iii Editorial. Announcing the affiliation of the International Society for Vaccine,

99 Safety and immunogenicity of an inactivated subunit influenza virus vaccine
combined with MF59 adjuvant emulsion in elderly subjects, immunized for
three consecutive influenza seasons

201 Kinetics of formation of neutralizing antibodies against vaccinia virus followinc

301 Edward Jenner's Inquiry; a bicentenary analysis

VACCINE

VOL. 17, NO. 5, FEBRUARY 1999



Contents

Conference Report

403 The public understanding of vaccination
Ft. E. Spier

Papers

406 The serum albumin-binding region of streptococcal protein G (BB) potentiates the immunogenicity of the G 130-230 RSV-A
protein
C. Ubon, N. Corvaia, J.-F. Haeuw, T. N. Nguyen, S. Stahl, J.-Y. Bonnefoy and C. Andreoni


415 Attempt to modify the immune response developed against F.IV gp120 protein by preliminary FIV DNA injection
A. M. Cuisinier, A. Meyer, B. Chatrenet, A. S. Verdier and A. Aubert


426 The effect of smoking on influenza, influenza vaccination efficacy and on the antibody response to influenza vaccination
M. Cruijff, C. Thijs, T. Govaert, K. Aretz, G. J. Dinant and A. Knoftnerus


433 An experimental marker vaccine and accompanying serological diagnostic test both based on envelope glycoprotein E2 of
classical swine fever virus (CSFV)
P. A. van Ffijn, H. G. P. van Gennip and R. J. M. Moormann

441 Immunogenicity of Actinobacillus ApxIA toxin epitopes fused to the E. coli heat-labile enterotoxin B subunit
M. M. Bagdasarian, M. Nagai, J. Frey and M. Bagdasarian

448 A single dose of an effective whole cell pertussis vaccine does not significantly increase protection in children primed with a less
effective vaccine
M. Rochette, G. De Serres, P. Duclos, D. Bolduc, P. Jutras, S. Gamache, Y.-D. Gagnon and S. A. Halperin

454 Protection against experimental infection with group B streptococcus by immunization with a bivalent protein vaccine
C. Larsson, M. Stalhammar-Carlemalm and G. Lindahl

459 Vaccination of mice with DNA plasmids coding for the Chlamydia trachomatis major outer membrane protein elicits an immune
response but fails to protect against a genital challenge
S. Pal, K. M. Bamhart, Qun Wei, A. M. Abai, E. M. Peterson and L. M. de la Maza

466 A randomised, double-blind, controlled trial of a killed L. major vaccine plus BCG against zoonotic cutaneous leishmaniasis in
Iran
A. Z. Moment, T. Jalayer, M. Emamjomeh, A. Khamesipour, F. Zicker, P. L. Ghassemi, Y. Dowlati, 1. Sharifi, M. Aminjavaheri,
A. Shafiei, M. H. Alimohammadian, Ft. Hashemi-Fesharki, K. Nasseri, T. Godal, P. G. Smith and F. Modabber

473 DNA inoculations with HIV-1 recombinant genomes that express cytokine genes enhance HIV-1 specific immune responses
Ann Hwee Lee, You Suk Suh and Young Chul Sung

480 High susceptibility of Mongolian gerbil (Meriones unguiculatus) to Borna disease virus
Y. Nakamura, T. Nakaya, K. Hagiwara, N. Momiyama, Y. Kagawa, H. Taniyama, C. Ishihara, T. Sata, T. Kurata and K. lkuta

490 IL-6 induces long-term protective immunity against a lethal challenge of influenza virus
Seung Woo Lee, Jin Won Youn, Baik Lin Seong and Young Cfnif Snih)

497 Immunization with recombinant Semliki Forest vlius inducus piot^ctioii c^nii^t iiillli^iua ch<illoih)u (n mi^o
P. Berglund, M. N. Fleeton, C. Smerdou and P. Liljestrom

508 Letter to the Editor
D. R. Nalin

_______________________________________

VACCINE

VOL. 17, NO. 6, FEBRUARY 1999



Contents

Reply

511 Mumps component in combined measles, mumps, and rubella vaccines
G. Wandel


Papers

512 The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide
polymers and polyethylene glycol
E. C. Lavelle, M.-K. Yeh, A. G. A. Coombes and S. S. Davis

