZeUssen, Jos H.H. Thijssen, andMarinus A. Blankenstein 314

Long-Term Exposure of Isolated Rat Islets of Langerhans to Supraphysiologic Glucose Concentrations Decreases
Insulin mRNA Levels
Isabetle Briaud, Christine Rouctult, Gerard Reach, and Vincent Poitout 319

Characteristics of Recovery From the Euthyroid Sick Syndrome Induced by Tumor Necrosis Factor Alpha
in Cancer Patients

R.A. Feelders, A.J.G. Swaak, J.A. Romijn, A.M.M. Eggermont, E.T. Tielens, G. Vreugdenhil, E. Endert,
H.G. van Eijk, and A. Berghout 324

Chronic Physiologic Hyperinsulinemia Impairs Suppression of Plasma Free Fatty Acids and Increases De Novo
Lipogenesis But Does Not Cause Dyslipidemia in Conscious Normal Rats
Sietse J. Koopmans, Rampratap S. Kushwaha, and Ralph A. DeFronw 330

Effect of Glucose on the Plasma Concentration and Urinary Excretion of Uridine and Purine Bases
Tetsuya Yamamoto, Yuji Moriwaki, Surnio Takahashi, Zenta Tsutsumi, Jun-ichi Yamakita,
Takashi Nakano, and Kazuya Higashino 338

Corticotropin-induced Reduction of Plasma Lipoprotein(a) Concentrations in Healthy Individuals and
Hemodialysis Patients: Relation to Apoliprotein(a) Size Polymorphism

MargretArnadottir, Anna-Lena Berg, Florian Kronenberg, Arno Lingenhel, Therese Hugosson, Jorgen Hegbrant,
and Peter Nilsson-Ehle 342

Metabolic Abnormalities in the Genetically Obese and Diabetic Otsuka Long-Evans Tokushima Fatty Rat Can Be
Prevented and Reversed by 2-Glucosidase Inhibitor

Mitsuyoshi Yamamoto, Dong Mei Jia, Ken-lchiro Ftthuinitsn, Issei Imoto, Yasayuki Kihara.
Yosihide Hirohata, and Makoto Otsuki 347

(Continued on following page)


Relationship of Visceral Adipose Tissue to Metabolic Risk Factors for Coronary Heart Disease: Is There a
Contribution of Subcutaneous Fat Cell Hypertrophy?
P. Imbeault, S. Lemieux, D. Prud'homme, A. Tremblay, A. Nadeau, J.-P. Despres, and P. Mauriege 355

Campestanol (24-methyl-5a-cholestan-3313-ol) Absorption and Distribution in New Zealand White Rabbits: Effect
of Dietary Sitostanol
Guorong Xu, Gerald Salen, G.S. Tint, A.K. Batta, and Sarah Shefer 363

Urinary Excretion ofApoliprotein(a) Fragments in Type I Diabetes Mellitus Patients
M. Clodi, R. Oberbauer, G. Bodlaj, J. Hofinann, G. Maurer, and K. Kostner 369

Does Paracentesis ofAscites Influence Measurements of Bone Mineral or Body Composition by Dual-Energy
X-Ray Absorptiometry?
Kent Valentin Haderslev, Ole Lander Svendensen, and Michael Staun 373

Age-Related Changes in Sex Hormones Affect the Sex Difference in Serum Leptin Independently of Changes
in Body Fat
Richard N. Baumgartner, Debra L. Waters, John E. Morley, P. Patrick, George D. Montoya, and Philip J. Carry 378

Improved Glucose Tolerance in Rats Treated With the Dipeptidyl Peptidase IV (CD26) Inhibitor lle-Thiazolidide
Robert P. Pauly, Hans-UlrichDemuth, FredRonche, Jorn Schmidt, Heather A. White, Francis Lynn,
Christopher H.S. Mcintosh, and Raymond A. Pederson 385

Reduced Cortisol Potentiates the Exercise-Induced Increase in Corticotropin to a Greater Extent in Trained
Compared With Untrained Men

Pedro Del Corral, Renan Sampedro, Mike Hartsell, Edward T. Howley, Mary Sue Younger, Muhammad Ashraf,
Hugo Eiler, Bill Law Jr, and Dixie L. Thompson 390

