STATISTICS IN MEDICINE

VOLUME 18, No. 1, January 1999


A Unified Approach to the Analysis of Case-distribution (Case-only) Studies 1
S. Greenland


Describing Time and Age Variations in the Risk of Radiation-induced Solid Tumour 17
Incidence in the Japanese Atomic Bomb Survivors Using Generalized Relative and
Absolute Risk Models
M. P. Little, C R. Muirhead and M. W. Charles


Classifying Individuals Based on Predictors of Random Effects 35
R.H.LylesandlXu


A Markov Model for Measuring Vaccine Efficacy for Both Susceptibility to Infection and 53
Reduction in Infectiousness for Prophylactic HIV Vaccines
I. M. Longing Jr„ M, G. Hudgens, M. E, Halloran and K. Sagatelian


Monitoring Paired Binary Surgical Outcomes Using Cumulative Sum Charts 69
S. H. Sterner, R. J. Cook and V. T. Farewell


Sample Size Formula with a Continuous Outcome for Unequal Group Sizes and Unequal 87
Variances
H, J, A, Schouten


Sample Size Determination for Proving Equivalence Based on the Ratio of Two Means for 93
Normally Distributed Data
D. Hauschke, M, Kieser, E. Diletti and M. Burke

LETTERS TO THE EDITOR 107

_______________________________________

STATISTICS IN MEDICINE

VOL . 18, No. 2, January 1999

Applying Bayesian Ideas to the Development of Medical Guidelines 117
M.B. Landrum andS.-L T. Normand


Evaluation of the Bias in Using the Time to the First Event when the Inter-event Intervals 139
have a Weibull Distribution
M. S. Rose, A. M. Gillis and R, S. Sheldon



Estimation of Post-lead-time Survival Under Dependence Between Lead-time and Post- 155
lead-time Survival
J.'L Xu, R. M. Fagerstrom and P. C. Prorok


Estimating and Comparing Univariate Associations with Application to the Prediction of 163
AdultObesity
At. S, Pepe, R. C. Whitaker and K. Seidel


Two-state Mixed Renewal Processes for Chronic Disease 175
R. J. Cook E, T. M. Ng, J. Mukherjee and D. Vaughan .


Investigation of Excess Environmental Risk Around Putative Sources: Stone's Test with 189
Covariate Adjustment
T. Morton'J ones, P. Diggle and P. Elliott


A Regression Model for Multivariate Random Length Data 199
H. X. Bamhart, A. S, Kosinski and A, R. Sampson


Goodness-of-fit for GEE: An Example with Mental Health Service Utilization 213
N. J. Norton, J. D. Bebchuk, C. L. Jones, S. R. Lipsitt, P. J. Catalano, G. E. P. Zahner
and G. M. Fit^maurice


B Lymphocyte Migration to the Bone Marrow of Humans is not Random 223
M. S. May o, E. Paramithiotis and M. D. Cooper


LETTER TO THE EDITOR 233


BOOK REVIEW 239
A. V. Panfilov and A. V. Holden (eds). Computational Biology of the Heart

_______________________________________

STATISTICS IN MEDICINE

VOL 18, No. 3 , February 1999


Redesign of Trials Under Different Enrolment Mixes 241
C. L. Meinert


Commentary on ^Redesign of Trials Under Different Enrolment Mixes' by Curtis L. 253
Meinert
N. L Geller


Planning Group Sizes in Clinical Trials with a Continuous Outcome and Repeated 255
Measures
H. J. A. Schouten


Construction of Uniform-balanced Cross-over Designs for any Odd Number of Treatments 265
P. Prescott


Comparing Several Score Tests for Interval Censored Data 273
M.P. Fay


Criticism of a Hierarchical Model Using Bayes Factors 287
J. H. Albert


Semi-parametric Estimation of Age-Time Specific Infection Incidence from Serial 307
Prevalence Data
N. J. D. Nagelkerke, S. Heisterkamp, M, Borgdorff, J. Broekmans and
H, van Houwelingen


TUTORIAL IN BIOSTATISTICS 321
Meta-analysis: Formulating, Evaluating, Combining, and Reporting
S. -L T. Normand

LETTER TO THE EDITOR 361

_______________________________________

STATISTICS IN MEDICINE

VOLUME 18, No. 4, February 1999

0
An Issue of Statistical Analysis in Controlled Multi-centre Studies: How shall we Weight 365
the Centres?
Z. Lin


R2: A Useful Measure of Model Performance when Predicting a Dichotomous Outcome 375
A. Ash and M. Shwartz