530 Measles immunity and vaccination policy in Catalonia
A. Dominguez, J. Vidal, P. Plans, G. Carmona, P. Godoy, J. Batalia and L. Salleras


535 Immunization with a LEAPS' heteroconjugate containing a CTL epitope and a peptide from beta-2-microglobulin elicits a
protective and DTH response to herpes simplex virus type 1
K. S. Rosenthal, H. Mao, W. 1. Home, C. Wright and D. Zimmerman

543 A comparative study of PENTA(TM) vaccine booster doses given at 12, 15 or 18 months of age
D. W. Scheifele, R. Guasparini and P. Lavigne

551 Efficacy of SAG-2 oral rabies vaccine in two species of jackal (Canis adustus and Canis mesomelas)
J. Bingham, C. L. Schumacher, F. W. G. Hill and A. Aubert

559 Infection, immunisation and atherosclerosis: is there a link?
D. J. Lamb and G. A. A. Ferns

565 An aerosol challenge model of Bordetella pertussis infection as a potential bioassay for acellular pertussis vaccines
D. K. L. Xing, P. G. Das, L. Williams, C. Canthaboo, J. Tremmil and M. J. Corbel

577 A peptide construct containing B-cell and T-cell epitopes from the foot-and-mouth disease viral VPi protein induces efficient
antiviral protection
0. M. Volpina, A. Yu. Surovoy, M. N. Zhmak, M. A. Kuprianova, D. 0. Koroev, A. V. Chepurkin, A. S. Toloknov and V. T. lvanov

585 Safety and immunogenicity of hepatitis A vaccine in infants: a candidate for inclusion in the childhood vaccination programme
M. Piazza, A. Safary, A. Vegnente, Fi. Soncini, P. Pensati, M. Sardo, Ft. Orlando, G. Tosone and L. Picciotto

589 Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime
T. Hanke, V. C. Neumann, T. J. Blanchard, P. Sweeney, A. V. S. Hill, G. L. Smith and A. McMichael

597 The use of Toxorhynchites splendens for identification and quantitation of serotypes contained in the tetravalent live attenuated
dengue vaccine
N. Jirakanj'anakit, M. M. Khin, S. Yoksan and N. Bhamarapravati

602 Hepatitis B vaccination in mentally retarded: Effectiveness after 11 years
A. Vellinga, P. Van Damme, J. J. Weyler, Ft. Vranckx and
A. Meheus


607 Induction of mucosal and systemic immune response by oral immunization with H. py/or/lysates encapsulated in poly(D,L-lactide-
co-glycolide) microparticles
S. Y. Kim, H. J. Doh, J. S. Ahn, Y. J. Ha, M. H. Jang, S. I. Chung and H. J. Park

_______________________________________

VACCINE
Volume 17 Number 9-10 5 March 1999

Contents.

Letters to the Editor
1015 Efficacy of Vi polysaccharide vaccine against Salmonella typhi
S. C. Arya

1016 Letter to the Editor
C. E. Hormaeche

Papers
1017 Humoral and cellular immunity induced by antigens adjuvanted with colloidal iron hydroxide
H. Leibi, Ft. Tomasits, P. Bruhl, A. Kerschbaum, M. M. Eibi and J. W. Mannhalter

1024 Effect of vaccination against Mycoplasma hyopneumoniae in pig herds with an all-in/all-out production system
D. Maes, H. Deluyker, M. Verdonck, F. Castryck, C. Miry, B. Vrijens, W. Verbeke, J. Viaene and A. de Kruif

1035 Enhanced immunogenicity of hepatitis B surface antigen by insertion of a helper T cell epitope from tetanus toxoid
M. V. Chengalvala, Ft. A. Bhat, B. M. Bhat, S. K. Vernon and M. D. Lubeck

1042 Recent immunization against measles does not interfere with the sero-response to yellow fever vaccine
/. Stefano, H. K. Sato, C. S. Pannuti, T. M. Ornoto, G. Mann, M. S. Freire, A. M. Y. Yamamura, P. F. C. Vasconcelos,
G: W. Oselka, L. W. Weckx, M. F. Salgado, L. F. 0. Noale and V. A. U. F. Souza

1047 MHC class I- and class ll-restricted processing and presentation of microencapsulated antigens
Y. Men, R. Audran, C. Thomasin, G. Eberi, S. Demotz, H. P. Me Me, B. Gander and G. Corradin