Hypothalamic-Pituitary-Adrenal Axis and Sympathetic Nervous System Activities in Pima Indians and Caucasians
P. Antonio Tataranni, Giovanni Cizza, Soren Snitker, Frank Gucciardo, Angela Lotsikas,
George P. Chrousos, and Eric Ravussin 395

Biliary Cholesterol and Bile Acid Excretion Do Not Increase in Hamsters Fed Cereal-Based Diets
Containing Cholesterol
Guowen Cai and Timothy P. Carr 400

The Blood Vessel, Linchpin of Diabetic Lesions
Gerard E. Plante, Jude Alfred, arid Mouna Chakir 406

Announcement 410

Metabolism
Vol. 48, No. 4, April 1999

CONTENTS

Preliminary Report: Effect ofMasoprocol on Glucose Transport and Lipolysis by Isolated Rat Adipocytes
May a S. Go\vri, Gerald M. Reaven, and Salmon Azhar 411



Free Cholesterol Deposition in the Cornea of Human Apolipoprotein A-ll Transgenic Mice With Functional
Lecithin.'Cholesterol Acyltransferase Deficiency
Josep Julve-Gil, Elena Ruiz-Perez., Ricardo P. Casaroli-Marano, Africa Marzall-Casacuberta,
Joan Carles Escola-Gil, Francesc Gonzalez-Sastre, and Francisco Blanco-Vaca 415



Regulation of Brain Glucose Transporters by Glucose and Oxygen Deprivation
Brian A. Bruckner, Chandramohan V, Ammini, Marissa P. Otal, Mohan K. Raiwda, and Peter W. Stacpoole 422



Adenosine Triphosphate-Sensitive Potassium Channels Are Involved in Insulin-Mediated Glucose Transport
in Humans
Taro Wasada, Chizuru Watanabe, Tomoko Nakagami, and Yasuhiko lwamoto 432



Elevated Serum Levels of Tumor Necrosis Factor Alpha in Normal-Weight Women With Polycystic
Ovary Syndrome
Frank Gonzalez., Kuldip Thusu, EhadAbdel-Rahman, Ami Prabhala, Madonna Tomani, and Paresh Dandona 437



Nerve Conduction andAntioxidant Levels in Experimentally Diabetic Rats; Effects of Streptozotocin Dose
and Diabetes Duration
P. Sytze Van Dam, B. Sweder VanAsbeck, Bert Bravenboer, Johannes F.L.M. Van Oirschot, Joannes J.M. Marx,
and Willem Hendrik Gispen 442



Differences in Amyloid Deposition in Islets of Transgenic Mice Expressing Human Islet Amyloid Polypeptide
Versus Human Islets Implanted Into Nude Mice
Gunilla Westermark, Per Westermark, Decio L. EUirik, Claes Hellerstrom, Niles Fox, Donald F. Steiner,
and A me Andersson 448



Effects of Dietary Fatty Acids on Lipid Metabolism in Streptozotocin-induced Diabetic Rats
M.D. Giron, F. Sanchez P. Hortelano, J.L. Periago, andM,D. Suarez 455



Epinephrine Stimulates Human Muscle Lipoprotein Lipase Activity In Vivo
Steen B. Pedersen, Jens F. Bah, Palle Hoick, Ole Schmin, and Bjorn Richelsen 461



Exogenous Hyperinsulinemia Causes Insulin Resistance, Hyperendothelinemia, and Subsequent Hypertension
in Rats
Chi-Chang Juan, Victor S. Fang, Ching-Fai Kwok, Jing-Cheng Perng, You-Chung Chou, and Low-Tone Ho 465



Effects ofHypoosmolality on Whole-Body Lipolysis in Man
Stefan Bilz., Ronald Ninnis, and Ulrich Keller 472



Changes in Islet Capillary Angioarchitecture Coincide With Impaired B-Cell Function But Not With Insulin
Resistance in Male Otsuka-Long-Evans-Tokushima Fatty Rats: Dimorphism of the Diabetic Phenotype
at an Advanced Age
Akira MUuno, Yoshihiko Noma, Masamichi Kuwajima, Takashi Murakami, Min Zhu, and Kenji Shima 477