Latent Variables, Measurement Error and Methods for Analysing Longitudinal Binary and 385
Ordinal Data
M. Palta and C.-Y. Lin


The Estimation of Lifetime Risk and Average Age at Onset of a Disease Using a 397
Multivariate Exponential Hazard Rate Model
G. E. Fraser and D. J. Shavlik


Potential for Bias in Estimating Human Fecundability Parameters: A Comparison of 411
Statistical Models
//. Zhou and C, R. Weinberg


A Multivariate Approach for Assessing Severity of Acute Graft-versus-host Disease in 423
Bone Marrow Transplantation
R. S. Parrish, L J. Haflett, K. D. Bridges and P. J. Henslee-Downey


Mixture Models for Cancer Survival Analysis: Application to Population-based Data with 441
Covariates
R. De Angelis, R. Capocaccia, T. Hakulinen, B. Soderman and A. Verdecchia


Probabilistic Analysis of Global Performances of Diagnostic Tests: Interpreting the Lorenz 455
Curve-based Summary Measures
W.-C. Lee


Using Missing Data Methods in Genetic Studies with Missing Mutation Status 473
T. Leong, S. R. LipsiU and J. G. lbrahim


STATISTICS IN THE MEDICAL LITERATURE: 3 487

BOOK REVIEWS 491
B. S. Everitt and S. Rabe-Hesketh, The Analysis of Proximity Data. Chap T, Le, Applied
Survival Analysis. David Machin, Michael J. Campbell, Peter M, Payers and Main P K
Pinol, Sample Size Tables for Clinical Studies. B. P. Butler, M. G. Cox, 5. L R. Ellison
and W. A. Hardcastle (eds). Statistics Software Qualification: Reference Data Sets.

_______________________________________

STATISTICS IN MEDICINE


VOL. 18, No. 5 , March 1999

Geographically Masking Health Data to Preserve Confidentiality 497
At. P. Armstrong, G. Rushton and D. L. Zimmerman


Estimating AIDS Incidence and Jack-knife Variance from a Continuous Delay Distribution 527
and Incomplete Data
J. Cui


Explaining Community-level Variance in Group Randomized Trials 539
Z. Feng, P. Diehr, Y. Yasui, B, Evans, S. Beresford and T. D. Koepsell


Methods for Combining Rates from Several Studies 557
X.-H, Zhou, E. J. Brifendine and M. B, Pritz


Estimation of the Average Correlation Coefficient for Stratified Bivariate Data 567
L M, Rubenstein and C. S. Davis


Bootstrap Approach for Constructing Confidence Intervals for Population Pharmacokinetic 581
Parameters. 1. A Use of Bootstrap Standard Error
A, Yafufle and M, Ishiguro


Bootstrap Approach for Constructing Confidence Intervals for Population Pharmacokinetic 601
Parameters. II. A Bootstrap Modification of Standard Two-stage (STS) Method for
Phase I Trial
A. Yafune and M. Ishiguro

Exact Simultaneous Confidence Bands for a Collection of Univariate Polynomials in 613
Regression Analysis
M, R. Kosorok and R. Qu


BOOK REVIEWS 621
G. Melvyn Howe, People, Environment, Disease and Death. Bart K. Holland, Probability
Without Equations - Concepts for Clinicians. Luigi Pace and Alessandra Salvan,
Principles of Statistical Inference from a Neo-Fisherian Perspective. A. A. Afifi and
V. Clark, Computer-aided Multivariate Analysis (3rd edn). B, C. Carlin and T, A. Louis,
Bayes and Empirical Bayes Methods for Data Analysis. Eleanor McFadden,
Management of Data in Clinical Trials. R. Todd Ogden, Essential Wavelets for
Statistical Applications and Data Analysis.

_______________________________________

_______________________________________

STATISTICS IN MEDICINE
VOL 18, No. 8, April 1999


Exact and Asymptotic Tests for Homogeneity in Several 2 x 2 Tables 893
I. M. Reis, K. F. Hirji and A. A. Afifi


Assessing Heterogeneity and Correlation of Paired Failure Times with the Bivariate Frailly 907
Model
X. Xue and Y. Din§


A Hierarchical Bayesian Approach to Age-specific Back-calculation of Cancer Incidence 919
Rates
M, Mezzetti and C. Robertson


Sample Allocation for Overlapping Domains in a Pliysician Survey willi a Limited 935
Population
A. M. Zaslavsky, T. V. Williams and P. D. Cleary