1057 Production of a highly immunogenic subunit ISCOM vaccine against Bovine Viral Diarrhea Virus
S. Kamstrup, L. Roensholt, M. H. Jensen and K. Dalsgaard

1065 Biodegradable microspheres containing influenza A vaccine: immune response in mice 
A. K. Hubert, U. Fritzsche and T. Kissel

1074 Mucosal and systemic immune responses induced after oral delivery of vaccinia virus recombinants
M. M. Gherardi and M. Esteban

1084 Randomised, controlled trial with the trypsin-modified inactivated poliovirus vaccine: assessment of intestinal immunity with live
challenge virus
L. Piirainen, M. Stenvik, M. Floivainen, J. Eskola, E. C. Beuvery and T. Hovi

1091 A novel immunization method to induce cytotoxic T-lymphocyte responses (CTL) against plasmid-encoded herpes simplex virus
type-1 glycoprotein D
P. E. Cruz, P. L. Khalil, T. D. Dryden, H. C. Chiou, P. S. Fink, S. J. Berberich and N. J. Bigley

1100 A live attenuated chimeric recombinant parainfluenza virus (PIV) encoding the internal proteins of PIV type 3 and the surface
glycoproteins of PIV type 1 induces complete resistance to PIV1 challenge and partial resistance to PIV3 challenge
T. Tao, M. H. Skiadopoulos, A. P. Durbin, F. Davoodi, P. L. Collins and B. P. Murphy

1109 Immunization of dogs and cats with a DNA vaccine against rabies virus
J. E. Osorio, C. C. Tomlinson, Ff. S. Frank, E. J. Haanes, K. Hush low, J. R. Haynes and D. T. Stinchcomb

1117 Cross-protective efficacy of a bovine viral diarrhea virus (BVDV) type 1 vaccine against BVDV type 2 challenge
H. J. Dean and Ft. Leyh

1125 Evaluation of a new recombinant DNA hepatitis B vaccine (Shanvac-B)
P. Abraham, F. P. Mistry, M. R. Bapat, G. Sharma, G. R. Fteddy, K. S. N. Prasad and V. Ftamanna

1130 Comparison between targeted and untargeted systemic immunizations with adjuvanted urease to cure Helicobacter pylori
infection in mice
B. Guy, C. Hessler, S. Fourage, B. Rokbi and M.-J. Quentin Millet

1136 Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony
stimulating factor gene in intramuscular DNA immunization
J. H. Cho, S. W. Lee and Y. C. Sung

1145 Defective immune response to tetanus toxoid in hemodialysis patients and its association with diphtheria vaccination
S. Kruger, M. Seyfarth, K. Sack and B. Kreft

1151 Expression, processing, and immunogenicity of the structural proteins of Venezuelan equine encephalitis virus from recombinant
baculovirus vectors
L. A. Hodgson, G. V. Ludwig and J. F. Smith

1161 Prevention of infection of influenza virus in DQ6 mice, a human model, by a peptide vaccine prepared according to the cassette
theory
N. Matsuki, K. Ogasawara, K. Takami, K. Namba, A. Takahashi, Y. Fukui, T. Sasazuki, K. lwabuchi, R. A. Good and K. Onoe

1169 Haemophifus influenzae type b conjugate vaccine stability: catalytic depolymerization of PRP in the presence of aluminum
hydroxide
A. W. Sturgess, K. Flush, R. J. Charbonneau, J. 1. Lee, D. J. West, R. D. Sitrin and J. P. Hennessey Jr.

1179 Evaluation of the stability and immunogenicity of autoclaved and nonautoclaved preparations of a vaccine against American
tegumentary leishmaniasis
P. M. De Luca, W. Mayrink, C. R. Alves, S. G. Coutinho, M. P. Oliveira, A. L. Bertho, V. P. Toledo, C. A. Costa, 0. Genaro and
S. C. F. Mendonqa

1186 Secondary vaccination with vaccinia virus recombinants: role of residual virulence of recombinants and immunogenicity of
extrinsic antigens
L. Kutinova, V. Ludvikova, S. Nemeckova, P. Hainz, V. Simonova and V. Vonka