Altered Purine and Glycogen Metabolism in Skeletal Muscle During Exercise in Patients With Heart Failure
Toru Kinugawa, Kazukide Ogino, Masahiko Kato, Tatsuo Kato, Shuichi Osaki, Akihiro Endo, Osamu Igawa,
Ichiro Hisatome, Chiaki Shigemasa, and Edward W. Holmes 484



Effects of Soybean Protein and Very Low Dietary Cholesterol on Serum Lipids, Biliary Lipids, and Fecal Sterols
in Humans
William C. Duane 489
Acute Effects ofAdrenergic-Mediated Ischemia on Nerve Conduction in Subjects With Type 2 Diabetes
Robert V. Hogikyan, John J. Wald, Eva L. Feldman, Douglas A. Greene, Jeffrey B. Halter, and Mark A. Supiano 495



Changes in Thryoid Function Tests During Short-Term Salsalate Use
Robert J. McConnell 501



Lipoic Acid Acutely Induces Hypoglycemia in Fasting Nondiabetic and Diabetic Rats
Mogher Khamaisi, AssafRudich, Ruth Potashnik, Hans J. Tritschler, Alisa Gutman, and Nava Bashan 504



Metformin-induced Resumption of Normal Menses in 39 of 43 (91%) Previously Amenorrheic Women
With the Polycystic Ovary Syndrome
C.J. Glueck, Ping Wang, Robert Fontaine, Trent Tracy, and Luann Sieve-Smith 511



Effects of Fructose and Xylitol on the Urinary Excretion ofAdenosine, Undine, and Purine Bases
Tetsuya Yamamoto, Yuji Moriwaki, Surnio Takahashi, Zenta Tsutsumi, Jun-ichi Yamakita, and Kazuya Higashino 520



Growth Hormone (GH) Response to GH-Releasing Peptide-6 and GH-Releasing Hormone in Normal-Weight
and Overweight Patients With Non-Insulin-Dependent Diabetes Mellitus
D. Micic, Dj. Macut, V. Popovic, A. KendereSki, M. Sumarac-Dumanovid, S. Zoric, C. Dieguez, and F.F. Casanueva 525



Low-Density Lipoprotein Particle Size and Coronary Artery Disease in a Childhood-Onset Type I
Diabetes Population
John R. Erbey, David Robbins, Kimberly K-Z. Forrest, and TrevorJ. Orchard 531



Age-Related Differences in Corticosterone Secretion in Female Rats
Ming-Jae Lo, Mei-Mei Kau, Jiann-Jong Chen, Jiun-Ylh Yeh, Ho Lin, Shyi-Wu Wang, and Paulas S, Wang 535

Metabolism
Vol 48, No 6, June 1999

CONTENTS

Preliminary Report serum Leptin Is Associat With Serum Uric Acid Concentration in human
Berild Fruehwald-Schulies, Athim Peters, wemer KeriL Juirgnn Beyer, and Andreas Pjurner 677

Preliminary Report: Functional and Molecular Expression of Intestinal Oligopeptide Transporter (Pept-I) After a
Brief Fast
Manikhavasagar Thamotharan, Shahab Z. Bawani, Xiaodong Zhou, and Siamak A. Adibi 681

Pitfalls in the Use of2-0ctynoic Acid as an In Vivo Model of Medium-Chain Acyl-Coenzyme A Dehydrogenase
Deficiency: Ketone Turnover and Metabolite Studies in the Rat
Janice M. Fletcher and James J. Pitt 685


Inhibition by Retinoids ofBenzo(A)pyrene Metabolism Catalvzed by 3-Methhvlebolanthrene Induceed rat
Dong-Yang Huang, Taira Ohnishi, Houbo Juing, AizoFurukawa , and Yoshlyuki lchikawa 689

Role of Chloride and Inhibitory Action of Inorganic Nitrate on Gonadotropin-Stimulated Steroidogenesis in
Mouse Leydig Tumor Cells
N.S. Panesar 693

Glucose Tolerance and Insulin Resistance in the JCR:LA-Corpulent Rat: Effect ofMiglitol (Bay m 1099)
J. C. Russell, S.E. Graham, andP.J. Dolphin 701

4

Substrate Interactions in the Short- and Long-Term Regulation of Renal Glucose Oxidation
Mary C. Sugden, Mark J. Holness, Elaine Donald, and Harjinder Lall 707