A Comparison of Mixed Effects Logistic Regression Models for Binary Response Data 947
with Two Nested Levels of Clustering
T. R. Ten Have, A. R. Kunselman and L Tran


Planning and Analysis of Repeated Measures at Key Time-points in Clinical Trials 961
Sponsored by Pharmaceutical Companies
W. J. Shih and H. Quan


A Visualization of Cross-over Data Using Linear Functions 975
W. E. Miller


Multivariate Non-parametric Methods for Mann-Whitney Statistics to Analyse Cross-over 989
Studies with Two Treatment Sequences
J.'W. Jung and G. G. Koch


BOOK REVIEWS 1019
T. W. Anderson and J, D. Finn, The New Statistical Analysis of Data. S. B. Gerber and
K. E. Voelkl, The SPSS Guide to the New Statistical Analysis of Data. Hans Riedwyl,
Lineare Regression und Verwandtes.

_______________________________________

STATISTICS IN MEDICINE
VOL 18, NO. 9 , May 1999


Multivariate Competing Risks 1023
J. Wohlfahrt, P. K. Andersen and M. Melbye


Is the AIDS Incubation Time Changing? A Back-calculation Approach 1031
S. Deuffic and D. Costagliola


Group Testing in Presence of Classification Errors 1049
D. Gupta and R. Malina


Adjusting for Measurement Error to Assess Health Effects of Variability in Biomarkers 1069
R, H. Lyles, A. Muno^ J. Xu, J, M. G. Taylor and J. S. Chmiel


Interval Estimation of the Common Odds Ratio from ^(2x2) Tables Under Cluster 1087
Sampling
M, D. Begg and K. S, Panageas


Dichotomization of Continuous Measurements Using Generalized Additive Modelling - 1101
Application in Predicting Intrapartum Caesarean Delivery
L K Hin, T. K, Lau, M. S. Rogers and A. M. Z Chang

A Transition Rate Model for First Admissions to Psychiatric Institutions 1111
A, J. Oldehinkel


Mixtures of Proportional Hazards Regression Models 1119
0. Rosen and M. Tanner


Comparing Treatment Variances in Repeated Measures Bioavailability Trials 1133
G. Jiang and S. K. Sarkar

LETTER TO THE EDITOR 1151

_______________________________________

STATISTICS IN MEDICINE
VOL 18, NO. 10, May 1999


Accrual Strategies for Phase I Trials with Delayed Patient Outcome 1155
P. F. Thall, I J. Lee, C.-H. Tseng and E. H. Estey


Comparing Two Prevalence Rates in a Two-phase Design Study 1171
X.-H. Zhoit, P. Castelluccio, S. L. Hui and C. A. Rodenberg


A Strategic View of Randomized Trial Design in Low-incidence Paediatric Cancer 1183
R. Sposto and D. 0. Stram


Exact Test Size and Power of a Gaussian Error Linear Model for an Internal Pilot Study 1199
C. S. Coffey and K. E. Mailer


Estimation and Comparison of Rates of Change in Longitudinal Studies with Informative 1215
Drop-outs
G. Touloumi, S. J. Pocock, A. G, Babiker and J. H. Darbyshire


Interval-censored Survival Data with Informative Examination Times: Parametric Models 1235
and Approximate Inference
C.P. Farrington and N. J. Gay


A Discriminant Analysis Extension to Mixed Models 1249
L. Tomasko, R. W. Helms and S. M. Snapinn


Joint Effects on Cancer Risk of Age at Childbirth, Time Since Birth and Attained Age: 1261
Circumventing the Problem of Collinearity
G. Albrektsen, /. Heuch and G, Kvale



Process Control Procedures to Augment Quality Control of Leukocyte-reduced Red Blood 1279
Cell Products
S, J. Finch, J. B, Chen, C, H. Chen, M. M. Hail, V. Matkovich, B. Wenz H. Brandwein
andJ. Whitbread


BOOK REVIEW 1291
David Bowers, Statistics Further From Scratch: For Health Care Professionals.