1193 Activation of spleen lymphocytes by plasmid DNA
E. Yu. Rykova, P. P. Laktionov and V. V. Vlassov

1201 Pan DR binding sequence provides T-cell help for induction of protective antibodies against Plasmodium yoe///sporozoites
E. D. Franke, S. L. Hoffman, J. B. SacciJr., R. Wang, Y. Charoenvit, E. Appella, R. Chesnut, J. Alexander, M.-F. DelGuercioand
A. Sette

1206 Intra-nasal infection of macaques with Yellow Fever (YF) vaccine strain 17D: a novel and economical approach for YF
vaccination in man
M. Niedrig, N. Stolte, D. Fuchs, G. Hunsmann and C. Stahl-Hennig

1211 The business of science and the science of business in the quest for an AIDS vaccine
M. P. HHIeman

1223 A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF.
l. Vaccine characterization and efficacy studies in mice
l. Babai, S. Samira, Y. Barenholz, Z. Zakay-Rones and E. Kedar

1239 A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF.
II. Induction of TH1 and TH2 responses in mice
l. Babai, S. Samira, Y. Barenholz, Z. Zakay-Rones and E. Kedar

1251 Size fractionation of bacterial capsular polysaccharides for their use in conjugate vaccines
P. Costantino, F. Norelli, A. Giannozzi, S. D'Ascenzi, A. Bartoloni, S. Kaur, D. Tang, Ft. Seid, S. Viti, R Paffetti, M. Bigio,
C. Pennatini, G. Averani, V. Guarnieri, E. Gallo, N. Ravenscroft, C. Lazzeroni, R. Rappuoli and C. Ceccarini

1264 Vaccination of pigs against pseudorabies virus with plasmid DNA encoding glycoprotein D
B. L. Haagmans, E. M. A. van Rooij, M. Dubeiaar, T. G. Kimman, M. C. Horzinek, V. E. C. J. Schijns and A. T. J. Bianchi

1272 Construction and murine immunogenicity of recombinant Bacille Calmette Guerin vaccines expressing the B subunit of
Escherichia coli heat labile enterotoxin
C. M. M. Hayward, P. O'Gaora, D. B. Young, G. E. Griffin, J. Thole, T. Ft. Hirst, L. R. Ft. Castello'Branco and D. J. M. Lewis '

1282 The major Epstein-Barr virus (EBV) envelope glycoprotein gp340 when incorporated into Iscoms primes cytotoxic T-cell
responses directed against EBV lymphoblastoid cell lines
A. D. Wilson, K. Lovgren-Bengtsson, M. Villacres-Ericsson, B. Morein and A. J. Morgan

_______________________________

VACCINE

VOL. 17, NO. SUPPLEMENT 1, JULY 1999


Preface
S1 Adult immunization in Asia-Introduction
K.Mulholland


Introduction

S3 The global impact of influenza on morbidity and mortality
L. Simonsen


S11 The burden of pneumococcal disease among adults in developed and developing countries: what is and is not known
D. S. Fedson and J. A. G. Scott

Influenza

S19 Epidemiological data on influence in Asian countries
A. W. Hampson

S24 The importance of global surveillance of influenza
D. Lavanchy

S26 Poultry and the influenza H5N1 outbreak in Hong Kong, 1997: Abridged chronology and virus isolation
K. F. Shortridge

S30 Surveillance and impact of influenza in Europe
M. Ayrnard, M. Valette, B. Una, D. Thouvenot and the members of Groupe Regional d'Observation de la Grippe and European
Influenza Surveillance Scheme

S42 Surveillance and impact of influenza in the United States
A. Klirnov, L. Simonsen, K. Fukuda and N. Cox

S47 Complications of influenza and benefits of vaccination
K. L. Nichol

S53 Immunization against influenza in the elderly: the Argentinian experience, 1993-1997
D. Stamboulian, p. E. Bonvehi, F. M. Nacinovich and R. W. Ruttimann

S57 Assessment of effectiveness of Vaxigrip
H. Jianping, F. Xin, L. Changshun, Z Bo, G. Unxiu, X. Wei and S. Jiande


S59 Immunization against influenza among working adults: the Philippines experience
F. Ausseil

S63 Vaccination of the older adult: the Australian experience
A. W. Hampson

S67 Clinical effectiveness and cost effectiveness of influenza vaccination among healthy working adults
K. L. Nichol