Properties of Native and In Vitro Glycosylated Forms of the Glucagon-Like Peptide-I Receptor Antagonist
Exendin(9-39)
Janet A. Meurer, Jerry R. Colca, Philip S. Barton, andAke P. Elhammer 716

Synergistic Interaction of Magnesium and Vanadate on Glucose Metabolism in Diabetic Rats
Masafumi Matsuda, Lawrence Mandarine, and Ralph A. DeFronzo 725

Isotopic Enrichment of Amino Acids in Urine Following Oral Infusions ofL-[l-(13)C]Phenylalanine and
L-[l-(13)C]Lysine in Humans: Confounding Effect of D-[(13)C]Amino Acids
Pauline B. Darling, Rachelle Bross, Linda J. Wykes, Ronald 0. Ball, and Paul B. Pencharz 732

Effect of Reduced Inspired Oxygen on Fetal Growth and Maternal Glucose Metabolism in Rat Pregnancy
Firas Saker, Deepak M. Voora, Supriya D. Mahajan, Ilknur Kilig, Faramarz lsmail-Beigi, and Satish C. Kalhan 738

Leptin Serum Levels Are Not Correlated With Disease Activity in Patients With Rheumatoid Arthritis
Hans-Joachim Anders, Markus Rilll, Armin Heuf elder, Oliver Loch, and Manfred Schattenkirchner 745

Black-White Differences in Postprandial Triglyceride Response and Postheparin Lipoprotein Lipase and Hepatic
Triglyceride Lipase Among Young Men

KarenE. Friday, SathanurR. Srinivasan,Abdalla Elkasabany, Caiping Dong, WendyA. 'Wattigney,
Edward Dalferes Jr, and Gerald S, Berenson 749

Effects of Different Insulin Infusion Rates on Heart Rate Variability in Lean and Obese Subjects
Giuseppe Paolisso, Daniela Manzella, Maria Rosaria Tagliamonte, Maria Rosaria Rizzo, Antonio Gambardella,
and Michele Varricchio 755

Growth Hormone Corrects Acidosis-induced Renal Nitrogen Wasting and Renal Phosphate Depletion and
Attenuates Renal Magnesium Wasting in Humans
Katia Mahlbacher, Anita Sicuro, Hans Gerber, Henry N. Halter, and Reto Krapf 763

Elevated Atrial Natriuretic Peptides and Early Renal Failure in Type 2 Diabetic Goto-Kakizaki Rats
D.L Vesely, W.R. GowerJr, J.R. Dietz R.M, Overton, L.C. dark, E.K. Antwi, andR.V Farese 771




Leukocyte Glycolysis and Lactate Output in Animal Sepsis and Ex Vivo Human Blood
Philip G. Haji-Michael, Laurence Ladriere, Abdullah Sener, Jean-Louis Vincent, and Willy J. Malaisse 779

15-Deoxy-Adelta (12 14) Prostaglandin J2: A Putative Endogenous Promoter ofAdipogenesis Suppresses the ob Gene
Dipali Sinha, Sankar Addya, Erik Murer, and Guenther Boden 786

Short-Term Glucocorticoid Adnunistration Decreases Both Hypothalamic and Pituitary Galanin Synthesis in the
Adult Male Rat
Rebecca S. Brogan, LisaK. Coney, William B. Wehrenherg, Gianlorenw Beretta, andAndrea Giustina 792

Chronic Ethanol Consumption Leads to Destabilization of Rat Liver 3-Galactoside «2,6-Sialyltransferase mRNA
Manjunatti N. Rao and M.R. Lakshman 797

Effects of Cigarette Smoking and Its Cessation on Body Weight and Plasma Leptin Levels
Barbara J. Nicklas, Naomi Tomoyasn, Joanne Muir, and Andrew P. Goldberg 804

Combined Effect of Vegetable Protein (soy) and Soluble Fiber Added to a Standard Cholesterol-Lowering Diet
David J .A. Jenkins, Cyril W,C. Kendall, Christine C. MellUng, Tina Parker, A. Venket Rao, SanjivAgarwal,
Renato Novokmet, Peter J.H. Jones, Mallmoud Raeini, Jon A. Story, Emily Furumoto, Edward Vldgen,
Larry C. Griffin, Stephen C. Cunnane, Mary Ann Ryan, and Philip W. Connelly 809