CORRECTION 1293

_______________________________________

STATISTICS IN MEDICINE
VOL 18, NO. 11, JUNE 1999


EDITORIAL 1295

Interim Analyses with Delayed Observations in Clinical Trials 1297
S. C. Choi and K J. Lee

Adaptive Design Improvements in the Continual Reassessment Method for Phase I Studies 1307
J.M.Heyd and B. P. Carlin


Optimal Multi-stage Designs for a Phase II Trial that Permits One Dose Escalation 1323
J. J. Hanfelt


Combining Mortality and Longitudinal Measures in Clinical Trials 1341
D. M. Finkelstein and D. A. Schoenfeld


A Bayesian Approach to Modelling the Natural History of a Chronic Condition from 1355
Observations with Intervention
B. A, Crqig, D. G. Fryback, R. Klein and B. E, K. Klein


A Simple Method for Analysing Overdispersion in Clustered Poisson Data 1373
J. N. K. Rao and A. J. Scott


Use of the Mann-Whitney U-test for Clustered Data 1387
B. Rosner and D. Grove


The Minimum Sum of Absolute Errors Regression: A Robust Alternative to the Least 1401
Squares Regression
S, C Narula, P. H. N. Saldiva, C. D. S. Andre, S. N. Elian, A. F. Ferreira and
V. Capelozzi


Testing Proportionality in the Proportional Odds Model Fitted with GEE 1419
T. R. Stiger, H. X. Bamhart and J. M. Williamson


_______________________________________

STATISTICS IN MEDICINE
VOL 18, No. 12, June 1999


Conditional Inference for Predictive Agreement 1435
V. T. Farewell and D, A. Sprott


Comparisons of Measures of Interclass Correlations: the General Case of Unequal Group 1451
Size
L. Perisic and B. Rosner


Selection Bias and Treatment Heterogeneity in Clinical Trials 1467
N. T. Longford


Sample Size Determination for Multiple Comparison Studies Treating Confidence Interval 1475
Width as Random
Z. Pan and L L Kupper


Testing for Centre Effects in Multi-centre Survival Studies: A Monte Carlo Comparison of 1489
Fixed and Random Effects Tests
P. K. Anderson, J. P. Klein and M.-J, Zhang


A Comparison of Some Simple Methods to Identify Geographical Areas with Excess 1501
Incidence o^a Rare Disease such as Childhood Leukaemia
N. R. Wray, F. E. Alexander, C R, Muirhead, E. Pukkala, L Schmidtmann and C Stiller


A Frailty Approach for Modelling Diseases with Variable Age of Onset in Families: The 1517
NHLBI Family Heart Study
K. D. Siegmundt A, A. Todorov and M. A, Province


Modelling Covariate Adjusted Mortality Relative to a Standard Population 1529
P. K. Andersen, M. M. Horowitz, J. P. Klein, G. Socie, J. V. Stone andM.-J, Zhang


Estimation of Mean Quality Adjusted Survival Time 1541
L. Z. Shen, E. Pulkstenis and M. Hoseyni


On Bayesian Calculations for Mixture Likelihoods and Priors 1555
R. E. Weiss, M. Cho and M. Yanuzii


BOOK REVIEWS 1571
Geoffrey M. Maruyama, Basics of Structural Equation Modeling. Anders Hald, A
History of Mathematical Statistics from 1750 to 1930.

STATISTICS IN MEDICINE
VOL 18, No. 13 , July 1999


Estimating the Sample Size for a r-test using an Internal Pilot 1575
J. S. Denne and C. Jennison


Analysing Repeated Measurements Data: A Practical Comparison of Methods 1587
R.Z. Omar, E. M. Wright, R. M. Turner and S. G. Thompson


Case-control Isotonic Regression for Investigation of Elevation in Risk Around a Point 1605
Source
P. Diggle, S. Morris and T. Morton-Jones


A Threshold Causal Model for Clinical Trials with Departures from Intended Treatment 1615
J.M.Albert


Monte Carlo Estimation of Extrapolation of Quality-adjusted Survival for Follow-up 1627
Studies
J.S.HwangandJ.-D. Wang


A Test to Detect Replication in HIVSerological Data Labelled by Birth Date Based on the 1641
Number of Matching Pairs in a Sample
D. Greenhalgh andM. T. Doyle


Use of Hierarchical Models for Meta-analysis: Experience in the Metabolic Ward Studies 1657
of Diet and Blood Cholesterol
C. Frost, R. Clarke and H. Beacon


The Analysis of a Bivariate Multi-state Markov Transition Model for Rheumatoid Arthritis 1677
with an Incomplete Disease History
P. J. Young, S. Weeden and J. R. Kirwan


Reporting Delay and Corrected Incidence of Multiple Sclerosis 1691
S. Esbjerg, N. Keiding and N. Koch-Henriksen


TUTORIAL IN BIOSTATISTICS 1707
Longitudinal Data Analysis (Repeated Measures) in Clinical Trials
P. S. Albert