Pneumococcus

S75 Epidemiological data on pneumococcal infections in Asian countries
F. Jamal

S79 Strategies for the control of pneumococcal diseases
K. Mulholland


S85 The clinical effectiveness of pneumococcal vaccination: a brief review
D. S. Fedson


S91 The additive benefits of influenza and pneumococcal vaccinations during influenza seasons among elderly persons with chronic
lung disease
K. L. Nichol

Public Health

S95 Considerations for adding pneumonia and influenza vaccines to public health programmes
M. A. Miller

S99 Private or national health insurance for adult vaccination in developed countries?
C. Hannoun

SI02 Importance of information for influenza control: the French experience
P. Saliou

SI05 Pneumococcal immunization and public health: the Canadian experience
J. S. Spika, D. Keresz, S. Deeks and J. A. Talbot

SI09 Summary and recommendations
Annex: Selected Country Reports

Influenza

S113 Influenza surveillance in Australia
A. W. Hampson

S115 Influenza surveillance in New Zealand
L. C. Jennings

Pneumococcus

S119 Pneumococcal infections in Victoria, Australia
G. Hogg and J. Strachan

SI22 Pneumococcal infections in New Zealand
0. Mansoor


_______________________________________

VACCINE

Volume 17, Number 23-24, August 1999


Contents


Short Communication

2941 Impaired antibody response after immunization of HIV-infected individuals with the polysaccharide vaccine against Salmonella
typhi (Typhim-VI^)
F. P. Kroon, J. T. van Dissel, E. Ravensbergen, P. H. Nibbering and R. van Furth

Papers

2946 Hepatitis B vaccination in infancy in The Gambia: protection against carriage at 9 years of age
S. Viviani, A. Jack, A. J. Hall, N. Maine, M. Mendy, Ft. Montesano and H. C. Whittle

2951 Neisseria meningitidis serogroup C polysaccharide and serogroUp B outer membrane vesicle conjugate as a bivalent
meningococcus vaccine candidate
L 0. Fukasawa, M. C. 0. Goria, R. P. F. Schenkman, L. R. Garcia, S. M. Cameiro, 1. Raw and M. M. Tanizaki

2959 Antigenic properties of the merozoite surface protein 1 gene of Plasmodium vivax
C. I. de Oliveira, G. Wunderlich, G. Levitus, I. S. Scares, M. M. Podrigues, M. Tsuji and H. A. del Portillo

2969 Potency test of inactivated Newcastle disease vaccines by monoclonal antibody blocking ELISA
E. Horvath, G. Czifra, E. Nagy, B. Engstrom and M. Merza

2974 Generation of antigen specific CD8^ cytotoxic T cells following immunization with soluble protein formulated with novel glycoside
adjuvants
N. A. Sheikh, P. Rajananthanan, G. S. Attard and W. J. W. Morrow

2983 Dose-dependent effects of IL-12 treatment to immune response induced after immunization with a recombinant respiratory
syncytial virus (RSV) fusion protein fragment
B. Werle, C. Fromantin, A. Alexandre, E. Kohli and P. Pothier

2991 Cytotoxic T lymphocytes to Ebola Zaire virus are induced in mice by immunization with liposomes containing lipid A
M. Rao, G. P. Matyas, F. Grieder, K. Anderson, P. B. Jahriing and C. Ft. Alving

2999 An acellular pertussis vaccine in healthy adults: safety and immunogenicity •
E. P. Ftothstein, Pennridge Pediatric Associates, E. L. Anderson, M. D. Docker, G. A. Poland, K. S. Reisinger, M. M. Blatter,
R. M. Jacobson,»C. M. Mink, D. Gennevois, A. E. lzu, F. Sinangil and A. G. M. Langenberg

3007 Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles
A. Frey, N. Mantis, P. A. Koziowski, A. J. Quayle, A. Bajardi, J. J. Perdomo, F. A. Robey and M. R. Neutra

3020 Development of biopharmaceuticals in plant expression systems: cloning, expression and immunological reactivity of human
cytomegalovirus glycoprotein B (UL55) in seeds of transgenic tobacco
E. S. Tackaberry, A. K. Dudani, F. Prior, M. Tocchi, R. Sardana, 1. Altosaar and P. R. Ganz

3030 Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines
J. Rice, C. A. King, M. B. Spellerberg, N. Fairweather and F. K. Stevenson