Metabolism()Clinical and Experimental

Vol 48, No 2, February 1999



Glycation of High-Density Lipoprotein Does Not Increase Its Susceptibility to Oxidation or Diminish Its
Cholesterol Efflux Capacity
David L. Rashduni, Vincent A. Rifici, Stephen H. Schneider, andAvedis K. Khachadurian 139

Hormonal Influences on Tryptophan Binding to Rat Hepatic Nuclei
Herschel Sidransky and Ethel Verney 144

Increased Dependence of Glucose Production on Peripheral Insulin in Diabetic Depancreatized Dogs
Adria Giacca, Richard McCall, Bernie Chan, and Zhi Qing Shi 153

Effect ofAmino Acids and Glucose on Exercise-Induced Gut and Skeletal Muscle Proteolysis in Dogs
Koichiro Hamada, Keitaro Matsumoto, Koji Okamura, Tatsuya Dot, Kaori Minehira, and Seiichi Shimiw 161

Impact of Insulin and Body Mass Index on Metabolic and Endocrine Variables in Polycystic Ovary Syndrome
Mario Ciampelli, Anna Maria Fulghesa, Francesco Cucinelli, Virginia Pavone, Elio Ronsisvalle, Maurmo Guido,
Alessandro Caruso, and Antonio Lan^one 167

Analysis ofTrinucleotide-Repeat Combination Polymorphism at the rod Gene in Patients With Type 2
Diabetes Mellitus
Xiaohong Yuan, Kentaro Yamada, Satomi Ishiyama-Shigemoto, Wasaku Koyama, and Kyohei Nonaka 173

Nitric Oxide Modulation of the Growth Hormone-Releasing Activity of Hexarelin in Young and Old Dogs
Antonello E. Rigamonti, Silvano G. Cella, Nicolette Marazzi, and Eugenio E. MiiUer 176

Predictors of Adipose Tissue Lipoprotein Lipase in Middle-Aged and Older Men: Relationship to Leptin
and Obesity, But Not Cardiovascular Fitness
Dora M. Berman, Ellen M. Rogus, M. Jan Busby-While head, Leslie 1. Kahel, and Andrew P. Goldberg 183

Is the L-Arginine-Nitric Oxide Pathway Involved in Endotoxemia-induced Muscular Hypercatabolism in Rats?
P. Pernet, C. Coudray-Lucas, J. Le Boucher, L. Schlegel, J. Giboudeau, L. Cynober, and C. Aussel 190

Insulin Sensitivity and Serum Triglyceride Level in Obese White and Black Women: Relationship to Visceral
and Truncal Subcutaneous Fat
Matthew A. Marcus, Laura Murphy, F. Xavier Pi-Sunyer, and J canine B. Alba 194

Cholesterol-Lowering Nature of Unsaturated Fat in Rats May Be Due to Its Inability to Increase Hepatic Iron
Meira Fields and Charles G. Lewis 200

Glycated Hemoglobin and Lipid Peroxidation in Erythrocytes of Diabetic Patients
Masayuki Inouye, Takaya Mio, and Kimiaki Sumino 205

Long-Term Effects of Recombinant Human Erythropoietin Therapy on Growth Hormone Secretion in Uremic
Patients Undergoing Peritoneal Dialysis
Juan J. Diez, Pedro Iglesias, Julia Sastre, AbelardoAguilera, Maria A. Bajo, Javier Mender Antonio Gomez. Pan,
and Rafael Selgas 210

Leptin in Women With Eating Disorders
Yoshikatsu Nakai, Seiji Hamagaki, Seika Kato, Yutaka Seino, Ryaro Takagi, and Fumihiko Kurimoto 217

Effects ofHyperprolactinemia on Calcitonin Secretion in Male Rats
Chien-Chen Lu, Shiow-Chwen Tsai, William J.S. Huang, Chin-Lin Tsai. and Paidus S. Wang 221

Effect of Gender Differences and Estrogen Replacement Therapy on Vascular Reactivity
Daniel Perregaux, Ajay Chaudhuri, Priya Mohanty, Lahna Bukhari, Michael F. Wilson, Bong-Hee Sung,
and Paresh Dandona 227