LETTERS TO THE EDITOR 1733

_______________________________________

STATISTICS IN MEDICINE
VOL. 18, NO. 14, JULY 1999


CONTENTS

Preface 1739

Scientific and Organising Committees . 1740
Optimizing the Design of Clinical Trials

Optimum Biased-coin Designs for Sequential Treatment Allocation with Covariate 1741
Information
A. C. Atkinson

Discussion 1753

Bootstrap Methods for Adaptive Designs 1757
W. F, Rosenberger and F. Hu

Optimization of Testing Times and Critical Values in Sequential Equivalence Testing 1769
H.H. Müller and H. Schäfer

Discussion 1789

unobserved Covariates in the Two-sample Comparison of Survival Times: A Maximum 1791
Efficiency Robust Test
P. Broet. T. Moreau, J. Lellouch and B. Asselain

Discussion 1801
Optimizing the Analysis of Clinical Trials

Visit-driven Endpoints in Randomized HIV/AIDS Clinical Trials: Impact of Missing Data 1803
on Treatment Difference Measured on Summary Statistics
E. Le Corfec, S. Chevret and D. Costagliola

Discussion 1819

Estimation of the Treatment Effect in a Clinical Trial when Recurrent Events Define the 1821
Endpoint
C. Make and S. Chevret

Discussion 1831

Optimizing Drug Development Programmes

Combining Different Phases in the Development of Medical Treatments within a Single 1833
Trial
P. Bauer and M. Kieser


Continual Reassessment Methods in Phase I Trials of the Combination of Two Drugs in 1849
Oncology
A. Kramar, A. Lebecq and E. Candalh

A New Approach to Modelling the Relationship Between in Vitro and In Vivo Drug 1865
Dissolution / Absorption
A. Dunne, T. O'Hara andJ. Devane

Discussion 1877

Optimal Approaches for Marketed Drugs
Multivariate Outlier Detection Applied to Multiply Imputed Laboratory Data 1879
K, L Penny and l. T. Jolliffe

Discussion 1897

BOOK REVIEWS 1899
Thomas P. Hettmansperger and Joseph McKean, Robust Nonparametric Statistical
Methods. H. L, Koul and J. V. Deshpande (eds), Analysis of Censored Data.

_______________________________________

STATISTICS IN MEDICINE
VOL 18, No. 15, August 1999


Statistical Principles for Clinical Trials (ICH E9): An Introductory Note on an 1903
International Guideline
J. A, Lewis


Statistical Principles for Clinical Trials: ICH Harmonised Tripartite Guideline 1905
ICH E9 Expert Working Group


Using Missing Data Techniques to Explore the Lack of Survival Effect: Illustration with 1943
The CABG Patch Trial
J N. Rottman, B. Levin, M. C, Paik, W, K Tsai and J. T, Bigger, Jr.


Investigating Centre Effects in a Multi-centre Clinical Trial of Superficial Bladder Cancer 1961
T. Yamaguchi and K Ohashi


Simple Methods for Checking for Possible Errors in Reported Odds Ratios, Relative Risks 1973
and Confidence Intervals
P. N. Lee


A Bayesian Hierarchical Model for Multi-level Repeated Ordinal Data: Analysis of Oral 1983
Practice Examinations in a Large Anaesthesiology Training Programme
M. Tan, Y. Qu, E. Mascha and A. Schubert


Method of Medians for Lifetime Data with Weibull Models 1993
X He and W, K. Fung .


Bivariate Logistic Regression: Modelling the Association of Small for Gestational Age 2011
Births in Twin Gestations
C. V. Ananthand J. S. Preisser


On the Application of Integer-valued Time Series Models for the Analysis of Disease 2025
Incidence
M. Cardinal, R. Roy and J. Lambert


A Note on Interval Estimation of Kappa in a Series of 2x2 Tables 2041
K.-J.LuiandC.Kelly


Higher-moment Approaches to Approximate Interval Estimation for a Certain Intraclass 2051
Correlation Coefficient
K. H. Zou and M. P. McDermott


LETTER TO THE EDITOR 2063


_______________________________________

STATISTICS IN MEDICINE
VOL 18, No. 16, August 1999


Reasoning about Data with Directed Graphs 2067
D. Tritchler


A GEE Moving Average Analysis of the Relationship Between Air Pollution and 2077
Mortality for Asthma in Barcelona, Spain
M. Saez. A, Tobias, P. Muno^ and M. J. Campbell