3039 Differentiation of convalescent animals from those vaccinated against foot-and-mouth disease by a peptide ELISA
F. Shen, P. D. Chen, A. M. Walfield, J. Ye, J. House, F. Brown and C. Y. Wang

3050 The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice:
characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3
adjuvant
E. Y. Enioutina, D. Visic, Z. A. McGee and R. A. Daynes


3065 Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys
T. R. Jones, N. Obaldia III, R. A. Gramzinski, Y. Charoenvit, N. Kolodny, S. Kitov, H. L. Davis, A. M. Krieg and S. L Hoffman

3072 Immunization of rhesus monkeys with a mucosal prime, parenteral boost strategy protects against infection with Helicobacter
pylori
C. K. Lee, K. Soike, P. Giannasca, J. Hill, P. Weltzin, H. Kleanthous, J. Blanchard and T. P. Monath


3083 Response to HBV vaccine in relation to anti-HCV and anti-HBc positivity: a study in intravenous drug addicts
F. Minniti, V. Baldo, P. Triveflo, R. Bricolo, L. Di Furia, G. Renzulli and M. Chiaramonte


3086 Immune response to revaccination with meningococcal A and C polysaccharides in Gambian children following repeated
immunisation during early childhood
J. MacLennan, S. Obaro, J. Decks, D. Williams, L. Pais, G. Carlone, R. Moxon and B. Greenwood

3094 Safety and immunogenicity of MF59-adjuvanted influenza vaccine in the elderly
S. De Donate, D. Granoff, M. Minutello, G. Lecchi, M. Faccini, M. Agnello, F. Senatore, P. Vervveij, B. Fritzell and A. Podda

3102 Oral immunisation of mice with live Japanese encephalitis virus induces a protective immune response
C. Fiamakrishna, A. Desai, S. K. Shankar, A. Chandrarnuki and V. Ravi


3109 Quantitative analysis of lgG class and subclass and IgA serum response to Shigella sonnei and Shigella flexneri2a
polysaccharides following vaccination with Shigella conjugate vaccines
G. Hobin, Y. Keisari, Ft. Slepon, S. Ashkenazi and D. Cohen


3116 Prior immunity to a carrier enhances antibody responses to hCG in recipients of an hCG-camer conjugate vaccine
S. Shah, R. Ftaghupathy, 0. Singh, G. P. Talwar and A. Sodhi


3124 Venezuelan equine encephalitis virus vectors expressing HIV-1 proteins: vector design strategies for improved vaccine efficacy
/. J. Caley, M. R. Betts, N. L. Davis, R. Swanstrom, J. A. Frelinger and R. E. Johnston

3136 Construction and immunogenicity of DNA vaccine plasmids encoding four Plasmodium vivax candidate vaccine antigens
W. 0. Rogers, K. Gowda and S. L. Hoffman

3145 Human phase I vaccine trials of 3 recombinant asexual stage malaria antigens with Montanide ISA720 adjuvant
A. Saul, G. Lawrence, A. Smillie, C. M. Ftzepczyk, C. Reed, D. Taylor, K. Anderson, A. Stowers, R. Kemp, A. AHworth,
R. F. Anders, G. V. Brown, D. Pye, P. Schoofs, D. 0. living, S. L. Dyer, G. C. Woodrow, W. R. S. Briggs, R. Reber and
D. Sturchler

3160 Characterization of the humoral and cellular immune responses against hepatitis C virus core induced by DNA-based
immunization
G.-J. Hu, R. Y-H. Wang, D.-S. Han, H. J. Alter and J. W.-K. Shih


3171 Immunity obtained by gene-gun inoculation of a rotavirus DNA vaccine to the abdominal epidermis or anorectal epithelium
S. C. Chen, E. F. Fynan, H. B. Greenberg and J. E. Herrmann

3177 Patent Report

3179 Erratum

3180 Announcement
Call for Papers

VACCINE

VOL. 18, NO. 1-2, AUGUST 1999


Contents

Letter to the Editor

1 Field evaluation of the clinical effectiveness of vaccines against pertussis, measles, rubella and mumps: comments
R. Menta

Papers

3 Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particles
D. Diminsky, N. Moav, M. Gorecki and Y. Barenholz

18 Enhancement of DNA vaccine potency using conventional aluminum adjuvants
J. B. Ulmer, C. M. DeWitt, M, Chastain, A. Friedman, J. J. Do^nelly, W. L. McClements, M. J. Caulfield, K. E. Bohannon,
D. B. Volkin and Ft. K. Evans