Effect of Simvastatin in Addition to Chenodeoxycholic Acid in Patients With Cerebrotendinous Xanthomatosis
And Verrips, Ron A. Wevers, Bavel G.M. Van Engelen, Antoine Keyner, Bert G. Wolthers, Frederik Barkbof,
Anton Stalenhoef, Ruard De Graaf, Fokje Janssen-Zijlstra, Alwin Van Spreeken, and Fans J.M. Gabreels 233

Decreased Blood Flow But Unaltered Insulin Sensitivity of Glucose Uptake in Skeletal Muscle
of Chronic Smokers
E.M. Ronnernaa, T. Ronnernaa, T. Utriainen, M. Raitakan, H. Laine. T. Takala, O.-P. Pitkanen, 0. Kirvela,
J. Knuati, and P. Nuutila 239

The Reduction in Postprandial Lipemia After Exercise Is Independent of the Relative Contributions of Fat
and Carbohydrate to Energy Metabolism During Exercise
D. Malkova, A.E. Hardman, R.J. Bowness, and I.A. Macdonald 245

Long-Lasting Antidiabetic Effect of a Dipeptidyl Peptidase IV-Resistant Analog of Glucagon-Like Peptide-I
Remy Burcelin, Wanda Dolci, and Bernard Thorens 252

Hepatic and Gut Clearance of Catecholamines in the Conscious Dog
ChangAn Chu, Dana K. Sindelar, Doss W. Neal, andAlan D. Cherrington 259

Colonic Bacterial Activity and Serum Lipid Risk Factors for Cardiovascular Disease
David J.A. Jenkins, Vladimir Vaksan, A. Venketeshwer Rao, Edward Vidgen, Cyril W.C. Kendall, Nauman Tariq,
Pierre WUrsch, Brigitte Koellreutter, Nalini Shiwnarain, and Roger Jeffcoat 264

Folate Status, Homocysteine Metabolism, and Methylene Tetrahydrofolate Reductase Genotype in Rural South
African Blacks With a History of Pregnancy Complicated by Neural Tube Defects
Johan B. Ubbink, Arnold Christianson, Megan J. Bester, M argot 1. Van Alien, Philip A. Venter, Rhena Delport,
Henk J. Blom, Annatjie van der Merw'e, Hendrik Potgieter, and W.J. Hayward Vermaak 269

Metabolism
Clinical and Experimental


Vol 48, No 7, July 1999


CONTENTS


Alterations in the Activity of Several Glycohydrolases in Red Blood Cell Membrane From Type 2 Diabetes
Mellitus Patients

Giancarlo Goi, Chiara Bairati, Giovanni Segalini, Alberto B. Burlino, Luca Massaccesi, Augusto Lovagnini,
and Adriana Lombardo 817


Lipoprotein Response to a National Cholesterol Education Program Step II Diet With and Without
Energy Restriction
Mary M. Flynn, Joseph M. Zmuda, Dragana Milosavljevic, Marjorie J. Caldwell, and Peter N. Herbert 822


2-Chloroadenosine Reverses Hyperglycernia-induced Inhibition ofPhosphoinositide Synthesis in Cultured Human
Retinal Pigment Epithelial Cells and Prevents Reduced Nerve Conduction Velocity in Diabetic Rats
koichi Kato, Thommey P. Thomas, Martin J. Stevens, Douglas A. Greene. and Jiro Nakamura 827


Impact of Different Low-Density Lipoprotein (LDL) Receptor Mutations on the Ability ofLDL to Support
Lymphocyte Proliferation
Javier Martine^-Botas, Yajaira Suarez., Ayeleth Reshef, Pilar Carrero, Henar Ortega, Diego Gome'L-Coronado,
Jose Luis Teruel, Eran Leitersdorf, and MiguelA. Lasuncion 834


Relationship Between Serum Leptin and the Insulin-Like Growth Factor-1 System in Humans
B.L. Gregoire Nyomba, Michelle Johnson, Lori Berard, and Liam J. Murphy 840


Production ofEndothelin by Cultured Human Endothelial Cells Following Exposure to Nicotine or Caffeine
William 0. Lee and Stephen M. Wright 845


Evaluation of Phenylalanine and Tyrosine Metabolism in Late Human Pregnancy
Paul G. Whittaker, Choy H. Lee, Brendan G. Cooper, and Roy Taylor 849