I . Spatial Smoothing of Cancer Survival: A Bayesian Approach 2087
K. Osnes and 0, 0. Aalen


Estimation of the Direct and Indirect Effects of Vaccination 2101
M, Haber


An Approximate CUSUM Procedure for Surveillance of Health Events 2111
G. Rossit L. Lampugnani and M. Marchi


Analysis of Time-dependent Covariates in Failure Time Data 2123
U. Aydemir, S. Aydemir and P, Dirschedl


Modelling Study Quality in Meta-analysis 2135
D. Tritchler


A New Proposal to Adjust Moran's I for Population Density 2147
R. M. Assunqao and E. A. Reis


Adverse Effects of Chorionic Villus Sampling: A Meta-analysis 2163
B. A. Brumback, L B. Holmes and L. M. Ryan


The Impact of Measurement Error on the Comparison of Two Treatments Using a 2177
Responder Analysis
L. Oppenheimer and U. Kher


_______________________________________

STATISTICS IN MEDICINE
VOL. 18, NO. 17-18 September 1999


Preface 2189

Modelling Ordered Categorical Data: Recent Advances and Future Challenges 2191
A. Agresti


Some Practical Issues in Binary Data Analysis 2209
D. Collett and K. Stepniewska


A Review of Some Extensions to Generalized Linear Models 2223
J. K. Lindsey


Marginal Modelling of Multivariate Categorical Data 2237
G. Molenberghs and E. Lesaffre


Dispersion Models and Longitudinal Data Analysis 2257
B . J0rgensen and M. Tsao


A Unified Theory for Sequential Clinical Trials 2271
J. Whitehead


Group Sequential Analyses for the Mean Function of a Repeated Measure Process 2287
X. J. Hu and S. W. Lagakos


Emerging and Recurrent Issues in Drug Development 2301
C. Anello


Statistics versus Statistical Science in the Regulatory Process 2311
N. T. Longford and J. A. Nelder


Controversies About Sponsor Initiated Re-analyses of Clinical Trial Data in the Licensing 2321
Process
J. Rohmel



Diagnostic Statistical Procedures in Medical Meta-analyses 2331
I. Olkin


Meta-analysis by Random Effect Modelling in Generalized Linear Models 2343
M. Aitkin


Event History Analysis and Inference from Observational Epidemiology 2353
N. Keiding


State Duration Models in Clinical and Observational Studies 2365
J. F. Lawless and D. Y. T. Fong


Issues in the Statistical Analysis of Small Area Health Data 2377
J. Wakefleld and P. Elliott


Statistical Thinking in Functional and Structural Magnetic Resonance Neuroimaging 2401
N. Lange


Analysis of Recurrent Events: Application to a Clinical Trial of Colony Stimulating Factor 2409
with the Endpoint of Febrile Neutropenia
S. Matsui and K Ohashi


Ignorability and Bias in Clinical Trials 2421
D. F, Heitjan


Non-ignorable Missing Covariates in Generalized Linear Models 2435
S. R. Lipsitz, J. G. lbrahim, M-H. Chen and H. Peterson


Missing Data Perspectives of the Fluvoxamine Data Set: A Review 2449
G. Molenberghs, E. J. T. Goetghebeur, S. R. Lipsitz, M. G. Kenward, E. Lesaffre and
B. Michiels


On Summary Measures Analysis of the Linear Mixed Effects Model for Repeated 2465
Measures When Data are Not Missing Completely at Random
R. J, Little and T. Raghunathan


Multivariate Linear Mixed Models for Multiple Outcomes 2479
M, Sammel, X. Lin and L. Ryan


Innovations in Bayes and Empirical Bayes Methods: Estimating Parameters, Populations 2493
and Ranks
F. A. Louis and W. Shen


Sonic Adaptive Monte Carlo Methods for Bayesian Inference 2507
L. Tierney and A. Mira


On Non-parametric Maximum Likelihood Estimation of the Bivariate Survivor Function 2517
R. L. Prentice


Assessment and Comparison of Prognostic Classification Schemes for Survival Data 2529
E. Graf, C Schmoor, W. Sauerbrei and M. Schumacher


BOOK REVIEWS 2547
E, B. Andersen, Introduction to the Statistical Analysis of Categorical Data.
Stanfon A. Glantz, Primer of Biostatistics. GudmundR. lversen and Mary Gergen,
Statistics, the Conceptual Approach. E. Babbie and F, Halley, Adventures in Social
Research. Data Analysis Using SPSS for Windows.

_______________________________________