29 Immunization of mice with P6 of nontypeable Haemophilus influenzae'. kinetics of the antibody response and lgG subclasses
W. H. Badr, D. Loghmanee, R. J. Karalus, T. F. Murphy and Y. Thanavala

38 the role of cAMP in mucosal adjuvanticity of Escherichia coli heat-labile enterotoxin (LT)
& Cheng, L. Cardenas-Freytag and J. D. Clements

50 Delineation of a neutralizing subregion within the immunodominant epitope (GH loop) of foot-and-mouth disease virus which
does not contain the RGD motif
F. Brown, N. Benkirane, D. Umal, H. Halimi, J. F. E. Newman, M. H. V. Van Ftegenmortel, J.-P. Briand and S. Muller

57 Over a decade of experience with a yeast recombinant hepatitis B vaccine
S. Assad and A. Francis

68 Immunization with plasmid DNA encoding the envelope glycoprotein of Japanese Encephalitis virus confers significant
protection against intracerebral viral challenge without inducing detectable antiviral antibodies
M. S. Ashok and P. N. Rangarajan

76 Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination
B.-W. U, S. Zhang, K. C. Curtis and G. J. We'll

82 Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in children
T. G. Boyce, W. C. Gruber, S. D. Coleman-Dockery, E. C. Sannella, G. W. Reed, M. Wolff and P. F. Wright

89 Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice
C. A. Moreno, Ft. Rodriguez, G. A. Oliveira, V. Ferreira, R. S. Nussenzweig, Z. R. Moya Castro, J. M. Calvo-Calle and E. Nardin

100 A population-based study on tetanus antitoxin levels in the Netherlands
H. E. de Melker, S. van den Hof, G. A. M. Berbers, N. J. D. Nagelkerke, H. C. Ftumke and M. A. E. Conyn-van Spaendonck

109 Evaluation of a 74-kDa transferrin-binding protein from Moraxeila {Branhamella) catarrhalis as a vaccine candidate
D. Chen, J. C. McMichael, K. Ft. VanDerMeid, A. W. Masi, E. Bortell, J. D. Caplan, D. N. Chakravarti and V. L. Barniak

119 AIDS vaccination studies using feline immunodeficiency virus as a model: immunisation with inactivated whole virus suppresses
viraemia levels following intravaginal challenge with infected cells but not following intravenous challenge with cell-free virus
D. Matteucci, M. Pistello, P. Mazzetti, S. Giannecchini, P. Isola, A. Merico, L. Zaccaro, A. Rizzuti and M. Bendinelli

131 Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from
Neisseria meningitidis class 1 porin
M. Christodoulides, E. Ftattue and J. E. Heckels

140 Novel aggregate structure adjuvants modulate lymphocyte proliferation and Thi and Th2 cytokine profiles in ovalbumin
immunized mice
P. Rajananthanan, G. S. Attard, N. A. Sheikh and W. J. W. Morrow


153 Expression of a recombinant form of the V antigen of Yersinia pestis, using three different expression systems
S. Carr, J. Miller, S. E. C. Leary, A. M. Bennett, A. Ho and E. D. Williamson


160 Safety and immunogenicity testing of an intranasal group B meningococcal native outer membrane vesicle vaccine in healthy
volunteers
J. J. Drabick, S. L Brandt, E. E. Moran, N. B. Saunders, D. R. Shoemaker and W. D. Zollinger


173 Prolonged expression of IFN)' induced by protective blood-stage immunization against Plasmodium yoelii malaria
P. S. Patterson, S. C. Bosshardt, V. Udhayukumar, L. Xiao, M. Kidd, R. L. Hunter and A. A. Lal

181 Immunogenicity of an inactivated Rift Valley fever vaccine in humans: a 12-year experience
P. Ft. Pittman, C. T. Uu, T. L. Cannon, R. S. Makuch, J. A. Mangiafico, P. H. Gibbs and C. J. Peters

190 Enhancement of the immune response to poorly immunogenic gangliosides after incorporation into very small size
proteoliposomes (VSSP)
F. Estevez, A. Carr, L. Solorzano, 0. Valiente, C. Mesa, 0. Barroso, G. Victoriano Sierra and L. E. Femandez

198 Patent Report

201 Erratum