The Codon 64 Polymorphism of the ^-Adrenergic Receptor Gene Is Not Associated With Coronary Heart Disease
or Insulin Resistance in Nondiabetic Subjects and Non-Insulin-Dependent Diabetic Patients
Arto Pulkkinen, Anu Kareinan, Laura Saarinen, Sami Heikkinen, Seppo Lehto, and Markka Laakso 853


Basal Insulin Hypersecretion in Insulin-Resistant Zucker Diabetic and Zucker Fatty Rats: Role of Enhanced
Fuel Metabolism
Yun-Ping Zhou, Brian N. Cockburn, William Pugh, and Kenneth S. Polonsky 857


Insulin Activation of Pyruvate Dehydrogenase Complex Is Enhanced by Exercise Training
Naoya Nakai, Yu^o Sato, Yoshiharu Oshida, Noriaki Fujitsuka, Atsushi Yoshimura, and Yoshiharu Shimomura 865


A High-Trans Fatty Acid Diet and Insulin Sensitivity in Young Healthy Women
Anne M. Louheranta, Anu K. Turpeinen, Helvi M. Vidgren, Ursula S. Sch\vab, and Matti 1.J. Unsitupa 870


GLUT3 Protein and mRNA in Autopsy Muscle Specimens
Charles A. Stuart, Gary Wen, andJieJiang 876


Low-Density Lipoprotein (LDL) Oxidizability Before and After LDL Apheresis
Markus G. Donner, Klaus G. Parhofer, Werner 0. Richter, and Peter Schwandt 881


Effects of Acute Euglycemic Hyperinsulinemia on Urinary Nitrite/Nitrate Excretion and Plasma Endothelin-1
Levels in Men With Essential Hypertension and Normotensive Controls
Andr^ej Surdacki, Michal Nowicki, Joerg Sandmann, Dimilrios Tsikas, Olga Krus7.elnicka-Kwiatkowska,
Francis^ekKokot, JacekS. Dubiel, andJuergen C. Froelich 887


Evidence of a State of Increased Insulin Resistance in Preeclampsia
Risto Kaaja, Hannele Laivuori, Markku Laakso, Matti J. Tikkanen, and Olavi Ylikorkala 892


Effects ofGliclazide Versus Metformin on the Clinical Profile and Lipid Peroxidation Markers in Type 2 Diabetes
Daniel Tessier, Pierre Maheux, Abdelouahed KhalU, and Tamas Fiilop 897

(Continued on following page)

(Contents continued)


Protective Effect of an Aldose Reductase Inhibitor Against Bone Loss in Galactose-Fed Rats: Possible
Involvement of the Polyol Pathway in Bone Metabolism
Masaaki Inaba, Makoto Terada, Yoshiki Nishiwwa, Atsushi Shioi, Eiji Ishimura, Shuzo Otani, and Hirotoshi Morii 904


Impact of Acute Epinephrine Removal on Hepatic Glucose Metabolism During Stress Hormone Infusion
Owen P. McGllinness, Robert T. Snowden, Christopher Moran, Doss W. Neal, Toshiko Fujiwara,
and Man D. Cherrington 910


Splanchnic Utilization of Enteral Alanine in Humans
Alberto Batte^ati, Michael Haisch, David J. Brillon, and Dwight E. Matthews 915


The Value of Combined Radionuclide and Magnetic Resonance Imaging in the Diagnosis and Conservative
Management of Minimal or Localized Osteomyelitis of the Foot in Diabetic Patients
Lydia Vesco, Hatem Boulahdour, Selim Hamissa, Sandrine Kret^, Jean-Lac Monta^el, Leon Perlemuter,
MichelMeignan, andAlainRahmouni 922


Temporal Association Between Obesity and Hyperinsulinemia in Children, Adolescents, and Young Adults:
The Bogalusa Heart Study
Sathanur R. Srinivasan, Leann Myers, and Gerald S. Berenson 928


The Amylin Analog Prami intide Improves Glycemic Control and Reduces Postprandial Glucagon Concentrations
in Patients With Type I Diabetes Mellitus
Birgit Nyholm, Lotte 0rskov, Karen Y. Hove, Claus H. Gravholt, Niels Miller, K. George M.M. Alberti, Chris Moyses,
Orville Kolterman, and Ole SchmiU 935
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